Latest & greatest articles for acetaminophen

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acetaminophen or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on acetaminophen and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for acetaminophen

1. Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial. (Abstract)

Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial. Opioid-induced ventilatory depression and hypoxemia is common, severe, and often unrecognized in postoperative patients. To the extent that nonopioid analgesics reduce opioid consumption, they may decrease postoperative hypoxemia.To test the hypothesis that duration of hypoxemia is less in patients given intravenous acetaminophen than those given placebo.Randomized (...) , placebo-controlled, double-blind trial conducted at 2 US academic hospitals among 570 patients who were undergoing abdominal surgery, enrolled from February 2015 through October 2018 and followed up until February 2019.Participants were randomized to receive either intravenous acetaminophen, 1 g (n = 289), or normal saline placebo (n = 291) starting at the beginning of surgery and repeated every 6 hours until 48 postoperative hours or hospital discharge, whichever occurred first.The primary outcome

2020 JAMA

2. Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial (Full text)

Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine (...) RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Pediatr Actions . 2020 Jul;222:79-84.e2. doi: 10.1016/j.jpeds.2020.01.058. Epub 2020 Apr 24. Oral Paracetamol vs Oral Ibuprofen in Patent Ductus Arteriosus: A Randomized, Controlled, Noninferiority Trial , , , , , , , , , , Affiliations Expand Affiliations 1 Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Pediatrics, Research

2020 EvidenceUpdates PubMed abstract

3. Comparing the analgesic effect of intravenous paracetamol with morphine on patients with renal colic pain: A meta-analysis of randomized controlled studies

Comparing the analgesic effect of intravenous paracetamol with morphine on patients with renal colic pain: A meta-analysis of randomized controlled studies Comparing the Analgesic Effect of Intravenous Paracetamol With Morphine on Patients With Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Review Am J Emerg Med Actions . 2020 Apr 2;S0735-6757(20)30217-5. doi: 10.1016/j.ajem.2020.03.061. Online ahead of print. Comparing the Analgesic Effect of Intravenous Paracetamol With Morphine on Patients With Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies , , , Affiliations Expand Affiliations 1 Department

2020 EvidenceUpdates

4. Acetaminophen vs. NSAIDs during COVID-19 pandemic

and clinical recommendations for COVID-19. We offer this common sense review about treating pain and fever for viral infections: Relieving fever and treating pain are comfort measures that can help people stay active and/or maintain good eating and sleeping patterns, but are NOT needed to shorten the duration of illness. Acetaminophen (generic and Tylenol, also the same as paracetamol and Panadol, etc.) can help some types of pain and can lower the temperature in fever. Follow package instructions and do (...) that ibuprofen or other NSAIDs are dangerous in COVID-19 infection, but for various reasons acetaminophen/paracetamol is generally the safest alternative to treat symptomatic fever or for mild pain. Thomas L. Perry MD, FRCPC Sick patients with COVID 19 pneumonia are being treated with fluid restriction. Adding NSAIDs would increase the risk of renal failure. Best to use acetaminophen or just nonpharmaceutical treatments like warm sponging and a fan. Leave a Reply Your email address will not be published

2020 Therapeutics Letter

5. Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. (Full text)

Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adverse events. In particular, incidence of wheezing and asthma among children taking paracetamol compared to ibuprofen, remain (...) unsettled.We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen. A comprehensive search was conducted in five databases. RCTs reporting on cases of wheezing or asthma exacerbations in infants or children after the administration of paracetamol or ibuprofen were included. The pooled effect size was estimated using the Peto's odds ratio.Five RCTs with 85,095 children were included in the analysis

2020 BMC pulmonary medicine PubMed abstract

6. Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis. (Full text)

