Latest & greatest articles for colorectal cancer

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Top results for colorectal cancer

101. Colorectal Cancer Screening Evidence Brief

fruits and vegetables, fiber, and calcium). Awareness Given the data that colorectal cancer is increasing in younger individuals we must be more vigilant for signs and symptoms that could indicate a problem. I want to know if you develop blood in your stools, anemia, abdominal pain, or changes in bowel habits. However, it is also important to realize that early colon cancers and precancerous polyps do not commonly cause symptoms. 5 References American Academy of Family Physicians Statement: https (...) -decision making to discuss the risks and benefits • It is strongly recommended that all average risk patients 50 years and older should be screened for colon cancer • Extra vigilance for symptoms and risk factors of colon cancer (including family history in people aged 45-49) is advised given increasing colorectal cancer rates in this group. Definition of Average Risk This guidance applies to individuals at average risk for colorectal cancer. Patients not considered average risk include those

2019 Institute for Clinical Systems Improvement

102. New eUpdate featuring treatment algorithm for Early Colon Cancer

Breast/Ovarian Hereditary Cancer Syndromes Cancers of Unknown Primary Site Cancers of Unknown Primary Site Endocrine and Neuroendocrine Cancers Neuroendocrine Bronchial and Thymic Tumours • Neuroendocrine Gastroenteropancreatic Tumours • Adrenal Cancer • Thyroid Cancer Gastrointestinal Cancers Rectal Cancer • Biliary cancer • Gastric cancer • Oesophageal cancerCancer of the pancreas • Metastatic colorectal cancer • Anal cancer • Early colon cancer • Familial risk colorectal cancer • Hepatocellular (...) Algorithm eUpdate - Early Colon Cancer Algorithm Published: 23 September 2019. Authors: ESMO Guidelines Committee Clinical Practice Guidelines This eUpdate refers to the . R. Labianca, B. Nordlinger, G. D. Beretta, S. Mosconi, M. Mandalà, A. Cervantes, D. Arnold. Ann Oncol 2013; 24 (Suppl 6): vi64–vi72. Section Management of local/locoregional disease Algorithm Text update This eUpdate provides a new Figure 1. Therapeutic algorithm for treatment of localised colorectal cancer ESMO is a Swiss-registered

2019 European Society for Medical Oncology

103. Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness

Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness | CADTH.ca Find the information you need Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness Last updated: April 15 (...) , 2019 Project Number: RA1026-000 Product Line: Research Type: Devices and Systems Report Type: Reference List Result type: Report Question What is the clinical effectiveness of the fecal immunochemical test in detecting medical conditions other than colorectal cancer where occult blood detection is needed? What is the clinical effectiveness of the guaiac fecal blood occult test in detecting medical conditions other than colorectal cancer where occult blood detection is needed? Key Message

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

104. Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details

Type Gastrointestinal / Lung Indication Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar Funding Request For first-line treatment of patients with metastatic carcinoma of the colon or rectum, in combination with fluoropyrimidine based chemotherapy / For treatment of patients with unresectable advanced, metastatic or recurrent non-squamous non-small cell lung cancer, in combination with carboplatin/paclitaxel chemotherapy regimen Review Status Final Biosimilar Dossier Issued Pre (...) Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details | CADTH.ca Find the information you need Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Mvasi for Metastatic Colorectal Cancer / Non-Small Cell Lung Cancer Biosimilar – Details Project Number pCODR 10158 Brand Name Mvasi Generic Name Bevacizumab Strength 100 mg and 400 mg Tumour

