Latest & greatest articles for lorazepam

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Top results for lorazepam

1. Lorazepam

Lorazepam Top results for lorazepam - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 (...) or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for lorazepam The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence

2018 Trip Latest and Greatest

2. Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial. (Full text)

Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial. The use of benzodiazepines to control agitation in delirium in the last days of life is controversial.To compare the effect of lorazepam vs placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium in the setting of advanced cancer.Single-center, double-blind, parallel-group, randomized clinical (...) trial conducted at an acute palliative care unit at MD Anderson Cancer Center, Texas, enrolling 93 patients with advanced cancer and agitated delirium despite scheduled haloperidol from February 11, 2014, to June 30, 2016, with data collection completed in October 2016.Lorazepam (3 mg) intravenously (n = 47) or placebo (n = 43) in addition to haloperidol (2 mg) intravenously upon the onset of an agitation episode.The primary outcome was change in Richmond Agitation-Sedation Scale (RASS) score (range

2017 JAMA Controlled trial quality: predicted high PubMed abstract

3. The effectiveness of ibuprofen and lorazepam combination therapy in treating the symptoms of acute Migraine: A randomized clinical trial (Full text)

The effectiveness of ibuprofen and lorazepam combination therapy in treating the symptoms of acute Migraine: A randomized clinical trial Migraine is a common, episodic and debilitating disease. The migraineur not only suffers from pain, but also lives with a diminished to poor quality of life. Several medicinal therapies are used to abate the debilitating symptoms of this disease.The present study was conducted to determine the effectiveness of Ibuprofen and Lorazepam combination therapy (...) randomly divided into three groups of 30. The first group was administered 200 mg Ibuprofen capsules, the second group 400 mg Ibuprofen capsules and the third group a combination of 200 mg Ibuprofen capsules and 1 mg Lorazepam tablets. The medications were taken in the presence of the researcher. A checklist was used to assess the severity of headache and other migraine symptoms such as nausea, vomiting, photophobia and phonophobia in the patients, before and two hours after the intervention. Data were

2017 Electronic physician Controlled trial quality: uncertain PubMed abstract

4. Effects of Intramuscular Midazolam and Lorazepam on Acute Agitation in Non-Elderly Subjects - A Systematic Review. (Abstract)

Effects of Intramuscular Midazolam and Lorazepam on Acute Agitation in Non-Elderly Subjects - A Systematic Review. Benzodiazepines are commonly used for the treatment of acute agitation in a psychiatric setting.We searched MEDLINE, EMBASE, PsycINFO, and the Cochrane Central Register of Controlled Trials (CENTRAL) for relevant publications. Randomized trials evaluating intramuscular (IM) midazolam or lorazepam given as monotherapy or as add-on treatment, with more than 10 patients aged 18-65 (...) years, conducted in a psychiatric setting, and published between January 1, 1980, and February 3, 2016, were included. 16 studies from a search result of 5 516 studies were included. In total, 577 patients were treated with lorazepam IM 2-4 mg, and 329 patients were treated with midazolam IM 5-15 mg. It is unclear whether lorazepam IM or midazolam IM is as efficacious as an antipsychotic IM. It is a bit more certain that the combination of benzodiazepines IM and a low dose antipsychotic IM is more

2017 Pharmacopsychiatry

5. Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. (Abstract)

Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE). We aimed to critically assess all the available data on efficacy and tolerability of IV LZP compared

2016 Epilepsy & behavior : E&B

6. Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis. (Abstract)

Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis. Convulsive status epilepticus (CSE) is a neurological emergency in adults and children. However, whether a particular benzodiazepine is of superior efficacy and safety in management of CSE is controversial. We performed a meta-analysis to compare the outcome of lorazepam and diazepam for treating CSE. We searched the PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases from (...) differences and risk ratios for continuous and dichotomous variables, respectively. A total of six studies involving 970 patients were included in this analysis. The majority of patients were children (n=574) and 396 patients were adults. Meta-analysis showed no significant difference between the two treatment groups regarding seizure control and adverse effects regardless of patient age. This meta-analysis demonstrates that diazepam and lorazepam have equal efficacy and side effects for treating CSE

2016 Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

7. A Comparison of Midazolam, Lorazepam, and Diazepam for the Treatment of Status Epilepticus in Children: A Network Meta-analysis. (Abstract)

