Latest & greatest articles for colorectal cancer

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Top results for colorectal cancer

1401. Is virtual colonoscopy a cost-effective option to screen for colorectal cancer?

implications. Academic Radiology 1998;5:282-8. Indexing Status Subject indexing assigned by NLM MeSH Adult; Colonic Polyps /diagnosis /economics; Colonoscopy /economics; Colorectal Neoplasms /diagnosis /economics; Computer Simulation; Cost-Benefit Analysis; Feasibility Studies; Female; Humans; Image Processing, Computer-Assisted /economics; Male; Markov Chains; Mass Screening /economics; Sensitivity and Specificity; Tomography, X-Ray Computed /economics; User-Computer Interface AccessionNumber 21999001546 (...) Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? Is virtual colonoscopy a cost-effective option to screen for colorectal cancer? Sonnenberg A, Delco F, Bauerfeind P Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed

1999 NHS Economic Evaluation Database.

1402. Colorectal cancer screening in Italy: feasibility and cost-effectiveness in a model area

by NLM MeSH Colonic Neoplasms /epidemiology; Colonoscopy /economics; Colorectal Neoplasms /economics /prevention & Cost-Benefit Analysis; Feasibility Studies; Humans; Incidence; Italy /epidemiology; Mass Screening /economics; Occult Blood; Sigmoidoscopy /economics; control AccessionNumber 21999001362 Date bibliographic record published 31/08/2001 Date abstract record published 31/08/2001 NHS Economic Evaluation Database (NHS EED) Produced by the Centre for Reviews and Dissemination Copyright © 2019 (...) Colorectal cancer screening in Italy: feasibility and cost-effectiveness in a model area Colorectal cancer screening in Italy: feasibility and cost-effectiveness in a model area Colorectal cancer screening in Italy: feasibility and cost-effectiveness in a model area Sorrentino D, Paduano R, Bernardis V, Piccolo A, Bartoli E Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods

1999 NHS Economic Evaluation Database.

1403. Postoperative management of stage II/III colon cancer: a decision analysis

. Bibliographic details Michel P, Merle V, Chiron A, Ducrotte P, Paillot B, Hecketsweiler P, Czernichow P, Colin R. Postoperative management of stage II/III colon cancer: a decision analysis. Gastroenterology 1999; 117(4): 784-793 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Cohort Studies; Colonic Neoplasms /economics /pathology /therapy; Decision Support Techniques; Health Care Costs; Humans; Neoplasm Staging; Postoperative Care; Sensitivity and Specificity; Survival Analysis (...) Postoperative management of stage II/III colon cancer: a decision analysis Postoperative management of stage II/III colon cancer: a decision analysis Postoperative management of stage II/III colon cancer: a decision analysis Michel P, Merle V, Chiron A, Ducrotte P, Paillot B, Hecketsweiler P, Czernichow P, Colin R Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods

1999 NHS Economic Evaluation Database.

1404. The findings and impact of nonrehydrated guaiac examination of the rectum (FINGER) study: a comparison of 2 methods of screening for colorectal cancer in asymptomatic average-risk factors

reported. Study design Retrospective cohort study carried out at a single centre. No patients were lost to follow-up. Analysis of effectiveness The analysis of the clinical study was based on the intention to treat principle. The primary health outcomes used included the number of patients with a colonic source of occult gastrointestinal bleeding, with neoplastic lesions, adenomas, adenomas greater than or equal to 1 cm in diameter, adenocarcinoma, vascular ectasias, ulcerative colitis, Crohn disease (...) . Colorectal cancer screening in asymptomatic populations. Gut 1995;36(4):590-598. Indexing Status Subject indexing assigned by NLM MeSH Colonoscopy /economics; Colorectal Neoplasms /complications /diagnosis /economics; Diagnosis, Differential; Female; Gastrointestinal Hemorrhage /diagnosis /economics /etiology; Humans; Male; Medical Records; Middle Aged; Occult Blood; Predictive Value of Tests; Retrospective Studies; Risk AccessionNumber 21999008269 Date bibliographic record published 29/02/2000 Date

1999 NHS Economic Evaluation Database.

1405. Irinotecan in second-line treatment of metastatic colorectal cancer: improved survival and cost-effect compared with infusional 5-FU

the ULN (in the case of lever metastases, transaminase concentrations of 5 times ULN or less and bilirubin 1.5 times the ULN or less were permitted), and creatinine of 135 micromol/L or less. Patients were excluded if they had undergone prior treatment with topoisomerase I inhibitors, raltitrexed, or oxaliplatin. Also, if they had bulky disease (>50% hepatic involvement; >25% lung involvement, or abdominal mass >/= 10 cm), central nervous system metastases, or unresolved bowel obstruction or diarrhoea (...) the costs were incurred over a short time period, due to the short survival of patients with metastatic colorectal cancer. The unit costs were generally reported separately from the quantities of resources used. The economic evaluation included drug acquisition costs, administration costs (inpatient stay and disposable equipment), and expenses associated with complications of treatment and disease. These expenses were for visits to the oncologist, radiologist, gynaecologist, surgeon, dermatologist

