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Latest & greatest articles for irritable bowel syndrome
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Tenapanor (Ibsrela) - irritablebowelsyndrome Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs written for approved after September 1, 2012
In irritablebowelsyndrome, fecal microbiota transplantation improved symptoms at 3 months. El-Salhy M, Hatlebakk JG, Gilja OH, Bråthen Kristoffersen A, Hausken T. Efficacy of faecal microbiota transplantation for patients with irritablebowelsyndrome in a randomised, double-blind, placebo-controlled study. Gut. 2020;69:859-67. 31852769.
Alterations of Gut Microbiota in Patients With IrritableBowelSyndrome Based on 16S rRNA-Targeted Sequencing: A Systematic Review. Alterations of gut microbiota have been thought to be associated with irritablebowelsyndrome (IBS). Many studies have reported significant alterations of gut microbiota in patients with IBS based on 16S ribosomal RNA-targeted sequencing. However, results from these studies are inconsistent or even contradictory. We performed a systematic review to explore
Efficacy and Safety of Probiotics in IrritableBowelSyndrome: A Systematic Review and Meta-Analysis. Irritablebowelsyndrome is a functional gastrointestinaldisease. Evidence has suggested that probiotics may benefit IBS symptoms. However, clinical trials remain conflicting.To implement a systematic review and meta-analysis of clinical trials regarding the efficacy and safety of probiotics for IBS patients.We searched for relevant trials in Medline(1966 to Jan 2019), Embase(1974 to Jan 2019
Small Intestinal Bacterial Overgrowth in IrritableBowelSyndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. We conducted a systematic review and meta-analysis to compare the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with irritablebowelsyndrome (IBS) and controls.Electronic databases were searched up to December 2018 for studies reporting SIBO prevalence in patients with IBS. Prevalence rates, odds ratios (ORs), and 95% confidence intervals
Biofeedback for treatment of irritablebowelsyndrome. Irritablebowelsyndrome (IBS) is a prevalent condition that currently lacks highly effective therapies for its management. Biofeedback has been proposed as a therapy that may help individuals learn to exert conscious control over sympatho-vagal balance as an indirect method of symptom management.Our primary objective was to assess the efficacy and safety of biofeedback-based interventions for IBS in adults and children.We searched (...) the Cochrane Inflammatory BowelDisease (IBD) Group Specialized Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and the Allied and Complementary Medicine Database (AMED) from inception to 24 July 2019. We also searched reference lists from published trials, trial registries, device manufacturers, conference proceedings, theses, and dissertations.We judged randomized controlled trials
Mind-body treatments of irritablebowelsyndrome symptoms: An updated meta-analysis. Irritablebowelsyndrome (IBS) is a widespread chronic functional gastrointestinal (GI) disorder having bidirectional comorbidity with psychiatric disorders. This review focuses on psychological treatment of IBS, focusing on symptom severity rather than IBS diagnostic criteria. We chose this dimensional approach in order to assess mind-body effects as an alternative or complement to conventional medical
Efficacy of psychological therapies for irritablebowelsyndrome: systematic review and network meta-analysis. National guidelines for the management of irritablebowelsyndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this uncertainty.We searched the medical literature through January 2020 for randomised
Feeling down? A systematic review of the gut microbiota in anxiety/depression and irritablebowelsyndrome. Background Anxiety/depression and irritablebowelsyndrome (IBS) are highly prevalent and burdensome conditions, whose co-occurrence is estimated between 44 and 84%. Shared gut microbiota alterations have been identified in these separate disorders relative to controls; however, studies have not adequately considered their comorbidity. This review set out to identify case-control studies (...) comparing the gut microbiota in anxiety/depression, IBS, and both conditions comorbidly relative to each other and to controls, as well as gut microbiota investigations including measures of both IBS and anxiety/depression. Methods Four databases were systematically searched using comprehensive search terms (OVID Medline, Embase, PsycINFO, and PubMed), following PRISMA guidelines. Results Systematic review identified 17 studies (10 human, 7 animal). Most studies investigated the gut microbiota
Association between polymorphisms in the serotonin transporter gene-linked polymorphic region and risk for irritablebowelsyndrome in China: evidence based on a meta-analysis. 31272255 2020 03 26 2020 03 26 1473-2300 47 7 2019 Jul The Journal of international medical research J. Int. Med. Res. Association between polymorphisms in the serotonin transporter gene-linked polymorphic region and risk for irritablebowelsyndrome in China: evidence based on a meta-analysis. 2810-2818 10.1177 (...) . eng Journal Article Meta-Analysis Systematic Review 2019 07 05 England J Int Med Res 0346411 0300-0605 0 SLC6A4 protein, human 0 Serotonin Plasma Membrane Transport Proteins IM Asian Continental Ancestry Group genetics China Genotype Humans IrritableBowelSyndrome epidemiology etiology pathology Polymorphism, Genetic Serotonin Plasma Membrane Transport Proteins genetics 5-HTTLPR Chinese population IBS-C irritablebowelsyndrome meta-analysis polymorphism 2019 7 6 6 0 2020 3 27 6 0 2019 7 6 6 0
