Latest & greatest articles for lithium

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Top results for lithium

1. Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. (Abstract)

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes. Uncertainty surrounds the risks of lithium use during pregnancy in women with bipolar disorder. The authors sought to provide a critical appraisal of the evidence related to the efficacy and safety of lithium treatment during the peripartum period, focusing on women with bipolar disorder and their offspring.The authors conducted a systematic review and random (...) -effects meta-analysis assessing case-control, cohort, and interventional studies reporting on the safety (primary outcome, any congenital anomaly) or efficacy (primary outcome, mood relapse prevention) of lithium treatment during pregnancy and the postpartum period. The Newcastle-Ottawa Scale and the Cochrane risk of bias tools were used to assess the quality of available PubMed and Scopus records through October 2018.Twenty-nine studies were included in the analyses (20 studies were of good quality

2020 The American Journal of Psychiatry

2. Response to Char's comment: Comment on Li et al.: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. (Full text)

Response to Char's comment: Comment on Li et al.: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. We have read Char's comment1 . Thanks for readers' attention and valuable feedback on our article. Following was our response to Char's question about data overlap. Firstly, the meta-analysis reprocessed the existing data about COVID-19 patients in published articles, and involved no other information outside of the article. This article is protected

2020 Journal of medical virology PubMed abstract

3. Comment on Li et al.: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. (Full text)

Comment on Li et al.: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. I have read with great interest the article "COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis" by Li and colleagues1 . The authors have conducted a comprehensive search for articles concerning the clinical characteristics of Chinese patients with COVID-19. This article is protected by copyright. All rights reserved.This article

2020 Journal of medical virology PubMed abstract

4. Lithium Neurotoxicity Due to Second-Generation Antipsychotics Combined With Lithium: A Systematic Review. (Abstract)

Lithium Neurotoxicity Due to Second-Generation Antipsychotics Combined With Lithium: A Systematic Review. To study cases of lithium neurotoxicity (LN), both reversible (RLN) and irreversible (ILN), due to second-generation antipsychotics (SGAs) combined with lithium.A comprehensive search was conducted in MEDLINE, PsycINFO, EMBASE, and the Cochrane Library from their inception to July 31, 2017.Free terms and MeSH headings were combined as follows: [(lithium) AND (adverse events OR safety (...) OR side effects OR neurotoxicity OR neurologic manifestations OR central nervous system) AND (risperidone OR paliperidone OR olanzapine OR aripiprazole OR clozapine OR quetiapine OR ziprasidone OR amisulpride OR asenapine OR lurasidone OR iloperidone)]. Only English-language articles reporting about LN due to SGAs combined with lithium were selected.The age, sex, diagnostic categories, clinical features, lithium doses, serum lithium levels, antipsychotic dosages, causative factors, and preventive

2020 The Primary Care Companion for CNS Disorders

5. What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium. (Full text)

What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium. To systematically review the existing trials on optimal serum levels for lithium for maintenance treatment of bipolar disorder and to develop clinical recommendations.Systematic literature search. Discussion of major characteristics, limitations, methodological quality, and results of selected trials (...) . Delphi survey consisting of clinical questions and corresponding statements. For statements endorsed by at least 80% of the members, consensus was considered as having been achieved.With strict inclusion criteria no studies could be selected, making it difficult to formulate evidence-based recommendations. After loosening the inclusion criteria 7 trials were selected addressing our aims at least to some extent. Four of these studies suggest better efficacy being associated with lithium serum levels

2020 Bipolar disorders PubMed abstract

6. Lithium during pregnancy: malformations, fetotoxicity and uncertain long-term effects

Lithium during pregnancy: malformations, fetotoxicity and uncertain long-term effects Prescrire IN ENGLISH - Spotlight ''Lithium during pregnancy: malformations, fetotoxicity and uncertain long-term effects'', 1 April 2020 {1} {1} {1} | | > > > Lithium during pregnancy: malformations, fetotoxicity and uncertain long-term effects Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |  (...)  |   |  Spotlight Lithium during pregnancy: malformations, fetotoxicity and uncertain long-term effects FEATURED REVIEW Outside the context of pregnancy, lithium is the standard "mood stabiliser" for the treatment of bipolar disorder. What are the main known short-term and long-term consequences of in utero exposure to lithium? Full review (3 pages) available for download by subscribers. Abstract A meta-analysis of about 600 pregnant women exposed to lithium during the first