A Comparison of Midazolam, Lorazepam, and Diazepam for the Treatment of Status Epilepticus in Children: A Network Meta-analysis. Midazolam, lorazepam, and diazepam were recommended as emergent initial therapy for status epilepticus. However, there are no current studies to confirm the best agent for pediatric status epilepticus. We compared the efficacy of midazolam, lorazepam, and diazepam in treating pediatric status epilepticus using a network meta-analysis method. In total, 16 randomized (...) controlled trials containing 1821 patients were included. Nonintravenous midazolam, intravenous lorazepam, and intravenous diazepam were more successful in achieving seizure cessation when compared with nonintravenous diazepam (odds ratio = 2.23, 95% credibility interval: 1.62, 3.10; odds ratio = 2.71, 95% credibility interval: 1.25, 5.89; odds ratio = 2.65, 95% credibility interval: 1.12, 6.29; respectively). Among lorazepam, midazolam, and diazepam, midazolam had the highest probability (surface under

2016 Journal of child neurology

8. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. (Full text)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. Benzodiazepines are considered first-line therapy for pediatric status epilepticus. Some studies suggest that lorazepam may be more effective or safer than diazepam, but lorazepam is not Food and Drug Administration approved for this indication.To test the hypothesis that lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus.This double-blind, randomized clinical trial (...) was conducted from March 1, 2008, to March 14, 2012. Patients aged 3 months to younger than 18 years with convulsive status epilepticus presenting to 1 of 11 US academic pediatric emergency departments were eligible. There were 273 patients; 140 randomized to diazepam and 133 to lorazepam.Patients received either 0.2 mg/kg of diazepam or 0.1 mg/kg of lorazepam intravenously, with half this dose repeated at 5 minutes if necessary. If status epilepticus continued at 12 minutes, fosphenytoin

2014 JAMA Controlled trial quality: predicted high PubMed abstract

9. Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children

Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children BestBets: Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children Intranasal Lorazepam Is an Acceptable Alternative To Intravenous Lorazepam In The Control Of Acute Seizures In Children Report By: Anna Allan, Jayne Cullen - Final Year Medical Students Search checked by Dr Adrian Boyle - Emergency Department (...) Consultant Institution: University of Cambridge School of Clinical Medicine, Cambridge, UK Date Submitted: 2nd December 2011 Date Completed: 30th August 2013 Last Modified: 30th August 2013 Status: Green (complete) Three Part Question In [children presenting to the ED with seizures] is [intranasal Lorazepam an acceptable intervention] for achieving [termination of seizures]? Clinical Scenario A 4 year old child is brought to the Emergency Department by her parents. She presents with protracted seizures

2013 BestBETS

10. Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms

Randomised controlled trial: Pregabalin similar to lorazepam for alcohol withdrawal symptoms Pregabalin similar to lorazepam for alcohol withdrawal symptoms | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts (...) Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Pregabalin similar to lorazepam for alcohol withdrawal symptoms Article Text Therapeutics Randomised controlled trial Pregabalin similar to lorazepam for alcohol withdrawal symptoms Giovanni Addolorato 1 , Lorenzo Leggio 1 , 2

2010 Evidence-Based Medicine

11. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2008 PedsCCM Evidence-Based Journal Club

12. Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation (Full text)

Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation Cox C E, Reed S D, Govert J A, Rodgers J E, Campbell-Bright S, Kress J P, Carson S S Record Status This is a critical abstract of an economic evaluation that meets (...) in significantly lower overall costs and a greater number of ventilator-free days in comparison with intermittent lorazepam. The methodology and results were clearly reported and appear to have been valid. The authors' conclusions appear to be appropriate. Type of economic evaluation Cost-effectiveness analysis Study objective The objective was to assess the cost-effectiveness of the most commonly prescribed sedatives for mechanically ventilated, critically ill patients. Interventions In the base-case analysis

2008 NHS Economic Evaluation Database. PubMed abstract

13. Review: lorazepam provides the best control for status epilepticus

Review: lorazepam provides the best control for status epilepticus Review: lorazepam provides the best control for status epilepticus | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your (...) user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: lorazepam provides the best control for status epilepticus Article Text Treatment Review: lorazepam provides the best control for status epilepticus Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article

2007 Evidence-Based Nursing

14. Review: lorazepam provides the best control for status epilepticus (Full text)

Review: lorazepam provides the best control for status epilepticus Review: lorazepam provides the best control for status epilepticus | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password (...) * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: lorazepam provides the best control for status epilepticus Article Text Therapeutics Review: lorazepam provides the best control for status epilepticus Free J Craig Henry , MD , Robert Holloway , MD, MPH Statistics from Altmetric.com Prasad K, Al

2007 Evidence-Based Medicine PubMed abstract

15. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (Full text)

