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Latest & greatest articles for acne
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on acne or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on acne and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
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Acne treatment and clinical papers
Acne is a common skin condition characterised by whiteheads (or blackheads), pimples and oily skin. It can lead to possible scarring. It is typically caused when hair follicles become inflamed and the sebaceous glands in the skin are overactive. The over production of sebum and a combination of dead skin cells and dirt can clog follicles and pores causing a break out. Acne can affect any age group but it’s more common in adolescents.
There are many ways to treat acne depending on the severity of the case. Treatments include a range of medications such as topical retinoids, antibiotics and in severe cases isotretinoin is prescribed. Research is ongoing to determine the side effects and harms caused by these drugs. Clinical trials and studies are vital to assess treatment.
The Trip Database has an extensive collection of articles on acne ranging from clinical trials, systematic reviews, clinical guidelines and case reports. These can be found via searching the site.
Clascoterone (Winlevi) - acne Drug Approval Package: WINLEVI U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: WINLEVI Company: Cassiopea SpA Application Number: 213433 Approval Date: 8/26/2020 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) Date created: September 29, 2020
Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome. Metformin has been proposed as possibly a safer and more effective long-term treatment than the oral contraceptive pill (OCP) in women with polycystic ovary syndrome (PCOS). It is important to directly compare the efficacy and safety of metformin versus OCP in the long-term treatment of women with PCOS. This is an update of a Cochrane Review comparing insulin
New advice from the MHRA regarding cyproterone acetate: how does this affect prescribing of Co-cyprindiol/Dianette® for acne/hirsutism? July 2020 1 FSRH CEU Statement : New advice from the MHRA regarding cyproterone acetate: how does this affect prescribing of Co-cyprindiol/Dianette ® for acne/hirsutism? 13 July 2020 Background New data from a French cohort study  indicate that use of high dose cyproterone acetate (high dose products contain 50-100mg per tablet) is associated (...) acetate with ethinylestradiol Co-cyprindiol/Dianette ® tablets containing cyproterone acetate with ethinylestradiol are used for treatment of acne and hirsutism in women of reproductive age. In contrast to the high dose products described above, they contain only 2mg of cyproterone acetate; annual cumulative exposure to cyproterone acetate is only about 0.8g. The Yellow Card scheme has received no reports of meningioma associated with use of these low-dose products. The MHRA advises that although
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. Acne is an inflammatory disorder with a high global burden. It is common in adolescents and primarily affects sebaceous gland-rich areas. The clinical benefit of the topical acne treatments azelaic acid, salicylic acid, nicotinamide, sulphur, zinc, and alpha-hydroxy acid is unclear.To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha (...) -hydroxy acid, and sulphur) for acne.We searched the following databases up to May 2019: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trials registers.Clinical randomised controlled trials of the six topical treatments compared with other topical treatments, placebo, or no treatment in people with acne.We used standard methodological procedures expected by Cochrane. Key outcomes included participants' global self-assessment of acne
Association between circulating adipokines and acnevulgaris: A systematic review and meta-analysis. 30957881 2020 04 24 2020 04 24 1440-0960 60 4 2019 Nov The Australasian journal of dermatology Australas. J. Dermatol. Association between circulating adipokines and acnevulgaris: A systematic review and meta-analysis. e361-e364 10.1111/ajd.13035 Chang Hua-Ching HC https://orcid.org/0000-0003-3608-1394 Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan. Lin Ming-Hsiu (...) 0135232 0004-8380 0 Adiponectin 0 Biomarkers 0 Leptin IM AcneVulgaris blood diagnosis epidemiology physiopathology Adiponectin blood Adolescent Adult Age Factors Biomarkers blood Disease Progression Female Humans Leptin blood Male Prognosis Sensitivity and Specificity Severity of Illness Index Sex Factors Young Adult 2019 4 9 6 0 2020 4 25 6 0 2019 4 9 6 0 ppublish 30957881 10.1111/ajd.13035