2020 Prescrire

7. Twenty years of Lithium pharmacogenetics: A systematic review. (Abstract)

Twenty years of Lithium pharmacogenetics: A systematic review. Lithium is among the best proven treatments for patients diagnosed with Bipolar Disorder, however response to Lithium appears to be considerably variable among individuals and it has been suggested that this inconstancy in Lithium response could be genetically determined. Starting from this perspective, in the last few decades, a number of pharmacogenetic studies have attempted to identify genetic variants, which might be associated (...) with response to Lithium in bipolar patients, in order to develop a pharmacogenetics test to tailor treatment on patients, identifying who will benefit the most from therapy with Lithium. Within this context, authors have critically reviewed pharmacogenetic studies of Lithium response in bipolar disorder, suggesting strategies for future work in this field. Computerized searches of PubMed and Embase databases, for studies published between 1998 and January 2018, was performed: 1162 studies were identified

2020 Psychiatry research

8. Reply to Li et al.: Comment on "Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis". (Abstract)

Reply to Li et al.: Comment on "Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis".

2020 Sports medicine (Auckland, N.Z.)

9. Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design. (Full text)

Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design. Whether patients with adult bipolar disorder (BD) who have been clinically stabilized with lithium or lamotrigine should continue this medication is not established fully. This systematic review and meta-analysis evaluated the efficacy and safety (...) of lithium and lamotrigine for maintenance treatment in clinically stable patients with adult BD.This meta-analysis included only double-blind, randomized, placebo-controlled trials with an enrichment design that selected patients who responded acutely to lithium or lamotrigine. Reports prior to November 15, 2018, were retrieved from the PubMed/Cochrane Library/Embase. The primary outcome was the relapse rate due to any mood episode at the study endpoint. Other outcomes were relapse rates due to a manic

2020 Neuropsychopharmacology reports PubMed abstract

10. Effect of lithium on suicide and mortality in mood disorders: A systematic review. (Abstract)

Effect of lithium on suicide and mortality in mood disorders: A systematic review. To assess if lithium treatment in patients with mood disorders, for instance depression, bipolar disorders, and schizoaffective disorders, has an effect on total mortality and suicide.Systematic review and meta-analysis.Total mortality. Secondary outcome was suicide.PubMed and ClinicalTrials.gov. Eligible trials were randomized double-blind trials comparing lithium with placebo in patients with mood disorders who (...) were not already on lithium before randomization in order to avoid withdrawal effects in the placebo group.Two researchers extracted data independently. Data were analysed with Review Manager 5.3 (Peto odds ratio).We found 45 eligible studies. Only four studies reported any suicides or other deaths in the lithium or placebo group. There was a significant reduction in total mortality (two versus nine), odds ratio 0.28 (95% confidence interval 0.08 to 0.93). There was no statistically significant

2020 The International journal of risk & safety in medicine

11. In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms. (Abstract)

In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms. Despite recent advances in molecular biology and genetics, the development of intracranial aneurysms (IA) is still poorly understood. Elucidation of the processes occurring in the IA wall is essential for a better understanding of IA pathophysiology. We sought to analyze the current evidence from histological, molecular and genetic studies of IA.We systematically searched PubMed, Scopus, Web

2020 Brain pathology (Zurich, Switzerland)

12. Lithium treatment for unipolar major depressive disorder: Systematic review. (Abstract)

Lithium treatment for unipolar major depressive disorder: Systematic review. The potential value of lithium treatment in particular aspects of unipolar major depressive disorder remains uncertain.With reports of controlled trials identified by systematic searching of Medline, Cochrane Library, and PsycINFO literature databases, we summarized responses with lithium and controls followed by selective random-effects meta-analyses.We identified 36 reports with 39 randomized controlled trials: six (...) for monotherapy and 12 for adding lithium to antidepressants for acute major depression, and 21 for long-term treatment. Data for monotherapy of acute depression were few and inconclusive. As an adjunct to antidepressants, lithium was much more effective than placebo ( p<0.0001). For long-term maintenance treatment, lithium was more effective than placebo in monotherapy ( p=0.011) and to supplement antidepressants ( p=0.038), and indistinguishable from antidepressant monotherapy.The findings indicate efficacy