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. Lorazepam is currently recommended for sustained sedation of mechanically ventilated intensive care unit (ICU) patients, but this and other benzodiazepine drugs may contribute to acute brain dysfunction, ie, delirium and coma, associated with prolonged hospital stays, costs, and increased mortality. Dexmedetomidine induces sedation via (...) with dexmedetomidine or lorazepam for as many as 120 hours. Study drugs were titrated to achieve the desired level of sedation, measured using the Richmond Agitation-Sedation Scale (RASS). Patients were monitored twice daily for delirium using the Confusion Assessment Method for the ICU (CAM-ICU).Days alive without delirium or coma and percentage of days spent within 1 RASS point of the sedation goal.Sedation with dexmedetomidine resulted in more days alive without delirium or coma (median days, 7.0 vs 3.0; P

2007 JAMA Controlled trial quality: predicted high PubMed abstract

16. Lorazepam or diazepam in paediatric status epilepticus

Lorazepam or diazepam in paediatric status epilepticus BestBets: Lorazepam or diazepam in paediatric status elipticus Lorazepam or diazepam in paediatric status elipticus Report By: Vince Choudhery - Specialist Registrar Search checked by Will Townend - Specialist Registrar Emergency Medicine Institution: North Western Emergency Medicine Specialist Registrar NW Rotation Current web editor: Richard Body - Clinical Research Fellow Date Submitted: 1st March 2000 Date Completed: 24th May 2006 Last (...) Modified: 21st April 2006 Status: Green (complete) Three Part Question In [children in status epilepticus] is [lorazepam better than diazepam] at [safely terminating the seizure]? Clinical Scenario A 2 year old is brought to the emergency department with a first presentation of fitting secondary to febrile illness. She has been fitting for >30 minutes. You obtain intravenous access and wonder if lorazepam or diazepam would be best at terminating the fit safely. Search Strategy Medline 1966-9/99 using

2006 BestBETS

17. Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam (Full text)

Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Intramuscular haloperidol-promethazine sedates violent or agitated patients more quickly than intramuscular lorazepam Article Text Therapeutics

2006 Evidence-Based Mental Health PubMed abstract

18. Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. (Abstract)

Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. In sub-Saharan Africa, rectal diazepam or intramuscular paraldehyde are commonly used as first-line anticonvulsant agents in the emergency treatment of seizures in children. These treatments can be expensive and sometimes toxic. We aimed to assess a drug and delivery system that is potentially more effective, safer, and easier to administer than those (...) presently in use.We did an open randomised trial in a paediatric emergency department of a tertiary hospital in Malawi. 160 children aged over 2 months with seizures persisting for more than 5 min were randomly assigned to receive either intranasal lorazepam (100 microg/kg, n=80) or intramuscular paraldehyde (0.2 mL/kg, n=80). The primary outcome measure was whether the presenting seizure stopped with one dose of assigned anticonvulsant agent within 10 min of administration. The primary analysis

2006 Lancet Controlled trial quality: predicted high

19. Clonazepam and lorazepam in acute mania: a Bayesian meta-analysis. (Abstract)

Clonazepam and lorazepam in acute mania: a Bayesian meta-analysis. Clonazepam and lorazepam are used in the treatment of acute mania but trial results are conflicting.Studies were identified by searching MEDLINE and EMBASE for lorazepam or clonazepam in acute mania between 1966 and 2000. Seven randomized controlled trials were found comparing clonazepam or lorazepam to placebo, haloperidol or lithium in acute mania. Data on 206 patients were analyzed.The heterogeneity of trial designs (...) ): 1.41 (95% PI 0.12 to 2.67). Lorazepam did not yield statistically significant standardized responses for any of the three models: model (a): 0.79 (95% PI -0.29 to 1.89), model (b): 0.77 (95% PI -0.57 to 2.24) and model (c): 0.74 (-0.82 to 2.20). Haloperidol yielded statistically significant standardized responses in the three models but lithium effect was statistically significant only in model (a). Safety data were in line with the usual safety profile of benzodiazepines.Trial designs were

2004 Journal of Affective Disorders

20. A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus

A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus Cock H R, Schapira A H Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions (...) followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Lorazepam was compared with diazepam as first-line treatment for convulsive status epilepticus (CSE). The dose of lorazepam was 4 mg intravenously (i.v.), repeated up to 2 times. The dose of diazepam was 10 mg i.v., repeated up to 3 times. Type of intervention Treatment. Economic study type Cost-effectiveness analysis. Study population The study population comprised patients aged over

2002 NHS Economic Evaluation Database.