Latest & greatest articles for colorectal cancer

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Top results for colorectal cancer

1361. Colorectal cancer screening under the age of 50 is less cost-effective

. The authors recommend further efforts to evaluate the indirect costs associated with CRC screening that were not considered in this study. Source of funding Funded in part by Grants-in-Aid for Scientific Research (No. 09670384) from the Ministry of Education and Science and Culture of Japan and Cancer Research (No. 8-2) from the Ministry of Health and Welfare of Japan. Bibliographic details Nakama H, Zhang B, Fukazawa K. Colorectal cancer screening under the age of 50 is less cost-effective. GI Cancer (...) 2001; 3(5): 371-374 Other publications of related interest Kronborg O, Fenger C, Olsen J, Jorgensen OD, Sondergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 1996;348:1467-71. Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 1996;348:1472-6. Lieberman DA. Cost-effectiveness model for colon cancer screening. Gastroenterology

2001 NHS Economic Evaluation Database.

1362. Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer: a cost-effectiveness analysis

in average risk adults. In: Young GP, et al., (eds). Prevention and early detection of colorectal cancer. Philadelphia: WB Saunders; 1996. p. 321-56. Winawer SJ, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology 1997;112:594-642. Indexing Status Subject indexing assigned by NLM MeSH Anti-Inflammatory Agents, Non-Steroidal /economics /therapeutic use; Aspirin /economics /therapeutic use; Colonoscopy /economics; Colorectal Neoplasms /epidemiology /prevention & Cost (...) Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer: a cost-effectiveness analysis Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer: a cost-effectiveness analysis Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer: a cost-effectiveness analysis Ladabaum U, Chopra C L, Huang G, Scheiman J M, Chernew M E, Fendrick A M Record Status This is a critical abstract of an economic evaluation that meets the criteria

2001 NHS Economic Evaluation Database.

1363. Value and cost of follow-up after adjuvant treatment of patients with Dukes' C colonic cancer

Value and cost of follow-up after adjuvant treatment of patients with Dukes' C colonic cancer Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2001 NHS Economic Evaluation Database.

1364. Cost-effectiveness of colorectal cancer screening Full Text available with Trip Pro

Cost-effectiveness of colorectal cancer screening Cost-effectiveness of colorectal cancer screening Cost-effectiveness of colorectal cancer screening McMahon P M, Bosch J L, Gleason S, Halpern E F, Lester J S, Gazelle G S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study (...) and the conclusions drawn. Health technology Four strategies for the screening of colorectal cancer (CRC) were analysed: colonoscopy (CSCPY), double-contrast barium enema examination (DCBE), faecal occult blood testing (FOBT), and flexible sigmoidoscopy (FS). All of these are widely used in current practice. Type of intervention Screening. Economic study type Cost-effectiveness analysis. Study population The characteristics of the patient population studied were unclear. It seemed that the patient population

2001 NHS Economic Evaluation Database.

1365. Decision analysis for the cost-effective management of recurrent colorectal cancer

Park K C, Schwimmer J, Shepherd J E, Phelps M E, Czernin J R, Schiepers C, Gambhir S S. Decision analysis for the cost-effective management of recurrent colorectal cancer. Annals of Surgery 2001; 233(3): 310-319 PubMedID Other publications of related interest Comment: Annals of Surgery 2001;233:320-1. Indexing Status Subject indexing assigned by NLM MeSH Colorectal Neoplasms /economics /mortality /pathology; Cost-Benefit Analysis; Decision Trees; Direct Service Costs; Fluorodeoxyglucose F18; Humans (...) Decision analysis for the cost-effective management of recurrent colorectal cancer Decision analysis for the cost-effective management of recurrent colorectal cancer Decision analysis for the cost-effective management of recurrent colorectal cancer Park K C, Schwimmer J, Shepherd J E, Phelps M E, Czernin J R, Schiepers C, Gambhir S S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary

