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Effect of exercise training for five years on all cause mortality in older adults-the Generation 100 study: randomised controlled trial. To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years).Randomised controlled trial.General population of older adults in Trondheim, Norway.1567 of 6966 individuals born between 1936 and 1942.Participants were randomised to two sessions weekly of high (...) intensity interval training at about 90% of peak heart rate (HIIT, n=400), moderate intensity continuous training at about 70% of peak heart rate (MICT, n=387), or to follow the national guidelines for physical activity (n=780; control group); all for five years.All cause mortality. An exploratory hypothesis was that HIIT lowers mortality more than MICT.Mean age of the 1567 participants (790 women) was 72.8 (SD 2.1) years. Overall, 87.5% of participants reported to have overall good health, with 80
of about 3.5 for covid-19. The model predicted that school closures and isolation of younger people would increase the total number of deaths, albeit postponed to a second and subsequent waves. The findings of this study suggest that prompt interventions were shown to be highly effective at reducing peak demand for intensive care unit (ICU) beds but also prolong the epidemic, in some cases resulting in more deaths long term. This happens because covid-19 related mortality is highly skewed towards older (...) Effect of school closures on mortality from coronavirus disease 2019: old and new predictions. To replicate and analyse the information available to UK policymakers when the lockdown decision was taken in March 2020 in the United Kingdom.Independent calculations using the CovidSim code, which implements Imperial College London's individual based model, with data available in March 2020 applied to the coronavirus disease 2019 (covid-19) epidemic.Simulations considering the spread of covid-19
mortality and discharge disposition in elderly trauma patients over the age of 65 y. J Surg Res 2018;230:13-9. Alabaf Sabbaghi S, De Souza D, Sarikonda P, Keevil VL, Wallis SJ, Romero-Ortuno R. Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team. Aging Medicine 2018;1:120-124. Basic D, Shanley C. Frailty in an older inpatient population: using the clinical frailty scale to predict (...) patient outcomes. J Aging Health 2015;27:670-85. Cardona M, Lewis ET, Kristensen MR, Skjot-Arkil H, Ekmann AA, Nygaard HH, et al. Predictive validity of the CriSTAL tool for short-term mortality in olderpeople presenting at Emergency Departments: a prospective study. Eur Geriatr Med 2018;9:891-901. Cheung A, Haas B, Ringer TJ, McFarlan A, Wong CL. Canadian Study of Health and Aging Clinical Frailty Scale: Does It Predict Adverse Outcomes among Geriatric Trauma Patients? J Am Coll Surg 2017;225:658
that they are overlooked in the consultation with health care professionals because of their age. They have felt that they are being belittled and not taken seriously. It may therefore be justified to investigate, problematise and, if necessary, improve the attitudes of health care personnel towards pain in the older persons. In studies with qualitative methodology, both personnel in health care and older persons 1 with pain have experienced that health care professionals have insufficient knowledge about pain (...) For a description of the age composition of the patient populations in included studies and the handling of assessing the certainty of the scientific basis, see “Main findings”. Background and aim Several common pain drugs may not be suitable for the treatment of older persons (65 years and older) due to an increased risk of adverse events, which in some cases may be serious. In the light of this problem, long-term pain conditions are the focus of this evaluation. In addition, several problems and shortcomings
Bendamustine for relapsed multiple myeloma (all ages) NHS England » Bendamustine for relapsed multiple myeloma (all ages) Cookies on the NHS England and NHS Improvement website We’ve put some small files called cookies on your device to make our site work. We’d also like to use analytics cookies. These send information about how our site is used to a service called Google Analytics. We use this information to improve our site. Let us know if this is OK. We’ll use a cookie to save your choice (...) . You can before you choose. Change my preferences I'm OK with analytics cookies Search Search Menu . If you are a member of the public looking for health advice, go to the . And if you are looking for the latest travel information, and advice about the government response to the outbreak, go to the . Bendamustine for relapsed multiple myeloma (all ages) Document first published: 9 July 2020 Page updated: 22 July 2020 Topic: , , Publication type: , Document PDF 112 KB 15 pages Document PDF 58 KB 5
