Latest & greatest articles for asthma

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This page lists the very latest high quality evidence on asthma and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Top results for asthma

981. Alexander technique for chronic asthma. (Abstract)

Alexander technique for chronic asthma. "The Alexander technique" is a taught form of physical therapy involving a series of movements designed to correct posture and bring the body into natural alignment with the object of helping it to function efficiently, and is reported to aid relaxation. Some practitioners claim benefits for those who desire greater ease and efficiency of breathing, including asthmatics.The objective of this review was to evaluate the efficacy of the Alexander technique (...) in people with chronic, stable asthma.The specialised register of the Cochrane Airways Group, the Cochrane Complementary Medicine Field trials register and the bibliographies of relevant articles were searched.Randomised controlled trials of Alexander technique for the improvement of the symptoms of chronic, stable asthma, comparing the treatment with either another intervention or no intervention.No trials were found that met the selection criteria.Robust, well-designed randomised controlled trials

2000 Cochrane

982. Limited (information only) patient education programs for adults with asthma. (Abstract)

Limited (information only) patient education programs for adults with asthma. A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information (...) about asthma, its causes and its treatment. This review focused on the effects of limited asthma education.The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma.We searched the Cochrane Airways Group trials register and reference lists of articles.Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age.Trial quality was assessed

2000 Cochrane

983. Inhaled vs oral steroids for adults with chronic asthma. (Abstract)

Inhaled vs oral steroids for adults with chronic asthma. To determine therapeutically equivalent doses of inhaled versus oral steroids for adults with chronic asthma.The Cochrane Airways Group trials register was searched using the terms: (drug delivery systems OR ((nebuli* OR inhal* OR MDI) AND oral*)) AND ( steroid* OR corticosteroid* OR glucocorticoid* OR beclomethasone OR betamethasone OR fluticasone OR cortisone OR dexamethasone OR hydrocortisone OR prednisolone OR prednisone (...) OR triamcinolone).Randomised controlled trials were selected of at least 4 weeks duration and included patients over the age of 15 years with chronic asthma. Trials compared inhaled steroids and oral prednisolone or prednisone; where the maximum dose for inhaled steroids was 2000 mcg/day and prednisolone 60 mg (on alternate days).Two independent reviewers screened 1285 titles and abstracts from the electronic search, bibliography searches and other contacts. Of these, 10 trials met previously defined inclusion

2000 Cochrane

984. Early emergency department treatment of acute asthma with systemic corticosteroids. Full Text available with Trip Pro

Early emergency department treatment of acute asthma with systemic corticosteroids. The airway edema and secretions associated with acute asthma are most effectively treated with anti-inflammatories such as corticosteroids delivered by inhaled, oral, intravenous or intra-muscular routes. There is an unresolved debate about the use of systemic corticorticoids in the early treatment of acute asthma for emergency department patients.To determine the benefit of treating patients with acute asthma (...) with systemic corticosteroids within an hour of presenting to the emergency department (ED).Randomised controlled trials were identified from the Cochrane Airways Group Asthma Register. Primary authors and content experts were contacted to identify eligible studies. Bibliographies from included studies and known reviews were searched.Only randomised controlled trials (RCTs) or quasi-randomised trials were eligible for inclusion. Studies were included if patients presenting to the ED with acute asthma were

2000 Cochrane

985. House dust mite control measures for asthma. (Abstract)

House dust mite control measures for asthma. The major allergen in house dust comes from mites. Chemical, physical and combined methods of reducing mite allergen levels are intended to reduce asthma symptoms in people who are sensitive to house dust mites.The objective of this review was to assess the effects of reducing exposure to house dust mite antigens in the homes of mite-sensitive asthmatics.We searched the Cochrane Airways Group trials register, checked reference lists of articles (...) and hand-searched Respiration (1980 to 1996) and Clinical and Experimental Allergy (1980 to 1996).Randomised trials of mite control measures in asthmatic people known to be sensitive to house dust mites.Two reviewers applied the trial inclusion criteria and extracted the data independently. One reviewer applied the trial quality assessment criteria. Study authors were contacted to clarify information.Twenty-three trials were included, with four trials awaiting assessment. There was little difference