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis. Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease. Although some studies have suggested a risk of renal impairment after the use of acetaminophen, the effect of acetaminophen on the risk of renal impairment is unclear. The purpose of this research was to demonstrate any correlation linking (...) acetaminophen treatment and renal impairment.We performed a systematic review and meta-analysis of the association between acetaminophen and renal impairment in adults by searching Cochrane Library, PubMed, and Embase databases from initiation to June 16, 2019.Of 13,097 articles identified, 5 studies (2 cohort studies and 3 case-control studies) with a total of 13,114 participants were included. In the random-effects meta-analysis of the cohort study, acetaminophen use was shown to have statistically

2020 Kidney research and clinical practice PubMed abstract

7. Randomized Clinical Trial of IV Acetaminophen as an Adjunct to IV Hydromorphone for Acute Severe Pain in Emergency Department Patients

, David F, Scholl L. Increases in drug and opioid-involved overdose deaths United States, 2010-2015. MMWR Morb Mortal Wkly Rep 2016;65:1445-52. Skinner HB. Multimodal acute pain management. Am J Orthop 2004;33:5-9. McNicol ED, Ferguson MC, Haroutounian S, Carr DB, Schumann R. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev 2016;(5):CD007125. Chang AK, Bijur PE, Ata A, et al. Randomized clinical trial of intravenous acetaminophen (...) Randomized Clinical Trial of IV Acetaminophen as an Adjunct to IV Hydromorphone for Acute Severe Pain in Emergency Department Patients Randomized Clinical Trial of Intravenous (IV) Acetaminophen as an Adjunct to IV Hydromorphone for Acute Severe Pain in Emergency Department Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several

2020 EvidenceUpdates

8. Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. (Full text)

Efficacy and safety of modified-release paracetamol for acute and chronic pain: a systematic review protocol. Paracetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever. It is available as immediate release (IR) and modified-release (MR) formulation. In 2017, European Medicines Agency recommended a suspension of marketing of MR paracetamol in the European Union. Benefit-risk balance of these products has been assessed as negative as data showed (...) that existing procedures for overdose management may not be efficient. Since MR paracetamol is still available in other countries (Australia and USA) and there is no available systematic review (SR) of efficacy and safety of MR paracetamol in the literature, we have decided to perform one to evaluate available data from randomised clinical trials (RCTs).Using predefined search criteria, we will search EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and WHO International

2020 BMJ open PubMed abstract

9. Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis. (Full text)

Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis. Background: Indomethacin and ibuprofen, two commonly used prostaglandin inhibitors, are the drugs of choice for patent ductus arteriosus. However, paracetamol is an alternative choice when these drugs are ineffective or contraindicated. This study aimed to confirm paracetamol's efficacy and safety compared with those of other drugs or placebos for patent (...) qualitative summaries or meta-analyses. Results: The final analyses included 15 trials (N = 1,313). No significant differences were noted between paracetamol and ibuprofen except for shorter mean days needed for patent ductus arteriosus closure, lower risk of gastrointestinal bleeding, and hyperbilirubinemia. No significant difference existed between paracetamol and indomethacin. Oral paracetamol was more effective than placebo in infants weighing 1,501-2,500 g. Conclusions: Our study findings tentatively

2020 Frontiers in pediatrics PubMed abstract

10. Intravenous Acetaminophen (Paracetamol) for Postcraniotomy Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials. (Abstract)

Intravenous Acetaminophen (Paracetamol) for Postcraniotomy Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Acute pain control after supratentorial craniotomy is considered among the most important indicators of postoperative recovery. The aim of this study was to determine the effects of intravenous acetaminophen on postcraniotomy pain.We searched databases including Embase, Scopus, Medline, Cochrane Library, and Web of Science until April 2019. Cochran Q test and I2 (...) of stay (SMD, -0.04; 95% CI, -0.24 to 0.16; P = 0.69; I2 = 0.0%) did not significantly change after paracetamol intake.The results of this systematic review and meta-analysis indicate that preoperative intravenous administration of acetaminophen is associated with decreased postoperative pain, need for rescue analgesics, and dosages of analgesics after craniotomy surgery.Copyright © 2019 Elsevier Inc. All rights reserved.

