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Latest & greatest articles for fatigue
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Randomized Controlled Trial to Examine the Impact of Aquatic Exercise Training on Functional Capacity, Balance, and Perceptions of Fatigue in Female Patients With Multiple Sclerosis To assess the effects of an 8-week aquatic exercise training program on functional capacity, balance, and perceptions of fatigue in women with multiple sclerosis (MS).Randomized controlled design.Referral center of an MS society.Women (N=32; mean age ± SD, 36.4±8.2y) with diagnosed relapsing-remitting MS. After (...) undergoing baseline testing by a neurologist, participants were allocated to either an intervention (aquatic training program, n=17) or a control group (n=15).The intervention consisted of an 8-week aquatic training program (3 supervised training sessions per week; session duration, 45-60min; 50%-75% estimated maximum heart rate).Six-minute walk test (6-MWT), balance (Berg Balance Scale [BBS]), and perceptions of fatigue (Modified Fatigue Impact Scale; [MFIS]) at baseline and after the 8-week
Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis Autoimmune hepatitis (AIH) is an immune-mediated liver disease currently treated by immunosuppressive medications with significant side effects. Thus, novel mechanistic treatments are greatly needed. We performed prospective deep immunophenotyping of blood immune cells in patients with acute AIH before and after corticosteroid therapy. Blood samples from 26 patients (...) exhaustion. Coculture experiments suggested the Tregs could not efficiently suppress interferon-γ secretion by NK cells. Both Tregs and NK cells had high expression of liver infiltration and T helper 17 plasticity-associated marker CD161 (P = 0.04). Pretreatment and CD161pos NK cells expressed high levels of perforin and granzyme B, consistent with an activated effector phenotype (P < 0.05). Lectin-like transcript 1, a ligand for CD161, is expressed on intrahepatic B cells, monocytes, and neutrophils
Course of maternal fatigue and its associated factors during the first 6Â months postpartum: a prospective cohort study To identify the course of maternal fatigue during the first 6 months postpartum and to determine factors associated with it.A prospective cohort study.Women (N = 2,697) in 13 Japanese hospitals provided longitudinal data using self-report questionnaires at five time points. Maternal fatigue was assessed using the Postnatal Accumulated Fatigue Scale. We focused on the effect (...) of maternal age and parity on the course of maternal fatigue and used a mixed between/within-subjects analysis of variance. Factors associated with maternal fatigue were analysed using stepwise multiple regression.In the 6-month postpartum period, the level of fatigue was highest at 1 month and significantly decreased from 1-4 months postpartum. Primiparas showed a significantly higher level of fatigue than multiparas during hospital stay and their levels of fatigue more closely approximated the 1-month
Prognostic indices of inflammatory markers, cognitive function and fatigue for survival in patients with localised colorectal cancer Inflammation promotes the development of malignancy, while a variety of systemic markers of inflammation predict for worse cancer outcomes including recurrence and survival. Here, we evaluate the prognostic impact of cytokine concentrations, full blood count (FBC) differential ratios, cognitive function and fatigue on survival in patients with localised colorectal (...) cancer (CRC).Data are from a prospective longitudinal study comparing cognitive function and fatigue in patients with CRC who did (n=173) and did not (n=116) receive adjuvant/neoadjuvant chemotherapy. Baseline blood results (prior to any chemotherapy) included cytokines and FBC from which neutrophil lymphocyte ratio, lymphocyte monocyte ratio, platelet lymphocyte ratio and platelet monocyte ratio were derived. Fatigue was measured with the Functional Assessment of Cancer Therapy-Fatigue subscale
Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease. Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is terminal, progressive neurological condition for which there are no curative treatments. Among people with ALS/MND, fatigue is a common and debilitating symptom, which is characterised by reversible motor weakness and whole-body tiredness that is only partially relieved by rest. The effectiveness of pharmacological or non-pharmacological (...) treatments for fatigue in ALS/MND is not yet established.To assess the effects of pharmacological and non-pharmacological interventions for fatigue in ALS/MND.We searched the following databases on 5 September 2017: Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL Plus, and ERIC. We also searched two clinical trials registries.We selected randomised and quasi-randomised controlled trials of any intervention which sought to reduce fatigue for people with ALS/MND. We
Cyclic fatigue resistance of three rotary file systems in a dynamic model after immersion in sodium hypochlorite. To evaluate the effect of immersion in 3% sodium hypochlorite solution in the resistance to cyclic fatigue of three nickel-titanium (NiTi) rotary file systems, ProTaper Next (PTN), Hyflex CM (CM), and Hyflex EDM (EDM), in a mechanical model featuring axial movement. Ninety instruments of three different NiTi rotary file systems, PTN (size 25, 0.06 taper), CM (25, 0.06), and EDM (25 (...) performed better to cyclic fatigue followed by CM and then PTN. Immersion in NaOCl decreased the resistance to cyclic fatigue of all tested instruments, but affected more those manufactured from CM wire.