2001 NHS Economic Evaluation Database.

1366. Presymptomatic diagnosis of hereditary colorectal cancer

changed. Findings by SBU Alert This is a translation of version 1, published on February 2, 2000. The latest version of this report is not available in English. People with a hereditary disposition for colorectal cancer are at high risk for developing cancer during their lifetime. Methods are available both to determine whether such a predisposition exists and to detect early stages of cancer. Given this information, patients can be screened via regular examination of the colon (coloscopy) and in some (...) and prophylactic colectomy in patients with heriditary non-polyposis colorectal cancer mutations. Ann Intern Med 1998;15:787-796. Vasen HF, van Ballegooijen M, Kleibeuker JK, Taal BG, Griffioen G, Nagengast FM et al. A cost-effectiveness analysis of colorectal screening of hereditary non-polyposis colorectal carcinoma gene carriers. Cancer 1998;82:1632-37. SBU Assessment presents a comprehensive, systematic assessment of available scientific evidence. The certainty of the evidence for each finding

2001 Swedish Council on Technology Assessement

1367. Corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Full Text available with Trip Pro

Corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Gastrointestinal and ovarian cancers are common cancers. The incidence of associated malignant bowel obstruction in patients with advanced cancers of these types is not known, and the best management of these patients is controversial. Inappropriate management may result in uncontrolled (faeculant) vomiting, pain and distress. Management of the symptoms can include (...) of corticosteroids.A comprehensive list of all studies was provided by an extensive search of the electronic databases, relevant journals, reference lists, the grey literature, contact with investigators and other search strategies outlined in the methods.As the review concentrates on the 'best evidence' available of the role of corticosteroids in malignant bowel obstruction due to advanced gynaecological and gastrointestinal cancer the inclusion criteria were kept fairly broad so as to include all studies

2000 Cochrane

1368. Surgery for the resolution of symptoms in malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. (Abstract)

Surgery for the resolution of symptoms in malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Intestinal obstruction commonly occurs in progressive advanced gynaecological and gastrointestinal cancers. Management of these patients is difficult due to the patients deteriorating mobility and function (performance status), the lack of further chemotherapeutic options and the high mortality and morbidity associated with palliative surgery. There are marked variations (...) scientific studies on intestinal obstruction due to advanced gynaecological and gastrointestinal cancer, in order to assess the efficacy of surgery.A comprehensive list of studies was provided by an extensive search of electronic databases, relevant journals, bibliographic databases, conference proceedings, reference lists, the grey literature, personal contact and the world wide web.As the review concentrates on the 'best evidence' available of the role of surgery in malignant bowel obstruction

2000 Cochrane

1369. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. (Abstract)

Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Some epidemiological studies have suggested that high dietary intake of calcium and fibre reduces colorectal carcinogenesis. Available data are not sufficient to serve as a basis for firm dietary advice. We undertook a multicentre randomised trial to test the effect of diet supplementation with calcium and fibre on adenoma (...) recurrence.We randomly assigned 665 patients with a history of colorectal adenomas to three treatment groups, in a parallel design: calcium gluconolactate and carbonate (2 g elemental calcium daily), fibre (3.5 g ispaghula husk), or placebo. Participants had colonoscopy after 3 years of follow-up. The primary endpoint was adenoma recurrence. Analyses were by intention to treat.23 patients died, 15 were lost to follow-up, 45 refused repeat colonoscopy, and five developed severe contraindications

2000 Lancet Controlled trial quality: predicted high

1370. The effect of fecal occult-blood screening on the incidence of colorectal cancer. (Abstract)

The effect of fecal occult-blood screening on the incidence of colorectal cancer. Both annual testing for fecal occult blood and biennial testing significantly reduce mortality from colorectal cancer. However, the effect of screening on the incidence of colorectal cancer remains uncertain, despite the diagnosis and removal of precancerous lesions in many persons who undergo screening.We followed the participants in the Minnesota Colon Cancer Control Study for 18 years. A total of 46,551 people (...) between 1986 and 1992. Study participants have been followed with respect to newly diagnosed cases of colorectal cancer and deaths. Follow-up has been more than 90 percent complete.During the 18-year follow-up period, we identified 1359 new cases of colorectal cancer: 417 in the annual-screening group, 435 in the biennial-screening group, and 507 in the control group. The cumulative incidence ratios for colorectal cancer in the screening groups as compared with the control group were 0.80 (95 percent

