and four evidence based guidelines were identified regarding the use of antibiotics for acute asthma exacerbations. Tags asthma, amoxicillin, anti-bacterial agents, azithromycin, cefazolin, cefuroxime, clindamycin, erythromycin, fluoroquinolones, penicillins, vancomycin, Asthma, Asthmas, asthmatic, asthmatics, Severe, acute, exacerbation, Antibiotic, Antibiotics, anti-bacterial Files Rapid Response Summary of Abstracts Published : March 23, 2017 Related Content Follow us: © 2019 Canadian Agency (...) Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines | CADTH.ca Find the information you need Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Antibiotics for Acute Asthma Exacerbations: Clinical Effectiveness, Cost-Effectiveness, and Guidelines Published on: March 23, 2017 Project Number

Lungs deposition and pharmacokinetic study of submicron budesonide particles in Wistar rats intended for immediate effect in asthma The purpose of the present investigation was to study the aerosolization, lungs deposition and pharmacokinetic study of inhalable submicron particles of budesonide in male Wistar rats. Submicron particles were prepared by antisolvent nanoprecipitation method and freeze-dried to obtain free flowing powder. The freeze-drying process yielded dry powder with desirable

SQ HDM SLIT-tablet for house dust mite allergic asthma SQ HDM SLIT-tablet for house dust mite allergic asthma | Innovation Observatory toggle menu Menu Search View All Filter by Speciality Filter by Year Filter by Category This search function provides links to outputs produced by NIHR Innovation Observatory. These are briefing notes or reports on new or repurposed technologies. This search will not return all technologies currently in development as these outputs are produced as required (...) for our stakeholders. > > > SQ HDM SLIT-tablet for house dust mite allergic asthma SQ HDM SLIT-tablet for house dust mite allergic asthma March 2017 Innovation Observatory Voice Leave a Reply Your email address will not be published. Required fields are marked * Post Comment Name * Email * Website PDF Report Connect to the Innovation Observatory Twitter Related Posts October 2018 Apremilast works by suppressing the activity of inflammatory pathway caused by molecules such as interleukins and tumour

Asthma in adolescence affects daily life and school attendance – Two cross‐sectional population‐based studies 10 years apart The aim of this study was to study the impact of asthma on daily life, school absenteeism and physical education. In addition, to describe asthma triggers at school.Two cross-sectional population-based studies ten years apart.Within the OLIN-studies, in 2003 (n = 3,327) and in 2013 (n = 2,345) adolescents (14-15 years) answered an expanded ISAAC questionnaire (...) . Of these, 8% and 11%, respectively with current asthma participated in this study.Between the years 2003-2013, the proportion of adolescents reporting that asthma interfered with daily life had increased, in 2013, girls were significantly more affected than boys. The proportion reporting a worsening of asthma at school had decreased, but it was still over a quarter. The proportion of absenteeism from school and from physical education was at the same level both years. Asthma triggers were described

Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial. Professionally delivered integrated pest management (IPM) interventions can reduce home mouse allergen concentrations, but whether they reduce asthma morbidity among mouse-sensitized and exposed children and adolescents is unknown.To determine the effect of an IPM intervention on asthma morbidity among mouse-sensitized and exposed (...) children and adolescents with asthma.Randomized clinical trial conducted in Baltimore, Maryland, and Boston, Massachusetts. Participants were mouse-sensitized and exposed children and adolescents (aged 5-17 years) with asthma randomized to receive professionally delivered IPM plus pest management education or pest management education alone. Enrollment occurred between May 2010 and August 2014; the final follow-up visit occurred on September 25, 2015.Integrated pest management consisted of application

Mepolizumab for treating severe refractory eosinophilic asthma Mepolizumab for treating se Mepolizumab for treating sev vere ere refr refractory eosinophilic asthma actory eosinophilic asthma T echnology appraisal guidance Published: 25 January 2017 nice.org.uk/guidance/ta431 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility The recommendations in this guidance represent (...) inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Mepolizumab for treating severe refractory eosinophilic asthma (TA431) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 29Contents Contents 1 Recommendations 4 2 The technology 5 3

