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Latest & greatest articles for colorectal cancer
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Targeting parallel bypass signaling to combat adaptive resistance to BRAF inhibition in colorectalcancer 29854868 2018 11 14 2331-4737 5 3-4 2018 Mar Oncoscience Oncoscience Targeting parallel bypass signaling to combat adaptive resistance to BRAF inhibition in colorectalcancer. 57-58 10.18632/oncoscience.401 Gao Chenxi C Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Hu Jing J Department (...) of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. eng Editorial 2018 04 29 United States Oncoscience 101636666 2331-4737 BRAF CRC FAK resistance the Wnt/b-catenin pathway CONFLICTS OF INTEREST The authors declare no potential conflicts of interest. 2018 04 16 2018 04 16 2018 6 2 6 0 2018 6 2 6 0 2018 6 2 6 1 epublish 29854868 10.18632/oncoscience.401 401 PMC5978442 Sci Signal. 2012 Jan 10;5(206):ra3 22234612 Proc Natl Acad
The safety and clinical efficacy of recombinant human granulocyte colony stimulating factor injection for coloncancer patients undergoing chemotherapy. The present study was designed to evaluate safety and efficacy of recombinant human granulocyte colony stimulating factor (G-CSF) injection and whether this regimen could reduce the incidence of adverse events caused by chemotherapy.A total of 100 patients with coloncancer who were treated with chemotherapy in our hospital from January 2011 (...) , the incidence of liver dysfunction in the treatment group was lower than that of the control group, without statistical significance. The incidence of myalgia in the treatment was higher than that of the control group without statistical significance.The present study indicated that G-CSF injection after chemotherapy is safe and effective for preventing adverse events in coloncancer patients with chemotherapy.
Perspectives on the evolving state of the art management of gastrointestinal stromal tumoursGastrointestinal stromal tumours (GISTs) represent a very exciting tumour entity for the medical oncologist. There has been extensive clinical and preclinical research dissecting the natural behaviour, molecular landscape and therapeutic responsiveness of this rare mesenchymal tumour. Various molecular subtypes of GIST have a differing prognostic and predictive relevance in the state of the art (...) management of the disease. Emerging mature clinical trial data gathered over the last one and half decade provided substantial molecular profiling information in understanding the success and eventual failure of treatment. In our review of the most relevant literature we aim to guide the clinician in tailoring neoadjuvant, adjuvant and palliative treatment of GIST alongside the different, now well established molecular subgroups of GISTs.
Association of baseline absolute neutrophil counts and survival in patients with metastatic colorectalcancer treated with second-line antiangiogenic therapies: exploratory analyses of the RAISE trial and validation in an electronic medical record data se In the RAISE trial, ramucirumab+leucovorin/fluorouracil/irinotecan (FOLFIRI) improved the median overall survival (mOS) of patients with previously treated metastatic colorectalcancer versus patients treated with placebo+FOLFIRI but had
Safety data from the phase III Japanese ACHIEVE trial: part of an international, prospective, planned pooled analysis of six phase III trials comparing 3 versus 6 months of oxaliplatin-based adjuvant chemotherapy for stage III coloncancer The International Duration Evaluation of Adjuvant chemotherapy project investigated whether a shorter duration of oxaliplatin-based adjuvant chemotherapy was as effective as 6 months of identical chemotherapy for resected stage III coloncancer. As part (...) of this project, we report safety data from the Japanese ACHIEVE study (JFMC47-1202-C3).ACHIEVE was an open-label, multicentre trial randomising patients with stage III coloncancer to receive 3 m or 6 m of mFOLFOX6/CAPOX after surgery. Choice of regimen was declared before randomisation by a site investigator.Between August 2012 and June 2014, 1313 patients were enrolled and, of those, 1277 were analysed for the safety analysis, with 635 in arm 6 (mFOLFOX6, n=158; CAPOX, n=477) and 642 in arm 3 (mFOLFOX6, n
Long-Term Effectiveness of Sigmoidoscopy Screening on ColorectalCancer Incidence and Mortality in Women and Men: A Randomized Trial. The long-term effects of sigmoidoscopy screening on colorectalcancer (CRC) incidence and mortality in women and men are unclear.To determine the effectiveness of flexible sigmoidoscopy screening after 15 years of follow-up in women and men.Randomized controlled trial. (ClinicalTrials.gov: NCT00119912).Oslo and Telemark County, Norway.Adults aged 50 to 64 years (...) in women.Norwegian government and Norwegian Cancer Society.
