Latest & greatest articles for fatigue

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fatigue or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on fatigue and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for fatigue

201. General practitioners' perceptions of chronic fatigue syndrome and beliefs about its management, compared with irritable bowel syndrome: qualitative study. Full Text available with Trip Pro

General practitioners' perceptions of chronic fatigue syndrome and beliefs about its management, compared with irritable bowel syndrome: qualitative study. To compare general practitioners' perceptions of chronic fatigue syndrome and irritable bowel syndrome and to consider the implications of their perceptions for treatment.Qualitative analysis of transcripts of group discussions.A randomly selected sample of 46 general practitioners in England.The participants tended to stereotype patients (...) with chronic fatigue syndrome as having certain undesirable traits. This stereotyping was due to the lack of a precise bodily location; the reclassification of the syndrome over time; transgression of social roles, with patients seen as failing to conform to the work ethic and "sick role" and conflict between doctor and patient over causes and management. These factors led to difficulties for many general practitioners in managing patients with chronic fatigue syndrome. For both conditions many

2004 BMJ

202. Fatigue in neurological disorders. (Abstract)

Fatigue in neurological disorders. Chronic fatigue is a typical symptom of neurological diseases, and is most disabling in multiple sclerosis, postpoliomyelitis, poststroke, and in chronic fatigue syndrome. Disorders of neuromuscular junction transmission and metabolic diseases cause muscle fatigability, which is characterised by failure to sustain the force of muscle contraction (peripheral fatigue). Fatigue is also seen in diseases that affect the central, peripheral, and autonomic nervous (...) systems (central fatigue). Enhanced perception of effort and limited endurance of sustained physical and mental activities are the main characteristics of central fatigue. Metabolic and structural lesions that disrupt the usual process of activation in pathways interconnecting the basal ganglia, thalamus, limbic system, and higher cortical centre are implicated in the pathophysiological process of central fatigue. A state of pre-existing relative hypocortisolaemia might sensitise the hypothalamic

2004 Lancet

203. Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. Full Text available with Trip Pro

Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). Galantamine hydrobromide, an acetyl cholesterone inhibitor, has pharmacological properties that might benefit patients with CFS.To compare the efficacy and tolerability of galantamine hydrobromide in patients with CFS.Randomized, double-blind trial conducted June 1997 through July 1999 at 35 (...) received matching placebo tablets 3 times per day.The primary efficacy variable was the global change on the Clinician Global Impression Scale after 4, 8, 12, and 16 weeks of treatment. Secondary outcomes were changes in core symptoms of CFS on the Chalder Fatigue Rating Scale, the Fibromyalgia Impact Questionnaire, and the Pittsburgh Sleep Quality Index; changes in quality of life on the Nottingham Health Profile; and assessment of plasma-free cortisol levels and cognitive performance on a computer

2004 JAMA Controlled trial quality: predicted high

204. Exercise therapy for chronic fatigue syndrome. (Abstract)

Exercise therapy for chronic fatigue syndrome. Chronic fatigue syndrome (CFS) is an illness characterised by persistent medically unexplained fatigue. CFS is a serious health-care problem with a prevalence of up to 3%. Treatment strategies for CFS include psychological, physical and pharmacological interventions.To investigate the relative effectiveness of exercise therapy and control treatments for CFS.CCDANCTR-Studies and CENTRAL were searched using "Chronic Fatigue" and Exercise. The Journal (...) of Chronic Fatigue Syndrome and CFS conferences were handsearched. Experts in the field were contacted. Clinicaltrials.gov and controlled-trials.com were searched.Only Randomised Controlled Trials (RCT) including participants with a clinical diagnosis of CFS and of any age were included.The full articles of studies identified were inspected by two reviewers (ME and HMG). Continuous measures of outcome were combined using standardised mean differences. An overall effect size was calculated for each

