Latest & greatest articles for fatigue

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on fatigue or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on fatigue and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

What is Trip?

Trip is a clinical search engine designed to allow users to quickly and easily find and use high-quality research evidence to support their practice and/or care.

Trip has been online since 1997 and in that time has developed into the internet’s premier source of evidence-based content. Our motto is ‘Find evidence fast’ and this is something we aim to deliver for every single search.

As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news.

For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com

Top results for fatigue

161. Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety

Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety CADTH Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation CADTH. Modafinil for sleep disorders and fatigue secondary to multiple sclerosis: a review of the clinical efficacy and safety . Ottawa: Canadian Agency for Drugs and Technologies in Health (CADTH). 2012 Authors' conclusions No conclusions can be drawn on the efficacy of modafinil compared to methylphenidate or amphetamines due to the absence of head-to-head clinical trials. Relative to placebo, modafinil was associated

2012 Health Technology Assessment (HTA) Database.

162. Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety

Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable (...) , provided that attribution is given to CADTH. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners’ own terms and conditions. TITLE: Modafinil for Sleep Disorders and Fatigue Secondary to Multiple Sclerosis: A Review of the Clinical Efficacy and Safety DATE: 27 July 2012 CONTEXT AND POLICY ISSUES Modafinil is a central nervous

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

163. Cognitive and graded activity training can alleviate persistent fatigue after stroke: a randomized, controlled trial Full Text available with Trip Pro

Cognitive and graded activity training can alleviate persistent fatigue after stroke: a randomized, controlled trial Fatigue is a common, persistent consequence of stroke, and no evidence-based treatments are currently available to alleviate fatigue. A new treatment combining cognitive therapy (CO) with graded activity training (GRAT), called COGRAT, was developed to alleviate fatigue and fatigue-related symptoms. This study compared the effectiveness of the COGRAT intervention with a CO-only (...) intervention after a 3-month qualification period without intervention.This randomized, controlled, assessor-blind clinical trial was conducted in 8 rehabilitation centers. Eighty-three stroke patients (>4 months after stroke) were randomly assigned to 12 weeks of CO or COGRAT after qualification. Seventy-three patients completed treatment and 68 were available at follow-up. Primary outcomes (Checklist Individual Strength-subscale Fatigue (CIS-f); self-observation list-fatigue (SOL-f)) and secondary

2012 EvidenceUpdates Controlled trial quality: predicted high

164. Carnitine for fatigue in multiple sclerosis. Full Text available with Trip Pro

Carnitine for fatigue in multiple sclerosis. Fatigue is reported to occur in up to 92% of patients with multiple sclerosis (MS) and has been described as the most debilitating of all MS symptoms by 28% to 40% of MS patients.To assess whether carnitine (enteral or intravenous) supplementation can improve the quality of life and reduce the symptoms of fatigue in patients with MS-related fatigue and to identify any adverse effects of carnitine when used for this purpose.A literature search (...) and a manufacturer (Source Naturals, United States) of carnitine formulation was contacted to determine if they knew of other clinical trials. No language restrictions were applied.Full reports of published and unpublished randomized controlled trials and quasi-randomized trials of any carnitine intervention in adults affected by multiple sclerosis with a clinical diagnosis of fatigue associated with multiple sclerosis were included.Data from the eligible trials was extracted and coded using a standardized data

2012 Cochrane

165. A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients Full Text available with Trip Pro

A Progressive Postresection Walking Program Significantly Improves Fatigue and Health-Related Quality of Life in Pancreas and Periampullary Cancer Patients As patients with pancreas and periampullary cancer (PPC) experience improved survival rates and longevity, the focus shifts toward living life while surviving cancer. Fatigue is the most commonly reported symptom in all cancer patients. Exercise has been found to effectively decrease fatigue levels and improve physical functioning in cancer (...) patients.One hundred two patients with resected PPC consented to participate in this study and were randomized to either an intervention group (IG) or a usual care group (UCG). Subjects completed visual analog scales, the FACIT-Fatigue Scale and the Short Form-36v2 after surgery and again 3 to 6 months after hospital discharge.Patients in the IG and UCG were comparable with regard to demographics, comorbidities, cancer type and staging, type of resection, preoperative fatigue and pain levels, adjuvant

2012 EvidenceUpdates Controlled trial quality: uncertain

166. Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: a systematic review

Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: a systematic review Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

167. Systematic review of the impact of erythropoiesis-stimulating agents on fatigue in dialysis patients

Systematic review of the impact of erythropoiesis-stimulating agents on fatigue in dialysis patients Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