2019 CADTH - Pan Canadian Oncology Drug Review

105. Updated treatment recommendations for Early Colon Cancer

Hereditary Cancer Syndromes Cancers of Unknown Primary Site Cancers of Unknown Primary Site Endocrine and Neuroendocrine Cancers Neuroendocrine Bronchial and Thymic Tumours • Neuroendocrine Gastroenteropancreatic Tumours • Adrenal Cancer • Thyroid Cancer Gastrointestinal Cancers Rectal Cancer • Biliary cancer • Gastric cancer • Oesophageal cancerCancer of the pancreas • Metastatic colorectal cancer • Anal cancer • Early colon cancer • Familial risk colorectal cancer • Hepatocellular carcinoma (...) Updated treatment recommendations for Early Colon Cancer Early Colon Cancer Treatment Recommendations | ESMO Welcome to the EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY , the leading European professional organisation for medical oncology. Search Careers at ESMO ESMO Oncology Journals Our journals offer ESMO members and the oncology community a globally visible platform to publish scientific studies, and a highly credible source of educational updates.​ Connect with ESMO Discover ESMO's new social

2019 European Society for Medical Oncology

106. Post-polypectomy and post-colorectal cancer resection surveillance guidelines

words 3 | P a g e Abstract These consensus guidelines were jointly commissioned by the British Society of Gastroenterology, the Association of Coloproctology of Great Britain and Ireland and Public Health England. They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorectal imaging in people aged 18 and over. They are the first guidelines that take into account the introduction of national bowel cancer screening. For the first time, they also (...) Health England; PHE) and supported by NHS England (NHSE). These guidelines consider the use of surveillance colonoscopy and non-colonoscopic colorectal imaging in people aged 18 and over and are an update of current BSG/ACPGBI post-polypectomy and post-CRC resection colorectal surveillance guidelines (first published in 2002, last revised in 2010 [containing evidence up to 2006]) (14, 15); they are the first guidelines that take into account the introduction of national bowel cancer screening

2019 British Society of Gastroenterology

107. Guidelines for the management of hereditary colorectal cancer

; Strength of recommendation: strong) o We suggest that when abdominal-perineal excision can be avoided, a standard low anterior resection is a reasonable option to treat rectal cancers in LS patients, even though the residual colon is at high-risk of metachronous neoplasia. (GRADE of evidence: low; Strength of recommendation: weak) o We recommend that gastric, small bowel, or pancreatic surveillance in LS patients is only performed in the context of a clinical trial. (GRADE of evidence: low; Strength (...) neoplasia. ATZ: anal transitional zone. BSG: British Society of Gastroenterology. BSGM: British society of genetic medicine. CHRPE: congenital hypertrophy retinal pigmentation epithelium. CI: confidence intervals. COX-2: Cyclooxygenase-2 . CRC: colorectal cancer. CSSC: Clinical Services and Standards Committee. EHTG: European Hereditary Tumour Group. EOCRC: Early onset CRC. ESGE: European Society of Gastrointestinal Endoscopy. FAP: Familial adenomatous polyposis. FDR: First-degree relative. FH: family

2019 British Society of Gastroenterology

108. Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details

Strength 15 mg & 20 mg Tumour Type Gastrointestinal Indication Metastatic Colorectal Cancer Funding Request Treatment of adult patients with mCRC who have been previously treated with, or are not candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF biological agents, and, if RAS wild-type, anti-EGFR agents Review Status Notification to Implement Issued Pre Noc Submission No NOC Date January 25, 2018 Manufacturer Taiho Pharma Canada (...) Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details | CADTH.ca Find the information you need Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Trifluridine and Tipiracil (Lonsurf) for Metastatic Colorectal Cancer Resubmission – Details Project Number pCODR 10173 Brand Name Lonsurf Generic Name Trifluridine and Tipiracil

2019 CADTH - Pan Canadian Oncology Drug Review

109. Encorafenib, Binimetinib, and Cetuximab in <i>BRAF</i> V600E-Mutated Colorectal Cancer. Full Text available with Trip Pro

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer. Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy. Inhibition of BRAF alone has limited activity because of pathway reactivation through epidermal growth factor receptor signaling.In this open-label, phase 3 trial, we enrolled 665 patients with BRAF V600E-mutated metastatic colorectal (...) with metastatic colorectal cancer with the BRAF V600E mutation. (Funded by Array BioPharma and others; BEACON CRC ClinicalTrials.gov number, NCT02928224; EudraCT number, 2015-005805-35.).Copyright © 2019 Massachusetts Medical Society.

