Latest & greatest articles for asthma

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Top results for asthma

221. Bronchial thermoplasty for treatment of asthma

Bronchial thermoplasty for treatment of asthma Bronchial thermoplasty for treatment of asthma Bronchial thermoplasty for treatment of asthma HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Bronchial thermoplasty for treatment of asthma. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' conclusions Bronchial thermoplasty (...) is a minimally invasive treatment that uses heat to reduce the smooth muscle in the lungs that constricts the airway during asthma attacks. This procedure is intended for treatment of severe, persistent asthma in patients who are age 18 years or older and who have asthma that has not been well controlled by long-acting bronchodilators and inhaled corticosteroids. Relevant Questions: How effective is bronchial thermoplasty for asthma treatment? Is bronchial thermoplasty a safe treatment for asthma? Have

2016 Health Technology Assessment (HTA) Database.

222. Aerivio Spiromax (salmeterol xinafoate / fluticasone propionate) - Asthma or Pulmonary Disease, Chronic Obstructive

Aerivio Spiromax (salmeterol xinafoate / fluticasone propionate) - Asthma or Pulmonary Disease, Chronic Obstructive 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2016. Reproduction is authorised provided the source is acknowledged. 23 June 2016 EMA/486136/2016 Committee for Medicinal Products (...) : Aerivio Spiromax is indicated in adults aged 18 years and older. Asthma Aerivio Spiromax is indicated in the regular treatment of asthma where use of a combination product (inhaled corticosteroid and long-acting ß 2 -agonist) is appropriate: - patients not adequately controlled with inhaled corticosteroids and ‘as needed’ inhaled short acting ß 2 -agonist or - patients already adequately controlled on both inhaled corticosteroid and long-acting ß 2 -agonist. Chronic Obstructive Pulmonary Disease (COPD

2016 European Medicines Agency - EPARs

223. Airexar Spiromax (salmeterol / fluticasone propionate) - Asthma or Pulmonary Disease, Chronic Obstructive

Airexar Spiromax (salmeterol / fluticasone propionate) - Asthma or Pulmonary Disease, Chronic Obstructive 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 23 June 2016 EMA/486131/2016 Committee for Medicinal Products for Human Use (CHMP) Assessment report Airexar Spiromax International non-proprietary name: salmeterol (...) of patients at Community level. The application concerns a hybrid medicinal product as defined in Article 10(3) of Directive 2001/83/EC and refers to a reference product for which a marketing authorisation is or has been granted in a Member State on the basis of a complete dossier in accordance with Article 10b of Directive 2001/83/EC. The applicant applied for the following indication: Airexar Spiromax is indicated in adults aged 18 years and older. Asthma Airexar Spiromax is indicated in the regular

2016 European Medicines Agency - EPARs

224. Cinqaero (reslizumab) - Asthma

Cinqaero (reslizumab) - Asthma 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 23 June 2016 EMA/CHMP/481610/2016 Committee for Medicinal Products for Human Use (CHMP) Assessment report CINQAERO International non-proprietary name: reslizumab Procedure No. EMEA/H/C/003912/0000 Note Assessment report as adopted by the CHMP (...) /481610/2016 Page 3/108 3. Benefit-Risk Balance 100 4. Recommendations 107 Assessment report EMA/CHMP/481610/2016 Page 4/108 List of abbreviations % predicted FEV 1 actual FEV 1 divided by standard predicted FEV 1 times 100% ACQ Asthma Control Questionnaire ADA anti-drug antibody ADR adverse drug reaction AE(s) adverse event(s) ALT alanine aminotransferase ANCOVA analysis of covariance anti-IgE anti-immunoglobulin E (omalizumab) anti-IL-5 mAb anti-human interleukin-5 monoclonal antibody AQLQ Asthma

2016 European Medicines Agency - EPARs

225. “Management of the patient with eosinophilic asthma: a new era begins” Jantina C. de Groot, Anneke ten Brinke and Elisabeth H.D. Bel. ERJ Open Res 2015; 1: 00024-2016. Full Text available with Trip Pro

“Management of the patient with eosinophilic asthma: a new era begins” Jantina C. de Groot, Anneke ten Brinke and Elisabeth H.D. Bel. ERJ Open Res 2015; 1: 00024-2016. [This corrects the article DOI: 10.1183/23120541.00024-2015.].