Cystic Fibrosis ColorectalCancer Screening Consensus Recommendations Cystic Fibrosis ColorectalCancer Screening Consensus Recommendations - Gastroenterology Email/Username: Password: Remember me Search AGA Journals Search Terms Search within Search Volume 154, Issue 3, Pages 736–745.e14 Cystic Fibrosis ColorectalCancer Screening Consensus Recommendations x Denis Hadjiliadis Affiliations Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania Correspondence Reprint (...) Institute of Oncology, Milan, Italy 5 , x Albert B. Lowenfels Affiliations New York Medical College, Valhalla, New York 6 on behalf of the x Cystic Fibrosis ColorectalCancer Screening Task Force x Amy Leigh Braid x Amy Leigh Braid , x Joanne Cullina x Joanne Cullina , x Anne Daggett x Anne Daggett , x Aliza Fink x Aliza Fink , x Andrea Gini x Andrea Gini , x Denis Hadjiliadis x Denis Hadjiliadis , x Paul F. Harron x Paul F. Harron , x Sarah Hempstead x Sarah Hempstead , x Alexander Khoruts x Alexander
Computed Tomography Colonography vs Colonoscopy for ColorectalCancer Surveillance After Surgery Recommendations for surveillance after curative surgery for colorectalcancer (CRC) include a 1-year post-resection abdominal-pelvic computed tomography (CT) scan and optical colonoscopy (OC). CT colonography (CTC), when used in CRC screening, effectively identifies colorectal polyps ≥10 mm and cancers. We performed a prospective study to determine whether CTC, concurrent with CT, could substitute (...) for OC in CRC surveillance.Our study enrolled 231 patients with resected stage 0-III CRC, identified at 5 tertiary care academic centers. Approximately 1 year after surgery, participants underwent outpatient CTC plus CT, followed by same-day OC. CTC results were revealed after endoscopic visualization of sequential colonic segments, which were re-examined for discordant findings. The primary outcome was performance of CTC in the detection of colorectal adenomas and cancers using endoscopy
Factors That Contribute to Differences in Survival of Black vs White Patients With ColorectalCancer Previous studies reported that black vs white disparities in survival among elderly patients with colorectalcancer (CRC) were because of differences in tumor characteristics (tumor stage, grade, nodal status, and comorbidity) rather than differences in treatment. We sought to determine the contribution of differences in insurance, comorbidities, tumor characteristics, and treatment receipt (...) to disparities in black vs white patients with CRC 18-64 years old.We used data from the National Cancer Database, a hospital-based cancer registry database sponsored by the American College of Surgeons and the American Cancer Society, on non-Hispanic black (black) and non-Hispanic white (white) patients, 18-64 years old, diagnosed from 2004 through 2012 with single or first primary invasive stage I-IV CRC. Each black patient was matched, based on demographic, insurance, comorbidity, tumor, and treatment
New-Onset Cardiovascular Morbidity in Older Adults With Stage I to III ColorectalCancer Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectalcancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I (...) to III colorectalcancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408). Results Median age at diagnosis of colorectalcancer was 78 years (range, 66 years to 106 years), and median follow-up was 8 years since diagnosis. The 10-year cumulative incidence of new-onset CVD and CHF were 57.4% and 54.5% compared with 22% and 18% for control, respectively ( P < .001
Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic ColorectalCancer: A Randomized Phase III Trial (PRODIGE 9) Purpose Conflicting results are reported for maintenance treatment with bevacizumab during chemotherapy-free intervals (CFI) in metastatic colorectalcancer after induction chemotherapy. Patients and Methods In this open-label, phase III, randomized controlled trial, we compared the tumor control duration (TCD) observed with bevacizumab (...) maintenance and with no treatment (observation) during CFI subsequent to induction chemotherapy with 12 cycles of fluorouracil, leucovorin, and irinotecan plus bevacizumab. After disease progression, the induction regimen was repeated for eight cycles, followed by a new CFI. Results From March 2010 to July 2013, 491 patients were randomly assigned. Disease progression or death occurred during induction chemotherapy in 85 patients (17%); 261 patients (53%) had at least one reinduction, 107 (22%) had two
of therapy was noninferior to 6 months, with a 3-year rate of disease-free survival of 83.1% and 83.3%, respectively (hazard ratio, 1.01; 95% CI, 0.90 to 1.12). Among patients with cancers that were classified as T4, N2, or both, the disease-free survival rate for a 6-month duration of therapy was superior to that for a 3-month duration (64.4% vs. 62.7%) for the combined treatments (hazard ratio, 1.12; 95% CI, 1.03 to 1.23; P=0.01 for superiority).Among patients with stage III coloncancer receiving (...) Duration of Adjuvant Chemotherapy for Stage III ColonCancer. Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a fluoropyrimidine has been standard adjuvant therapy in patients with stage III coloncancer. However, since oxaliplatin is associated with cumulative neurotoxicity, a shorter duration of therapy could spare toxic effects and health expenditures.We performed a prospective, preplanned, pooled analysis of six randomized, phase 3 trials that were conducted
