Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4)
Latest & greatest articles for asthma
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on asthma or other clinical topics then use Trip today.
This page lists the very latest high quality evidence on asthma and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.
What is Trip?
Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.
Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.
As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.
For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via firstname.lastname@example.org
Do clinical guidelines introduced with practice based education improve care of asthmatic and diabetic patients? A randomised controlled trial in general practices in east London. To determine whether locally developed guidelines on asthma and diabetes disseminated through practice based education improve quality of care in non-training, inner city general practices.Randomised controlled trial with each practice receiving one set of guidelines but providing data on the management of both (...) conditions.24 inner city, non-training general practices.East London.Recording of key variables in patient records (asthma: peak flow rate, review of inhaler technique, review of asthma symptoms, prophylaxis, occupation, and smoking habit; diabetes: blood glucose concentration, glycaemic control, funduscopy, feet examination, weight, and smoking habit); size of practice disease registers; prescribing in asthma; and use of structured consultation "prompts."In practices receiving diabetes guidelines
Efficacy of ipratropium bromide in acute childhood asthma: a meta-analysis Efficacy of ipratropium bromide in acute childhood asthma: a meta-analysis Efficacy of ipratropium bromide in acute childhood asthma: a meta-analysis Osmond M H, Klassen T P Authors' objectives To establish if ipratropium bromide, when given in conjunction with beta2-agonists, is beneficial to the health of children suffering with acute asthma. Searching MEDLINE was searched from 1966 to 1992 for articles published (...) in the English language using the following MeSH terms: 'N-isopropylatropine' and (explode) 'child', and 'asthma' and (explode) 'child'. The reference lists of all available primary and review articles were searched for relevant literature, and the two oldest studies included were searched forward in time using the Science Citation Index. The authors of all the selected studies were contacted for additional material. Study selection Study designs of evaluations included in the review Randomised, double-blind
Self-management teaching programs and morbidity of pediatric asthma: a meta-analysis Self-management teaching programs and morbidity of pediatric asthma: a meta-analysis Self-management teaching programs and morbidity of pediatric asthma: a meta-analysis Bernard-Bonnin A C, Stachenko S, Bonin D, Charette C, Rousseau E Authors' objectives To assess the impact of self-management teaching programmes on the morbidity of paediatric asthma. Searching MEDLINE, Index Medicus, American Journal (...) of Nursing International Index, Dissertation Abstracts Online Database and the bibliographies of retrieved articles were searched. Authors of preliminary or pilot studies were contacted. Only English or French literature published between 1970 and 1991 were searched with the keywords 'asthma', 'education' and 'self-management programs'. Study selection Study designs of evaluations included in the review Randomised controlled trials (RCTs) were included. Specific interventions included in the review Self
A self-management program for adult asthma. Part II: cost-benefit analysis A self-management program for adult asthma. Part II: cost-benefit analysis A self-management program for adult asthma. Part II: cost-benefit analysis Taitel M S, Kotses H, Bernstein I L, Bernstein D I, Creer T L Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed (...) by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology An educational training programme for self-management of adult asthma. Type of intervention Educational intervention; Secondary prevention; Patient management. Economic study type Cost-effectiveness analysis. Study population Adult patients with moderate to severe asthma as described by themselves. In all cases, asthma had been adequately controlled by medical treatment. Patients were excluded from
that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Protocol therapy for acute episodes of asthma, treated in an emergency department. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population Asthmatic patients aged 16 years or older, presenting to the emergency (...) Protocol therapy for acute asthma: therapeutic benefits and cost savings Protocol therapy for acute asthma: therapeutic benefits and cost savings Protocol therapy for acute asthma: therapeutic benefits and cost savings McFadden E R, Elsanadi N, Dixon L, Takacs M, Deal E C, Boyd K K, Idemoto B K, Broseman L A, Panuska J, Hammons T, Smith B, Caruso F, McFadden C B, Shoemaker L, Warren E L, Hejal R, Strauss L, Gilbert I A Record Status This is a critical abstract of an economic evaluation
Controlled trial of an audit facilitator in diagnosis and treatment of childhood asthma in general practice Controlled trial of an audit facilitator in diagnosis and treatment of childhood asthma in general practice Controlled trial of an audit facilitator in diagnosis and treatment of childhood asthma in general practice Bryce F P, Neville R G, Crombie I K, Clark R A, McKenzie P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of an audit facilitator in the diagnosis and treatment of childhood asthma in general practice. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Children of both sexes aged between 1 and 15 inclusive, with symptoms suggestive
Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Theophylline, in addition to its bronchodilator effect, may attenuate inflammation in asthma. We did a double-blind placebo-controlled study of the effect of oral theophylline on the inflammatory response of the bronchial mucosa to inhalation of allergen in 19 atopic asthmatic subjects. Bronchoscopy and bronchial biopsy were done 24 hours after allergen inhalation before and after six weeks of treatment with oral slow (...) inflammatory response to allergen inhalation in atopic asthma.
