Latest & greatest articles for knee osteoarthritis

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Top results for knee osteoarthritis

1. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial (Full text)

of knee OA. © 2020 Samumed, LLC. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. Similar articles Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi: 10.1016/j.joca.2017.07.006. Epub 2017 Jul 13. Osteoarthritis Cartilage. 2017. PMID: 28711582 Clinical Trial. Deshmukh (...) Actions Cite Display options Display options Format Share Permalink Copy Page navigation Arthritis Rheumatol Actions . 2020 May 20. doi: 10.1002/art.41315. Online ahead of print. Lorecivivint, a Novel Intraarticular CDC-Like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial , , , , , , , , , , , Affiliations Expand Affiliations 1 Samumed LLC, San Diego, California. 2 Tufts

2020 EvidenceUpdates PubMed abstract

2. The Non-Surgical Management of Hip & Knee Osteoarthritis

involvement and disease progression varies. Osteoarthritis is diagnosed at a median of 55 years of age, and patients may live approximately 30 years with the disease. Patients with OA may present to providers with minimal symptoms or have incidental findings on physical examination or radiologic testing. Patients with symptomatic OA typically present with joint pain, aching, stiffness, and limited walking ability.[29] Knee OA is usually bilateral but one knee may be affected more severely; hip OA (...) annually in direct healthcare costs. The combination of direct and indirect costs for OA and related disorders is estimated to be $461 billion.[18] Hip and knee joint replacements represent a major portion of these costs.[17] The indirect costs associated with OA greatly surpass healthcare costs and exert significant personal costs for people with OA due to work loss and premature retirement, leading to loss of income and subsequent reductions in personal savings.[17] Osteoarthritis also causes

2020 VA/DoD Clinical Practice Guidelines

3. Effectiveness of <i>Curcuma longa</i> Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. (Abstract)

Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomatic knee osteoarthritis and knee effusion-synovitis.Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials (...) Registry: ACTRN12618000080224).Single-center study with patients from southern Tasmania, Australia.70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis.2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks.The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities

2020 Annals of Internal Medicine

4. In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. (Abstract)

In knee OA, physical therapy reduced pain and improved function more than glucocorticoid injections at 1 year. Deyle GD, Allen CS, Allison SC, et al. Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med. 2020;382:1420-9. 32268027.

2020 Annals of Internal Medicine

5. Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials

), the visual analog scale (VAS), the EuroQol VAS, the International Knee Documentation Committee, the Tegner score, the Lequesne Scale, the Knee injury Osteoarthritis Outcome Score, satisfaction rate, and adverse events. Subgroup analyses was performed for patients with different doses, types, and times of PRP interventions and grades of OA. The Review Manager Database was used to analyze the included studies. Results: Twenty-six randomized controlled trials involving 2430 patients were included. The WOMAC (...) Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 26 Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19

2020 EvidenceUpdates

6. Cooled radiofrequency ablation provides extended clinical utility in the management of knee osteoarthritis: 12-month results from a prospective, multi-center, randomized, cross-over trial comparing cooled radiofrequency ablation to a single hyaluronic aci (Full text)

DH, et al. Number of persons with symptomatic knee osteoarthritis in the US: impact of race and ethnicity, age, sex, and obesity: symptomatic knee OA in the US. Arthritis Care Res. 2016;68(12):1743–1750. doi: 10.1002/acr.22897. - - - KS&R, Inc. Halyard-sponsored qualitative market research, OA Pain Landscape & Patient Journey. 2015. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd Edition. J Am Acad Orthop Surg. 2013;21(9):577–9 (...) PMCID: DOI: Item in Clipboard Full-text links Cite Abstract Background: Safe and effective non-surgical treatments are an important part of the knee osteoarthritis (OA) treatment algorithm. Cooled radiofrequency ablation (CRFA) and hyaluronic acid (HA) injections are two commonly used modalities to manage symptoms associated with knee OA. Methods: A prospective 1:1 randomized study was conducted in 177 patients comparing CRFA to HA injection with follow-ups at 1, 3, 6 and 12 months. HA subjects

2020 EvidenceUpdates PubMed abstract

7. An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis

, but a greater incidence of diarrhoea occurred with diacerein (10.2% vs 3.7%). Diarrhoea was considered mild-to-moderate in all but one case with complete resolution. Conclusions: Diacerein was non-inferior to celecoxib in reducing knee OA pain and improving physical function. Diacerein also demonstrated a good safety profile. Trial registration: A multicentre study on the effect of DIacerein on Structure and Symptoms vs Celecoxib in Osteoarthritis is a National Institutes of Health ( ) and European Clinical (...) An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID

2020 EvidenceUpdates

8. Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials (Full text)

demonstrated that there were significant differences between Kinesio Taping groups and control groups in terms of visual analog scale (VAS), Western Ontario and MacMaster Universities Osteoarthritis Index (WOMAC) scale and flexion range of motion. Kinesio Taping is effective in improving pain and joint function in patients with knee OA. Keywords: Kinesio Taping; knee joint; osteoarthritis; systematic review. © 2020 Melese et al. Conflict of interest statement The authors report no conflicts of interest (...) Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials Effectiveness of Kinesio Taping on the Management of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly

2020 EvidenceUpdates PubMed abstract

9. Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis

Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis Comparative effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other (...) effects of combined physical therapy with Kinesio taping and physical therapy in patients with knee osteoarthritis: a systematic review and meta-analysis , , , , , Affiliations Expand Affiliations 1 Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi, Taiwan. 2 School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 3 Department of Neurology, Chang Gung Memorial Hospital, Chiayi, Taiwan. 4 Department of Nursing, Chang Gung University

2020 EvidenceUpdates

10. Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis

Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features (...) of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-Analysis , , , , , , , , Affiliations Expand Affiliations 1 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A. 2 Loyola University Chicago, Chicago, Illinois, U.S.A. 3 Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University, Medical Center, Chicago, Illinois, U.S.A.. Electronic address

2020 EvidenceUpdates

11. Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?

Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Prescrire IN ENGLISH - Spotlight ''Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated?'', 1 July 2020 {1} {1} {1} | | > > > Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |  (...)  |   |   |   |   |   |   |   |  Spotlight Intra-articular hyaluronic acid injection for knee osteoarthritis: efficacy and adverse effects underestimated? Queries and Comments Prescrire concluded in 2016 that the harm-benefit balance of hyaluronic acid by intra-articular injection seemed unfavourable. Several readers have since expressed their profound disagreement, citing the effects noted in their daily practice. How can

2020 Prescrire

12. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial (Full text)

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Fam Med Actions . 2020 May;18(3):235-242. doi: 10.1370/afm.2520. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliations 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk. 2 Jockey Club School of Public Health and Primary Care

2020 EvidenceUpdates PubMed abstract

13. The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial

The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May 6;269215520916859. doi: 10.1177/0269215520916859. Online ahead of print. The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial , Affiliations Expand Affiliation 1 Department of Rehabilitation, Medical Academy

2020 EvidenceUpdates

14. Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. (Abstract)

Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N (...)  = 220) with symptomatic, radiologically confirmed knee osteoarthritis were recruited between April 20, 2015, and January 10, 2017. The last participant visit occurred on August 15, 2017.Participants were randomized to biomechanical footwear involving shoes with individually adjustable external convex pods attached to the outsole (n = 111) or to control footwear (n = 109) that had visible outsole pods that were not adjustable and did not create a convex walking surface.The primary outcome was knee

2020 JAMA

15. Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

Full-text links Cite Abstract Objective: Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods: This double-blind, randomised, phase III study enrolled adults in Europe and Japan with moderate-to-severe OA who had not responded to or could not tolerate standard-of-care analgesics. Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8 (...) weeks (three doses). Co-primary end points were change from baseline to week 24 in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function, and Patient's Global Assessment of OA (PGA-OA). Joint safety and neurological assessments continued throughout the 48-week study. Results: From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically

2020 EvidenceUpdates

16. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Full text)

of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Paper presented at: Seminars in arthritis and rheumatism; 1990. doi:10.1099/00221287-136-2-327 - - Kon E, Filardo G, Drobnic M, et al. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthroscopy. 2012;20(3):436–449. doi:10.1007/s00167-011-1713-8 - - Raeissadat SA, Tabibian E, Rayegani SM, Rahimi-Dehgolan S, Babaei-Ghazani A. An inestigation into the efficacy of intra-articular ozone (O2-O3 (...) MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show

2020 EvidenceUpdates PubMed abstract

17. Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT (Full text)

Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you (...) need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Both total and partial knee replacement were effective and offered similar clinical outcomes at 5 years. {{author}} {{($index , , , , , , , , , , , , & . David J Beard 1, * , Loretta J Davies 1 , Jonathan A Cook 2 , Graeme MacLennan 2 , Andrew Price 1 , Seamus Kent 3 , Jemma Hudson 2 , Andrew Carr 1 , Jose Leal 3 , Helen Campbell 3 , Ray Fitzpatrick 3 , Nigel Arden 1 , David Murray 1

2020 NIHR HTA programme PubMed abstract

18. The short-term efficacy of mud therapy for knee osteoarthritis: A meta-analysis. (Full text)

The short-term efficacy of mud therapy for knee osteoarthritis: A meta-analysis. The objective of this review is to systematically evaluate the short-term efficacy of mud therapy in the treatment of knee osteoarthritis (KOA).Randomized controlled trials, in which treatment of KOA is mud therapy, were included by systematically searching the PubMed, Embase, and the Cochrane Library databases.According to inclusion criteria and searching method, 11 articles, containing a total of 1106 patients (...) , were included in the study. Our results showed significant differences in visual analog scale pain score and Western Ontario and McMaster Universities Osteoarthritis Index (pain, stiffness, function). In addition, the heterogeneity of study included is lower (I < 25%).According to the results of this meta-analysis, mud therapy can effectively alleviate the pain and improve joint function for KOA.

2020 Medicine PubMed abstract

19. Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. (Full text)

Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation in knee OA have reported conflicting results. Further (...) research is needed to clarify the effects of vitamin D on patient-reported outcomes and determine whether there are patient subgroups who may benefit from the supplementation. The aim of this individual patient data (IPD) meta-analysis is to identify patient-level predictors of treatment response to vitamin D supplementation on pain and physical function.A systematic literature search will be conducted for RCTs of vitamin D supplementation on knee OA. Authors of original RCTs will be contacted

2020 BMJ open PubMed abstract

20. Invited commentary on- "The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: A systematic review and meta-analysis" (2020 Jan 21; 75:24-34). (Abstract)

Invited commentary on- "The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: A systematic review and meta-analysis" (2020 Jan 21; 75:24-34). 32171802 2020 04 25 1743-9159 77 2020 Mar 12 International journal of surgery (London, England) Int J Surg Invited commentary on- "The efficacy and safety of extracorporeal shockwave therapy in knee osteoarthritis: A systematic review and meta-analysis" (2020 Jan 21; 75:24-34). 14 S1743-9191(20)30225-9 10.1016/j.ijsu (...) .2020.03.013 Yin Li L Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Department of Orthopaedics, Panzhihua Central Hospital, Panzhihua, Sichuan, China. Yu Bin B Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: yubinol@163.com. eng Letter 2020 03 12 England Int J Surg 101228232 1743-9159 IM Extracorporeal shockwave therapy Knee osteoarthritis

2020 International journal of surgery (London, England)