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Latest & greatest articles for colorectal cancer
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on colorectal cancer or other clinical topics then use Trip today.
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Can nut consumption improve coloncancer survival? 30363796 2018 11 14 2415-1289 3 2018 Translational gastroenterology and hepatology Transl Gastroenterol Hepatol Can nut consumption improve coloncancer survival? 73 10.21037/tgh.2018.09.14 Aune Dagfinn D Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Department of Nutrition, Bjørknes University College, Oslo, Norway. Department of Endocrinology, Morbid Obesity and Preventive Medicine
Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on ColorectalCancer Detection: A Community-Based Cohort Study. The fecal immunochemical test (FIT) is commonly used for colorectalcancer (CRC) screening. Despite demographic variations in stool hemoglobin concentrations, few data exist regarding optimal positivity thresholds by age and sex.To identify programmatic (multitest) FIT performance characteristics and optimal FIT quantitative hemoglobin positivity (...) thresholds in a large, population-based, screening program.Retrospective cohort study.Kaiser Permanente Northern and Southern California.Adults aged 50 to 75 years who were eligible for screening and had baseline quantitative FIT results (2013 to 2014) and 2 years of follow-up. Nearly two thirds (411 241) had FIT screening in the previous 2 years.FIT programmatic sensitivity for CRC and number of positive test results per cancer case detected, overall and by age and sex.Of 640 859 persons who completed
Recent advances in colorectalcancer screening 30276360 2018 11 14 2589-0514 4 3 2018 Sep Chronic diseases and translational medicine Chronic Dis Transl Med Recent advances in colorectalcancer screening. 139-147 10.1016/j.cdtm.2018.08.004 Li Dan D Department of Gastroenterology, Kaiser Permanente Medical Center, Santa Clara, CA 95051, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. eng Editorial 2018 09 17 China Chronic Dis Transl Med 101679934 2095 (...) -882X Colonoscopy Colorectalcancer Screening 2018 06 26 2018 10 3 6 0 2018 10 3 6 0 2018 10 3 6 1 epublish 30276360 10.1016/j.cdtm.2018.08.004 S2095-882X(18)30060-4 PMC6160607 Lancet. 2013 Apr 6;381(9873):1185-93 23414648 Am J Surg Pathol. 2004 Nov;28(11):1452-9 15489648 Gastroenterology. 2016 Nov;151(5):870-878.e3 27443823 CA Cancer J Clin. 2017 May 6;67(3):177-193 28248415 Gastroenterology. 2015 Sep;149(3):777-82; quiz e16-7 26226577 Am J Gastroenterol. 2012 Sep;107(9):1315-29; quiz 1314, 1330
percentage points; 95% CI, 0.1%-6.8%) and any colorectalcancer screening (18.3% vs 14.5%; difference, 3.8 percentage points; 95% CI, 0.6%-7.0%). We observed large variation across health centers in effectiveness (FIT completion differences range, -7.4 percentage points to 17.6 percentage points) and implementation (proportion who were mailed a FIT range, 6.5% to 68.2%). The number needed to mail to achieve a completed FIT was 4.8 overall, and 4.0 in clinics that mailed a FIT reminder.An EHR-embedded (...) Effectiveness of a Mailed ColorectalCancer Screening Outreach Program in Community Health Clinics: The STOP CRC Cluster Randomized Clinical Trial Approximately 24 million US individuals receive care at federally qualified health centers, which historically have low rates of colorectalcancer screening. The US Preventive Services Task Force recommends routine colorectalcancer screening for individuals aged 50 to 75 years.To determine the effectiveness of an electronic health record (EHR
New Development of Biomarkers for GastrointestinalCancers: From Neoplastic Cells to Tumor Microenvironment Biomarkers refer to a plethora of biological characteristics that can be quantified to facilitate cancer diagnosis, forecast the prognosis of disease, and predict a response to treatment. The identification of objective biomarkers is among the most crucial steps in the realization of individualized cancer care. Several tumor biomarkers for gastrointestinal malignancies have been applied (...) in the clinical setting to help differentiate between cancer and other conditions, facilitate patient selection for targeted therapies, and to monitor treatment response and recurrence. With the coming of the immunotherapy age, the need for a new development of biomarkers that are indicative of the immune response to tumors are unprecedentedly urgent. Biomarkers from the tumor microenvironment, tumor genome, and signatures from liquid biopsies have been explored, but the majority have shown a limited
Macrophage repolarisation therapy in colorectalcancer 30116595 2018 08 17 2059-7029 3 5 2018 ESMO open ESMO Open Macrophage repolarisation therapy in colorectalcancer. e000426 10.1136/esmoopen-2018-000426 Halama Niels N Department of Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases, UniversitatsKlinikum Heidelberg, Heidelberg, Germany. eng Journal Article 2018 08 03 England ESMO Open 101690685 2059-7029 Podcast Competing interests: None declared. 2018 8 18 6 0
