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Latest & greatest articles for fatigue
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A randomized controlled trial of home-based exercise for cancer-related fatigue in women during and after chemotherapy with or without radiation therapy. Few studies have evaluated an individualized home-based exercise prescription during and after cancer treatment.The purpose of this study was to evaluate the effectiveness of a home-based exercise training intervention, the Pro-self Fatigue Control Program on the management of cancer-related fatigue.Participants (N = 119) were randomized (...) into 1 of 3 groups: group 1 received the exercise prescription throughout the study; group 2 received their exercise prescription after completing cancer treatment; and group 3 received usual care. Patients completed the Piper Fatigue Scale, General Sleep Disturbance Scale, Center for Epidemiological Studies-Depression Scale, and Worst Pain Intensity Scale.All groups reported mild fatigue levels, sleep disturbance, and mild pain, but not depression. Using multilevel regression analysis, significant
of these differences was statistically significant.Similar to earlier results using pharmacologic doses, substitution treatment with 50 mg of DHEA in DHEA-deficient and severely tired primary SS patients does not help against fatigue better than placebo. This may relate to the prohormone nature of DHEA and its recently described defective intracrine tissue-specific conversion to active sex steroids in SS. (...) Dehydroepiandrosterone (DHEA) substitution treatment for severe fatigue in DHEA-deficient patients with primary Sjogren`s Syndrome Primary Sjögren's syndrome (SS) is characterized by fatigue and low levels of serum dehydroepiandrosterone/dehydroepiandrosterone sulfate (DHEA/DHEAS). Our aim was to study whether SS patients with severe fatigue and low serum DHEAS values benefit from DHEA substitution (50 mg/day).A multicenter, investigator-based, powered, randomized controlled clinical trial
Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. The presence of the retrovirus xenotropic murine leukaemia virus-related virus (XMRV) has been reported in peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Considering the potentially great medical and social relevance of such a discovery, we investigated whether this finding could (...) be confirmed in an independent European cohort of patients with chronic fatigue syndrome.Analysis of a well defined cohort of patients and matched neighbourhood controls by polymerase chain reaction.Certified (ISO 15189) laboratory of clinical virology in a university hospital in the Netherlands. Population Between December 1991 and April 1992, peripheral blood mononuclear cells were isolated from 76 patients and 69 matched neighbourhood controls. In this study we tested cells from 32 patients and 43
Carnitine for fatigue in multiple sclerosis. Fatigue is reported to occur in up to 92% of patients with multiple sclerosis (MS) and has been described as the most debilitating of all MS symptoms by 28% to 40% of MS patients.To assess whether carnitine (enteral or intravenous) supplementation can improve the quality of life and reduce the symptoms of fatigue in patients with MS-related fatigue and to identify any adverse effects of carnitine when used for this purpose.A literature search (...) was contacted to determine if they knew of other clinical trials. No language restrictions were applied.Full reports of published and unpublished randomized controlled trials and quasi-randomized trials of any carnitine intervention in adults with a clinical diagnosis of fatigue associated with multiple sclerosis were included.Data from the eligible trials was extracted and coded using a standardized data extraction form and entered into RevMan 5. Discrepancies were to be resolved by discussion with a third
Nurse led, home based self help treatment for patients in primary care with chronic fatigue syndrome: randomised controlled trial. To evaluate the effectiveness of home delivered pragmatic rehabilitation-a programme of gradually increasing activity designed collaboratively by the patient and the therapist-and supportive listening-an approach based on non-directive counselling-for patients in primary care with chronic fatigue syndrome/myalgic encephalomyelitis or encephalitis (CFS/ME).Single (...) four months' training, including supervised practice, in each of the interventions. GP treatment as usual was unconstrained except that patients were not to be referred for systematic psychological therapies during the treatment period. Main outcome measures The primary clinical outcomes were fatigue and physical functioning at the end of treatment (20 weeks) and 70 weeks from recruitment compared with GP treatment as usual. Lower fatigue scores and higher physical functioning scores denote better
Effect of epoetin alfa on survival and cancer treatment-related anemia and fatigue in patients receiving radical radiotherapy with curative intent for head and neck cancer To evaluate the effect of epoetin alfa on local disease-free survival (DFS), overall survival (OS), and cancer treatment-related anemia and fatigue in patients with head and neck cancer receiving radical radiotherapy with curative intent.Patients (N = 301) with hemoglobin (Hb) less than 15 g/dL were randomly assigned (...) weeks postradiotherapy and annually for 5 years. Cancer treatment-related anemia and fatigue were evaluated with the Functional Assessment of Cancer Therapy-Anemia and Functional Assessment of Cancer Therapy-Head and Neck. Adverse events were recorded up to 12 weeks postradiotherapy.Hb levels increased from baseline with epoetin alfa. The median duration of local DFS was not statistically different between groups (observation, 35.42 months; epoetin alfa, 31.47 months; hazard ratio, 1.04; 95% CI
