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(SCD) is characterized by chronic pain and episodic acute pain caused by vasoocclusive crises, often requiring high doses of opioids for prolonged periods. In humanized mouse models of SCD, a synthetic cannabinoid has been found to attenuate both chronic and acute hyperalgesia. The effect of cannabis on chronic pain in adults with SCD is unknown. Objective: To determine whether inhaled cannabis is more effective than inhaled placebo in relieving chronic pain in adults with SCD. Design, setting (...) . Roy NB, Fortin PM, Bull KR, Doree C, Trivella M, Hopewell S, Estcourt LJ. Roy NB, et al. Cochrane Database Syst Rev. 2017 Jul 3;7(7):CD012380. doi: 10.1002/14651858.CD012380.pub2. Cochrane Database Syst Rev. 2017. PMID: 28672087 Free PMC article. Review. Show more similar articles References National Conference of State Legislatures State medical marijuana laws. Accessed May 31, 2019. Kosiba JD, Maisto SA, Ditre JW. Patient-reported use of medical cannabis for pain, anxiety, and depression
among critically ill patients admitted to an intensive care unit with an infection (Gacouin et al., 2020). The effects of cannabis use and cannabinoids, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), on immune functioning are complex and not yet well understood. However, a growing body of preclinical studies and several studies involving humans suggest that THC and CBD can affect the immune system, including suppressing its ability to mount a response to fight off infections (Cabral (...) COVID 19, Alcohol and Cannabis Use www.ccsa.ca • www.ccdus.ca Canadian Centre on Substance Use and Addiction • Centre canadien sur les dépendances et l’usage de substances Page 1 COVID-19, Alcohol and Cannabis Use This backgrounder to the infographic, COVID-19, Alcohol and Cannabis Use, describes some of the evidence-based associations between COVID-19, alcohol and cannabis use. It is intended for a broad audience, including health professionals, policy makers and researchers
with maternal marijuana use in the first trimester, but not for the second or third trimester was observed. As no new evidence was found in the updated search, there continues to be insufficient evidence to demonstrate an association between cannabis smoking and the incidence of cancer in offspring. Conclusion: There is insufficient evidence to demonstrate an association between parental cannabis use and subsequent risk of developing any malignancies in offspring. 7.Are cannabis or cannabinoids an effective (...) Cancer and the Health Effects of Cannabis and Cannabinoids: An update of the systematic review by the National Academies of Sciences, Engineering, and Medicine (2017) Consensus Study Report Evidence Summary 23-2 A Quality Initiative of the Program in Evidence-Based Care (PEBC), Ontario Health (Cancer Care Ontario) Cancer and the Health Effects of Cannabis and Cannabinoids: An update of the systematic review by the National Academies of Sciences, Engineering, and Medicine (2017) Consensus Study
Counselling adolescents and parents about cannabis: A primer for health professionals While cannabis use among adolescents is frequent in Canada, youth do recognize the potential harms, and increasingly expect knowledgeable health care providers to discuss substance use in everyday practice. This practice point provides sound, evidence-based tools to help health professionals address non-medical (recreational) cannabis use and its related risks. After highlighting how to make the clinical (...) setting a safe space for youth to talk about psychoactive substances, specific strategies for approaching cannabis use in effective, developmentally appropriate ways are described. Consistent with current literature, screening questionnaires to help structure discussion and identify adolescents who may benefit from more specialized interventions are recommended. Because one in six adolescents who experiments with cannabis goes on to misuse it, appraising their willingness to change risky behaviours
on the lung and immune defenses. In ElSohly (ed.), Marijuana and the Cannabinoids, pp. 253–275. Totowa, New Jersey: Humana Press. Taylor, D. R., Poulton, R., Moffit, T. E., Ramankutty, P., & Sears, M. R. (2000). The respiratory effects of cannabis dependence in young adults. Addiction, 95(11), 1669–1677. Tetrault, J. M., Crothers, K., Moore, B. A., Mehra, R., Concato, J., & Fiellin, D. A. (2007). Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review (...) Group: https://www.cannabisrehab.org/ Cannabis Resources • Canadian Institute for Substance Use Research, Safer Cannabis Use: https://www.heretohelp.bc.ca/infosheet/safer-cannabis-use-marijuana-hash-hash-oil • Centre for Addiction and Mental Health, Canada’s Lower-Risk Cannabis Use Guidelines: https://www.camh.ca/-/media/files/pdfs---reports-and-books---research/canadas-lower-risk- guidelines-cannabis-pdf.pdf • Government of Canada, Cannabis in Canada: Get the facts: https://www.canada.ca/en
