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Latest & greatest articles for hypothermia
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on hypothermia or other clinical topics then use Trip today.
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Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score The HOPE score, based on covariates available at hospital admission, predicts the probability of in-hospital survival after extracorporeal life support (ECLS) rewarming of a given hypothermic cardiac arrest patient with accidental hypothermia. Our goal was to externally validate the HOPE score.We included consecutive hypothermic arrested patients who (...) underwent rewarming with ECLS. The sample comprised 122 patients. The six independent predictors of survival included in the HOPE score were collected for each patient: age, sex, mechanism of hypothermia, core temperature at admission, serum potassium level at admission and duration of CPR. The primary outcome parameter was survival to hospital discharge.Overall, 51 of the 122 included patients survived, resulting in an empirical (global) probability of survival of 42% (95% CI = [33-51
Therapeutic hypothermia for acute ischaemic stroke Ther Therapeutic h apeutic hypothermia for acute ischaemic ypothermia for acute ischaemic strok stroke e Interventional procedures guidance Published: 29 May 2019 www.nice.org.uk/guidance/ipg647 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take this guidance fully (...) . Nothing in this guidance should be interpreted in a way that would be inconsistent with compliance with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. 1 1 Recommendations Recommendations 1.1 Current evidence on the safety of therapeutic hypothermia for acute ischaemic stroke shows that there are serious
Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction Experimental trials suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial infarction. The objective of this study was to investigate the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicating acute myocardial infarction.Patients (n=40) with cardiogenic shock undergoing primary percutaneous coronary intervention without classic (...) indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control. The primary end point was cardiac power index at 24 hours; secondary end points included other hemodynamic parameters and serial measurements of arterial lactate.No relevant differences were observed for the primary end point of cardiac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0.31-0.52] versus 0.36
Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients. Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on mitochondria. Here we describe the effect of hypothermia on circulating mitochondrial (mt) DNA in a substudy of a multicenter randomized trial (the Target Temperature Management trial). Circulating levels of mtDNA were elevated
Thermal Suit or Forced Air Warming in Prevention of Perioperative Hypothermia: A Randomized Controlled Trial. To prevent perioperative hypothermia, forced air warming blanket was compared with a passive insulation suit.Prospective, open, randomized controlled trial.Thirty patients were scheduled for orthopedic spinal surgery. The intervention group (group TS) received the thermal suit T-Balance before premedication and throughout the perioperative period, whereas the control group (group C (...) ) received forced air warming (FAW) during surgery.No statistically significant difference (ns) was found between the groups for core temperature 30 minutes after induction of general anesthesia. Perioperative hypothermia occurred in 10 (66.7%) patients in group TS and 6 (40%) in group C (ns). For hypothermic patients, re-establishment of normothermia took significantly longer in group TS, mean 108 ± 111 minutes, than in group C, 33 ± 59.5 minutes (P = .03).The thermal suit did not prevent hypothermia
Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials Separate trials to evaluate therapeutic hypothermia after paediatric cardiac arrest for out-of-hospital and in-hospital settings reported no statistically significant differences in survival with favourable neurobehavioral outcome or safety compared to therapeutic normothermia. However, larger sample sizes might detect smaller clinical effects. Our aim was to pool data from identically conducted trials (...) to approximately double the sample size of the individual trials yielding greater statistical power to compare outcomes.Combine individual patient data from two clinical trials set in forty-one paediatric intensive care units in USA, Canada and UK. Children aged at least 48 h up to 18 years old, who remained comatose after resuscitation, were randomized within 6 h of return of circulation to hypothermia or normothermia (target 33.0 °C or 36.8 °C). The primary outcome, survival 12 months post-arrest
Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial. After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes.To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury.The Prophylactic Hypothermia (...) Trial to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT) was a multicenter randomized trial in 6 countries that recruited 511 patients both out-of-hospital and in emergency departments after severe traumatic brain injury. The first patient was enrolled on December 5, 2010, and the last on November 10, 2017. The final date of follow-up was May 15, 2018.There were 266 patients randomized to the prophylactic hypothermia group and 245 to normothermic management. Prophylactic
Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy. Hypoxic-ischaemic encephalopathy (HIE) is a serious birth complication affecting term and late preterm newborns. Although therapeutic hypothermia (cooling) has been shown to be an effective therapy for neonatal HIE, many cooled infants have poor long-term neurodevelopmental outcomes. In animal models of neonatal encephalopathy, inhaled xenon combined with cooling has been shown (...) to offer better neuroprotection than cooling alone.To determine the effects of xenon as an adjuvant to therapeutic hypothermia on mortality and neurodevelopmental morbidity, and to ascertain clinically important side effects of xenon plus therapeutic hypothermia in newborn infants with HIE. To assess early predictors of adverse outcomes and potential side effects of xenon.We used the standard strategy of the Cochrane Neonatal Review Group to search the Cochrane Library (2017, Issue 8), MEDLINE (from
Hypothermia Top results for hypothermia - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for hypothermia The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence
Effect of preoperative warming on intraoperative hypothermia: a randomized-controlled trial The purpose of this study was to evaluate the effects of preoperative forced-air warming on intraoperative hypothermia.In this randomized-controlled trial, adult patients scheduled for elective, non-cardiac surgery under general anesthesia were stratified by scheduled surgical duration (< 2.5 hr or ≥ 2.5 hr) and then randomized to a pre-warming group using a BairPaws™ forced-air warming system (...) for at least 30 min preoperatively or to a control group with warmed blankets on request. All patients were warmed intraoperatively via convective forced-air warming blankets. Perioperative temperature was measured using the SpotOn™ temperature system consisting of a single-use disposable sensor applied to the participant's forehead. The primary outcome was the magnitude of intraoperative hypothermia calculated as the area under the time-temperature curve for core temperatures < 36°C between induction
Hypothermia for newborns with hypoxic-ischemic encephalopathy Therapeutic hypothermia is a standard of care for infants ≥36 weeks gestational age (GA) with moderate-to-severe hypoxic-ischemic encephalopathy. Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria. Cooling for infants <35 weeks GA is not recommended. Passive cooling should be started promptly in community centres, in consultation with a tertiary care centre (...) image (MRI) is advised shortly after rewarming and, in cases where earlier findings do not match the clinical picture, a repeat MRI after 10 days of life is suggested. Multidisciplinary neurodevelopmental follow-up is recommended. Keywords: Hypoxic-ischemic encephalopathy; Therapeutic hypothermia
Flowchart: Hypoxic-ischaemic encephalopathy, Checklist for therapeutic hypothermia (cooling) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Checklist for therapeutic hypothermia If baby has a perinatal event and/or acidosis and meets the criteria below, therapeutic hypothermia may be indicated. Call (...) Retrieval Services Queensland immediately on 1300 799 127 to discuss the need for transfer and therapeutic hypothermia with a neonatologist. Therapeutic hypothermia criteria ? Evidence of acidosis or depression at birth, as indicated by at least one of the following: ? Apgar score = 5 at 10 minutes ? pH < 7.00 or a base excess equal to or worse than minus 12 mmol/L on a cord/arterial/venous/capillary blood gas obtained within 60 minutes of birth ? Mechanical ventilation or ongoing resuscitation for = 10
Flowchart: Hypoxic-ischaemic encephalopathy, Criteria for therapeutic hypothermia (cooling) Queensland Health State of Queensland (Queensland Health) 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/au/deed.en Queensland Clinical Guidelines, Guidelines@health.qld.gov.au Queensland Clinical Guidelines www.health.qld.gov.au/qcg Criteria for therapeutic hypothermia (cooling) Queensland Clinical Guideline: Hypoxic-ischaemic encephalopathy (HIE) F16.11-2-V8-R21 Does therapeutic hypothermia need (...) heart rate, periodic/irregular breathing, apnoea Reassess and document hourly for the first 6 hours following birth [refer to Checklist: Criteria for therapeutic hypothermia (cooling)] The baby presents with evidence of acute perinatal/ intrapartum hypoxia-ischaemia as suggested by at least one of the following: ? Apgar score = 5 at 10 minutes ? The blood gas (cord/arterial/venous/capillary) within 60 minutes of birth includes either a: ? pH < 7.00, or ? Base excess equal to or worse than minus 12
CRACKCast E140 – Accidental Hypothermia CRACKCast E140 – Accidental Hypothermia - CanadiEM CRACKCast E140 – Accidental Hypothermia In , , by Dillan Radomske January 2, 2018 This episode of CRACKCast covers Rosen’s Chapter 132, Accidental Hypothermia. Hypothermic patients will appear in the ED at any time and in any season. After listening to this podcast, you will be able to systematically approach these patients with ease. Shownotes: Rosen’s in Perspective Accidental hypothermia has been (...) something that has plagued the human race for time immemorial. It is something that will bring patients to your ED in any season. Don’t forget that today we are talking about accidental hypothermia (or primary hypothermia) – there are a myriad of other conditions causing secondary hypothermia (impaired heat production, impaired heat regulation) Infections – sepsis, meningitis, encephalitis Neurological – strokes, spinal cord injuries Toxic – EtOH intoxication, hypoglycemia Metabolic / endocrine