administration is a key factor in the tolerability and efficacy of colon preparation in colorectalcancer screening ]. 236-42 10.1016/j.gastrohep.2012.01.012 The quality and tolerability of antegrade (...) gut lavage bowel preparation are key elements in the success of population-based colorectalcancer screening . To evaluate cleansing quality and tolerability according to the timing of polyethylene glycol administration in persons undergoing colorectalcancer screening . Participants in colorectalcancer (...) residue following colon preparation Colonoscopy reaches the cecum Withdrawal time from cecum to is 6 minutes or more Complete removal of identified polyps (not piecemeal 2015 9. Effectiveness of screening colonoscopy in reducing the risk of death from right and left coloncancer : a large community-based study. OBJECTIVE: Screening colonoscopy's effectiveness in reducing colorectalcancer mortality risk in community populations is unclear, particularly for right- coloncancers , leading
cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages. OBJECTIVE: To assess the net balance of benefits and harms from routine aspirin use across clinically relevant age, sex 2016 7. The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectalcancer : a systematic review and economi The clinical effectiveness (...) (#1 or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for colorectalcancer The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many
The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of ColonCancer Background: CT-guided marking technique is rarely used in abdominal or urologic surgery. We developed and performed a marking technique for a small tumor, undetectable by ultrasound, using CT guidance before laparoscopic resection of the tumor. Case Presentation: A 73-year-old woman with a history of breast cancer underwent right colectomy with D3 lymph node dissection (...) for ascending coloncancer. Five years after the operation, a solitary tumor was found in the right pararenal region of the retroperitoneal space on enhanced abdominal CT. The tumor was 20 mm in diameter and undetectable by ultrasound, so we performed a marking technique using CT guidance before the operation. Placing the patient in a prone position on the CT table, a 22-gauge needle was inserted into the Gerota's fascia percutaneously and a mixed fluid containing India ink and Iopamidol was injected para
Efficacy of continuing anti-angiogenic agents in the second-line treatment for metastatic coloncancer depending on the KRAS mutation status: a meta-analysis Метаанализ исследований по оценке эффективности продолжения применения антиангиогенных препаратов во 2-й линии терапии больных метастатическим раком толстой кишки в зависимости от мутационного статуса гена KRAS | Федянин | Тазовая хирургия и онкология Тазовая хирургия и онкология | ISSN 2413-0583 (Print) ISSN 2686-9594 (Online) Войти Логин (...) исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России Россия 115478 Москва, Каширское шоссе, 24 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России Россия 115478 Москва, Каширское шоссе, 24 Список литературы 1. Bennouna J., Sastre J., Arnold D. et al. ML18147 Study Investigators. Continuation of bevacizumab after first progression in metastatic colorectalcancer (ML18147): a randomised phase 3 trial. Lancet Oncol 2013;14(1):29–37. PMID: 23168366
TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable RAS and BRAF wild-type metastatic colorectalcancer FOLFOXIRI plus bevacizumab is considered a standard option in the upfront treatment of clinically selected patients with metastatic colorectalcancer irrespective of RAS and BRAF molecular status. The randomised MACBETH and VOLFI studies showed that a modified FOLFOXIRI regimen (...) initially unresectable and previously untreated RAS and BRAF wild-type metastatic colorectalcancer patients are randomised to receive a standard treatment with mFOLFOX6 plus panitumumab or an experimental regimen with modified FOLFOXIRI (irinotecan 150 mg/m2, oxaliplatin 85 mg/m2, L-leucovorin 200 mg/m2, 5-fluoruracil 2400 mg/m2 48-hour continuous infusion) plus panitumumab up to 12 cycles, followed by panitumumab plus 5-fluorouracil and L-leucovorin until disease progression. The primary endpoint
Colorectalcancer Evidence Maps - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4
FOLFOX or CAPOX in Stage II to III ColonCancer: Efficacy Results of the Italian Three or Six Colon Adjuvant Trial Purpose Given the cumulative neurotoxicity associated with oxaliplatin, a shorter duration of adjuvant therapy, if equally efficacious, would be advantageous for patients and health-care systems. Methods The Three or Six Colon Adjuvant trial is an open-label, phase III, multicenter, noninferiority trial randomizing patients with high-risk stage II or stage III coloncancer (...) . Conclusion The Three or Six Colon Adjuvant trial failed to formally show noninferiority of 3 versus 6 months of treatment to the predefined margin of 20% relative increase. The results depended on the adjuvant regimen and risk. For CAPOX, 3 months were as good as 6 months; for FOLFOX, 6 months added extra benefit. Counter-intuitively, the low-risk patients benefitted more than the high-risk population from the 6-month duration. The choice of regimen and duration should depend on patient characteristics