Interaction Between Ambient Temperature, Hypoxia, and Load Carriage on Respiratory Muscle Fatigue. BACKGROUND: While respiratory muscle fatigue is present following load carriage activity at sea level, the effect of environmental conditions on respiratory strength while undertaking load carriage is unknown.METHODS: The effect of thoracic load carriage during walks (5.5 km) in four environments [(thermo-neutral sea level (SL), -10°C (C), 4300 m (H) and 4300 m at -10°C (HC)] was evaluated (...) on respiratory muscle fatigue. Ten subjects completed eight self-paced randomized treadmill walks comprising a variety of gradients, unloaded and loaded (18.2 kg), across the four environments. Respiratory muscle strength was measured via maximal inspiratory pressure (PImax) and expiratory pressure (PEmax) assessments.RESULTS: Submaximal walking in HC elicited respiratory muscle fatigue when compared to SL. Inspiratory muscle fatigue was independent of load. The relative change in PImax from baseline
Guideline for concussion/mild traumatic brain injury & persistent symptoms - FatigueFatigue // Brain Injury Guidelines Toggle navigation NAVIGATION > > > > > > > > > > > > > > > > > > Guideline For Concussion/Mild Traumatic Brain Injury & Persistent Symptoms 3rd Edition, for Adults over 18 years of age FatigueFatigue has been conceptualized as an experience of weariness or tiredness following mental or physical exertion, often resulting in a reduced capacity for work and limited efficiency (...) to respond to stimuli. Fatigue can be caused by psychological or physiological forces 1 and can be central or peripheral, which in lay terms is experienced as cognitive fatigue and physical fatigue or weariness. 2-4 Fatigue is one of the most pervasive symptoms following concussion/mTBI, with 27.8% of individuals experiencing persistent fatigue at 3 months post-injury. 5 The perception of fatigue can be out of proportion to exertion or may even occur without any exertion. 6 One study reported a level
Physical Activity to Reduce Fatigue in Rheumatoid Arthritis: A Randomized Controlled Trial Effective treatments for rheumatoid arthritis (RA) fatigue are limited. We tested the effect of a pedometer-based intervention on increasing physical activity and decreasing fatigue among individuals with RA.Participants completed baseline questionnaires; had 1 week of activity monitoring; were randomized to control (education [EDUC]), pedometer and step-monitoring diary (PED), or pedometer and diary plus (...) step targets (PED+) groups, and were followed for 21 weeks. At week 10, questionnaires were administered by phone to all participants. During the final week, all participants again had 1 week of activity monitoring. Primary outcomes were changes in average weekly steps and fatigue (Patient-Reported Outcomes Measurement Information System 7-item questionnaire) from baseline to week 21. Secondary outcomes were self-reported disease activity, physical function, pain interference, and depressive
not necessarily be an initial complaint, but is still regarded as a markedly significant and debilitating symptom, are also included. Definition There are numerous definitions and classifications of fatigue, reflecting the multitude of interpretations, depending on being a patient, a physician, a biologist, or a physiologist. A common and practical definition defined fatigue as a sensation of exhaustion during or after usual activities, or a feeling of inadequate energy to begin these activities. Chen MK (...) Assessment of fatigue Assessment of fatigue - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Assessment of fatigue Last reviewed: February 2019 Last updated: June 2018 Summary Fatigue may be a symptom of almost any medical condition. For the purpose of this topic, the differentials discussed concentrate on people presenting with fatigue or where fatigue is the only symptom. Conditions in which fatigue may