1999 NHS Economic Evaluation Database.

1406. An economic evaluation of Tomudex (raltitrexed) and 5-fluorouracil plus leucovorin in advanced colorectal cancer

trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia. European Journal of Cancer 1995;31A:1945-54. Cunningham D, Zalcberg JR, Rath U, et al. Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. Annals of Oncology 1996;7:961-5. Indexing Status Subject indexing assigned by NLM MeSH Antineoplastic Agents /economics /therapeutic use; Colorectal Neoplasms /drug therapy /economics (...) An economic evaluation of Tomudex (raltitrexed) and 5-fluorouracil plus leucovorin in advanced colorectal cancer An economic evaluation of Tomudex (raltitrexed) and 5-fluorouracil plus leucovorin in advanced colorectal cancer An economic evaluation of Tomudex (raltitrexed) and 5-fluorouracil plus leucovorin in advanced colorectal cancer Groener M G, van Ineveld B M, Byttebier G, van Hout B A, Rutten F F Record Status This is a critical abstract of an economic evaluation that meets the criteria

1999 NHS Economic Evaluation Database.

1407. Oxaliplatin: a review of its use in the management of metastatic colorectal cancer

a combination of 5-fluorouracil and calcium folinate. Various dose and administration schedules were used. Chronomodulation, the administration of varying doses of oxaliplatin at differing times of the day, was used in some studies. Participants included in the review Patients who had been diagnosed as having metastatic colorectal carcinoma and who were aged between 18 and 75 years. The patients were generally required to have biopsy-proven adenocarcinoma, measurable recurrent or metastatic disease, a WHO (...) , Adkins J C, Plosker G L, Goa K L. Oxaliplatin: a review of its use in the management of metastatic colorectal cancer. Drugs and Aging 1999; 14(6): 459-475 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Animals; Antineoplastic Agents /therapeutic use; Clinical Trials as Topic; Colorectal Neoplasms /drug therapy /pathology; Drug Interactions; Humans; In Vitro Techniques; Neoplasm Metastasis /drug therapy; Organoplatinum Compounds /adverse effects /pharmacokinetics /pharmacology

1999 DARE.

1408. Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis

to September 1998) and a review of the references was undertaken to identify English-language articles. The search was undertaken using the MeSH terms 'colorectal, colon, and rectal neoplasm' or textword terms 'colorectal, colon, and rectal cancer' combined with the MeSH terms 'estrogen, estrogen replacement therapy' or textword terms 'hormone replacement therapy, postmenopausal hormones, noncontraceptive hormones'. Study selection Study designs of evaluations included in the review Observational studies (...) analyses were performed within categories of hormone use (ever use, current use and duration of current use) and cancer type (colon cancer, rectal cancer, colorectal cancer). Included studies used several cut off points for duration of hormone use (e.g. 4, 5, and 6 years). Participants included in the review Postmenopausal women. Pre-menopausal women were excluded from the analysis where possible. Outcomes assessed in the review Estimates of the risk of cancers of the colon or rectum in relation

1999 DARE.

1409. Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis

being conducted by the Women's Health Initiative which will examine colon cancer as a primary outcome. Results from this study are expected in 2006. Bibliographic details Nanda K, Bastian L A, Hasselblad V, Simel D L. Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis. Obstetrics and Gynecology 1999; 93(5 Part 2 Supplement S): 880-888 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Colorectal Neoplasms /mortality /prevention & Female; Hormone Replacement (...) were extracted by two authors using a pretested data extraction sheet with disagreements being resolved by consensus: study design; study size; tumour site; multivariable adjusted odds ratio (OR) or relative risk (RR) with 95% confidence intervals; years of HRT use; and factors used to estimate adjusted RR. Relative risk and 95%CI were calculated by recency of HRT use, by duration of use of HRT, and by colon cancer subsite. Women who had never used HRT were used as the reference group. The OR from