2020 Journal of psychopharmacology (Oxford, England)

13. Clinical Lactation Studies of Lithium: A Systematic Review. (Full text)

Clinical Lactation Studies of Lithium: A Systematic Review. Background: There is substantial evidence that postpartum prophylaxis with lithium lowers the rate of relapse in bipolar disorder. However, it is contraindicated during breastfeeding due to the high variability of the transfer into breast milk. Aims: We conducted a systematic review of the current evidence of studies assessing the transfer of lithium to lactating infants and short-term infant outcomes. Methods: An a priori protocol (...) was designed based on PRISMA guidelines. Searches in PubMed and LactMed were conducted until September 2018. Studies assessing lithium pharmacokinetic parameters and short-term infant outcomes were included. Quality was assessed using a checklist based on international guidelines (i.e., FDA). Results: From 344 initial studies, 13 case reports/series with 39 mother-child dyads were included. Only 15% of studies complied with ≥50% of the items on the quality assessment checklist. Infants breastfeed a mean

2020 Frontiers in pharmacology PubMed abstract

14. Comment on: "Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-analysis" and Subsequent Comment/Author Reply from Li et al. (Abstract)

Comment on: "Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-analysis" and Subsequent Comment/Author Reply from Li et al. 31696450 2020 02 19 1179-2035 50 3 2020 Mar Sports medicine (Auckland, N.Z.) Sports Med Comment on: "Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-analysis" and Subsequent Comment/Author Reply from Li et al. 629-632 10.1007/s40279-019-01216-4 Borszcz Fernando Klitzke FK

2020 Sports medicine (Auckland, N.Z.)

15. Relationship between suicide mortality and lithium in drinking water: A systematic review and meta-analysis. (Abstract)

Relationship between suicide mortality and lithium in drinking water: A systematic review and meta-analysis. Lithium at therapeutic doses has protective effects against suicide in clinical practice. This meta-analysis aimed to investigate the relationship between lithium concentration in drinking water and suicide mortality in the general population.A systematic search was conducted in Web of Knowledge, PubMed, ScienceDirect, and Scopus to find papers reporting the crude relationship between (...) drinking water lithium and suicide incidence in the general population until June 2019. The pooled effect measure was expressed as odds ratio (OR) and 95% confidence interval (CI) using the random-effects model.We retrieved 308 English original articles, of which 13 ecologic studies with a total sample size of 939 regions and one cohort study with a sample size of 3,740,113 people were eligible for the meta-analysis. A significant relationship was found between the lithium concentration in drinking

2020 Journal of Affective Disorders

16. Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses. (Abstract)

Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses. To assess whether bipolar disorder (BD) increases the rate of dementia and whether lithium is related to a lower risk of dementia in BD.A total of 10 studies (6859 BD; 487 966 controls) were included in the meta-analysis to test whether BD is a risk factor for dementia. In addition, five studies (6483 lithium; 43 496 non-lithium) were included in the meta-analysis about the potential (...) protective effect of lithium in BD.BD increases the risk of dementia (odds ratio (OR): 2.96 [95% CI: 2.09-4.18], P < 0.001), and treatment with lithium decreases the risk of dementia in BD (OR: 0.51 [95% CI: 0.36-0.72], P < 0.0001). In addition, secondary findings from our systematic review showed that the risk of progression to dementia is higher in BD than in major depressive disorder (MDD). Moreover, the number of mood episodes predicted the development of dementia in BD.Individuals with BD

2020 Acta Psychiatrica Scandinavica

17. Systematic review and practical guideline for the prevention and management of the renal side effects of lithium therapy. (Abstract)