2004 Cochrane

205. Chronic fatigue syndrome, treatment

Chronic fatigue syndrome, treatment Chronic fatigue syndrome, treatment Chronic fatigue syndrome, treatment Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Chronic fatigue syndrome, treatment. Lansdale: HAYES, Inc.. Directory Publication. 2004 Authors' objectives A number of different treatments, including pharmacologic, behavioral, and physical therapy (...) modalities, have been used for chronic fatigue syndrome (CFS). The goal of treatment is relief of symptoms, which include chronic fatigue and weakness, along with a variety of other symptoms, such as fever, myalgia, arthralgia, headache, confusion or impaired cognitive function, and sometimes depression. Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Fatigue Syndrome, Chronic /therapys Language Published English Country of organisation United

2004 Health Technology Assessment (HTA) Database.

206. Chronic fatigue syndrome, diagnosis

Chronic fatigue syndrome, diagnosis Chronic fatigue syndrome, diagnosis Chronic fatigue syndrome, diagnosis Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation Chronic fatigue syndrome, diagnosis. Lansdale: HAYES, Inc.. Directory Publication. 2004 Authors' objectives Chronic fatigue syndrome (CFS) is characterized by a state of profound, persistent, and debilitating (...) fatigue that significantly impairs daily activity level. It is associated with a variety of complaints, chiefly related to the neuromuscular, neuropsychiatric, and immunological systems. The goal of the diagnostic process for this disorder is to exclude more clearly definable disorders though traditional medical assessment as well as special studies and tests. This process employs specific diagnostic criteria, particularly those associated with the psychiatric, immunologic, infectious

2004 Health Technology Assessment (HTA) Database.

207. Cost-effectiveness of cognitive behavioural therapy, graded exercise and usual care for patients with chronic fatigue in primary care

Cost-effectiveness of cognitive behavioural therapy, graded exercise and usual care for patients with chronic fatigue in primary care Cost-effectiveness of cognitive behavioural therapy, graded exercise and usual care for patients with chronic fatigue in primary care Cost-effectiveness of cognitive behavioural therapy, graded exercise and usual care for patients with chronic fatigue in primary care McCrone P, Ridsdale L, Darbishire L, Seed P Record Status This is a critical abstract (...) of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Three strategies for the treatment of patients with chronic fatigue syndrome (CFS) were examined. The strategies were cognitive-behavioural therapy (CBT), graded exercise therapy (GET), and usual general practitioner (GP) care plus

2004 NHS Economic Evaluation Database.

208. An evaluation of the environmental and health effects of vehicle exhaust catalysts in the UK

An evaluation of the environmental and health effects of vehicle exhaust catalysts in the UK An evaluation of the environmental and health effects of vehicle exhaust catalysts in the UK An evaluation of the environmental and health effects of vehicle exhaust catalysts in the UK Hutchinson E J, Pearson P J Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology The use of vehicle exhaust catalysts (VECs) was investigated. Type of intervention Primary prevention. Economic study type Cost-benefit analysis. Study population The study population comprised all urban residents in Great Britain. Setting The study setting was the community. The economic study was carried out in London, UK. Dates to which data relate The effectiveness data

2004 NHS Economic Evaluation Database.

209. Needs in health and the use of health services in the immigrant population in Catalonia. Exhaustive revision of the scientific literature

Needs in health and the use of health services in the immigrant population in Catalonia. Exhaustive revision of the scientific literature Needs in health and the use of health services in the immigrant population in Catalonia. Exhaustive revision of the scientific literature Needs in health and the use of health services in the immigrant population in Catalonia. Exhaustive revision of the scientific literature Catalan Agency for Health Technology Assessment and Research Record Status (...) This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Catalan Agency for Health Technology Assessment and Research. Needs in health and the use of health services in the immigrant population in Catalonia. Exhaustive revision of the scientific literature. Barcelona: Catalan Agency for Health Information, Assessment and Quality (CAHIAQ -formerly CAHTA). 2004 Authors' objectives