2000 NEJM Controlled trial quality: uncertain

1371. Management of upper gastro-intestinal cancers

Management of upper gastro-intestinal cancers Management of upper gastro-intestinal cancers Management of upper gastro-intestinal cancers NHS Centre for Reviews and Dissemination Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NHS Centre for Reviews and Dissemination. Management of upper gastro-intestinal cancers. University of York (...) . Effective Health Care 6(4). 2000 Authors' objectives This bulletin aims to summarise the available evidence on the management of upper gastro-intestinal cancers. Authors' conclusions Most people with cancer of the upper gastro-intestinal system survive for only a few months after diagnosis. Long-term (five-year) survival rates for England and Wales for oesophageal, stomach and pancreatic cancer are 9%, 12%, and 3% respectively. These survival rates are generally worse than those reported by other

2000 Health Technology Assessment (HTA) Database.

1372. A systematic review of laparoscopic-assisted resection of colorectal malignancies

with open colectomy. 2. To assess the laparoscopic treatment of colorectal malignancies in relation to long-term survival rates and the risk of tumor implantation in the laparoscopic port sites. Authors' conclusions The ASERNIP-S review group recommended a classification of 2: 'The safety and/or efficacy of the procedure cannot be determined at present due to an evidence base of incomplete and/or poor quality. Further research should be conducted to establish safety and/or efficacy'. Project page URL (...) A systematic review of laparoscopic-assisted resection of colorectal malignancies A systematic review of laparoscopic-assisted resection of colorectal malignancies A systematic review of laparoscopic-assisted resection of colorectal malignancies Australian Safety and Efficacy Register of New Interventional Procedures - Surgical Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has

2000 Health Technology Assessment (HTA) Database.

1373. Guidance on the use of laparoscopic surgery for colorectal cancer

Guidance on the use of laparoscopic surgery for colorectal cancer Guidance on the use of laparoscopic surgery for colorectal cancer Guidance on the use of laparoscopic surgery for colorectal cancer National Institute for Clinical Excellence Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation National Institute for Clinical Excellence. Guidance on the use (...) of laparoscopic surgery for colorectal cancer. London: National Institute for Clinical Excellence (NICE). Technology Appraisal Guidance 17. 2000 Authors' objectives To provide guidance on the use of laparoscopic surgery for colorectal cancer. Authors' conclusions Guidance 1.1 For colorectal cancer, open rather than laparoscopic resection should be the preferred surgical procedure. 1.2 Laparoscopic surgery should only be undertaken for colorectal cancer as part of a randomised controlled clinical trial

2000 Health Technology Assessment (HTA) Database.

1374. [Colorectal cancer screening in Finland: conditions and effects]

information on the possible justification for introducing screening for colorectal cancer in Finland. This report aims to present the facts in sufficient amount and detail for health policy decisions. Authors' conclusions Like in other industrialised countries, in Finland colorectal cancer is an important cause of premature death. The disease can be detected in symptomless persons at an early, localised stage, when it often is possible to give curative treatment. Screening aims at reducing mortality (...) . Screening for colorectal cancer is being considered in many European countries, but no country at present offers screening for its population. Active follow-up of risk groups takes place in several countries, including Finland; the extent of these programmes varies. Many alternative methods are available for screening. Detection of occult blood in stools is the most common primary test. If blood is detected, the next examination can be either endoscopy or radiography of the colon. Colonoscopy has been

2000 Health Technology Assessment (HTA) Database.

1375. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. (Abstract)

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.387 patients previously untreated with chemotherapy (other than adjuvant) for advanced colorectal cancer were randomly (...) , reversible, non-cumulative, and manageable.Irinotecan combined with fluorouracil and calcium folinate was well-tolerated and increased response rate, time to progression, and survival, with a later deterioration in quality of life. This combination should be considered as a reference first-line treatment for metastatic colorectal cancer.