Systematic review and practical guideline for the prevention and management of the renal side effects of lithium therapy. Lithium is the first line therapy of bipolar mood disorder. Lithium-induced nephrogenic diabetes insipidus (Li-NDI) and lithium nephropathy (Li-NP, i.e., renal insufficiency) are prevalent side effects of lithium therapy, with significant morbidity. The objective of this systematic review is to provide an overview of preventive and management strategies for Li-NDI and Li-NP (...) . For this, the PRISMA guideline for systematic reviews was used. Papers on the prevention and/or treatment of Li-NDI or Li-NP, and (influenceable) risk factors for development of Li-NDI or Li-NP were included. We found that the amount of evidence on prevention and treatment of Li-NDI and Li-NP is scarce. To prevent Li-NDI and Li-NP we advise to use a once-daily dosing schedule, target the lowest serum lithium level that is effective and prevent lithium intoxication. We emphasize the importance of monitoring for Li

2020 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

18. Re: "The Impact of Placebo Response Rates on Clinical Trial Outcome: A Systematic Review and Meta-Analysis of Antidepressants in Children and Adolescents with Major Depressive Disorder" by Li Y, Huang J, He Y, Yang J, Lv Y, Liu H, Liang L, Zheng Q, and Li (Abstract)

Re: "The Impact of Placebo Response Rates on Clinical Trial Outcome: A Systematic Review and Meta-Analysis of Antidepressants in Children and Adolescents with Major Depressive Disorder" by Li Y, Huang J, He Y, Yang J, Lv Y, Liu H, Liang L, Zheng Q, and Li 31603715 2020 02 11 1557-8992 30 1 2020 Feb Journal of child and adolescent psychopharmacology J Child Adolesc Psychopharmacol Re: "The Impact of Placebo Response Rates on Clinical Trial Outcome: A Systematic Review and Meta-Analysis (...) of Antidepressants in Children and Adolescents with Major Depressive Disorder" by Li Y, Huang J, He Y, Yang J, Lv Y, Liu H, Liang L, Zheng Q, and Li L (J Child Adolesc Psychopharmacol 29:712-720, 2019). 55-56 10.1089/cap.2019.0127 Kirsch Irving I Program in Placebo Studies, Harvard Medical School, Boston, Massachusetts. eng Letter 2019 10 11 United States J Child Adolesc Psychopharmacol 9105358 1044-5463 IM 2019 10 12 6 0 2019 10 12 6 0 2019 10 12 6 0 ppublish 31603715 10.1089/cap.2019.0127

2020 Journal of Child and Adolescent Psychopharmacology

19. Lithium can cause hyperthyroidism as well as hypothyroidism: A systematic review of an under-recognised association. (Abstract)

Lithium can cause hyperthyroidism as well as hypothyroidism: A systematic review of an under-recognised association. Hypothyroidism is a well-documented consequence of lithium treatment. Less well known is a possible association between lithium therapy and hyperthyroidism. This may have clinical implications as rapid changes in thyroid hormones may worsen a person's affective state, while symptoms of hyperthyroidism can mimic those of mania. We therefore systematically reviewed the published (...) literature for evidence of lithium-induced hyperthyroidism.We searched PubMed, Embase and CINAHL for articles where individuals developed biochemically confirmed hyperthyroidism (with or without clinical symptoms), while on lithium therapy for an affective illness. We included case reports, case series, cross-sectional, case control and cohort studies.We included 52 studies, 39 of which were individual case reports and 3 were case series. There were 10 cross-sectional or case control or cohort studies

2020 The Australian and New Zealand journal of psychiatry

20. Lithium and valproate serum level fluctuations within the menstrual cycle: a systematic review. (Abstract)

Lithium and valproate serum level fluctuations within the menstrual cycle: a systematic review. Some women affected by mood disorders experience mood instability during the premenstrual phase. Assuming that fluctuations in drug serum levels may contribute to the worsening of mood symptoms, we carried out a systematic review of available studies that investigated changes in lithium and valproate levels in relation to menstrual phases. We selected five studies; four of which assessed menstrual (...) fluctuations in lithium serum levels and one in valproate levels. Study samples included women in their fertile age affected by bipolar disorder, epilepsy as well as healthy ones. Preliminary results showed a close relationship between cyclic premenstrual exacerbation of affective symptoms and a significant decrease in lithium levels during the luteal phase, despite stable oral doses, in bipolar women. In healthy women, lithium levels were influenced by neither menstrual cycle phases nor oral

2020 International clinical psychopharmacology