f , x W. Burke Affiliations Stony Brook Medicine, Stony Brook, NY, USA c DOI: | Publication History Published online: January 13, 2020 Accepted: December 11, 2019 ; Received: October 24, 2019 ; To view the full text, please login as a subscribed user or . Click to view the full text on ScienceDirect. Highlights • Tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) affect the human endocannabinoid system. • Cannabinoids reduce chemotherapy induced nausea or vomiting (CINV (...) ) and neuropathic pain. • Each state has its own regulations for medical and recreational cannabis use. • Effects of cannabinoids on chemotherapy, immunotherapy, and tumor growth remain under investigation. • Providers should focus indications, alternatives, risks and benefits of medical cannabis use to make appropriate referrals. Keywords: , , , , , To access this article, please choose from the options below Log In Register Purchase access to this article Claim Access If you are a current subscriber
A systematic review of technology-based psychotherapeutic interventions for decreasing cannabis use in patients with psychosis. Persistent use of cannabis in persons with psychosis is associated with poor symptomatic and functional outcomes and increased healthcare costs. Face-to-face psychological interventions (e.g., Cognitive Behavioral Therapy- [CBT], Motivation Enhancement Therapy- [MET]) are widely used in treating problematic cannabis use. We aimed to comprehensively review the efficacy (...) of technology-based psychological interventions (TBPIs) in decreasing cannabis use, the design of TBPIs, and TBPI-related preferences in individuals with psychosis. For the systematic review, we searched six major databases from their inception to November 27, 2019. We included empirical articles of quantitative and qualitative methodologies related to TBPIs in individuals with psychosis and cannabis misuse and used narrative synthesis to report results. Only eight articles were found showing
State marijuana laws and opioid overdose mortality. The opioid epidemic in the United States is a national public health crisis. In recent years, marijuana legalization has been increasingly adopted by state governments as a policy intervention to control the opioid epidemic under the premise that marijuana and opioids are substitutive substances. The purpose of this systematic review is to synthesize the empirical evidence regarding the impact of state marijuana laws on opioid overdose (...) mortality and other opioid-related health outcomes.A comprehensive search of the research literature in 18 bibliographic databases returned 6640 records, with 5601 abstracts reviewed, 29 full text articles screened for eligibility, and 16 eligible studies included in the systematic review. Comprehensive Meta-Analysis software was used to generate summary estimates, forest plots, funnel plots, and heterogeneity statistics.Of the 16 eligible studies, 4 assessed the association of state marijuana law
Cannabis use in individuals at clinical high-risk for psychosis: a comprehensive review. The objectives of this review were to understand the prevalence of cannabis use and how cannabis is associated with transition to psychosis, symptoms, cognition, trauma and family history in clinical high risk (CHR) for psychosis individuals.A systematic literature review was conducted to find studies that examined cannabis use in CHR individuals, with no limitations on the geographical area, and included (...) publications up to November 2018. Studies were screened for inclusion based on detailed criteria, and data were extracted on cannabis use and associated outcomes. A quantitative synthesis by meta-analysis was performed where appropriate, otherwise, a qualitative synthesis was conducted.Overall, 36 studies met inclusion criteria with an average age of 20.1 years and 58.4% males. Prevalence of lifetime cannabis use was 48.7%, whereas current cannabis use was 25.8% and the prevalence of cannabis use disorder
Efficacy of Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review. Objective: Cannabinoid hyperemesis syndrome (CHS) is characterized by cyclic vomiting, abdominal pain, and alleviation of symptoms via hot showers in chronic cannabinoid users. Capsaicin is recommended as a reasonable first-line treatment approach for CHS despite limited clinical evidence regarding its use. The objective of this study is to systematically review the efficacy data for capsaicin (...) in CHS. Data Sources: A literature search using keywords related to cannabinoids, emesis, and capsaicin was performed in MEDLINE, CINAHL, and EMBASE from inception through March 31, 2019. Study Selection and Data Extraction: Studies and published abstracts in which capsaicin was used for CHS and clinical outcomes were reported were eligible for inclusion. Data Synthesis: A total of 241 articles were screened, of which 5 full-text articles and 6 conference abstracts were included. Full-text case