Nitric oxide breath analysis for the management of asthma Nitric oxide breath analysis for the management of asthma Nitric oxide breath analysis for the management of asthma HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Nitric oxide breath analysis for the management of asthma. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors (...) ' objectives The measurement of nitric oxide (NO) concentration in expired breath has been introduced as an adjunct to or replacement for established clinical and laboratory assessments of asthma control to guide the management of asthma. Measurement of fractional exhaled nitric oxide (FENO) is a noninvasive diagnostic technique. The NO molecules exhaled in breath can be measured using a handheld electrochemical sensor or a large, stationary chemiluminescence gas analyzer. Controversy: NO, which

Nitric oxide breath analysis for the diagnosis of asthma Nitric oxide breath analysis for the diagnosis of asthma Nitric oxide breath analysis for the diagnosis of asthma HAYES, Inc Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc. Nitric oxide breath analysis for the diagnosis of asthma. Lansdale: HAYES, Inc. Directory Publication. 2016 Authors (...) ' objectives The measurement of nitric oxide (NO) concentration in expired breath has been introduced as an adjunct to or replacement for the established clinical and laboratory assessments for the diagnosis of asthma. Measurement of fractional exhaled nitric oxide (FENO) is a noninvasive diagnostic technique. The NO molecules exhaled in breath can be measured using a handheld electrochemical sensor or a large, stationary chemiluminescence gas analyzer. Controversy: NO, which is normally produced

Australian Asthma Handbook Australian Asthma Handbook | Australian Asthma Handbook Know what you're looking for? Australia's National Guidelines for Asthma Management The Australian Asthma Handbook provides best-practice, evidence-based guidance translated into practical advice for primary care health professionals. The Handbook is proudly published by Australia's lead asthma authority, the National Asthma Council Australia. Australian Asthma Handbook v2.0 Version 2.0 continues to set (...) the standard for practical, evidence-based advice for primary care chronic disease management. To learn more about the latest update, visit the Version 2.0 . National Asthma Council Australia We are the national authority for asthma knowledge, setting the standard for asthma care. For more health professional resources and education, visit The Australian Asthma Handbook has been officially endorsed by: Stay up to date Join our health professional community and stay informed on Handbook updates Disclaimer

Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma. Although asthma is a chronic disease, the expected rate of spontaneous remissions of adult asthma and the stability of diagnosis are unknown.To determine whether a diagnosis of current asthma could be ruled out and asthma medications safely stopped in randomly selected adults with physician-diagnosed asthma.A prospective, multicenter cohort study was conducted in 10 Canadian cities from January 2012 to February 2016. Random (...) digit dialing was used to recruit adult participants who reported a history of physician-diagnosed asthma established within the past 5 years. Participants using long-term oral steroids and participants unable to be tested using spirometry were excluded. Information from the diagnosing physician was obtained to determine how the diagnosis of asthma was originally made in the community. Of 1026 potential participants who fulfilled eligibility criteria during telephone screening, 701 (68.3%) agreed

Adult Asthma Care: Promoting Control of Asthma Clinical Best Practice Guidelines Adult Asthma Care: Promoting Control of Asthma Second Edition MAY 2017Disclaimer These guidelines are not binding on nurses or the organizations that employ them. The use of these guidelines should be flexible, and based on individual needs and local circumstances. They neither constitute a liability nor discharge from liability. While every effort has been made to ensure the accuracy of the contents at the time (...) , and published in its entirety, without modification, in any form, including in electronic form, for educational or non-commercial purposes. Should any adaptation of the material be required for any reason, written permission must be obtained from RNAO. Appropriate credit or citation must appear on all copied materials as follows: Registered Nurses’ Association of Ontario. (2017). Adult Asthma Care: Promoting Control of Asthma (2nd ed.). Toronto, ON: Registered Nurses’ Association of Ontario. This work