2016 ERJ open research

226. Acetaminophen and Asthma - A Small Sigh of Relief? (Abstract)

Acetaminophen and Asthma - A Small Sigh of Relief? 27532835 2016 08 24 2018 12 02 1533-4406 375 7 2016 Aug 18 The New England journal of medicine N. Engl. J. Med. Acetaminophen and Asthma--A Small Sigh of Relief? 684-5 10.1056/NEJMe1607629 Litonjua Augusto A AA From the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School - both in Boston. eng Editorial Comment United States N Engl J Med 0255562 0028-4793 362O9ITL9D (...) Acetaminophen AIM IM N Engl J Med. 2016 Aug 18;375(7):619-30 27532828 Acetaminophen Asthma drug therapy Humans 2016 8 18 6 0 2016 8 18 6 0 2016 8 25 6 0 ppublish 27532835 10.1056/NEJMe1607629

2016 NEJM

227. Decline in Lung Function in Childhood Asthma. (Abstract)

Decline in Lung Function in Childhood Asthma. 27532852 2016 08 18 2018 12 02 1533-4406 375 7 2016 08 18 The New England journal of medicine N. Engl. J. Med. Decline in Lung Function in Childhood Asthma. e13 10.1056/NEJMc1608228 Weiss Scott T ST McGeachie Michael J MJ eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Inflammatory Agents AIM IM N Engl J Med. 2016 May 12;374(19):1842-52 27168434 N Engl J Med. 2016 Aug 18;375(7):e13 27532853 N Engl J Med. 2016 Aug 18;375(7):e13 (...) 27532854 Anti-Inflammatory Agents therapeutic use Asthma physiopathology Female Humans Lung physiology Male 2016 8 18 6 0 2016 8 18 6 0 2016 8 19 6 0 ppublish 27532852 10.1056/NEJMc1608228 10.1056/NEJMc1608228#SA3

2016 NEJM

228. Decline in Lung Function in Childhood Asthma. Full Text available with Trip Pro

Decline in Lung Function in Childhood Asthma. 27532853 2016 08 18 2018 12 02 1533-4406 375 7 2016 08 18 The New England journal of medicine N. Engl. J. Med. Decline in Lung Function in Childhood Asthma. e13 10.1056/NEJMc1608228 Huang Michelle M Nepean Hospital, Sydney, NSW, Australia. Bhurawala Habib H University of Sydney, Sydney, NSW, Australia. Nanan Ralph R University of Sydney, Sydney, NSW, Australia. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Inflammatory (...) Agents AIM IM N Engl J Med. 2016 May 12;374(19):1842-52 27168434 N Engl J Med. 2016 Aug 18;375(7):e13 27532852 Anti-Inflammatory Agents therapeutic use Asthma physiopathology Female Humans Lung physiology Male 2016 8 18 6 0 2016 8 18 6 0 2016 8 19 6 0 ppublish 27532853 10.1056/NEJMc1608228 10.1056/NEJMc1608228#SA1

2016 NEJM

229. Decline in Lung Function in Childhood Asthma. Full Text available with Trip Pro

Decline in Lung Function in Childhood Asthma. 27532854 2016 08 18 2018 12 02 1533-4406 375 7 2016 08 18 The New England journal of medicine N. Engl. J. Med. Decline in Lung Function in Childhood Asthma. e13 10.1056/NEJMc1608228 Bibalo Cristina C University of Trieste, Trieste, Italy. Longo Giorgio G University of Trieste, Trieste, Italy. Ventura Alessandro A University of Trieste, Trieste, Italy. eng Letter Comment United States N Engl J Med 0255562 0028-4793 0 Anti-Inflammatory Agents AIM IM N (...) Engl J Med. 2016 May 12;374(19):1842-52 27168434 N Engl J Med. 2016 Aug 18;375(7):e13 27532852 Anti-Inflammatory Agents therapeutic use Asthma physiopathology Female Humans Lung physiology Male 2016 8 18 6 0 2016 8 18 6 0 2016 8 19 6 0 ppublish 27532854 10.1056/NEJMc1608228 10.1056/NEJMc1608228#SA2

2016 NEJM

230. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. Full Text available with Trip Pro

Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking.In a multicenter, prospective, randomized, double-blind, parallel-group trial, we enrolled 300 children (age range (...) , 12 to 59 months) with mild persistent asthma and assigned them to receive either acetaminophen or ibuprofen when needed for the alleviation of fever or pain over the course of 48 weeks. The primary outcome was the number of asthma exacerbations that led to treatment with systemic glucocorticoids. Children in both groups received standardized asthma-controller therapies that were used in a simultaneous, factorially linked trial.Participants received a median of 5.5 doses (interquartile range, 1.0

2016 NEJM Controlled trial quality: predicted high

231. Early origins of asthma (and allergy) Full Text available with Trip Pro

Early origins of asthma (and allergy) Asthma is the most common chronic disease starting in childhood and persisting into adulthood in many cases. During childhood, different forms of asthma and wheezing disorders exist that can be discriminated by the mechanisms they are caused by. Specific genetic constellations and exposure against environmental factors during early childhood and in utero play a decisive role in the early development of the disease. Epigenetic mechanisms which are master (...) regulators of gene transcription and thus govern the accessibility and use of genome information, have recently been identified as a "third power" determining many features in the early development of asthma and allergy.