2004 Health Technology Assessment (HTA) Database.

210. Fatigue and anaesthetists

their tiredness may have had an adverse effect either upon themselves or their patient. 2.3. The Working Time regulations are directed toward limiting the number of hours that doctors can work for safety reasons. 2.4. Workload pressures, insufficient numbers of personnel and increasing complexity of procedures all magnify the problem of fatigue. This has been recognised in publications by anaesthetic bodies in America 1 and Australia and New Zealand 2 . 2.5. This document explores the problem of fatigue (...) in view of the current concern about manpower, distribution of workload and the effect of age).” 4 2.8. The British Medical Association’s 2001 Annual Representative Meeting passed a resolution commissioning their Board of Science to report into the dangers of tired doctors driving home after prolonged periods of work, and to investigate the effects of sleep deprivation on doctors, their wellbeing and their patients. 3. Fatigue and Driving 3.1. A study by the Royal Society for the Prevention

2004 Association of Anaesthetists of GB and Ireland

211. Assessment and management of cancer-related fatigue in adults. (Abstract)

Assessment and management of cancer-related fatigue in adults. Fatigue is one of the most prevalent and distressing symptoms of cancer, and is a common side-effect of many of the treatments available for the management of malignant disease. We critically assess the evidence for cancer-related fatigue and its treatment in adults. Little is known about the cause and mechanisms of fatigue, and research into methods of alleviating the condition has focused on treatment for anaemia and behavioural (...) interventions, such as exercise, both of which are effective in reducing fatigue. Although research into the condition has increased considerably in the past decade, important gaps in knowledge remain.

2003 Lancet

212. Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. Full Text available with Trip Pro

Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. To determine the subjective response to iron therapy in non-anaemic women with unexplained fatigue.Double blind randomised placebo controlled trial.Academic primary care centre and eight general practices in western Switzerland.144 women aged 18 to 55, assigned to either oral ferrous sulphate (80 mg/day of elemental iron daily; n=75) or placebo (n=69) for four weeks.Level (...) of fatigue, measured by a 10 point visual analogue scale.136 (94%) women completed the study. Most had a low serum ferritin concentration; fatigue, depression, and anxiety were similar in both groups at baseline. Both groups were also similar for compliance and dropout rates. The level of fatigue after one month decreased by -1.82/6.37 points (29%) in the iron group compared with -0.85/6.46

2003 BMJ Controlled trial quality: predicted high

213. Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash

Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash van Hout M S, Wekking E M, Berg I J, Deelman B G CRD summary This review assessed the effectiveness of psychologically based (...) treatments for 'chronic toxic encephalopathy' (CTE), chronic whiplash-associated disorder and chronic fatigue syndrome. The authors concluded that cognitive-behaviour therapy plus graded activity may improve symptoms of CTE. The conclusions were based on a small number of studies and study quality was not systematically assessed, so the conclusions may not be reliable. Authors' objectives To assess the effect of (neuro)psychological treatments for chronic toxic encephalopathy (CTE) and the comparable

2003 DARE.

214. Sleep loss and fatigue in residency training: a reappraisal. (Abstract)

Sleep loss and fatigue in residency training: a reappraisal. Reduced sleep time is commonplace for many interns and residents. Recent studies, however, suggest that sleep loss and fatigue result in significant neurobehavioral impairments in healthy young adults. We reviewed studies addressing the effects of sleep loss on cognition, performance, and health in surgical and nonsurgical residents. We describe the effectiveness of countermeasures for sleepiness, including recent work-hour (...) restrictions. A more complete understanding of the issues of sleep loss during residency training can inform innovative strategies to minimize the effects of sleepiness and fatigue on patient care and resident safety.