Mepolizumab (Nucala, GlaxoSmithKline plc.) for the Treatment of Severe Asthma with Eosinophilia: Effectiveness, Value, and Value-Based Price Benchmarks ©Institute for Clinical and Economic Review, 2016 Mepolizumab (Nucala®, GlaxoSmithKline plc.) for the Treatment of Severe Asthma with Eosinophilia: Effectiveness, Value, and Value- Based Price Benchmarks Final Report March 14, 2016 Institute for Clinical and Economic Review ©Institute for Clinical and Economic Review, 2016 Page i Final Report (...) . Public and Representative Private Insurer Coverage Policies 59 Appendix D. Previous Systematic Reviews and Technology Assessments 63 Appendix E. Ongoing Studies 64 Appendix F. Comparative Clinical Effectiveness Supplemental Information 66 Appendix G. Comparative Value Supplemental Information 70 Appendix H. Conflict of Interest Disclosures 73 ©Institute for Clinical and Economic Review, 2016 Page iv Final Report - Mepolizumab List of Acronyms Used in this Report ACQ Asthma Control Questionnaire ACT

A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma We present results from the first phase III trial of once-daily tiotropium add-on to inhaled corticosteroids (ICS) plus one or more controller therapies in adolescents with severe symptomatic asthma.In this double-blind, parallel-group trial (NCT01277523), 392 patients aged 12-17 years were randomised to receive once-daily tiotropium 5 µg or 2.5 µg, or placebo, as an add-on to ICS plus other controller (...) therapies over 12 weeks. The primary and key secondary end-points were change from baseline (response) in peak forced expiratory volume in 1 s (FEV1) within 3 h post-dosing (FEV1(0-3h)) and trough FEV1, respectively, after 12 weeks of treatment.Tiotropium 5 µg provided numerical improvements in peak FEV1(0-3h) response, compared with placebo (90 mL; p=0.104), and significant improvements were observed with tiotropium 2.5 µg (111 mL; p=0.046). Numerical improvements in trough FEV1 response and asthma

Smartinhaler for asthma Smartinhaler for asthma Smartinhaler for asthma Medtech innovation briefing Published: 11 January 2017 nice.org.uk/guidance/mib90 pathways Summary Summary The technology technology described in this briefing is Smartinhaler. It is a technology that monitors the activation of a person's asthma inhaler. This information is uploaded to a mobile or cloud-based application. The inno innovativ vative aspect e aspect is that this has the potential to allow real-time monitoring (...) of adherence to asthma treatments. This information can be used to give reminders and share data between patients and clinicians. The intended place in ther place in therap apy y would be for people with asthma in the community setting, together with personalised asthma plans and regular clinical review. The k ke ey points from the e y points from the evidence vidence summarised in this briefing are from 5 randomised controlled trials from the UK, Australia and New Zealand, including a total of 589 people

Randomised controlled trial: Possible protective effect of prenatal omega-3 long-chain polyunsaturated fatty acids supplementation on persistent wheeze and asthma in early childhood Possible protective effect of prenatal omega-3 long-chain polyunsaturated fatty acids supplementation on persistent wheeze and asthma in early childhood | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your (...) polyunsaturated fatty acids supplementation on persistent wheeze and asthma in early childhood Article Text Therapeutics/Prevention Randomised controlled trial Possible protective effect of prenatal omega-3 long-chain polyunsaturated fatty acids supplementation on persistent wheeze and asthma in early childhood Karen Best , Maria Makrides Statistics from Altmetric.com Commentary on: Bisgaard H, Stokholm J, Chawes BL, et al . Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. N Engl