2016 Molecular and cellular pediatrics

232. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. Full Text available with Trip Pro

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. The Amish and Hutterites are U.S. agricultural populations whose lifestyles are remarkably similar in many respects but whose farming practices, in particular, are distinct; the former follow traditional farming practices whereas the latter use industrialized farming practices. The populations also show striking disparities in the prevalence of asthma, and little is known about the immune responses underlying (...) in a murine model of experimental allergic asthma.Despite the similar genetic ancestries and lifestyles of Amish and Hutterite children, the prevalence of asthma and allergic sensitization was 4 and 6 times as low in the Amish, whereas median endotoxin levels in Amish house dust was 6.8 times as high. Differences in microbial composition were also observed in dust samples from Amish and Hutterite homes. Profound differences in the proportions, phenotypes, and functions of innate immune cells were also

2016 NEJM

233. Innate Immunity in Asthma. Full Text available with Trip Pro

Innate Immunity in Asthma. 27518667 2016 08 19 2018 12 02 1533-4406 375 5 2016 Aug 04 The New England journal of medicine N. Engl. J. Med. Innate Immunity in Asthma. 477-9 10.1056/NEJMe1607438 Chatila Talal A TA From the Division of Immunology, Boston Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston. eng R01 AI065617 AI NIAID NIH HHS United States Editorial Comment United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2016 Aug 4;375(5):411-21 (...) 27518660 Agriculture Animals Asthma immunology Environmental Exposure Female Humans Immunity, Innate Male 2016 8 13 6 0 2016 8 16 6 0 2016 8 20 6 0 ppublish 27518667 10.1056/NEJMe1607438 PMC5037902 NIHMS817591 N Engl J Med. 2011 Feb 24;364(8):701-9 21345099 N Engl J Med. 2006 Nov 23;355(21):2226-35 17124020 J Exp Med. 2009 Dec 21;206(13):2869-77 19995952 Science. 2012 Jul 27;337(6093):431-5 22837519 N Engl J Med. 2002 Sep 19;347(12):869-77 12239255 Nat Rev Immunol. 2010 Dec;10 (12 ):861-8 21060319 N

2016 NEJM

234. Maternal smoking in pregnancy and its influence on childhood asthma Full Text available with Trip Pro

Maternal smoking in pregnancy and its influence on childhood asthma Maternal smoking in pregnancy (MSP) is a large modifiable risk factor for pregnancy related mortality and morbidity and also the most important known modifiable risk factor for asthma. This review summarises the effects of MSP throughout infancy, childhood and adolescence with regards to asthma (development and severity). Firstly, the direct damage caused by nicotine on fetal lung development, fetal growth and neuronal (...) differentiation is discussed, as well as the indirect effects of nicotine on placental functioning. Secondly, the effects of MSP on later immune functioning resulting in increased infection rate are summarised and details are given on the effects of MSP modulating airway hyperreactivity, reducing lung function and therefore increasing asthma morbidity. Furthermore, epigenetic effects are increasingly being recognised. These can also result in transgenerational detrimental effects induced by cigarette smoke

2016 ERJ open research

235. A multidisciplinary team case management approach reduces the burden of frequent asthma admissions Full Text available with Trip Pro

A multidisciplinary team case management approach reduces the burden of frequent asthma admissions Up to 10% of asthmatics have "difficult asthma"; however, they account for 80% of asthma-related expenditure and run the highest risk of acute severe exacerbations. An estimated 75% of admissions for asthma are avoidable. Guidelines advise that these patients be managed by an experienced specialist multidisciplinary team (MDT). We aimed to assess the impact of a case management strategy delivered (...) via specialist MDTs on acute healthcare utilisation of patients with frequent asthma admissions. An MDT (consultant, specialist nurse, physiotherapist and psychologist) case management strategy was introduced in 2010 at University Hospital Southampton Foundation Trust (Southampton, UK) to support patients with frequent asthma admissions during admission and then in clinic. To assess efficacy, we systematically searched the hospital database for patients acutely admitted for asthma on two or more