External Application of Herbal Medicines for AcneVulgaris: A Systematic Review and Meta Analysis. The objective of this systematic review is to critically evaluate the evidence of the effectiveness and safety of external application of herbal medicines (EAHM) for acne vurgalis (AV).English, Chinese and Korean language databases were searched up to May 2018. Randomized clinical trials (RCTs) that reported the effects of EAHM for AV were included and analysed.A total of 10 randomized trials (...) with 656 AV patients were identified. A meta-analysis of two RCTs indicated that EAHM had a significant effect on improving primary outcome 'global assessment' compared with placebo (mean difference (MD) = -2.62, confidence interval (CI) = -4.84 to -0.40, p = 0.02). Furthermore, data extracted from two RCTs showed that EAHM significantly reduce primary outcome 'inflammatory lesion count of acne' (MD = -1.25, CI = -1.68 to -0.83, p < 0.00001) and 'non-inflammatory lesion count of acne' (MD = -1.32, CI
Prevention of Cutibacterium acnes infection in arthroscopic shoulder surgery: a systematic review. Cutibacterium acnes is a gram-positive anaerobe that can lead to postoperative shoulder infections. The purpose of this study was to determine the incidence of C acnes infections following shoulder arthroscopy and evaluate the efficacy of perioperative antibiotic prophylaxis in the prevention of these infections.A systematic review was performed by searching PubMed, the Cochrane Library (...) , and Embase to identify studies that evaluated the prevalence and clinical indications of C acnes infections after various arthroscopic shoulder surgical procedures. Patients were assessed based on positive culture rates, the contraction of infection, and antibiotic regimens used to prevent infection.A total of 9 studies (1 level I, 5 level II, 1 level III, and 2 level IV) met the inclusion criteria, including a total of 3758 patients with a mean age of 59.9 years (range, 17-87 years) at the time
Platelet-rich plasma in noninvasive procedures for atrophic acne scars: A systematic review and meta-analysis. The use of platelet-rich plasma (PRP) combined with noninvasive, nonenergy procedures for atrophic acne scars has shown promise. To date, there has not been a systematic review or meta-analysis of the effectiveness of this therapy.To use meta-analysis to compare Goodman and Baron qualitative scores, patient satisfaction outcomes, and adverse effects in patients undergoing combination (...) procedures with PRP, combination procedures without PRP, and noninvasive monotherapy without PRP in the treatment of patients with atrophic acne scars.The Pubmed and Cochrane library databases were searched for relevant studies published before May 1, 2019. PRISMA guidelines were utilized. Studies that compared the use of PRP in combination with a noninvasive procedure and therapies without PRP for the treatment of atrophic acne scars were included. Cochrane's handbook was utilized to assess
Systematic review of the epidemiology of acnevulgaris. A systematic review was conducted on epidemiology studies on acne obtained from a Web of Science search to study risk factors associated with acne presentation and severity. A strong association was observed between several risk factors - family history, age, BMI and skin type - and acne presentation or severity in multiple studies. The pooled odds ratio of 2.36 (95% CI 1.97-2.83) for overweight/obese BMI with reference to normal (...) /underweight BMI and the pooled odds ratio of 2.91 (95% CI 2.58-3.28) for family history in parents with reference to no family history in parents demonstrate this strong association. In addition, a pooled odds ratio of 1.07 (95% CI 0.42-2.71) was obtained for sex (males with reference to females). However, the association between other factors, such as dietary factors and smoking, and acne presentation or severity was less clear, with inconsistent results between studies. Thus, further research
Trifarotene (Aklief) - topical treatment of acnevulgaris Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs written for approved after September 1
Topical benzoyl peroxide for acne. Acne is a common, economically burdensome condition that can cause psychological harm and, potentially, scarring. Topical benzoyl peroxide (BPO) is a widely used acne treatment; however, its efficacy and safety have not been clearly evaluated.To assess the effects of BPO for acne.We searched the following databases up to February 2019: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trials registers (...) and checked the reference lists of relevant randomised controlled trials (RCTs) and systematic reviews.We included RCTs that compared topical BPO used alone (including different formulations and concentrations of BPO) or as part of combination treatment against placebo, no treatment, or other active topical medications for clinically diagnosed acne (used alone or in combination with other topical drugs not containing BPO) on the face or trunk.We used standard methodological procedures as expected
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. Acnevulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association (...) the pilosebaceous unit, is a critical aspect of the genetic predisposition to severe acne.