[Chronic fatigue syndrome: state of the evidence and assessment of intervention modalities in Quebec] Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec [Chronic fatigue syndrome: state of the evidence and assessment of intervention modalities in Quebec] Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec [Chronic fatigue syndrome: state of the evidence and assessment of intervention (...) modalities in Quebec] Rouleau G, Ceppi U, Hjelholt Pedersen V, Dagenais P Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Rouleau G, Ceppi U, Hjelholt Pedersen V, Dagenais P. Le syndrome de fatigue chronique. Etat des connaissances et evaluation des modes d'intervention au Quebec. [Chronic fatigue syndrome: state
Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome. Chronic fatigue is increasingly common. Conventional medical care is limited in treating chronic fatigue, leading some patients to use traditional Chinese medicine therapies, including herbal medicine.To assess the effectiveness of traditional Chinese medicine herbal products in treating idiopathic chronic fatigue and chronic fatigue syndrome.The following databases were searched (...) for terms related to traditional Chinese medicine, chronic fatigue, and clinical trials: CCDAN Controlled Trials Register (July 2009), MEDLINE (1966-2008), EMBASE (1980-2008), AMED (1985-2008), CINAHL (1982-2008), PSYCHINFO (1985-2008), CENTRAL (Issue 2 2008), the Chalmers Research Group PedCAM Database (2004), VIP Information (1989-2008), CNKI (1976-2008), OCLC Proceedings First (1992-2008), Conference Papers Index (1982-2008), and Dissertation Abstracts (1980-2008). Reference lists of included studies
(odds ratio [OR], 1.10 per unit increase; 95% confidence interval [CI], 1.03-1.16; P = .002) and fatigue score (OR, 1.14 per unit increase; 95% CI, 1.08-1.21; P < .001). Subsequent error was also associated with burnout (ORs per 1-unit change: depersonalization OR, 1.09; 95% CI, 1.05-1.12; P < .001; emotional exhaustion OR, 1.06; 95% CI, 1.04-1.08; P < .001; lower personal accomplishment OR, 0.94; 95% CI, 0.92-0.97; P < .001), a positive depression screen (OR, 2.56; 95% CI, 1.76-3.72; P < .001 (...) Association of resident fatigue and distress with perceived medical errors. Fatigue and distress have been separately shown to be associated with medical errors. The contribution of each factor when assessed simultaneously is unknown.To determine the association of fatigue and distress with self-perceived major medical errors among resident physicians using validated metrics.Prospective longitudinal cohort study of categorical and preliminary internal medicine residents at Mayo Clinic
Interventions for post-stroke fatigue. Fatigue after stroke is common and distressing to patients. The best way to treat this fatigue is uncertain. Theoretically, several different interventions may be of benefit.To determine whether any treatment for fatigue after stroke reduces the proportion of patients with fatigue, or fatigue severity, or both, and to determine the effect of treatment on health-related quality of life, disability, dependency and death, and whether such treatments are cost (...) with stroke where fatigue was a primary or secondary endpoint.The two review authors who scrutinised references independently extracted data. We performed a narrative review; we had intended to perform a meta-analysis but this was not possible as the interventions were too diverse for data to be combined.We identified three trials. One randomised 83 patients with emotional disturbance after stroke to fluoxetine or placebo. After correcting for differences in fatigue severity at baseline
Fatigue during breast cancer radiotherapy: An initial randomized study of cognitive-behavioral therapy plus hypnosis The study purpose was to test the effectiveness of a psychological intervention combining cognitive-behavioral therapy and hypnosis (CBTH) to treat radiotherapy-related fatigue.Women (n = 42) scheduled for breast cancer radiotherapy were randomly assigned to receive standard medical care (SMC) (n = 20) or a CBTH intervention (n = 22) in addition to SMC. Participants assigned (...) to receive CBTH met individually with a clinical psychologist. CBTH participants received training in hypnosis and CBT. Participants assigned to the SMC control condition did not meet with a study psychologist.Fatigue was measured on a weekly basis by using the fatigue subscale of the Functional Assessment of Chronic Illness Therapy (FACIT) and daily using visual analogue scales.Multilevel modeling indicated that for weekly FACIT fatigue data, there was a significant effect of the CBTH intervention
Effects of pulmonary rehabilitation on fatigue, functional status and health perceptions in patients with chronic obstructive pulmonary disease: a randomized controlled trial To test the effects of pulmonary rehabilitation on fatigue, functional status and health perceptions in patients with chronic obstructive pulmonary disease.Randomized controlled trial.Pulmonary outpatient department.Thirty patients randomly assigned to a rehabilitation (3 men, 9 women, mean age 66 (+/-2) years (...) ) or a control group (10 men, 4 women, mean age 64 (+/-2) years).The patients in the rehabilitation group participated in a multidisciplinary rehabilitation programme comprising exercise training twice weekly, for a 12-week period, nutritional and self-care advice, and education about disease and energy conservation strategies.Fatigue, functional limitations due to fatigue, functional performance and satisfaction, six-minute walking distance, hand grip strength and health perception were assessed at baseline