Adverse reactions of sorafenib, sunitinib, and imatinib in treating digestive system tumors This study was conducted to assess the adverse reactions caused by multi-target tyrosine kinase inhibitor treatment of gastrointestinal tumors.We carried out a retrospective study of drug-related adverse reactions in 115 patients who were treated with sorafenib, sunitinib, and imatinib for primary hepatocellular carcinoma or gastrointestinal stromal tumors from October 2003 to March 2012 at the Peking (...) University International Hospital.The total incidence of adverse reactions of sorafenib, sunitinib, and imatinib in patients with hepatocellular carcinoma and gastrointestinal stromal tumors was > 80%. The main adverse reactions of sorafenib were hypertension in 38 patients (33.3%) and diarrhea in 28 patients (24.4%). Sunitinib was associated with higher incidence and greater grade 3-4 toxicity. The common toxicities were skin color changes in 105 patients (90.9%), hand-foot skin reactions in 65 patients
Impact of GITumor Board on Patient Management and Adherence to Guidelines As the burden of cancer on the population and the health care system continues to increase with more complicated treatment options, the need for multidisciplinary teams to be as efficient as possible becomes more vital. Our study aimed to evaluate the consistency of GITumor Board (GI TB) recommendations with international guidelines, the adherence of physicians involved in patient care to TB recommendations (...) , and the impact on the management of patients.A prospective cohort study was conducted from January to June 2016 at our institution, which is a major tertiary hospital that provides comprehensive cancer care. All cases presented at the GI TB during this period were included. Data regarding adherence to National Comprehensive Cancer Network guidelines, adherence to TB recommendations, and changes made to the management of patients were collected weekly from the GI TB in a data collection form.Of the 104
Non-exposed endoscopic wall-inversion surgery for gastrointestinal stromal tumor Laparoscopic and endoscopic cooperative surgery (LECS) is an accepted method of laparoscopic wedge resection, which is minimally invasive, for gastrointestinal stromal tumors (GISTs). We established a type of LECS achieving a full-thickness resection, non-exposed endoscopic wall-inversion surgery (NEWS), in an effort to prevent exposure of the peritoneal cavity to gastric intraluminal contents. We employed (...) this surgical technique in 28 gastric GIST patients. We failed to complete NEWS in the initial two patients and in one patient with a largetumor (40 mm × 35 mm), but otherwise carried out the procedure successfully. Although a learning effect is speculated to occur, based on a decreasing trend in the operation time, the median operation time was 184 minutes showing that NEWS is still a time-consuming method. No significant differences were recognized in tumor size or location, except near
Effect of a Digital Health Intervention on Receipt of ColorectalCancer Screening in Vulnerable Patients: A Randomized Controlled Trial. Screening for colorectalcancer (CRC) reduces mortality, yet more than one third of age-eligible Americans are unscreened.To examine the effect of a digital health intervention, Mobile Patient Technology for Health-CRC (mPATH-CRC), on rates of CRC screening.Randomized clinical trial. (ClinicalTrials.gov: NCT02088333).6 community-based primary care practices (...) to be screened within 6 months, discussed screening with their provider, and had a screening test ordered. Half of mPATH-CRC participants (53%; 118 of 223) "self-ordered" a test via the program.Participants were English speakers in a single health care system.A digital health intervention that allows patients to self-order tests can increase CRC screening. Future research should identify methods for implementing similar interventions in clinical care.National Cancer Institute.
Colonoscopy and ColorectalCancer Mortality in the Veterans Affairs Health Care System: A Case-Control Study. Colonoscopy is widely used in the Veterans Affairs (VA) health care system for colorectalcancer (CRC) prevention, but its effect on CRC mortality is unknown.To determine whether colonoscopy is associated with decreased CRC mortality in veterans and whether its effect differs by anatomical location of CRC.Case-control study.VA-Medicare administrative data.Case patients were veterans (...) aged 52 years or older who were diagnosed with CRC between 2002 and 2008 and died of the disease by the end of 2010. Case patients were matched to 4 control patients without prior CRC on the basis of age, sex, and facility. Conditional logistic regression was performed to calculate odds ratios (ORs) for exposure to colonoscopy, with adjustment for race, Charlson Comorbidity Index score, selected chronic conditions, nonsteroidal anti-inflammatory drug use, and family history of CRC.Exposure