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Latest & greatest articles for fatigue
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fatigue or other clinical topics then use Trip today.
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Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. To test the efficacy of a graded aerobic exercise programme in the chronic fatigue syndrome.Randomised controlled trial with control treatment crossover after the first follow up examination.Chronic fatigue clinic in a general hospital department of psychiatry.66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance.Random allocation to 12 (...) exercise treatment compared with eight of 30 patients who completed flexibility treatment. Analysis by intention to treat gave similar results (17/33 v 9/33 patients better). Fatigue, functional capacity, and fitness were significantly better after exercise than after flexibility treatment. 12 of 22 patients who crossed over to exercise after flexibility treatment rated themselves as better after completing exercise treatment 32 of 47 patients rated themselves as better three months after completing
Cognitive behaviour therapy for the chronic fatigue syndrome: a randomized controlled trial. To evaluate the acceptability and efficacy of adding cognitive behaviour therapy to the medical care of patients presenting with the chronic fatigue syndrome.Randomised controlled trial with final assessment at 12 months.An infectious diseases outpatient clinic.60 consecutively referred patients meeting consensus criteria for the chronic fatigue syndrome.Medical care comprised assessment, advice (...) associated with a poor outcome changed more with cognitive behaviour therapy than with medical care alone.Adding cognitive behaviour therapy to the medical care of patients with the chronic fatigue syndrome is acceptable to patients and leads to a sustained reduction in functional impairment.
Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. No somatic treatment has been found to be effective for chronic fatigue syndrome (CFS). Antidepressant therapy is commonly used. Fluoxetine is recommended in preference to tricyclic agents because it has fewer sedative and autonomic nervous system effects. However, there have been no randomised, placebo-controlled, double-blind studies showing the effectiveness of antidepressant therapy in CFS. We have (...) (Actometer), which were applied on the day treatment started and on the last day.The two groups were well matched in terms of age, sex distribution, employment and marital status, and duration of CFS. There were no significant differences between the placebo and fluoxetine-treated groups in the change during the 8-week treatment period for any dimension of CFS. There was no change in subjective assessments of fatigue, severity of depression, functional impairment, sleep disturbances, neuropsychological
Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Cognitive behavioural therapy in the treatment of chronic fatigue syndrome Best L, Stevens A Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Best L, Stevens A. Cognitive behavioural therapy (...) in the treatment of chronic fatigue syndrome. Southampton: Wessex Institute for Health Research and Development (WIHRD) 1996 Authors' objectives The author aims to determine whether the proposal for cognitive behavioural therapy to be available in the management of CFS, in order to supplement existing programmes of care, is justified. Authors' conclusions The authors recommend CBT as out-patient treatment for a certain group of people, but say that the criteria for the selection of those who would gain most
Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Empirical parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease Lightfoot R W, Luft B J, Rahn D W, Steere A C, Sigal L H, Zoschke D C, Gardner P, Britton M C (...) Patients in endemic areas with chronic fatigue and myalgia and a positive serologic result for Lyme disease. Setting Primary care. The study was conducted in the USA. Dates to which data relate Not reported. Source of effectiveness data Review of previous studies. Outcomes assessed in the review False positive rates and toxicity rates due to treatment. Study designs and other criteria for inclusion in the review Decisions on the relevance of the studies were based on the methods followed for patient
Red blood cell magnesium and chronic fatigue syndrome. The hypotheses that patients with chronic fatigue syndrome (CFS) have low red blood cell magnesium and that magnesium treatment would improve the wellbeing of such patients were tested in a case-control study and a randomised, double-blind, placebo-controlled trial, respectively. In the case-control study, 20 patients with CFS had lower red cell magnesium concentrations than did 20 healthy control subjects matched for age, sex, and social
1991LancetControlled trial quality: predicted high
Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. Twenty-seven adults with a diagnosis of the chronic fatigue syndrome were enrolled in a double-blind, placebo-controlled study of acyclovir therapy. The patients had had debilitating fatigue for an average of 6.8 years, accompanied by persisting antibodies to Epstein-Barr virus early antigens (titers greater than or equal to 1:40) or undetectable levels of antibodies to Epstein-Barr virus (...) the trial, similar numbers improved with acyclovir therapy and with placebo (11 and 10, respectively). Neither acyclovir treatment nor clinical improvement correlated with alterations in laboratory findings, including titers of antibody to Epstein-Barr virus or levels of circulating immune complexes or of leukocyte 2',5'-oligoadenylate synthetase. Subjective improvement correlated with various measures of mood. We conclude that acyclovir, as used in this study, does not ameliorate the chronic fatigue