-exertional malaise (PEM)/exertional exhaustion, unrefreshing sleep, cognitive and autonomic dysfunction, myalgia, arthralgia, headaches, and sore throat and tender lymph nodes (without palpable lymphadenopathy), with symptoms lasting at least 6 months. Komaroff AL. Myalgic encephalomyelitis/chronic fatigue syndrome: a real illness. Ann Intern Med. 2015 Jun 16;162(12):871-2. http://annals.org/article.aspx?articleid=2322808 http://www.ncbi.nlm.nih.gov/pubmed/26075760?tool=bestpractice.com The fatigue (...) =bestpractice.com to PEM/exertional exhaustion in ME/CFS as defined by the Canadian Consensus Criteria, Carruthers BM, Jain AK, De Meirleir KL, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. 2003 [internet publication]. http://med.stanford.edu/content/dam/sm/chronicfatigue/documents/overview/CanadianCriteriaCFS2003.pdf Jason LA, Evans M, Porter N, et al. The development of a revised Canadian myalgic encephalomyelitis chronic
Static and fatigue strength of a novel anatomically contoured implant compared to five current open-wedge high tibial osteotomy plates The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower.Six fourth (...) -generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates. All bone-implant constructs were subjected to static compression load to failure and load-controlled cyclic fatigue failure testing, according to a previously defined testing protocol. The mechanical stability was investigated by considering different criteria and parameters: maximum forces, the maximum number of loading cycles
The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression.Cross-sectional cohort study.Recruitment was from four stroke units in the UK.Participants were assessed within four to six weeks of first stroke; those with high levels of depressive symptoms (score ⩾7 Brief Assessment Schedule Depression Cards) were (...) excluded.Participants were assessed after stroke on the Fatigue Severity Scale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Beck Anxiety Index, Sleep Hygiene Index, 6m walk test, and measures of cognitive ability.Of the 371 participants recruited, 103 were excluded and 268 were assessed. Of the latter, the mean age was 67.7 years (SD 13.5) and 168 (63%) were men. The National Institutes of Health Stroke Scale mean score was 4.96 (SD 4.12
Exercise performance, haemodynamics, and respiratory pattern do not identify heart failure patients who end exercise with dyspnoea from those with fatigue The two main symptoms referred by chronic heart failure (HF) patients as the causes of exercise termination during maximal cardiopulmonary exercise testing (CPET) are muscular fatigue and dyspnoea. So far, a physiological explanation why some HF patients end exercise because of dyspnoea and others because of fatigue is not available. We (...) assessed whether patients referring dyspnoea or muscular fatigue may be distinguished by different ventilator or haemodynamic behaviours during exercise.We analysed exercise data of 170 consecutive HF patients with reduced left ventricular ejection fraction in stable clinical condition. All patients underwent maximal CPET and a second maximal CPET with measurement of cardiac output by inert gas rebreathing at peak exercise. Thirty-eight (age 65.0 ± 11.1 years) and 132 (65.1 ± 11.4 years) patients
Effects of nurse-led home-based exercise & cognitive behavioral therapy on reducing cancer-related fatigue in patients with ovarian cancer during and after chemotherapy: A randomized controlled trial High levels of fatigue have been documented in ovarian cancer patients. However, increased levels of fatigue are positively associated with a high risk of sleep disturbance and depression.To investigate the feasibility of a nurse-led home-based exercise and cognitive behavioral therapy (E&CBT (...) ) for ovarian cancer adults with cancer-related fatigue on outcomes of fatigue, plus other secondary outcomes (sleep disturbance and depression), either during or after completion of primary cancer treatment.Randomized, single-blind control trial.Gynaecologic oncology department of the First Hospital of Jilin University in China.72 eligible women who recently had surgery and completed their first cycle of adjuvant chemotherapy were randomly assigned to two groups.The experimental group received exercise