2016 ERJ open research

236. The puzzle of immune phenotypes of childhood asthma Full Text available with Trip Pro

a critical role in asthma patients as they produce different cytokines associated with asthma. Epigenetic findings showed different acetylation and methylation patterns for children with allergic and non-allergic asthma. On a posttranscriptional level, miRNAs are regulating factors identified to differ between asthma patients and healthy controls and also indicate differences within asthma phenotypes. Metabolomics is another exciting chapter important for endotyping asthmatic children. Despite (...) The puzzle of immune phenotypes of childhood asthma Asthma represents the most common chronic childhood disease worldwide. Whereas preschool children present with wheezing triggered by different factors (multitrigger and viral wheeze), clinical asthma manifestation in school children has previously been classified as allergic and non-allergic asthma. For both, the underlying immunological mechanisms are not yet understood in depth in children. Treatment is still prescribed regardless

2016 Molecular and cellular pediatrics

237. Alair bronchial thermoplasty system for adults with severe difficult to control asthma

utilisation, safety, and predictive models of response to BT August 2018 Efficacy of Bronchial Thermoplasty in Korean Open-label single-group treatment study. 9 patients at 1 Korean centre Patients with severe difficult to control asthma Primary: Quality of Life Questionnaire for Adult Korean Asthmatics at 3 months. Secondary: the same measure at 6 months and acute exacerbations at 3 and 6 months February 2015 Alair bronchial thermoplasty system for adults with severe difficult to control asthma (MIB71) © (...) Alair bronchial thermoplasty system for adults with severe difficult to control asthma Alair bronchial thermoplasty system for adults Alair bronchial thermoplasty system for adults with se with sev vere difficult to control asthma ere difficult to control asthma Medtech innovation briefing Published: 11 July 2016 nice.org.uk/guidance/mib71 pathways Summary Summary The Alair bronchial thermoplasty system is designed to reduce the amount of smooth muscle in the airway walls, with the aim

2016 National Institute for Health and Clinical Excellence - Advice

238. Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study Full Text available with Trip Pro

Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy - a cohort linkage study To examine the effect of maternal exposure to asthma medications on the risk of congenital anomalies.Meta-analysis of aggregated data from three cohort studies.Linkage between healthcare databases and EUROCAT congenital anomaly registries.519 242 pregnancies in Norway (2004-2010), Wales (2000-2010) and Funen, Denmark (2000-2010).Exposure defined as having at least one (...) prescription for asthma medications issued (Wales) or dispensed (Norway, Denmark) from 91 days before to 91 days after the pregnancy start date. Odds ratios (ORs) were estimated separately for each register and combined in meta-analyses.ORs for all congenital anomalies and specific congenital anomalies.Overall exposure prevalence was 3.76%. For exposure to asthma medication in general, the adjusted OR (adjOR) for a major congenital anomaly was 1.21 (99% CI 1.09-1.34) after adjustment for maternal age

2016 EvidenceUpdates

239. Severe angina pectoris in asthma attack: a case report Full Text available with Trip Pro

Severe angina pectoris in asthma attack: a case report Asthma is a chronic inflammatory disorder of the airways related to the obstruction of reversible airflow. Asthma presents as recurrent attacks of cough and dyspnea. Poor control causes recurrent admissions to the ICU, and mortality is related to poor drug compliance and follow-up. Angina pectoris is a syndrome of recurrent chest discomfort related to myocardial ischemia. The presence of these two disorders rarely has been reported. We (...) reported a 12-year-old boy who was referred with exacerbation of asthma and developed angina pectoris during hospitalization. He had labored breathing and diffuse wheezing. During treatment of the asthma, the patient developed severe chest pain due to shunt formation and coronary hypoxia, caused by the sole administration of ventolin, since oxygen had been disconnected. After receiving appropriate therapy, both his asthma and angina recovered, and, to date, he has not experienced angina pectoris again.

2016 Electronic physician

240. The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. Full Text available with Trip Pro

The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia. Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell disease. Asthma is common in children with sickle-cell disease and is associated with increased incidence of vaso-occlusive pain events, acute chest syndrome episodes, and earlier death. Risk factors for asthma exacerbation and an acute chest syndrome episode are similar, and both can present with shortness (...) of breath, chest pain, cough, and wheezing. Despite overlapping risk factors and symptoms, an acute exacerbation of asthma or an episode of acute chest syndrome are two distinct entities that need disease-specific management strategies. Although understanding has increased about asthma as a comorbidity in sickle-cell disease and its effects on morbidity, substantial gaps remain in knowledge about best management. Copyright © 2016 Elsevier Ltd. All rights reserved.

2016 Lancet