168. Supporting Staff at Risk for Compassion Fatigue

lead to compassion fatigue. 6 Anecdotes: Two members of the working group provided the following reflections on their work: In a perfect world, (the birth of a child) would be the happiest time for parents; however, we rarely see this in our jobs. The majority of the families we see are dealing with too many crises to see this as a happy time. (Reflection by a Family Visitor) Visiting complex clients in their homes can be emotionally exhausting, overwhelming, isolating and unpredictable. We can (...) Supporting Staff at Risk for Compassion Fatigue Supporting Staff at Risk for Compassion Fatigue Prepared for Region of Peel Public Health Elizabeth Walker, RN BScN, CCHN(C) Cheryl Morin, RN, BScN Nicole Labrie, RN, BScN, CCHN(C) October 1, 2012 ii Table of Contents Key Take Home Messages 1 Executive Summary 2 1 Issue 5 2 Context 7 3 Literature Search 11 4 Applicability and Transferability 19 5 Recommendations 24 References 26 Appendices 27 Appendix A: Concept Model 28 Appendix B: Search

2012 Peel Health Library

169. Internet-based CBT improves fatigue severity, physical function and school attendance in adolescents with chronic fatigue syndrome

Internet-based CBT improves fatigue severity, physical function and school attendance in adolescents with chronic fatigue syndrome Internet-based CBT improves fatigue severity, physical function and school attendance in adolescents with chronic fatigue syndrome | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see (...) our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Internet-based CBT improves fatigue severity, physical function and school attendance in adolescents with chronic fatigue

2012 Evidence-Based Mental Health

170. Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial. (Abstract)

Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial. Chronic fatigue syndrome is characterised by persistent fatigue and severe disability. Cognitive behavioural therapy seems to be a promising treatment, but its availability is restricted. We developed Fatigue In Teenagers on the interNET (FITNET), the first dedicated internet-based therapeutic program for adolescents with this disorder (...) , and compared its effectiveness with that of usual care.Adolescents aged 12-18 years with chronic fatigue syndrome were assigned to FITNET or usual care in a 1:1 ratio at one tertiary treatment centre in the Netherlands by use of a computer-generated blocked randomisation allocation schedule. The study was open label. Primary outcomes were school attendance, fatigue severity, and physical functioning, and were assessed at 6 months with computerised questionnaires. Analysis was by intention to treat

2012 Lancet Controlled trial quality: predicted high

171. Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis

Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2012 DARE.

172. Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials Full Text available with Trip Pro

Paulo). 2008;6(2):195-199. de Oliveira Campos MP, Riechelmann R, Martins LC, Hassan BJ, Casa FB, Del Giglio A. Guarana (Paullinia cupana) improves fatigue in breast cancer patientsundergoing systemic chemotherapy. J Altern Complement Med. 2011;17(6):505-512. Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans. J Psychopharmacol. 2007;21(1):65-70. Madden J, Newton S. Why am I so tired (...) Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials Paulinia cupana (Guaraná) for the treatment of cancer related fatigue in patients undergoing radiation therapy or chemotherapy: a meta-analysis of three clinical trials -CELLMED | Korea Science Article Info. Article Info. / Pages.6.1-6.4 / 2011 / 2233-8985(eISSN) DOI QR Code Paulinia cupana (Guaraná) for the treatment of cancer

2011 TANG [HUMANITAS MEDICINE]

173. Case 15-2011: a 19-year-old South african woman with headache, fatigue, and vaginal discharge. (Abstract)

Case 15-2011: a 19-year-old South african woman with headache, fatigue, and vaginal discharge.

2011 NEJM

174. [Treatment of chronic fatigue syndrome CFS/ME]

[Treatment of chronic fatigue syndrome CFS/ME] Behandling av kronisk utmattelsessyndrom CFS/ME [Treatment of chronic fatigue syndrome CFS/ME] Behandling av kronisk utmattelsessyndrom CFS/ME [Treatment of chronic fatigue syndrome CFS/ME] Larun L, Brurberg KG, Fonhus MS, Kirkerhei I Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Larun L (...) , Brurberg KG, Fonhus MS, Kirkerhei I. Behandling av kronisk utmattelsessyndrom CFS/ME. [Treatment of chronic fatigue syndrome CFS/ME] Oslo: Norwegian Knowledge Centre for the Health Services (NOKC). Rapid Reviews. 2011 Authors' conclusions Cognitive behavioural therapy and graded exercise therapy is likely to be effective for people with chronic fatigue syndrome. For other treatment strategies the quality of evidence is very low or even non-existing implying that more research is needed before we can