2000 Cochrane

986. Long acting beta-agonists versus theophylline for maintenance treatment of asthma. (Abstract)

Long acting beta-agonists versus theophylline for maintenance treatment of asthma. Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles.To assess the comparative efficacy, safety and side-effects of long-acting beta-agonists and theophylline in the maintenance treatment of asthma.Randomised, controlled trials (RCTs) were (...) identified using the Cochrane Airways Group register. The register was searched using the following terms: asthma and theophylline and long acting beta-agonist or formoterol or foradile or eformoterol or salmeterol or bambuterol or bitolterol. Titles and abstracts were then screened to identify potentially relevant studies. The bibliography of each RCT was searched for additional RCTs. Authors of identified RCTs were contacted for other relevant published and unpublished studies.All included studies were

2000 Cochrane

987. Beclomethasone for asthma in children: effects on linear growth. Full Text available with Trip Pro

Beclomethasone for asthma in children: effects on linear growth. Inhaled steroids play a central role in the management of childhood asthma. There is concern about their side effects, especially on growth. However asthma may also cause growth retardation. Growth rates are not stable, so randomised controlled parallel group studies are needed to assess the impact of inhaled steroids on growth. This review is confine to one inhaled steroid, beclomethasone, that is known to have significant levels (...) of systemic absorption.To determine whether inhaled beclomethasone cause significant delay in the linear growth of children with asthma.The Cochrane Airways Group asthma register was searched. Bibliographies from included studies, and known reviews were searched for additional citations. Personal contact with colleagues and researchers working in the field of asthma were made to identify potentially relevant trials.Randomized, controlled trials comparing the effects of beclamethasone to non-steroidal

2000 Cochrane

988. Dietary marine fatty acids (fish oil) for asthma. Full Text available with Trip Pro

Dietary marine fatty acids (fish oil) for asthma. Epidemiological studies suggest that a diet high in marine fatty acids (fish oil) may have beneficial effects on inflammatory conditions such as rheumatoid arthritis and possibly asthma.1. To determine the effect of marine n-3 fatty acid (fish oil) supplementation in asthma. 2. To determine the effect of a diet high in fish oil in asthma.The Cochrane Airways Review Group register was search using the terms: marine fatty acids OR diet (...) OR nutrition OR fish oil OR eicosapentaenoic acid OR EPA. Bibliographies of retrieved trials were searched and fish oil manufacturers contacted.Randomised controlled trials in patients with asthma more than two years of age were included. The study duration had to be in excess of 4 weeks. Double blind trials were preferred, but single-blind and open trials were also reviewed for possible inclusion. Three reviewers read each paper, blind to its identity. Decisions concerning inclusion were made by simple

2000 Cochrane

989. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Full Text available with Trip Pro

Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Treatment of acute asthma is based on rapid reversal of bronchospasm and arresting airway inflammation. There is some evidence that intravenous magnesium can provide additional bronchodilation when given in conjunction with standard bronchodilating agents and corticosteroids. No systematic review of this literature has been completed on this topic.To examine the effect of additional intravenous magnesium (...) sulfate in patients with acute asthma managed in the emergency department.Randomised controlled trials were identified from the Cochrane Airways Review Group register. Bibliographies from included studies, known reviews and texts were searched. Primary authors and content experts were contacted.Randomised controlled trials or quasi-randomised trials were eligible for inclusion. Studies were included if patients presented with acute asthma and were treated with IV magnesium sulfate vs placebo.Data were

2000 Cochrane

990. Inhaled beta-agonists for asthma in mechanically ventilated patients. (Abstract)

Inhaled beta-agonists for asthma in mechanically ventilated patients. A small number of patients with acute severe asthma require intubation and positive pressure ventilation. The beneficial effects of inhaled bronchodilators on acute asthma in spontaneously breathing subjects are well established, but there remain important questions regarding inhaled beta2-agonists, for patients who are intubated and receiving ventilation.To determine the effects of inhaled beta-agonists on asthmatic patients (...) who require intubation and mechanical ventilation.Randomised controlled trials were sought from the Cochrane Airways Group Asthma Register. Primary authors and content experts were contacted to identify eligible studies and bibliographies from known reviews and texts were searched.Randomised, controlled clinical trials involving adult patients with acute asthma, who were intubated and supported with positive pressure ventilation. Studies were to be included if patients were treated with beta2