Adalimumab impact on fatigue measured by FACIT-F: a study of rheumatoid arthritis patients in Saudi Arabia The objective of the study was to assess the effectiveness of adalimumab as a treatment for fatigue in patients with rheumatoid arthritis (RA).Fatigue was monitored in patients with RA who were already on an adalimumab treatment regimen. Fatigue, general well-being, comorbidities, and disease activity were measured at baseline and ~8, 16, and 24 weeks, thereafter.Significant reductions (...) in fatigue scores and disease activity were observed from baseline to 6 months after. A predictive regression model of fatigue severity was proposed and was found to be significant, with RA disease activity as the most significant predictor of fatigue severity.This quasi-experimental study is a good starting point for research on the efficacy of adalimumab in treating fatigue in RA patients. The results here suggest that a randomized controlled trial assessing adalimumab as a treatment option for RA
Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer. To investigate the effects of oral zinc supplementation on fatigue intensity and quality of life of patients during chemotherapy for colorectal cancer.A prospective, randomized, double-blinded, placebo-controlled study was conducted with 24 patients on chemotherapy for colorectal adenocarcinoma in a tertiary care public hospital. The study patients received zinc capsules 35mg (Zinc Group, n=10 (...) ) or placebo (Placebo Group, n=14) orally, twice daily (70mg/day), for 16 weeks, from the immediate postoperative period to the fourth chemotherapy cycle. Approximately 45 days after surgical resection of the tumor, all patients received a chemotherapeutic regimen. Before each of the four cycles of chemotherapy, the Functional Assessment of Chronic Illness Therapy-Fatigue scale was completed. We used a linear mixed model for longitudinal data for statistical analysis.The scores of quality of life
Correlation between medication errors with job satisfaction and fatigue of nurses Medication errors which can cause several medical malfunctions, have been in the spotlight recently. Job satisfaction and fatigue seems to be related to the increase of medication errors in nursing.This study aimed to determine the correlation between the amount and type of medication errors with job satisfaction and fatigue of nurses working in Shahid Sadoughi hospital in Yazd-Iran.This is a descriptive study (...) by a cross-sectional and correlational approach conducted on all the nurses working in an educational hospital who have characteristics of samples. Participants were 170 nurses working in Shahid Sadooghi hospital in Yazd, Iran in 2012. The questionnaires of demographic characteristics, medication administration error and nurses' job satisfaction and fatigue by purposive sampling were used for gathering data. Validity and reliability were checked for internal consistency and stability. Data were analysed
Cancer-Related Fatigue in Post-Treatment Cancer Survivors: Theory-Based Development of a Web-Based Intervention Cancer-related fatigue (CrF) is the most common and disruptive symptom experienced by cancer survivors. We aimed to develop a theory-based, interactive Web-based intervention designed to facilitate self-management and enhance coping with CrF following cancer treatment.The aim of our study was to outline the rationale, decision-making processes, methods, and findings which led (...) of the content of the intervention, input from the target patient group and stakeholders, the design of the website features, and the initial user testing of the website.The cocreation of the intervention with the experts and service users allowed the design team to ensure that an acceptable intervention was developed. This evidence-based Web-based program is the ﬁrst intervention of its kind based on self-regulation model theory, with the primary aim of targeting the representations of fatigue and enhancing