2019 NEJM

110. Whole body MRI is effective for identifying metastatic disease in colorectal cancer patients. (Abstract)

Whole body MRI is effective for identifying metastatic disease in colorectal cancer patients. The studyTaylor S, Mallett S, Beare S et al. Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. Lancet Gastroenterol Hepatol 2019;4:529-37.This project was funded by the NIHR Health Technology Assessment Programme (project number 10/68/01).To read the full NIHR Signal, go to https (...) ://discover.dc.nihr.ac.uk/content/signal-000797/identifying-metastatic-disease-in-colorectal-cancer-with-whole-body-mri.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2019 BMJ

111. Effect of starting dose of regorafenib on overall survival of patients with metastatic colorectal cancer: a systematic review and meta-analysis Full Text available with Trip Pro

данных PubMed по различным комбинациям слов: colon cancer, colorectal cancer, rectal cancer, CRC, mCRC, или colon neoplasms [MeSH terms], rectal neoplasms [MeSH terms], colorectal neoplasms [MeSH terms] и regorafenib. Проведен поиск всех статей с публикацией по март 2019 г. Компьютерный поиск был дополнен изучением списка литературы обзорных статей и оригинальных работ, а также тезисов, представленных на конференциях ASCO (American Society of Clinical Oncology) и ESMO (European Society for Medical (...) , phase 3 trial. Lancet 2013; 381: 303-12. Van Cutsem E, Martinelli E, Cascinu S et al. Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single-Arm, Open-Label Phase IIIb CONSIGN Study. Oncologist 2019; 24 (2): 185-92. Schulz H, Janssen J, Strauss U.P et al. Clinical efficacy and safety of regorafenib (REG) in the treatment of metastatic colorectal cancer (mCRC) in daily practice in Germany: Final results of the prospective

2019 Journal of Modern Oncology

112. Follow-up strategies for patients treated for non-metastatic colorectal cancer. Full Text available with Trip Pro

Follow-up strategies for patients treated for non-metastatic colorectal cancer. This is the fourth update of a Cochrane Review first published in 2002 and last updated in 2016.It is common clinical practice to follow patients with colorectal cancer for several years following their curative surgery or adjuvant therapy, or both. Despite this widespread practice, there is considerable controversy about how often patients should be seen, what tests should be performed, and whether these varying (...) strategies have any significant impact on patient outcomes.To assess the effect of follow-up programmes (follow-up versus no follow-up, follow-up strategies of varying intensity, and follow-up in different healthcare settings) on overall survival for patients with colorectal cancer treated with curative intent. Secondary objectives are to assess relapse-free survival, salvage surgery, interval recurrences, quality of life, and the harms and costs of surveillance and investigations.For this update, on 5

2019 Cochrane

113. Inflammatory Bowel Disease and the Risk of Prostate Cancer: A Meta-analysis of Cohort Studies Full Text available with Trip Pro

Inflammatory Bowel Disease and the Risk of Prostate Cancer: A Meta-analysis of Cohort Studies Inflammatory Bowel Disease and the Risk of Prostate Cancer: A Meta-analysis of Cohort Studies | Research Square Browse Tools & Services Your Cart This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted (...) as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article Inflammatory Bowel Disease and the Risk of Prostate Cancer: A Meta-analysis of Cohort Studies Wen-Qing Lian, Hong-Xing Huang, Fa-Jiang Li, Liang-Hua Chen Wen-Qing Lian Zhongshan Affiliated Hospital of Sun Yat-sen University Corresponding Author Hong-Xing Huang Zhongshan Affiliated Hospital of Sun Yat-sen University Fa-Jiang Li Zhongshan Affiliated Hospital of Sun Yat

2019 Research Square

114. Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer (Abstract)

Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer Colonic J pouch reconstruction has been found to be associated with a lower incidence of anastomotic leakage than straight anastomosis. However, studies on this topic are underpowered and retrospective. This randomized trial evaluated whether the incidence of anastomotic leakage was reduced after colonic J pouch reconstruction compared (...) with straight colorectal anastomosis following anterior resection for rectal cancer.This multicentre RCT included patients with rectal carcinoma who underwent low anterior resection followed by colorectal anastomosis. Patients were assigned randomly to receive a colonic J pouch or straight colorectal anastomosis. The main outcome measure was the occurrence of major anastomotic leakage. The incidence of global (major plus minor) anastomotic leakage and general complications were secondary outcomes. Risk