Salmeterol xinafoate as maintenance therapy compared with albuterol in patients with asthma. To compare the efficacy and safety of inhaled salmeterol xinafoate, a long-acting beta 2-adrenoceptor agonist, with that of albuterol, a short-acting inhaled beta 2-agonist, in the treatment of asthma.Randomized, double-blind, placebo-controlled, parallel-group study.Eleven outpatient clinical centers.A total of 322 male and female patients at least 12 years of age with chronic symptomatic asthma (...) requiring daily therapy.Patients were treated with salmeterol xinafoate (42 micrograms inhaled twice daily), albuterol (180 micrograms inhaled four times daily), or placebo (four times a day) for 12 weeks; patients in all three groups could use inhaled albuterol as backup medication for breakthrough symptoms.Serial 12-hour forced expiratory flow in 1 second (FEV1), peak expiratory flow (PEF), asthma symptoms, nocturnal awakenings due to asthma, episodes of asthma exacerbations
Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Guidelines on asthma management recommend that in patients who still have symptoms on treatment with low-dose inhaled corticosteroids the first step should be an increase in inhaled corticosteroid dose. The addition of long-acting inhaled beta 2-adrenoceptor agonists is another option. We have compared these two strategies (...) in a randomised, double-blind, parallel-group trial. We studied 429 adult asthmatic patients who still had symptoms despite maintenance treatment with 200 micrograms twice daily inhaled beclomethasone dipropionate (BDP). 3 did not provide verifiable data. Of the others, 220 were assigned salmeterol xinafoate (50 micrograms twice daily) plus BDP and 206 were assigned higher-dose BDP (500 micrograms twice daily) for 6 months. The mean morning peak expiratory flow increased from baseline in both groups
1994LancetControlled trial quality: predicted high
Reducing hospital admission through computer supported education for asthma patients. Grampian Asthma Study of Integrated Care (GRASSIC). To evaluate a personalised computer supported education programme for asthma patients.Pragmatic randomised trial comparing outcomes over 12 months between patients taking part in an enhanced education programme (four personalised booklets, sent by post) and patients receiving conventional oral education at outpatient or surgery visits.Hospital outpatient (...) clinics and general practices in north east Scotland.801 adults attending hospital outpatient clinics, with a diagnosis of asthma confirmed by a chest physician and pulmonary function reversibility of at least 20%.Numbers of hospital admissions, consultations with general practitioner for asthma, steroid courses used, bronchodilators and inhaled steroids prescribed, days of restricted activity, and disturbed nights.Patients with asthma judged too severe for randomisation between clinic care
Integrated care for asthma: a clinical, social, and economic evaluation. Grampian Asthma Study of Integrated Care (GRASSIC) To evaluate integrated care for asthma in clinical, social, and economic terms.Pragmatic randomised trial.Hospital outpatient clinics and general practices throughout the north east of Scotland.712 adults attending hospital outpatient clinics with a diagnosis of asthma confirmed by a chest physician and pulmonary function reversibility of at least 20%.Use (...) of bronchodilators and inhaled and oral steroids; number of general practice consultations and hospital admissions for asthma; sleep disturbance and other restrictions on normal activity; psychological aspects of health including perceived asthma control; patient satisfaction; and financial costs.After one year there were no significant overall differences between those patients receiving integrated asthma care and those receiving conventional outpatient care for any clinical or psychosocial outcome
Effectiveness of routine self monitoring of peak flow in patients with asthma. Grampian Asthma Study of Integrated Care (GRASSIC). To evaluate the effectiveness of routine self monitoring of peak flow for asthma outpatients.Pragmatic randomised trial.Hospital outpatient clinics and general practices in north east Scotland.Use of bronchodilators and inhaled and oral steroids; number of general practice consultations and hospital admissions for asthma; sleep disturbance and other restrictions (...) on normal activity; psychological aspects of health including perceived control of asthma.After one year there were no significant differences between patients randomised between self monitoring of peak flow and conventional monitoring. However, those given a peak flow meter recorded an increase in general practice consultations that was nearly significant. Among patients whose asthma was judged on entry to be more severe, those allocated to self monitoring used more than twice as many oral steroids
Regular vs as-needed inhaled salbutamol in asthma control. Recent studies have suggested that regular use of inhaled beta 2 agonists cause loss of asthma control as measured by worsening peak-flow rates, increased asthma symptoms, and more frequent need for supplementary bronchodilators. However, the magnitude of this effect and the reliability of investigator-originated definitions of control is unknown. We studied 341 people with asthma in a four-week, randomised, crossover trial of regular (...) salbutamol (2 puffs--200 micrograms--four times daily) for two weeks and as needed for two weeks. There were no significant differences in morning and evening peak-flow rates between treatments but asthma symptoms and supplementary bronchodilator use were significantly less frequent when salbutamol was given regularly. Asthma episodes occurred 1.39 (1.52) times per day during regular treatment and 2.44 (1.75) times per day during as-needed treatment (p < 0.0001) and 0.50 (0.56) vs 0.65 (0.66) times per
Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. In a previous study, we found that two years of treatment with an inhaled corticosteroid, budesonide, was more effective than treatment with an inhaled beta 2-agonist, terbutaline, in patients with newly diagnosed, generally mild asthma. We continued this study for a third year to investigate whether the steroid dose could be reduced or discontinued and what effect crossover of patients from beta 2-agonist (...) flow in the morning, P = 0.040). The condition of patients who were crossed over from terbutaline therapy to treatment with 1200 micrograms of budesonide per day improved. However, the degree of improvement in these patients appeared to be less than in those who were treated with budesonide at the beginning of the three-year study.Early treatment with inhaled budesonide results in long-lasting control of mild asthma. Maintenance therapy can usually be given at a reduced dose, but discontinuation
Effect of nitrogen dioxide and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation. Air pollution may enhance the airway response of asthmatic subjects to allergen inhalation. To test the hypothesis that sulphur dioxide and nitrogen dioxide alone or in combination could have a contributory role, we have studied the effect of 6 h exposure to air, 200 parts per billion (ppb) sulphur dioxide, 400 ppb nitrogen dioxide, and the two gases together on the airway (...) response to inhaled allergen in ten volunteers with mild atopic asthma. The subjects were exposed to the gases in random order at weekly visits, then challenged with pre-determined concentrations of Dermatophagoides pteronyssinus allergen 10 min after each exposure. The forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and cumulative breath units (CBU) of D pteronyssinus allergen required to produce a 20% fall in FEV1 (PD20FEV1) were measured after each exposure. Compared with air
Asthma and vitamin C Asthma and vitamin C Asthma and vitamin C Bielory L, Gandhi R Authors' objectives To define the role of vitamin C in the treatment of asthma. Searching MEDLINE was searched (search dates are unclear) for English language papers, and bibliographies of identified papers were examined. The search strategy is not given. Study selection Study designs of evaluations included in the review No restriction stated. Designs included: clinical trials, cross-sectional, prospective (...) and longitudinal studies, which were double-, single- or un-blinded, randomised or non-randomised, controlled or uncontrolled. Specific interventions included in the review The use of vitamin C in asthma and allergy. Participants included in the review No restrictions stated. The studies included had differing populations: adults and children with asthma, healthy adults, adults with seasonal allergic rhinitis and sailors, plus two animal studies were included. No detailed characteristics of the patients
Integrated care for asthma: a clinical, social, and economic evaluation Integrated care for asthma: a clinical, social, and economic evaluation Integrated care for asthma: a clinical, social, and economic evaluation Drummond N, Abdall M, Buckingham J K, Beattie J A, Lindsay T, Osman L M, Ross S J, Roy-Chaudhury A, Russell I, Turner M, Douglas J G, Legge J S, Friend J A, Grampian Asthma Study of Integrated Care (GRASSIC) Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Integrated care for asthma between specialist chest physicians and GPs. Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Adults (16 years and over) attending hospital outpatients' clinics
Comparison of oral-steroid sparing by high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma. It is not clear whether high doses of inhaled steroids have a greater sparing effect than low doses on the requirement for systemic steroids. In a randomised, double-blind, multicentre study, we compared the effects of high-dose (1500 micrograms/day) and low-dose (300 micrograms/day) inhaled beclomethasone dipropionate (BDP) in patients with severe asthma requiring a daily (...) oral prednisolone dose of 10-40 mg. During a 3-month run-in period, we tried to achieve optimum asthma control by means of oral steroid and inhaled BDP 300 micrograms/day. The patients were then allocated to high-dose (n = 71) or low-dose (n = 72) treatment by an independent observer who took into account various prognostic factors. BDP was administered by means of an aerosol inhaler with a spacer device. The dose of systemic steroid was reduced as much as possible during the 6-month study period
Leukotriene E4 and granulocytic infiltration into asthmatic airways. Sulphidopeptide leukotrienes are potent bronchoconstrictors and increase bronchial hyperreactivity, one of the hallmarks of asthma. We have demonstrated that leukotriene LTE4, the most stable of the sulphidopeptide leukotrienes, elicited an increase in the numbers of eosinophils and neutrophils in the lamina propria of the airway mucosa 4 h after inhalation in 4 asthmatic subjects. The numbers of eosinophils were, on average
Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment. To compare safety of salmeterol and salbutamol in treating asthma.Double blind, randomised clinical trial in parallel groups over 16 weeks.General practices throughout the United Kingdom.25,180 patients with asthma considered to require regular treatment with bronchodilators who were recruited by their general practitioner (n = 3516).Salmeterol (...) (Serevent) (50 micrograms twice daily) or salbutamol (200 micrograms four times a day) randomised in the ratio of two patients taking salmeterol to one taking salbutamol. All other drugs including prophylaxis against asthma were continued throughout the study.All serious events and reasons for withdrawals (medical and non-medical) whether or not they were considered to be related to the drugs.Fewer medical withdrawals due to asthma occurred in patients taking salmeterol than in those taking salbutamol