Gut Microbial Dysbiosis in the IrritableBowelSyndrome: A Systematic Review and Meta-Analysis of Case-Control Studies. Irritablebowelsyndrome (IBS) is the most common functional digestivecondition in the industrialized world. The gut microbiota plays a key role in disease pathogenesis.A systematic review and meta-analysis on case-control studies was conducted to determine whether there is gut microbial dysbiosis in participants with IBS in comparison with healthy controls and, if so (...) with the primary results. A subgroup analysis of Chinese studies was consistent with the primary results, except for fecal Bacteroides, which was increased in participants with IBS vs healthy controls (MD=0.29; 95% CI 0.13 to 0.46; P<0.01). Although substantial heterogeneity was detected (I2>75%) in most comparisons, the direction of the effect estimates is relatively consistent across studies.IBS is characterized by gut microbial dysbiosis. Prospective, large-scale studies are needed to delineate how gut
Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of IrritableBowelSyndrome: A systematic review and meta-analysis. Treatments that target alterations in gut microbiota may be beneficial for patients with irritablebowelsyndrome (IBS). A systematic review and meta-analysis was conducted of randomised clinical trials (RCTs) evaluating the efficacy and safety of probiotics, prebiotics and synbiotics. Factors considered in the analysis included global IBS symptoms (...) and/or abdominal pain, secondary symptoms and the frequency of adverse events. A total of 33 RCTs involving 4,321 patients were identified. Overall, probiotics significantly improved global IBS symptoms compared to placebos (standardised mean difference = -0.32, 95% confidence interval: -0.48 to -0.15; P <0.001), with significant heterogeneity between studies (I2 = 72%; P <0.001). This remained apparent in both single- and multi-strain probiotic interventions as well as synbiotic formulations. However
Candidate single nucleotide polymorphisms of irritablebowelsyndrome: a systemic review and meta-analysis. Genetic factors increase the risk of irritablebowelsyndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks.IBS - related polymorphisms studies from
5-Aminosalicylic acid for treatment of irritablebowelsyndrome: A protocol for a systematic review and meta-analysis. The global prevalence of irritablebowelsyndrome (IBS) is estimated to be as high as 15%, and it is estimated that IBS has a prevalence of approximately 10% to 20% in Western countries. Some trials showed mesalazine (5-aminosalicylic acid [5-ASA]) might be effective for IBS, but the results still need to be confirmed. Hence, this meta-analysis is designed to assess
The efficacy and safety of probiotics in patients with irritablebowelsyndrome: Evidence based on 35 randomized controlled trials. Irritablebowelsyndrome (IBS) is a functional boweldisorder that may involve disturbance of the gastrointestinal microbiota. We performed a systematic review and meta-analysis of the efficacy and safety of probiotics in patients with IBS.We searched the Cochrane Library, PubMed, EMBASE and Web of Science databases up to 1 April, 2019. Randomized controlled trials (...) with placebo, patients using probiotics had a lower incidence of persistence of symptoms (RR 0.79, 95% CI 0.70 to 0.89, P < 0.0001). Also, probiotics exerted a beneficial effect on global symptoms and the abdominal pain score (SMD -0.25, 95% CI -0.36 to -0.14, P < 0.00001), bloating score (SMD -0.15, 95% CI -0.27 to -0.03, P = 0.01), and flatulence score (SMD -0.20, 95% CI -0.35 to -0.05, P = 0.01). However, patients treated with probiotics had a higher incidence of any adverse event (RR 1.21; 95% CI 1.02
Comparison between the Effects of Acupuncture Relative to Other Controls on IrritableBowelSyndrome: A Meta-Analysis. Irritablebowelsyndrome (IBS) is a functional gastrointestinaldisorder with recurrent abdominal pain and altered defecation habits. We here attempted to determine the effect of acupuncture on IBS.Randomized controlled trials (RCTs) published in CNKI, VIP, Wanfang, PubMed, Cochrane Library, EMBASE, Web of science, and ClinicalTrials.gov till July 17, 2019 were searched (...) . Outcomes were total efficacy rates, overall IBS symptom scores, or global quality of life scores. Standardized mean difference (SMD) with 95% confidence intervals (CI) and risk ratio (RR) with 95% CI were calculated for meta-analysis.We included 41 RCTs involving 3440 participants for analysis. 8 RCTs compared acupuncture with sham acupuncture, among which 3 trials confirmed the biological effects of acupuncture, especially in treating abdominal pain, discomfort, and stool frequency. No significant
Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With IrritableBowelSyndrome Peppermint oil is frequently used to treat irritablebowelsyndrome (IBS), despite a lack of evidence for efficacy from high-quality controlled trials. We studied the efficacy and safety of small-intestinal-release peppermint oil in patients with IBS and explored the effects of targeted ileocolonic-release peppermint oil.We performed a double-blind trial of 190 patients with IBS (...) (according to Rome IV criteria) at 4 hospitals in The Netherlands from August 2016 through March 2018; 189 patients were included in the intent-to-treat analysis (mean age, 34.0 years; 77.8% female; 57.7% in primary care), and 178 completed the study. Patients were randomly assigned to groups given 182 mg small-intestinal-release peppermint oil, 182 mg ileocolonic-release peppermint oil, or placebo for 8 weeks. The primary endpoint was abdominal pain response, as defined by the US Food and Drug