A systematic review and meta-analysis of delay discounting and cannabis use. Delay discounting reflects the systematic reduction in the value of a consequence by delay to delivery. Theoretical and empirical work suggests that delay discounting is a key behavioral mechanism underlying substance use disorder. Existing work on cannabis use, however, is mixed with many studies reporting null results. The purpose of this review was to provide an in-depth assessment of the association between delay (...) discounting and cannabis use. We conducted metaregression analyses to determine the omnibus correlation between delay discounting and cannabis use, and to evaluate task-based and sample-based moderators. Studies included evaluated an association between delay discounting and cannabis quantity-frequency or severity measures in human participants (27 studies, 61 effect sizes, 24,782 participants). A robust variance estimation method was used to account for dependence among effect sizes. A significant
analgesia was observed for inhaled cannabis than synthetic cannabinoids. Analgesic effects were most commonly observed in tests of cold pain sensitivity, and hyperalgesic effects were most commonly observed in tests of electrical stimulation. Patterns of findings from studies with healthy subjects did not substantively differ from those with chronic noncancer pain. However, these observations are qualified by the high degree of inconsistency across studies and methodological heterogeneity. We offer (...) Cannabinoid effects on responses to quantitative sensory testing among individuals with and without clinical pain: a systematic review. There has been an explosion of interest in the utility of cannabinoids as potential analgesics. This systematic review critically synthesizes the evidence for cannabinoid analgesic effects on quantitative sensory testing outcomes in both healthy adults and patients with chronic noncancer pain. Our systematic review protocol is preregistered on PROSPERO
The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies. Glioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the efficacy of cannabinoids in animal models of GBM have been described, but the diversity of experimental conditions (...) and of outcomes hindered definitive conclusions about cannabinoids efficacy. A search in different databases (Pubmed, Web of Science, Scopus and SciELO) was conducted during June 2019 to systematically identify publications evaluating the effects of cannabinoids in murine xenografts models of GBM. The tumour volume and number of animals were extracted, and a random effects meta-analysis of these results was performed to estimate the efficacy of cannabinoids. The impact of different experimental factors
A systematic review of research on adolescent solitary alcohol and marijuana use in the United States. Alcohol use and marijuana use tend to be social activities among adolescents. Some youth use alcohol or marijuana while alone. This article provides a framework for examining the risk factors for and consequences of solitary alcohol and marijuana use, grounded in a motivational model that emphasizes coping with negative emotions, and provides the first systematic review of research on solitary (...) alcohol and marijuana use among middle school- and high school-aged adolescents in the United States.PubMed, PsycINFO and Web of Science were searched. Articles were included if they mention solitary alcohol or marijuana (or illicit drug) use among adolescents aged 12-18 years. Studies on non-human animals, college students, non-English language publications and articles exclusively about solitary tobacco or inhalant use were excluded. Overall, 22 articles were selected.Prevalence of adolescent
Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids: A Systematic Review and Meta-analysis. Cannabis withdrawal syndrome (CWS)-a diagnostic indicator of cannabis use disorder-commonly occurs on cessation of heavy and prolonged cannabis use. To date, the prevalence of CWS syndrome has not been well described, nor have the factors potentially associated with CWS.To estimate the prevalence of CWS among individuals with regular or dependent use (...) of cannabinoids and identify factors associated with CWS.A search of literature from database inception to June 19, 2019, was performed using MEDLINE, Embase, PsycINFO, Web of Science, the Cumulative Index to Nursing and Allied Health Literature, ProQuest, Allied and Complementary Medicine, and Psychiatry online, supplemented by manual searches of reference lists of included articles.Articles were included if they (1) were published in English, (2) reported on individuals with regular use of cannabinoids
The blind men and the elephant: Systematic review of systematic reviews of cannabis use related health harms. Cannabis is the third most used psychoactive substance worldwide. The legal status of cannabis is changing in many Western countries, while we have very limited knowledge of the public health impact of cannabis-related harms. There is a need for a summary of the evidence of harms and risks attributed to cannabis use, in order to inform the definition of cannabis risky use. We have (...) conducted a systematic review of systematic reviews, aiming to define cannabis-related harms. We included systematic reviews published until July 2018 from six different databases and following the PRISMA guidelines. To assess study quality we applied the AMSTAR 2 tool. A total of 44 systematic reviews, including 1,053 different studies, were eligible for inclusion. Harm was categorized in three dimensions: mental health, somatic harm and physical injury (including mortality). Evidence shows a clear