and work with each RACF on their prevention plans. This is an urgent need and we recommend the following immediate interventions: 1. RACFs must be linked to their Local Health Network (or equivalent). 2. Local Health Networks must have an outbreak management team and plan that is linked with RACFs. The team should include people with expertise in geriatric medicine, health care of olderpeople in aged care, infectious diseases and public health. Senior executives of LHNs need to lead these teams (...) Statement on COVID-19 Response in Residential Aged Care Facilities Statement on COVID-19 Response in Residential Aged Care Facilities Background Older Australians and New Zealanders living in residential aged care facilities (RACF) are more at risk of becoming very unwell or dying from COVID-19. The protection and care of olderpeople living in RACF is one of the most significant challenges faced by Australia and New Zealand during the pandemic. ANZSGM supports the use of the most up-to-date
: 10.1001/jamanetworkopen.2020.12252. Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive Mild Cognitive Impairment: A Randomized Clinical Trial , , , , , , , , Affiliations Expand Affiliations 1 Department of Neurology, Emory University School of Medicine, Atlanta, Georgia. 2 Division of General Medicine and Geriatrics, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. 3 Division of Cardiology, Department of Medicine, Emory (...) are associated with a unique cognitive protection. It is unclear if this is due to reduced blood pressure (BP) or angiotensin receptors type 1 blockade. Objective: To determine neurocognitive effects of candesartan vs lisinopril in older adults with mild cognitive impairment (MCI). Design, setting, and participants: This randomized clinical trial included participants aged 55 years or older with MCI and hypertension. Individuals were withdrawn from prior antihypertensive therapy and randomized in a 1 to 1
-CoV-2 spike protein (S-2P) in healthy adults. The trial was expanded to include 40 older adults, who were stratified according to age (56 to 70 years or ≥71 years). All the participants were assigned sequentially to receive two doses of either 25 μg or 100 μg of vaccine administered 28 days apart.Solicited adverse events were predominantly mild or moderate in severity and most frequently included fatigue, chills, headache, myalgia, and pain at the injection site. Such adverse events were dose (...) -dependent and were more common after the second immunization. Binding-antibody responses increased rapidly after the first immunization. By day 57, among the participants who received the 25-μg dose, the anti-S-2P geometric mean titer (GMT) was 323,945 among those between the ages of 56 and 70 years and 1,128,391 among those who were 71 years of age or older; among the participants who received the 100-μg dose, the GMT in the two age subgroups was 1,183,066 and 3,638,522, respectively. After the second
In older patients with NSTE-ACS, clopidogrel safely reduced bleeding compared with ticagrelor at 1 year. Gimbel M, Qaderdan K, Willemsen L, et al. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial. Lancet. 2020;395:1374-81. 32334703.
Age- and Weight-Adapted Dose of Prasugrel Versus Standard Dose of Ticagrelor in Patients With Acute Coronary Syndromes : Results From a Randomized Trial. The efficacy and safety of a reduced dose of prasugrel versus a standard dose of ticagrelor in elderly patients or those with a low body weight presenting with an acute coronary syndrome (ACS) are unknown.To investigate the effect of an age- and weight-adapted dose of prasugrel versus a standard dose of ticagrelor in patients with ACS (...) . (ClinicalTrials.gov: NCT01944800).Prespecified analysis of the multicenter, randomized ISAR-REACT 5 trial.23 centers in Germany and Italy.3997 patients with ACS planned for invasive management.Participants were randomly assigned to receive a standard dose of ticagrelor or prasugrel (reduced dose in the elderly or low-weight group and standard dose in the neither elderly nor low-weight group).The efficacy end point was a composite of death, myocardial infarction, or stroke, and the safety end point was bleeding
Environmental and behavioural interventions for reducing physical activity limitation and preventing falls in olderpeople with visual impairment. Impairment of vision is associated with a decrease in activities of daily living. Avoidance of physical activity in older adults with visual impairment can lead to functional decline and is an important risk factor for falls. The rate of falls and fractures is higher in olderpeople with visual impairment than in age-matched visually normal older (...) February 2020, with no language restrictions.Eligible studies were randomized controlled trials (RCTs) and quasi-randomized controlled trials (Q-RCTs) that compared environmental interventions, behavioral interventions or both, versus control (usual care or no intervention); or that compared different types of environmental or behavioral interventions. Eligible study populations were olderpeople (aged 60 and over) with irreversible visual impairment, living in their own homes or in residential
Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Lennox?Gastaut syndrome (LGS) in conjunction with clobazam, for patients 2 years of age and older. 1 Published 7 September 2020 1 SMC2263 cannabidiol 100mg/ml oral solution (Epidyolex®) GW Research Ltd 7 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice (...) is summarised as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Lennox- Gastaut syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced drop seizure frequency in the clobazam-treated subgroup of children and adults (aged 2 to 55 years