2020 World neurosurgery

11. Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis. (Abstract)

Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis. Acetaminophen is a widely used medication for fever and pain management during pregnancy. However, recent studies have found a possible connection between maternal prenatal acetaminophen use and attention deficit/hyperactivity disorder in children.We aimed to explore the association between maternal acetaminophen use during pregnancy and the risk (...) of attention deficit/hyperactivity disorder in offspring.PubMed, Embase, Web of Science and Cochrane Library were searched from their initial publications through November 2018 for studies.We included all studies that examined the association between maternal acetaminophen use during pregnancy and the risk of attention deficit/hyperactivity disorder in offspring if the authors reported odds ratios, risk ratios, hazard ratios, regression coefficient, standard error and 95% confidence intervals.Two reviewers

2020 The Australian and New Zealand journal of psychiatry

12. Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children. (Full text)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children. Background: Ibuprofen and paracetamol are the only antipyretics recommended in febrile children. According to international guidelines the choice of the drug should rely on the child's individual characteristics, while a controversial issue regards the combined or alternate use of the two drugs. Objective: To compare the efficacy and safety of combined (...) or alternating use of ibuprofen and paracetamol in children. Methods: A systematic review of literature was performed on Medline and Embase databases. The included studies were randomized controlled trials analyzing the efficacy of combined or alternating therapy with antipyretics in febrile children vs. monotherapy. A meta-analysis was performed to measure the effect of treatment on child's temperature and discomfort. Adverse effects were analyzed as secondary outcome. Results: Nine studies were included

2020 Frontiers in pediatrics PubMed abstract

13. Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials. (Full text)

Increasing Nonsteroidal Anti-inflammatory Drugs and Reducing Opioids or Paracetamol in the Management of Acute Renal Colic: Based on Three-Stage Study Design of Network Meta-Analysis of Randomized Controlled Trials. Background: Currently, although non-steroidal anti-inflammatory drugs (NSAIDs) were recommended for acute renal colic in the 2018 European Association of Urology guidelines, there are no specific NSAIDs and no specific routes of administration in this guideline. The clinical (...) practice of advocating intravenous opioids as the initial analgesia is still common out of the fear of adverse events from NSAIDs. Objectives: To comprehensively assess the efficacy and safety of NSAIDs, opioids, paracetamol, and combination therapy for acute renal colic. Methods: Ovid MEDLINE, Ovid EMbase, the Cochrane Library, Clinical Trials Registry Platform for Clinicaltrials.gov, and WHO International Clinical Trials Registry Platform were searched through February 2, 2018. Two reviewers selected

2020 Frontiers in pharmacology PubMed abstract

14. A Meta-Analysis of the Utility of Preoperative Intravenous Paracetamol for Post-Caesarean Analgesia. (Full text)

. Materials andMethods: By using the keywords (paracetamol OR acetaminophen) AND [cesarea* OR caesarea* OR cesaria* OR caesaria*], a systematic literature search was conducted using PubMed, Medline, Embase, Google Scholar and ClinicalTrials.gov databases for papers published in English between January 1, 1960 and March 1, 2019. Grey literature was searched as well. Results: Seven clinical trials were reviewed, while five randomized, placebo-controlled, double-blind studies were included in the final meta (...) A Meta-Analysis of the Utility of Preoperative Intravenous Paracetamol for Post-Caesarean Analgesia. Backgroundand objectives: Worldwide, the number of caesarean sections performed has increased exponentially. Some studies have reported better pain control and lower postoperative requirements for opioids when intravenous (IV) paracetamol was administered preoperatively. This meta-analysis thus aimed to investigate the utility of preoperative IV paracetamol for post-caesarean analgesia

2020 Medicina (Kaunas, Lithuania) PubMed abstract

15. Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study (Abstract)