1999 DARE.

1410. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology

in the review Prospective and retrospective studies were eligible for inclusion. Randomised trials were given more weight, but data from non-randomised trials, case series and surveys were also included. Specific interventions included in the review Studies of any monitoring strategy to detect people with asymptomatic metastatic disease following surgery for colon or rectal cancer were eligible for inclusion in the review. The interventions included in the review were colonoscopy, rigid and flexible (...) surgery for sporadic cases of colon or rectal cancer and were symptom free at study entry were eligible for inclusion. Where possible, the authors considered colon and rectal cancers separately. People with hereditary cancers were excluded. Outcomes assessed in the review Studies were eligible for inclusion if they included data on overall and disease-free survival, quality of life, toxicity, or cost-effectiveness. How were decisions on the relevance of primary studies made? An expert panel

1999 DARE.

1411. Whole-body pet imaging with (18F) fluorodeoxyglucose in management of recurrent colorectal cancer

. Authors' conclusions Positron emission tomography was more sensitive and specific than CT in the detection of recurrent colorectal cancer. Preoperative detection of a nonresectable tumour by PET may avoid unnecessary surgery, and thereby reduce the cost of patient treatment. CRD COMMENTARY - Selection of comparators The strategy of CT imaging was explicitly regarded as the comparator because it was a procedure routinely performed in the context in question. You, as a database user, should consider (...) Whole-body pet imaging with (18F) fluorodeoxyglucose in management of recurrent colorectal cancer Whole-body pet imaging with (18F) fluorodeoxyglucose in management of recurrent colorectal cancer Whole-body pet imaging with (18F) fluorodeoxyglucose in management of recurrent colorectal cancer Valk P E, Abella-Columna E, Haseman M K, Pounds T R, Tesar R D, Myers R W, Greiss H B, Hofer G A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion

1999 NHS Economic Evaluation Database.

1412. Adjuvant portal-vein infusion of fluorouracil and heparin in colorectal cancer: a randomised trial. European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group, the Gruppo Interdisciplinare Valutazione Interv (Abstract)

Adjuvant portal-vein infusion of fluorouracil and heparin in colorectal cancer: a randomised trial. European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group, the Gruppo Interdisciplinare Valutazione Interv There is conflicting evidence on the efficacy of regional adjuvant chemotherapy, via portal-vein infusion (PVI), after resection of colorectal cancer. We undertook a randomised controlled multicentre trial to investigate the efficacy of PVI (...) died. 5-year survival did not differ significantly between the groups (73 vs 72%; 95% Cl for difference -6 to 4). The control and PVI groups were also similar in terms of disease-free survival at 5 years (67 vs 65%) and the number of patients with liver metastases (79 vs 77%).PVI of fluorouracil, at a dose of 500 mg/m2 for 7 days, cannot be recommended as the sole adjuvant treatment for high-risk colorectal cancer after complete surgical excision. However, these results cannot eliminate a small

1998 Lancet Controlled trial quality: predicted high

1413. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. (Abstract)

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. In phase II trials, irinotecan is active in patients with advanced colorectal cancer, but the survival and clinical benefit of irinotecan compared with second-line fluorouracil by continuous infusion is not known.267 patients who had failed to respond to first-line fluorouracil, or whose disease had progressed after treatment with first-line (...) and 8.5 months (p=0.06) for irinotecan and fluorouracil, respectively. Both treatments were equally well tolerated. QoL was similar in both groups.Compared with fluorouracil by continuous infusion second-line irinotecan significantly improved survival in patients with advanced colorectal cancer.

1998 Lancet Controlled trial quality: uncertain

1414. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. (Abstract)

-of-life analysis, all significant differences, except on diarrhoea score, were in favour of the irinotecan group.Our study shows that despite the side-effects of treatment, patients who have metastatic colorectal cancer, and for whom fluorouracil has failed, have a longer survival, fewer tumour-related symptoms, and a better quality of life when treated with irinotecan than with supportive care alone. (...) Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. In phase II studies, irinotecan is active in metastatic colorectal cancer, but the overall benefit has not been assessed in a randomised clinical trial.Patients with proven metastatic colorectal cancer, which had progressed within 6 months of treatment with fluorouracil, were randomly assigned either 300-350 mg/m2 irinotecan every 3 weeks

1998 Lancet Controlled trial quality: uncertain

1415. Irinotecan as second line chemotherapy in colorectal cancer (preliminary report)

anti-tumour activity. These results have been confirmed in reports of randomised controlled trials which show a statistically significant improved survival for patients on irinotecan compared to either best supportive care or 5FU. Irinotecan appears to be a promising new agent in the treatment of colorectal cancer. However it is currently not possible to assess its cost effectiveness in detail. In common with other cytotoxic agents irinotecan is commonly associated with adverse reactions. Frequent (...) Irinotecan as second line chemotherapy in colorectal cancer (preliminary report) Irinotecan as second line chemotherapy in colorectal cancer (preliminary report) Irinotecan as second line chemotherapy in colorectal cancer (preliminary report) Smithies A, Stein K Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Smithies A, Stein K