Cannabidiol (Epidyolex) - As adjunctive therapy of seizures associated with Dravet syndrome (DS) in conjunction with clobazam, for patients 2 years of age and older. 1 Published 7 September 2020 1 SMC2262 cannabidiol 100mg/ml oral solution (Epidyolex®) GW Research Ltd 7 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised (...) as follows: ADVICE: following a full submission considered under the orphan process cannabidiol (Epidyolex ® ) is accepted for use within NHSScotland. Indication under review: for use as adjunctive therapy of seizures associated with Dravet syndrome, in conjunction with clobazam, for patients 2 years of age and older. In two phase III, placebo-controlled studies cannabidiol reduced convulsive seizure frequency in the clobazam-treated subgroup of children (aged 2 to 18 years) with Dravet syndrome
Brolucizumab (Beovu) - For the treatment of neovascular (wet) age-related macular degeneration (wAMD). 1 Published 7 September 2020 1 SMC2272 brolucizumab 120mg/mL solution for injection in pre- filled syringe (Beovu®) Novartis Pharmaceutical UK Ltd 07 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards and Area Drug and Therapeutics Committees (ADTCs) on its use in NHSScotland (...) . The advice is summarised as follows: ADVICE: following a full submission brolucizumab (Beovu®) is accepted for use within NHSScotland. Indication under review: in adults for the treatment of neovascular (wet) age-related macular degeneration (AMD). Non-inferiority of brolucizumab versus another anti-vascular endothelial growth factor medicine was demonstrated for mean change in best corrected visual acuity from baseline to week 48 in two phase III studies in patients with neovascular AMD. This advice
has declined in all age groups, and the olderage groups drive the overall reduction. We have that the UK case-fatality rate (CFR) has fallen substantially from its peak in April. One explanation is that, unlike in March and April, new cases are predominantly in younger people who have a better outcome. We, therefore, sought to examine trends in CFR over time to see if the fatality rate was declining across all age groups. Due to the absence of age-stratified case data in the UK (although we’re (...) 10 (week commencing 3rd March) till week 35 (week ending 31st August). In the early phase of the pandemic, deaths in Germany mirrored cases, but the recent trend is for cases to increase whilst deaths continue to decline. Crude estimates of the CFR over time show that for peopleaged 80 and over the average CFR was 29% up to week 18, fell to 17% in weeks 19 to 27, and for mid-July onwards the CFR was 11% – a decrease of 61%. A larger decrease is seen in the ages 60-79 with average CFR ~ 9
people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design: Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010-2017 ('ASPirin in Reducing Events in the Elderly (ASPREE)', n=19 114) in community-dwelling persons aged ≥70 years. Clinical characteristics were collected at baseline and annually. The endpoint was major GI bleeding that resulted in transfusion (...) City, Iowa, USA. 9 Division of Geriatrics, Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, Minnesota, USA. 10 Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare, Minneapolis, Minnesota, USA. PMID: 32747412 DOI: Item in Clipboard Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial Suzanne E Mahady et al. Gut . 2020 . Show details Display
of Physiotherapy, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. 3 Department of Kinesiology, University of Waterloo and Schlegel-UW Research Institute for Aging, Waterloo, Canada. 4 School of Health and Life Sciences, Institute of Applied Health Research, Centre for Living, Glasgow Caledonian University, Glasgow, UK. PMID: 32682416 PMCID: DOI: Free PMC article Item in Clipboard Physical fitness in older women with osteoporosis and vertebral fracture after a resistance and balance (...) fractures, but few studies have investigated the effect of exercise on outcomes of importance for this population. Post-intervention effects of exercise are even less studied. The objective of this study was to evaluate habitual walking speed and other health-related outcomes after cessation of a 3-month exercise intervention. Methods: This follow-up study was conducted 3 months post-intervention of a randomised controlled trial. A total of 149 community-dwelling Norwegian women aged 65 years or older
York, USA. 7 Aging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA. 8 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. PMID: 32710658 DOI: Item in Clipboard Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial Kenneth S Boockvar et al. J Am Geriatr Soc . 2020 . Show details Display options Display options Format J Am Geriatr Soc Actions . 2020 (...) College, New York, New York, USA. 7 Aging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA. 8 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. PMID: 32710658 DOI: Item in Clipboard Full-text links Cite Display options Display options Format Abstract Background/objectives: The Hospital Elder Life Program (HELP) has been shown to prevent delirium in hospitalized older adults. The objective