2011 Health Technology Assessment (HTA) Database.

175. Insufficient evidence for interventions for post-stroke fatigue

Insufficient evidence for interventions for post-stroke fatigue PEARLS Practical Evidence About Real Life Situations PEARLS are succinct summaries of Cochrane Systematic Reviews for primary care practitioners. They Insufficient evidence for interventions for post-stroke fatigue Clinical question How effective are interventions for post-stroke fatigue? Bottom line This review found 3 small, randomised controlled trials that recruited people with a stroke to 3 treatments - 2 different drug (...) treatments (fluoxetine and tirilazad) and one chronic disease self-management programme. At follow-up, there was no difference in fatigue levels between the patients who received the active treatments and those who received usual care or placebo. However, the trials were too small to provide firm conclusions and further trials are required. Currently, there is insufficient evidence to guide practice in treating fatigue following stroke. Caveat There were only 3 completed studies, providing data

2011 Publication 410

176. Preventing and Mitigating Nurse Fatigue in Health Care

and patient safety 1 defines nurse fatigue as: “A subjective feeling of tiredness (experienced by nurses) that is physically and mentally penetrative. It ranges from tired- ness to exhaustion, creating an unrelenting overall condition that interferes with individuals’ physical and cognitive ability to function to their normal capacity. It is multidimensional in both its causes and manifestations; it is influenced by many factors: physiological (e.g. circadian rhythm), psychological (e.g. stress, alertness (...) and patient safety 1 defines nurse fatigue as: “ A subjective feeling of tiredness (experienced by nurses) that is physically and mentally penetrative. It ranges from tiredness to exhaustion, creating an unrelenting overall condition that interferes with individuals’ physical and cog- nitive ability to function to their normal capacity. It is multidimensional in both its causes and manifestations; it is influenced by many factors: physiological (e.g. circadian rhythm), psychological (e.g. stress

2011 Registered Nurses' Association of Ontario

177. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Full Text available with Trip Pro

Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Trial findings show cognitive behaviour therapy (CBT) and graded exercise therapy (GET) can be effective treatments for chronic fatigue syndrome, but patients' organisations have reported that these treatments can be harmful and favour pacing and specialist health care. We aimed to assess effectiveness and safety of all (...) four treatments.In our parallel-group randomised trial, patients meeting Oxford criteria for chronic fatigue syndrome were recruited from six secondary-care clinics in the UK and randomly allocated by computer-generated sequence to receive specialist medical care (SMC) alone or with adaptive pacing therapy (APT), CBT, or GET. Primary outcomes were fatigue (measured by Chalder fatigue questionnaire score) and physical function (measured by short form-36 subscale score) up to 52 weeks after

2011 Lancet Controlled trial quality: predicted high

178. Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis

Exercise is an effective treatment modality for reducing cancer-related fatigue and improving physical capacity in cancer patients and survivors: a meta-analysis Untitled Document The CRD Databases will not be available from 08:00 BST on Friday 4th October until 08:00 BST on Monday 7th October for essential maintenance. We apologise for any inconvenience.

2011 DARE.

179. Cancer-related fatigue and rehabilitation: a randomized controlled multicenter trial comparing physical training combined with cognitive-behavioral therapy with physical training only and with no intervention Full Text available with Trip Pro

Cancer-related fatigue and rehabilitation: a randomized controlled multicenter trial comparing physical training combined with cognitive-behavioral therapy with physical training only and with no intervention Research suggests that cancer rehabilitation reduces fatigue in survivors of cancer. To date, it is unclear what type of rehabilitation is most beneficial.This randomized controlled trial compared the effect on cancer-related fatigue of physical training combined with cognitive behavioral (...) was included.The study was conducted at 4 rehabilitation centers in the Netherlands.All patients were survivors of cancer.Physical training consisting of 2 hours of individual training and group sports took place twice weekly, and cognitive-behavioral therapy took place once weekly for 2 hours.Fatigue was assessed with the Multidimensional Fatigue Inventory before and immediately after intervention (12 weeks after enrollment). The WLC group completed questionnaires at the same time points.Baseline fatigue did

2010 EvidenceUpdates Controlled trial quality: uncertain

180. Effect of retirement on major chronic conditions and fatigue: French GAZEL occupational cohort study. Full Text available with Trip Pro

Effect of retirement on major chronic conditions and fatigue: French GAZEL occupational cohort study. To determine, using longitudinal analyses, if retirement is followed by a change in the risk of incident chronic diseases, depressive symptoms, and fatigue. Design Prospective study with repeat measures from 7 years before to 7 years after retirement.Large French occupational cohort (the GAZEL study), 1989-2007. Participants 11 246 men and 2858 women.Respiratory disease, diabetes, coronary (...) heart disease and stroke, mental fatigue, and physical fatigue, measured annually by self report over the 15 year observation period; depressive symptoms measured at four time points.The average number of repeat measurements per participant was 12.1. Repeated measures logistic regression with generalised estimating equations showed that the cumulative prevalence of self reported respiratory disease, diabetes, and coronary heart disease and stroke increased with age, with no break in the trend around

2010 BMJ