Ibuprofen Plus Acetaminophen Versus Ibuprofen Alone for Acute Low Back Pain: An Emergency Department-based Randomized Study Patients with low back pain (LBP) are often treated with nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are modestly effective for LBP, but many patients with LBP continue to suffer despite treatment with these medications. We compared pain and functional outcomes 1 week after emergency department (ED) discharge among patients randomized to a 1-week course (...) of ibuprofen plus acetaminophen versus ibuprofen plus placebo.This was a randomized, double-blind study conducted in two urban EDs. Patients presenting with acute, nontraumatic, nonradicular LBP of no more than 2 weeks' duration were eligible for enrollment immediately prior to discharge from an ED if they had a score > 5 on the Roland Morris Disability Questionnaire (RMDQ), a 24-item validated instrument, indicating more than minimal functional impairment. All patients were given a standardized 10-minute

2020 EvidenceUpdates

16. Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. (Abstract)

Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. Newborn infants have the ability to experience pain. Hospitalised infants are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests.To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain (...) or pain associated with clinical conditions in neonates. To review the effects of various doses and routes of administration (enteral, intravenous or rectal) of paracetamol for the prevention or treatment of pain in neonates.We used the standard search strategy of the Cochrane Neonatal Review group to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 4), MEDLINE via PubMed (1966 to 9 May 2016), Embase (1980 to 9 May 2016), and CINAHL (1982 to 9 May 2016). We searched

2020 Cochrane

17. Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. (Abstract)

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal (...) or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported.To determine the effectiveness and safety of intravenous or oral paracetamol compared with placebo or no intervention, intravenous indomethacin, intravenous or oral ibuprofen, or with other cyclo-oxygenase inhibitors for treatment of an echocardiographically diagnosed PDA in preterm or low birth weight infants.We used the standard search strategy of Cochrane Neonatal to search the Cochrane

2020 Cochrane

18. Achilles tendinopathy: Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)

Achilles tendinopathy: Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) Paracetamol and NSAIDs | Prescribing information | Achilles tendinopathy | CKS | NICE Search CKS… Menu Paracetamol and NSAIDs Achilles tendinopathy: Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) Last revised in June 2020 Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) For detailed prescribing information on paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs), see the CKS

2020 NICE Clinical Knowledge Summaries

19. Post-herpetic neuralgia: Paracetamol and codeine

Post-herpetic neuralgia: Paracetamol and codeine Paracetamol and codeine | Prescribing information | Post-herpetic neuralgia | CKS | NICE Search CKS… Menu Paracetamol and codeine Post-herpetic neuralgia: Paracetamol and codeine Last revised in July 2017 Paracetamol and codeine For detailed prescribing information on paracetamol and codeine, please see the CKS topic on . © .

2020 NICE Clinical Knowledge Summaries

20. Association of acetaminophen exposure with increased risk of eczema in children: A meta-analysis. (Full text)

Association of acetaminophen exposure with increased risk of eczema in children: A meta-analysis. 30991122 2019 12 20 2019 12 20 1097-6787 81 2 2019 08 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. Association of acetaminophen exposure with increased risk of eczema in children: A meta-analysis. 642-644 S0190-9622(19)30603-6 10.1016/j.jaad.2019.04.017 Xiao Dongqiong D Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key (...) ), Ministry of Education, Chengdu, China. Electronic address: mudz@scu.edu.cn. eng Letter Meta-Analysis Review 2019 04 13 United States J Am Acad Dermatol 7907132 0190-9622 0 Analgesics, Non-Narcotic 362O9ITL9D Acetaminophen IM Acetaminophen administration & dosage therapeutic use Adolescent Analgesics, Non-Narcotic administration & dosage therapeutic use Child Child, Preschool Eczema epidemiology Humans Risk Factors 2018 12 10 2019 03 28 2019 04 10 2019 4 17 6 0 2019 12 21 6 0 2019 4 17 6 0 ppublish

2019 Journal of the American Academy of Dermatology PubMed abstract