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Latest & greatest articles for cyclobenzaprine
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Cyclobenzaprine Top results for cyclobenzaprine - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 (...) or #2) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for cyclobenzaprine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other
Is cyclobenzaprine useful for pain? RCT bias 5 - 15mg spasticity anti-muscarinic High dose CNS depressant T1/2 > 18h sedative Parkinsons rigidity Is cyclobenzaprine useful for pain? March - April 2017 Mailing Address: Therapeutics Initiative The University of British Columbia Department of Anesthesiology, Pharmacology & Therapeutics 2176 Health Sciences Mall Vancouver, BC Canada V6T 1Z3 Tel.: 604 822 0700 Fax: 604 822 0701 E-mail: email@example.com www.ti.ubc.ca 105 C yclobenzaprine is a tricyclic (...) molecule discovered in 1956 that is structurally related to amitriptyline and imipramine. Evaluated first as a possible tranquilizer, it was noted to have atropine-like properties in animals. 1 In Can- ada, Merck Frosst Research Laboratories envisaged cyclo- benzaprine as a centrally active skeletal muscle relaxant. 2 However, it was soon apparent that despite being sedative and anti-muscarinic, cyclobenzaprine was not useful for spasticity 3 , nor for rigidity in Parkinson’s disease 4 . Health Canada
Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial. Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination.To compare functional outcomes and pain at 1 week and 3 months after an ED visit for acute LBP among (...) patients randomized to a 10-day course of (1) naproxen + placebo; (2) naproxen + cyclobenzaprine; or (3) naproxen + oxycodone/acetaminophen.This randomized, double-blind, 3-group study was conducted at one urban ED in the Bronx, New York City. Patients who presented with nontraumatic, nonradicular LBP of 2 weeks' duration or less were eligible for enrollment upon ED discharge if they had a score greater than 5 on the Roland-Morris Disability Questionnaire (RMDQ). The RMDQ is a 24-item questionnaire
Long-term Use of Cyclobenzaprine for Pain Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should be considered along with other types (...) , posted on a web site, redistributed by email or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners? own terms and conditions. TITLE: Long-term Use of Cyclobenzaprine for Pain: A Review of the Clinical Effectiveness DATE
Cyclobenzaprine for the treatment of myofascial pain in adults. Myofascial pain (MP) is a painful condition characterized by pain transmitted from trigger points (TP) within myofascial structures (in the muscles), local or distant from the pain. TPs can produce a characteristic pattern of irradiated pain or autonomic symptoms when stimulated. Cyclobenzaprine, a muscle relaxant that suppresses muscle spasm without interfering with muscle function, is used in clinical management of MP to improve (...) quality of sleep and reduce pain.To assess efficacy and safety of cyclobenzaprine in treating MP.The Pain Palliative and Supportive Care Review Group's Specialised Register, CENTRAL, PubMed, EMBASE, LILACS and Scielo were searched in February 2009.All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome.Two review authors independently screened studies identified, extracted data, assessed trial quality and analyzed results.We
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia.Articles describing randomized, placebo-controlled trials of cyclobenzaprine in people with fibromyalgia were obtained from Medline, EMBase, Psyclit, the Cochrane Library, and Federal Research in Progress Database. Unpublished literature and bibliographies were also reviewed. Outcomes, including global improvement, treatment effects
Cyclobenzaprine and back pain: a meta-analysis Cyclobenzaprine and back pain: a meta-analysis Cyclobenzaprine and back pain: a meta-analysis Browning R, Jackson J L, O'Malley P G Authors' objectives To perform a systematic review of the effectiveness of cyclobenzaprine in the treatment of back pain. Searching MEDLINE (from January 1966 to December 1999), PsycLIT (from November 1887 to December 1999), CINAHL (from 1982 to 1999), EMBASE (from January 1974 to December 1999), AIDSLINE, HealthSTAR (...) , Cancerlit and MICROMEDEX were searched. The searches were conducted using the textwords and keywords (all languages) 'cyclobenzaprine', and the MeSH terms 'dibenzocycloheptenes' and 'propylamines' combined with the following textwords: 'back pain', 'backache', 'low back pain', 'lumbago', 'acute muscle spasm' or 'muscle spasm'. Other databases searched were the Cochrane Controlled Trials Register for randomised trials, the Cochrane Database of Systematic Reviews, and Federal Research in Progress
Cyclobenzaprine and back pain: a meta-analysis. Back pain is a common problem for which cyclobenzaprine hydrochloride is frequently prescribed.To perform a systematic review of cyclobenzaprine's effectiveness in the treatment of back pain.We searched MEDLINE, PsycLIT, CINAHL, EMBASE, AIDSLINE, HEALTHSTAR, CANCERLIT, the Cochrane Library, Micromedex, Federal Research in Progress, and the references of reviewed articles, and contacted Merck, Sharpe and Dohme for English-language, randomized (...) , placebo-controlled trials of cyclobenzaprine in adults with back pain. Outcomes included global improvement and 5 specific domains of back pain (local pain, muscle spasm, range of motion, tenderness to palpation, and activities of daily living). Study quality was assessed using the methods of Jadad. Summary outcomes were obtained using a random-effects model.Patients treated with cyclobenzaprine were nearly 5 times (odds ratio, 4.7; 95% confidence interval, 2.7-8.1) as likely to report symptom
Cyclobenzaprine in intractable pain syndromes with muscle spasm. The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by skeletal muscle spasm and tenderness. The investigation was double-blind and randomized, comparing cyclobenzaprine hydrochloride (10 mg three times a day) with diazepam (5 mg three times a day) and with placebo. After two weeks of treatment (...) , the 16 patients in the cyclobenzaprine group showed an overall improvement in pain variables as did the 16 patients in the diazepam group. No serious adverse reactions to cyclobenzaprine were observed in the study. However, dry mouth due to cyclobenzaprine's anticholinergic action and mild degrees of drowsiness were encountered more often than with diazepam or placebo.