Short-term effects of aerobic exercise on functional capacity, fatigue, and quality of life in patients with post-polio syndrome To investigate and compare the impact of hospital and home exercise programmes on aerobic capacity, fatigue, and quality of life in patients with post-polio syndrome.A prospective, randomized controlled trial.Department of Physical Medicine and Rehabilitation, University Hospital.Thirty-two patients were divided into two groups for either hospital- or home-based (...) aerobic exercise programme.Patients were assessed before and after the rehabilitation programme, with respect to functional capacity (pVo2), fatigue (Fatigue Severity Scale, Fatigue Impact Scale) and quality of life (Nottingham Heath Profile).After the exercise programme, improvement was observed in the hospital exercise group compared to a pre-exercise period in all Nottingham Heath Profile scores (except sleep scores), pVo2, Fatigue Severity Scale and Fatigue Impact Scale (cognitive, physical
when participants were tired, but only for some variables in some studies, or only for certain individuals. One study indicated that there was a learning effect for both sleep-deprived and non-sleep deprived states. Psychomotor skill performance Simulated performance There were 11 studies that assessed performance using simulation-based methods when a participant was rested and/or fatigued (Deaconson et al 1988; DeMaria et al 2005; Eastridge et al 2003; Grantcharov et al 2001; Jakubowicz et al 2005 (...) The effect of fatigue on surgeon performance and surgical outcomes: a systematic review Systematic Review The Effect of Fatigue on Surgeon Performance and Surgical Outcomes ASERNIP-S REPORT NO. 68 August 2009 Australian Safety & Efficacy Register of New Interventional Procedures – Surgical The Royal Australasian College of Surgeons ASERNIP S Australian Safety and Efficacy Register of New Interventional Procedures - Surgical - ASERNIP-S REVIEW OF THE EFFECT OF FATIGUE ON SURGERY & SURGICAL
when participants were tired, but only for some variables in some studies, or only for certain individuals. One study indicated that there was a learning effect for both sleep-deprived and non-sleep deprived states. Psychomotor skill performance Simulated performance There were 11 studies that assessed performance using simulation-based methods when a participant was rested and/or fatigued (Deaconson et al 1988; DeMaria et al 2005; Eastridge et al 2003; Grantcharov et al 2001; Jakubowicz et al 2005 (...) The effect of fatigue on surgeon performance and surgical outcomes: A systematic review Systematic Review The Effect of Fatigue on Surgeon Performance and Surgical Outcomes ASERNIP-S REPORT NO. 68 August 2009 Australian Safety & Efficacy Register of New Interventional Procedures – Surgical The Royal Australasian College of Surgeons ASERNIP S Australian Safety and Efficacy Register of New Interventional Procedures - Surgical - ASERNIP-S REVIEW OF THE EFFECT OF FATIGUE ON SURGERY & SURGICAL
Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults Hardy SE CRD summary The review did not find definitive evidence (...) of effectiveness of methylphenidate in medically ill older adults with depression, fatigue or apathy, although it appeared to be tolerated in the short term. Due to variation in outcomes, methodological flaws in the included studies and shortcomings in the review process, the reliability of the author's conclusions is not clear. Authors' objectives To assess the efficacy and tolerability of methylphenidate for the treatment of depressive symptoms, fatigue and apathy in medically ill older adults and adults
The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance The effect of fatigue on surgeon performance Sturm L Record Status This is a bibliographic record of an ongoing health technology assessment being undertaken by a member of INAHTA. Links to the published report and any other relevant documentation will be added when available. Citation Sturm L. The effect of fatigue on surgeon performance . Stepney: Australian Safety and Efficacy Register of New (...) Interventional Procedures -Surgical (ASERNIP-S). ASERNIP-S Report No 68. 2009 Authors' conclusions There is a paucity of evidence investigating the effects of sleep loss and fatigue on the performance of surgeons and subsequent clinical outcomes. The overall weight of (poor) evidence shows that clinical, academic, and cognitive performance are not proven to be affected by sleep deprivation or fatigue and that psychomotor performance may or may not be. Variations in results were in some cases attributable
Fatigue Predicts Mortality in Older Adults To determine the association between fatigue and survival over 10 years in a population of older community-dwelling primary care patients.Prospective cohort study.Medicare health maintenance organization and Veterans Affairs primary care programs.Older primary care patients (N=492).Fatigue, operationalized as feeling tired most of the time, was assessed at baseline. Mortality was ascertained from the National Death Index. Covariates included (...) demographics, comorbidity, cognitive function, depressive symptoms, body mass index, self-rated health, functional status, and gait speed.Mortality rates at 10 years were 59% (123/210) for older adults with fatigue, versus 38% (106/282) for those without fatigue (P<.001). After adjustment for multiple potential confounders, participants who were tired at baseline had a greater risk of death than those who were not (hazard ratio=1.44, 95% confidence interval=1.08-1.93).A single simple question "Do you feel