Adult asthma care: promoting control of asthma, second edition. Adult asthma care: promoting control of asthma, second edition. | National Guideline Clearinghouse success fail JUN 10 2017 2018 2019 14 Apr 2018 - 12 Jul 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group (...) at . TIMESTAMPS Search Sign In Username or Email * Password * Remember Me Don't have an account? The AHRQ National Guideline Clearinghouse (NGC, guideline.gov) Web site will not be available after July 16, 2018 because federal funding through AHRQ will no longer be available to support the NGC as of that date. For additional information, read our . Guideline Summary NGC:011235 2017 May NEATS Assessment Adult asthma care: promoting control of asthma, second edition. Registered Nurses' Association of Ontario

Asthma: diagnosis, monitoring and chronic asthma management. Asthma: diagnosis, monitoring and chronic asthma management. | National Guideline Clearinghouse success fail May JUN Jul 09 2017 2018 2019 08 Jun 2018 - 09 Jun 2018 COLLECTED BY Organization: Formed in 2009, the Archive Team (not to be confused with the archive.org Archive-It Team) is a rogue archivist collective dedicated to saving copies of rapidly dying or deleted websites for the sake of history and digital heritage. The group (...) at . TIMESTAMPS Search Sign In Username or Email * Password * Remember Me Don't have an account? The AHRQ National Guideline Clearinghouse (NGC, guideline.gov) Web site will not be available after July 16, 2018 because federal funding through AHRQ will no longer be available to support the NGC as of that date. For additional information, read our . Guideline Summary NGC:011311 2017 Nov 29 NEATS Assessment Asthma: diagnosis, monitoring and chronic asthma management. National Guideline Centre. Asthma: diagnosis

Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. Reduced intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n-3 LCPUFAs in pregnant women on the risk of persistent wheeze and asthma in their offspring.We randomly assigned 736 pregnant women at 24 weeks of gestation to receive 2.4 g of n-3 LCPUFA (fish oil) or placebo (olive oil (...) ) per day. Their children formed the Copenhagen Prospective Studies on Asthma in Childhood2010 (COPSAC2010) cohort and were followed prospectively with extensive clinical phenotyping. Neither the investigators nor the participants were aware of group assignments during follow-up for the first 3 years of the children's lives, after which there was a 2-year follow-up period during which only the investigators were unaware of group assignments. The primary end point was persistent wheeze or asthma

Benefit of hospital pharmacy intervention on the current status of dry powder inhaler technique in patients with asthma and COPD: a study from the Central Development Region, Nepal The majority of patients with asthma and chronic obstructive pulmonary disease (COPD) have been known to perform inhaler technique inadequately. We aimed to evaluate the benefit of hospital pharmacy intervention on the current status of dry powder inhaler (Rotahaler®) technique in such patients and the factors (...) associated with the correct use.A pre-post interventional study was conducted at the outpatient pharmacy in a teaching hospital of the Central Development Region, Nepal, in patients with asthma and COPD currently using a Rotahaler device. Patients' demographics and Rotahaler technique were assessed before intervention. Those who failed to demonstrate the correct technique were educated and trained by the pharmacist, and their technique was reassessed after 2 weeks of intervention. Descriptive statistics

Patient- and parent-initiated oral steroids for asthma exacerbations. Asthma is a chronic inflammatory disease of the airways affecting an estimated 334 million people worldwide. During severe exacerbations, patients may need to attend a medical centre or hospital emergency department for treatment with systemic corticosteroids, which can be administered intravenously or orally. Some people with asthma are prescribed oral corticosteroids (OCS) for self-administration (i.e. patient-initiated (...) ) or to administer to their child with asthma (i.e. parent-initiated), in the event of an exacerbation. This approach to treatment is becoming increasingly common.To evaluate the effectiveness and safety of patient- or parent-initiated oral steroids for adults and children with asthma exacerbations.We identified trials from Cochrane Airways' Specialised Register (CASR) and also conducted a search of the US National Institutes of Health Ongoing Trials Register ClinicalTrials.gov (www.clinicaltrials.gov