Statement R. Goodwin, C. Agbassi, E. Kennedy, J. Biagi, R. Wong, S. Welch, S. Berry, and the Gastrointestinal Disease Site Group Report Date: July 3, 2018 This document describes the CCO- GastrointestinalCancer Disease Site Group endorsement of The predictive effect of primary tumour location in the treatment of metastatic colorectalcancer: a Canadian consensus statement published in 2017 by Abrahao et al. The original publication is available at Current Oncology Vol 24, No 6 (2017) For information (...) , Agbassi C, Kennedy E, Biagi J, Wong R, Welch S, Berry S, and the Gastrointestinal Disease Site Group. The Role of Primary Tumour Location in the selection of Biologics for the Treatment of Unresectable Metastatic ColorectalCancer: An Endorsement of a Canadian Consensus Statement. Toronto (ON): Cancer Care Ontario; 2018 May. Program in Evidence-based Care Guideline No.: 2-31. Copyright This report is copyrighted by Cancer Care Ontario; the report and the illustrations herein may not be reproduced
Bowel Obstruction and Ventral Hernia After Laparoscopic Versus Open Surgery for Rectal Cancer in A Randomized Trial (COLOR II) The aim of this study was to evaluate the risk of bowel obstruction, incisional, and parastomal hernia following laparoscopic versus open surgery for rectal cancer.Laparoscopic surgery for rectal cancer has been adopted worldwide, after trials reported similar oncological outcomes compared with open surgery. Little is known about long-term morbidity, including bowel (...) in risk of bowel obstruction, incisional, or parastomal hernia following laparoscopic or open surgery for rectal cancer.Based on long-term morbidity outcomes, laparoscopic surgery for rectal cancer could be considered a routine technique as there are no differences with open surgery.
Three Versus 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Patients With Stage III ColonCancer: Disease-Free Survival Results From a Randomized, Open-Label, International Duration Evaluation of Adjuvant (IDEA) France, Phase III Trial Purpose Reduction of adjuvant treatment duration may decrease toxicities without loss of efficacy in stage III coloncancer. This could offer clear advantages to patients and health care providers. Methods In International Duration Evaluation of Adjuvant (...) Chemotherapy (IDEA) France, as part of the IDEA international collaboration, patient with coloncancer patients were randomly assigned to 3 and 6 months of modified FOLFOX6 (mFOLFOX6: infusional fluorouracil, leucovorin, and oxaliplatin) or capecitabine plus oxaliplatin (CAPOX) by physician choice. The primary end point was disease-free survival (DFS), and analyses were descriptive. Results A total of 2,010 eligible patients received either 3 or 6 months of chemotherapy (modified intention-to-treat
Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic ColorectalCancer: The FRESCO Randomized Clinical Trial. Patients with metastatic colorectalcancer (CRC) have limited effective and tolerable treatment options.To evaluate the efficacy and safety of oral fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, as third-line or later therapy in patients with metastatic CRC.FRESCO (Fruquintinib Efficacy and Safety in 3+ Line (...) ColorectalCancer Patients) was a randomized, double-blind, placebo-controlled, multicenter (28 hospitals in China), phase 3 clinical trial. From December 2014 to May 2016, screening took place among 519 patients aged 18 to 75 years who had metastatic CRC that progressed after at least 2 lines of chemotherapy but had not received VEGFR inhibitor therapy; 416 met the eligibility criteria and were stratified by prior anti-VEGF therapy and K-ras status. The final date of follow-up was January 17, 2017
Shortening adjuvant chemotherapy in stage III coloncancer: are we ready for a change? 29942667 2019 01 30 2059-7029 3 4 2018 ESMO open ESMO Open Shortening adjuvant chemotherapy in stage III coloncancer: are we ready for a change? e000392 10.1136/esmoopen-2018-000392 Roda Desamparados D CIBERONC, Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. Ciardiello Fortunato F Oncologia Medica, Dipartimento di Internistica Clinica e (...) Sperimentale 'F. Magrassi', Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Cervantes Andrés A CIBERONC, Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. eng Editorial 2018 06 20 England ESMO Open 101690685 2059-7029 coloncancer Competing interests: None declared. 2018 04 30 2018 05 01 2018 6 27 6 0 2018 6 27 6 0 2018 6 27 6 1 epublish 29942667 10.1136/esmoopen-2018-000392 esmoopen-2018-000392 PMC6012558 Ann Oncol. 2017