Efficacy of photodynamic therapy for the treatment of inflammatory acnevulgaris: A systematic review and meta-analysis. Photodynamic therapy (PDT) has emerged as the effective new method to treat acnevulgaris. However, no meta-analysis has been published on PDT for acnevulgaris currently.The current meta-analysis and systematic review were carried out to assess the safety and effect of PDT on treating acne vulgaris.The electronic databases, including EMBASE, Cochrane Library, and MEDLINE (...) , were systemically retrieved to identify relevant articles for meta-analysis. The primary outcome included mean percentage reduction in the inflammatory lesion count (MPRILC), while the secondary outcome included the total effective response (TER).Altogether 13 randomized controlled trials (RCTs) involving 701 subjects had been enrolled into the current meta-analysis. PDT had certain effect on acnevulgaris in terms of the outcomes of MPRILC (MD: 15.97, 95% CI: 11.93 to 20.00, P < .00001) and TER
A systematic review of treatments for acne scarring. Part 2: Energy-based techniques. Acne scarring is a very common problem, which can be extensive, and may lead to significant psychosocial morbidity. Multiple types of treatments are used to ameliorate atrophic scars with varying degrees of success. This paper provides an overview of the various energy-based modalities that are commonly employed against acne scarring.A comprehensive literature search of papers published since 2008 (...) was performed in order to determine the efficacy and adverse reactions of commonly used energy-based treatments against post-acne scarring.A total of 59 relevant articles were identified covering a multitude of different devices.Ablative lasers seem to achieve the highest degree of efficacy, albeit this is associated with significant pain and downtime, and the risk for long-term pigmentary changes. Non-ablative fractional photothermolysis (FP) has a much safer profile but cannot achieve as good cosmetic
Efficacy of Autologous Platelet-Rich Plasma Combined With Ablative Fractional Carbon Dioxide Laser for Acne Scars: A Systematic Review and Meta-Analysis. Acne scars are common and challenging clinical complications of acnevulgaris. Ablative fractional carbon dioxide (CO2) laser is a well-established treatment for acne scars; however, some postlaser adverse effects have been noted. Autologous platelet-rich plasma (PRP) can improve tissue regeneration. Several studies have investigated (...) the efficacy of combination therapy of CO2 laser and PRP for acne scars.The authors sought to conduct a meta-analysis of the efficacy of PRP combined with ablative fractional CO2 laser for treating acne scars by examining clinical trial results.A systematic review was performed by searching PubMed, Embase, Cochrane Library, and Web of Science, and a meta-analysis was conducted to assess the clinical outcomes after combination therapy of PRP and ablative fractional CO2 laser compared with laser alone.We
Acnevulgaris and risk of depression and anxiety: A meta-analytic review. Several studies have shown an association of acnevulgaris with depression and anxiety but a quantitative review has not yet been conducted.To conduct a systematic review and meta-analysis that elucidates the association of acnevulgaris with depression and anxiety.A systematic review and meta-analysis of literature published prior to October 1, 2019 from PubMed, PsycINFO, MEDLINE, and Cochrane databases was conducted. We (...) used a meta-analytic approach to perform a random effects analysis comparing individuals with and without acne. Subgroup analyses between studies included age, study setting, and geographic region.In all, 42 studies were included. We found a significant association of acnevulgaris with depression, r = 0.22 (95% CI: 0.17-0.26, p < .00001), and anxiety, r = 0.25 (95% CI: 0.19-0.31, p < .00001). Subgroup analyses and comparisons showed moderating influences based on factors including age, study
A Meta-analysis of the Evidence for Assisted Therapy with Platelet-Rich Plasma for Atrophic Acne Scars. A number of studies have investigated the role of platelet-rich plasma (PRP) as an assisted therapy for atrophic acne scars. However, the results are diverse, and no up-to-date meta-analysis was found that exclusively examined atrophic acne scar treatment.To perform a meta-analysis to assess improvements in the side effects of PRP and the effect of assisted therapy for atrophic acne (...) monitored side effects, including erythema and edema (in days), in the PRP groups; however, no significance was found.This review shows that PRP is a useful assisted therapy for atrophic acne scars, which can achieve better improvement.This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Homocysteine, folic acid, and vitamin B12 levels in patients on isotretinoin therapy for acnevulgaris: A meta-analysis. Oral isotretinoin (Iso) is one of the most commonly used drugs for patients with moderate-to-severe acne; however, its use has been associated with several adverse effects. Some studies have suggested an association between Iso therapy and homocysteine (Hcy), folic acid, and vitamin B12 plasma levels.To evaluate the changes in plasma Hcy, folic acid, and vitamin B12 levels (...) during Iso therapy for acne using meta-analytic methods.Five scientific databases (MEDLINE, EMBASE, Cochrane Library, SCOPUS, and Web of Science) were searched according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines up to December 2018. A review of 734 publications identified 10 studies that assessed plasma levels of Hcy, folic acid, and vitamin B12 during Iso therapy in acne patients.A total of 10 studies consisting of 592 patients were included
Vitamin D deficiency in patients with acnevulgaris: A systematic review and meta-analysis. 31578053 2020 02 12 1440-0960 61 1 2020 Feb The Australasian journal of dermatology Australas. J. Dermatol. Vitamin D deficiency in patients with acnevulgaris: A systematic review and meta-analysis. e146-e149 10.1111/ajd.13165 Acharya Prakash P https://orcid.org/0000-0003-2040-9199 Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal. Mathur Mahesh M https://orcid.org/0000-0001-7831