2002 JAMA

215. Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. (Abstract)

Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. beta-Blocker therapy remains substantially underused in cardiac patients despite its proven mortality benefits. Reluctance to prescribe these agents may derive from concerns about their association with symptoms of depression, fatigue, and sexual dysfunction.To determine the association of beta-blockers with depressive symptoms, fatigue, and sexual dysfunction by performing a quantitative review of randomized (...) treatments, placebo control, noncrossover design, enrollment of at least 100 patients, and a minimum of 6 months of follow-up. The initial search produced 475 articles, 42 of which met these criteria. Fifteen of these trials reported on depressive symptoms, fatigue, or sexual dysfunction and were selected for inclusion.For each trial, 1 author abstracted the frequency of adverse events in the beta-blocker and placebo groups and the numbers of patients randomized to the treatment groups. Two other authors

2002 JAMA

216. Systematic review of the current literature related to disability and chronic fatigue syndrome

Systematic review of the current literature related to disability and chronic fatigue syndrome Systematic review of the current literature related to disability and chronic fatigue syndrome Systematic review of the current literature related to disability and chronic fatigue syndrome Ganz N, Frame D, Estok R, Stone L, Ludensky V Authors' objectives The overall review objective was to assess how best to measure, monitor and treat disability in patients with chronic fatigue syndrome (CFS (...) , contract number 290-97-0016. Bibliographic details Ganz N, Frame D, Estok R, Stone L, Ludensky V. Systematic review of the current literature related to disability and chronic fatigue syndrome. Rockville, MD, USA: Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment; 66. 2002 Original Paper URL Other publications of related interest Ross SD, Estok RP, Frame D, Stone LR, Ludensky V, Levine CB. Disability and chronic fatigue syndrome: a focus on function. Arch Intern Med

2002 DARE.

217. Management of cancer symptoms: pain, depression, and fatigue

Management of cancer symptoms: pain, depression, and fatigue Management of cancer symptoms: pain, depression, and fatigue Management of cancer symptoms: pain, depression, and fatigue Carr D, Goudas L, Lawrence D, Pirl W, Lau J, DeVine D, Kupelnick B, Miller K Authors' objectives The objective was to determine the prevalence, method of assessment and the effectiveness of treatment for cancer-related pain, depression and fatigue in patients with cancer. This abstract will focus only (...) pharmacological and non-pharmacological cytotoxic or cytostatic therapy. 4. To determine the relative efficacy of current adjuvant physical or psychological treatments. 5. To determine the relative efficacy of current invasive surgical and nonsurgical treatments. 6. To evaluate the effectiveness of treatments for cancer-related pain associated with oral mucositis post-herpetic neuralgia. Searching Separate searches were performed for each area: cancer-related pain, depression and fatigue. For cancer-related

2002 DARE.

218. Systematic review and meta-analysis of interventions for postoperative fatigue

Systematic review and meta-analysis of interventions for postoperative fatigue Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2002 DARE.

219. Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions

Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions Servaes P, Verhagen C, Bleijenberg G Authors' objectives To review the literature concerning interventions to reduce fatigue in cancer patients. Searching MEDLINE, Current Contents and PsycLIT were searched from (...) 1980 to July 2001. The search terms combined the words 'cancer' (or 'Hodgkin's' or 'tumor' or 'tumour' or 'malign*' or 'haematolog*') and ('intervention' or 'exercise' or 'psychotherapy' or 'group' or 'counsel*') in the title and the word 'fatigue' in the title, keyword or abstract. Only studies published in English or Dutch were included. Study selection Study designs of evaluations included in the review Controlled intervention studies of adult cancer patients, with a sample size of 15 or greater

2002 DARE.

220. Management of cancer symptoms: pain, depression and fatigue

Management of cancer symptoms: pain, depression and fatigue Management of cancer symptoms: pain, depression and fatigue Management of cancer symptoms: pain, depression and fatigue Carr D, Goudas L, Lawrence D Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Carr D, Goudas L, Lawrence D. Management of cancer symptoms: pain, depression (...) and fatigue. Rockville: Agency for Healthcare Research and Quality (AHRQ). Evidence Report/Technology Assessment No. 61. 2002 Authors' objectives Despite dramatic advances in cancer biology and a widening array of treatment options, cancer continues to cause devastating suffering not only in the hundreds of thousands of patients who die of it each year in the United States, but also in some patients who are successfully treated and become cancer survivors. This report was produced on request from

2002 Health Technology Assessment (HTA) Database.