1998 Health Technology Assessment (HTA) Database.

1416. The management of colorectal cancer

Authors' objectives To summarise the research evidence which informed the Department of Health's Clinical Outcomes Group's guidance on commissioning cancer services, based on a series of systematic reviews. Authors' conclusions Colorectal (bowel) cancer is the second most common cause of cancer death in the UK. The disease is curable when not too far advanced and UK survival rates could be substantially improved with better management. Project page URL Indexing Status Subject indexing assigned by CRD (...) The management of colorectal cancer The management of colorectal cancer The management of colorectal cancer NHS Centre for Reviews and Dissemination Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation NHS Centre for Reviews and Dissemination. The management of colorectal cancer. York: University of York. Effective Health Care 3(6). 1998

1998 Health Technology Assessment (HTA) Database.

1417. Use of raltitrexed (Tomudex) in the management of metastatic colorectal cancer

development and implementation. J Clin Oncol 1995;13:502-12. 2. Germond C, Maroun, J, Zwaal C, Wong S, Gastro-intestinal Cancer Disease Site Group. Use of raltitrexed in the management of metastatic colorectal cancer. Curr Oncol 1999;6:217-23. Indexing Status Subject indexing assigned by CRD MeSH Antimetabolites, Antineoplastic /administration & Colorectal Neoplasms /drug therapy; Quinazolines /administration & Thiophenes /administration & dosage; dosage; dosage AccessionNumber 12003008191 Date (...) Use of raltitrexed (Tomudex) in the management of metastatic colorectal cancer Use of raltitrexed (Tomudex) in the management of metastatic colorectal cancer Use of raltitrexed (Tomudex) in the management of metastatic colorectal cancer Gastrointestinal Cancer Disease Site Group CRD summary This review assessing the role of raltitrexed in the management of metastatic colorectal cancer found that raltitrexed appears to have equivalent survival benefits to 5-fluorouracil plus leucovorin in people

1998 DARE.

1418. Follow-up of colorectal cancer: a meta-analysis

resection may, therefore, have been overstated in the review's conclusion. Implications of the review for practice and research The authors did not state any implications for practice or further research. Bibliographic details Rosen M, Chan L, Beart R W, Vukasin P, Anthone G. Follow-up of colorectal cancer: a meta-analysis. Diseases of the Colon and Rectum 1998; 41(9): 1116-1126 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Adult; Aged; Aged, 80 and over; Colorectal Neoplasms /diagnosis (...) to changes in symptoms only. Participants included in the review Patients who had undergone resection for colorectal cancer were included. Outcomes assessed in the review The outcome measures were the curative resection rates after recurrent cancer, the survival rates of curative re-resections, the length of survival after recurrence, and the cumulative 5-year survival. Curative resection for recurrent cancer was defined as no tumour left behind and no evidence of disease for at least 30 days post

1998 DARE.

1419. A meta-analysis of hormone replacement therapy and colon cancer in women

A meta-analysis of hormone replacement therapy and colon cancer in women A meta-analysis of hormone replacement therapy and colon cancer in women A meta-analysis of hormone replacement therapy and colon cancer in women Hebert-Croteau N Authors' objectives To investigate the association between hormone replacement therapy (HRT) and colon cancer. Searching MEDLINE and Cancerlit were searched (dates not stated). Keywords included: colorectal neoplasm or colonic neoplasm or gastrointestinal (...) of hormone replacement therapy and colon cancer in women. Cancer Epidemiology, Biomarkers and Prevention 1998; 7(8): 653-659 Other publications of related interest 1. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. 2. MacLennan SC, MacLennan AH, Ryan P. Colorectal cancer and oestrogen replacement therapy. A meta-analysis of epidemiologic studies. Medical Journal of Australia 1995;162:491-3. Indexing Status Subject indexing assigned by NLM MeSH Adult; Age

1998 DARE.

1420. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer

in the review Patients diagnosed with colon or rectal cancer. The mean age of participants was 63 years and 61% were male. Outcomes assessed in the review Outcomes assessed were: tumour response and survival rates. Complete response (CR) and partial response (PR) criteria adopted in individual trials followed the World Health Organization (WHO) recommendations and were identical in all trials. Patients with minimal response, stable disease, or tumour progression were considered to have had no response (...) to study this approach in the surgical adjuvant setting. Bibliographic details Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Journal of Clinical Oncology 1998; 16(1): 301-308 PubMedID Indexing Status Subject indexing assigned by NLM MeSH Antimetabolites, Antineoplastic /administration & Colorectal Neoplasms /drug therapy /mortality; Fluorouracil /administration & Humans; Infusions, Intravenous

1998 DARE.