2019 EvidenceUpdates

115. Treatment of superficial colon cancer by endoscopic submucosal dissection

Treatment of superficial colon cancer by endoscopic submucosal dissection Treatment of superficial colon cancer by endoscopic submucosal dissection - INAHTA Brief

2019 Haute Autorite de sante

116. Hereditary Gastrointestinal Cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

polyposis and colorectal cancer. Nat Genet 2015; 47: 668-671. 54. Moreira L, Pellise M, Carballal S et al. High prevalence of serrated polyposis syndrome in FIT-based colorectal cancer screening programmes. Gut 2013; 62: 476-477. 55. Carballal S, Rodriguez-Alcalde D, Moreira L et al. Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study. Gut 2016; 65: 1829- 1837. 56. Bosman F, Carneiro F, Hruban R, Theise N. WHO classification of tumours of the digestive (...) concerns associated to each genetic susceptibility. These guidelines aim to summarise the evidence-based data on hereditary colorectal cancer (CRC), gastric cancer (GC) and pancreatic cancer (PC) and provide useful clinical recommendations for identification and management of patients with hereditary gastrointestinal cancers. HEREDITARY NON-POLYPOSIS COLORECTAL CANCER SYNDROME (LYNCH SYNDROME) Prevalence and penetrance LS accounts for 1%–3% of all CRC diagnoses [1]. It is caused by germline mutations

2019 European Society for Medical Oncology

117. Perioperative FOLFOX 4 Versus FOLFOX 4 Plus Cetuximab Versus Immediate Surgery for High-Risk Stage II and III Colon Cancers: A Phase II Multicenter Randomized Controlled Trial (PRODIGE 22) (Abstract)

Perioperative FOLFOX 4 Versus FOLFOX 4 Plus Cetuximab Versus Immediate Surgery for High-Risk Stage II and III Colon Cancers: A Phase II Multicenter Randomized Controlled Trial (PRODIGE 22) Perioperative chemotherapy has proven valuable in several tumors, but not in colon cancer (CC).The aim of this study was to evaluate the efficacy and safety of perioperative chemotherapy in patients with locally advanced nonmetastatic CC.This is a French multicenter randomized phase II trial in patients

2019 EvidenceUpdates

118. Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review Full Text available with Trip Pro

Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review | bioRxiv Search for this keyword New Results Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review Igor Lopes dos Santos , Karlla Greick Batista Dias Penna , Megmar Aparecida dos Santos Carneiro , Larisse Silva Dalla Libera , Jéssica Enocencio Porto Ramos , Vera Aparecida Saddi doi: https://doi.org (...) in the review. The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs

2019 Cold Spring Harbor Laboratory

119. A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer Full Text available with Trip Pro

A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer | Research Square Browse Tools & Services Your Cart See the published version of this article at . This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint (...) on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research article A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer Chen Li, Xinli He, Lele Zhang, Lanying Li, Wenzhao Zhao Chen Li The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Xinli He The First Affiliated Hospital, and College

2019 Research Square

120. Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial (Abstract)

Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial Microsatellite-stable metastatic colorectal cancer is typically unresponsive to immunotherapy. This phase 3 study was designed to assess atezolizumab plus cobimetinib in metastatic colorectal cancer. Here, we report the comparison of atezolizumab plus cobimetinib or atezolizumab monotherapy versus (...) regorafenib in the third-line setting.IMblaze 370 is a multicentre, open-label, phase 3, randomised, controlled trial, done at 73 academic medical centres and community oncology practices in 11 countries. Patients aged at least 18 years with unresectable locally advanced or metastatic colorectal cancer, baseline Eastern Cooperative Oncology Group performance status of 0-1, and disease progression on or intolerance to at least two previous systemic chemotherapy regimens were enrolled. We used permuted

2019 EvidenceUpdates