2000 Lancet Controlled trial quality: uncertain

1376. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. (Abstract)

Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. The risks of colorectal cancer and adenoma, the precursor lesion, are believed to be influenced by dietary factors. Epidemiologic evidence that cereal fiber protects against colorectal cancer is equivocal. We conducted a randomized trial to determine whether dietary supplementation with wheat-bran fiber reduces the rate of recurrence of colorectal (...) adenomas.We randomly assigned 1429 men and women who were 40 to 80 years of age and who had had one or more histologically confirmed colorectal adenomas removed within three months before recruitment began to a supervised program of dietary supplementation with either high amounts (13.5 g per day) or low amounts (2 g per day) of wheat-bran fiber. The primary end point was the presence or absence of new adenomas at the time of follow-up colonoscopy. Subjects and physicians, including colonoscopists, were

2000 NEJM Controlled trial quality: predicted high

1377. Comparison of flourouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial. QUASAR Collaborative Group. (Abstract)

Comparison of flourouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial. QUASAR Collaborative Group. Standard adjuvant chemotherapy for colorectal cancer consists of fluorouracil with folinic acid or levamisole. The large QUASAR randomised trial aimed to investigate (in a two x two design) whether use of a higher dose of folinic acid or addition of levamisole to fluorouracil and folinic acid improved (...) survival.Patients with colorectal cancer, without evident residual disease, were randomly assigned fluorouracil (370 mg/m2) with high-dose (175 mg) or low-dose (25 mg) L-folinic acid and either active or placebo levamisole. The fluorouracil and folinic acid could be given either as six 5-day courses with 4 weeks between the start of the courses or as 30 once-weekly doses. Levamisole (50 mg) or placebo was given three times daily for 3 days repeated every 2 weeks for 12 courses. The primary endpoint

2000 Lancet Controlled trial quality: predicted high

1378. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. (Abstract)

Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal cancer. Irinotecan prolongs survival in patients with colorectal cancer that is refractory to treatment with fluorouracil and leucovorin. In a multicenter trial, we compared a combination of irinotecan, fluorouracil and leucovorin with bolus doses of fluorouracil and leucovorin (...) as first-line therapy for metastatic colorectal cancer. A third group of patients received irinotecan alone.Patients were randomly assigned to receive irinotecan (125 mg per square meter of body-surface area intravenously), fluorouracil (500 mg per square meter as an intravenous bolus), and leucovorin (20 mg per square meter as an intravenous bolus) weekly for four weeks every six weeks; fluorouracil (425 mg per square meter as an intravenous bolus) and leucovorin (20 mg per square meter

2000 NEJM Controlled trial quality: uncertain

1379. The cost effectiveness of self-expanding metal stents in the management of malignant left-sided large bowel obstruction Full Text available with Trip Pro

for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The study evaluated the cost-effectiveness of self-expanding metal stents to treat acute left-sided large bowel obstruction in colorectal carcinoma. The authors concluded that stenting showed reduction in hospital stay and costs, but further analysis was necessary due to small sample size (...) . The level of bias was likely to have been high and scope of the economic analysis limited. However, as indicated by the authors, results are suggestive of stenting being cost-effective and further research is warranted. Type of economic evaluation Cost-effectiveness analysis Study objective The study evaluated the cost-effectiveness of self-expanding metal stents to treat acute left-sided large bowel obstruction in colorectal carcinoma. Interventions Two interventions were compared: self-expanding metal

2000 NHS Economic Evaluation Database.

1380. Survival benefit of chemotherapy in metastatic colorectal cancer: a meta-analysis of randomized controlled trials

Survival benefit of chemotherapy in metastatic colorectal cancer: a meta-analysis of randomized controlled trials Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2000 DARE.