2000 Cochrane

991. Gastro-oesophageal reflux treatment for asthma in adults and children. Full Text available with Trip Pro

in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications.In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders. (...) Gastro-oesophageal reflux treatment for asthma in adults and children. Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number

2000 Cochrane

992. Speleotherapy for asthma. Full Text available with Trip Pro

and summarized descriptively.Three trials including a total of 124 asthmatic children met the inclusion criteria, but only one trial had reasonable methodological quality. Two trials reported that speleotherapy had a beneficial short-term effect on lung function. Other outcomes could not be assessed in a reliable manner.The available evidence does not permit a reliable conclusion as to whether speleo-therapeutic interventions are effective for the treatment of chronic asthma. Randomized controlled trials (...) Speleotherapy for asthma. Speleotherapy, the use of subterranean environments, is a therapeutic measure in the treatment of chronic obstructive airways diseases. It is virtually unknown in the UK or the US, but has considerable widespread use in some Central and Eastern European countries.To review evidence for the efficacy of speleotherapy in the treatment of asthma.We searched electronic databases (Medline, Embase, Cochrane Airways group database), contacted speleotherapy centres and experts

2000 Cochrane

993. Corticosteroids for acute severe asthma in hospitalised patients. (Abstract)

Corticosteroids for acute severe asthma in hospitalised patients. Corticosteroids are currently used routinely in the management of acute severe asthma. The optimal dose and route of administration continues to be debated. Some investigators have reported a greater benefit of higher doses of corticosteroids in the management of severe asthma, while others have not.To determine whether higher doses of systemic corticosteroids (oral, intravenous or intramuscular) are more effective than lower (...) doses in the management of patients with acute severe asthma requiring hospital admission.Randomised controlled trials were identified from the Cochrane Airways Group Asthma Register. In addition, primary authors and content experts were contacted to identify eligible studies. Bibliographies from included studies, known reviews and texts were also searched.Studies were selected for inclusion in the review if they met the following broad inclusion criteria: described as randomised controlled trials

2000 Cochrane

994. Caffeine for asthma. Full Text available with Trip Pro

Caffeine for asthma. Caffeine has a variety of pharmacological effects. It is chemically related to the drug theophylline which is used to treat asthma. Accordingly, interest has been expressed in its potential role as an asthma treatment. A number of studies have explored the effects of caffeine in asthma, this is the first review to systematically examine and summarise the evidence.Caffeine is a weak bronchodilator and it also reduces respiratory muscle fatigue. It has been suggested (...) that caffeine may reduce asthma symptoms. The objective of this review was to assess the effects of caffeine on lung function and identify whether there is a need to control for caffeine consumption prior to lung function testing.We searched the Cochrane Airways Group trials register and the reference lists of articles. We also contacted study authors.Randomised trials of oral caffeine compared to placebo in adults with asthma.Trial quality assessment and data extraction were done independently by two

2000 Cochrane

995. Physical training for asthma. (Abstract)

Physical training for asthma. Physical training programmes have been designed for asthmatic subjects with the aim of improving physical fitness, neuromuscular coordination and self-confidence. Habitual physical activity increases physical fitness and lowers ventilation during mild and moderate exercise thereby reducing the likelihood of provoking exercise -induced asthma. Exercise training may also reduce the perception of breathlessness through a number of mechanisms including strengthening (...) respiratory muscles. Subjectively, many asthmatics report that they are symptomatically better when fit, but results from trials have varied and have been difficult to compare because of different designs and training protocols.The purpose of this review was to assess evidence for the efficacy and effectiveness of physical training in asthma.We searched the Cochrane Airways Group trials register, Sportdiscus and Science citation index.Randomised trials in asthmatic subjects undertaking physical training

2000 Cochrane

996. Acupuncture for chronic asthma. (Abstract)

Acupuncture for chronic asthma. Acupuncture has traditionally been used to treat asthma in China and is used increasingly for this purpose internationally.The objective of this review was to assess the effects of acupuncture for the treatment of asthma or asthma-like symptoms.We searched the Cochrane Airways Group trials register, the Cochrane Complementary Medicine Field trials register and reference lists of articles.Randomised and possibly randomised trials using acupuncture to treat asthma (...) and asthma-like symptoms. Acupuncture could involve the insertion of needles or other forms of stimulation of acupuncture points.Trial quality was assessed by at least two reviewers independently. A reviewer experienced in acupuncture assessed the adequacy of the sham acupuncture. Study authors were contacted for missing information.Seven trials involving 174 people were included. Trial quality varied and results were inconsistent. No statistically significant or clinically relevant effects were found

2000 Cochrane

997. Holding chambers versus nebulisers for beta-agonist treatment of acute asthma. (Abstract)

Holding chambers versus nebulisers for beta-agonist treatment of acute asthma. In acute asthma inhaled beta-agonists are often administered to relieve bronchospasm by wet nebulisation, but some have argued that metered-dose inhalers with a holding chamber (spacer) can be equally effective. In the community setting nebulisers are more expensive, require a power source and need regular maintenance.There is controversy as to whether wet nebulisers are better than metered dose inhalers with holding (...) chambers to deliver beta2-agonist medications for acute asthma. Comparisons of hospital and home use are also of interest. The objective of this review was to assess the effects of holding chambers compared to nebulisers for the delivery of beta2-agonists for acute asthma.We searched the Cochrane Airways Group trials register and the Cochrane Controlled Trials Register.Randomised trials in adults and children (from two years of age) with asthma, where holding chamber beta2-agonist delivery was compared

2000 Cochrane

998. Combined inhaled anticholinergic agents and beta-2-agonists for initial treatment of acute asthma in children. (Abstract)

Combined inhaled anticholinergic agents and beta-2-agonists for initial treatment of acute asthma in children. Anti-cholinergic agents and beta2-agonist drugs are both bronchodilators used to reverse acute bronchospasm in children with asthma. These drugs have different modes of action, so may have complementary or additive effects.The objective of this review was to assess the effects of adding inhaled anti-cholinergics to beta2-agonists in acute paediatric asthma.We searched Medline (1966 (...) only one dose of anti-cholinergic inhalation was added to beta2-agonist therapy, there was an improvement in forced expiratory volume in one second after 60 minutes with combination therapy (weighted mean difference 16.1%, 95% confidence interval 5.5 to 26. 7% reduction). There was no reduction in hospital admission (odds ratio 0.80, 95% confidence interval 0.35 to 1.82, using a random effects model). For multiple doses in children with severe asthma, there was a reduction in forced expiratory

2000 Cochrane

999. Family therapy for asthma in children. (Abstract)

Family therapy for asthma in children. Psychosocial and emotional factors are important in childhood asthma. Nevertheless, drug therapy alone continues to be the main treatment. Treatment programmes that include behavioural or psychological interventions have been developed to improve disturbed family relations in the families of children with severe asthma. These approaches have been extended to examine the efficacy of family therapy to treat childhood asthma in a wider group of patients (...) . This review systematically examines these studies.Recognition that asthma can be associated with emotional disturbances has led to the investigation of the role of family therapy in reducing the symptoms and impact of asthma in children. The objective of this review was to assess the effects of family therapy as an adjunct to medication for the treatment of asthma in children.We searched the Cochrane Airways Group trials register, Psychlit and Psychinfo.Randomised trials comparing children undergoing

2000 Cochrane

1000. Corticosteroids for preventing relapse following acute exacerbations of asthma. (Abstract)

the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.The Cochrane Airways Group "Asthma and Wheez* RCT" register was searched using the terms: a) Asthma OR Wheez* b) Glucocorticoid OR Steroid* AND c) Exacerbat* OR Relapse* OR Emerg*. In addition, authors of all included studies were contacted to determine (...) Corticosteroids for preventing relapse following acute exacerbations of asthma. Acute asthma is responsible for many emergency department visits annually. Between 12-16% will relapse to require additional interventions within two weeks of ED discharge. Treatment of acute asthma is based on rapid reversal of bronchospasm and reducing airway inflammation and this review examines the evidence for using systemic corticosteroids to improve outcomes after discharge from the ED.To determine

2000 Cochrane