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Latest & greatest articles for magnesium
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Magnesium for skeletal muscle cramps. Skeletal muscle cramps are common and often occur in association with pregnancy, advanced age, exercise or motor neuron disorders (such as amyotrophic lateral sclerosis). Typically, such cramps have no obvious underlying pathology, and so are termed idiopathic. Magnesium supplements are marketed for the prophylaxis of cramps but the efficacy of magnesium for this purpose remains unclear. This is an update of a Cochrane Review first published in 2012 (...) , and performed to identify and incorporate more recent studies.To assess the effects of magnesium supplementation compared to no treatment, placebo control or other cramp therapies in people with skeletal muscle cramps. SEARCH METHODS: On 9 September 2019, we searched the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, CINAHL Plus, AMED, and SPORTDiscus. We also searched WHO-ICTRP and ClinicalTrials.gov for registered trials that might be ongoing or unpublished, and ISI Web
Magnesium sulfate as neuroprotection in preterm birth [Type here] Magnesium sulfate as neuroprotection in preterm birth The guideline was approved by DSOG (Danish Society of Obstetrics and Gynecology) in spring, 2020. Members of the working group: Noor Al-Saudi, Lene Drasbek Huusom, Zenia Leegaard Funch Jensen, Rikke Krabek, Ulla Birgitte Christiansen, Cecilie Lapirtis, Mads Langager Larsen, Annette Wind Olesen, Berit Woetmann Pedersen, Dorthe Thisted, Hanne Trap Wolf, Tine Brink Henriksen (...) ~ 10 mL (2,26 mmol calcium) in case of magnesium intoxication. ( ????) This should be managed in close cooperation with the anesthesiologic department. v MgSO4 is not in itself an indication for continuous CTG monitoring. ( ????) Danish guideline Full version 1 Titel Magnesium sulfat som neuroprotektion ved præterme fødsler Forfattere Noor Al-Saudi Yngre Øst Lene Drasbek Huusom Ældre (Tovholder) Øst Zenia Leegaard Funch Jensen Yngre Øst Rikke Krabek Yngre Øst Ulla Birgitte Christiansen Ældre Vest
Serum magnesium and the incidence of coronary artery disease over a median 27 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study and a meta-analysis. Low serum magnesium (Mg) concentrations have been associated with higher coronary artery disease (CAD) risk. A previous Atherosclerosis Risk in Communities (ARIC) Study article that evaluated the Mg-CAD association, based on 319 events occurring over 4-7 y, identified a sex-interaction whereby the inverse Mg-CAD association
Shortened postpartum magnesium sulfate treatment vs traditional 24h for severe preeclampsia: a systematic review and meta-analysis of randomized trials. Objectives: This meta-analysis aimed to compare the benefits and risks of shortened magnesium sulfate with traditional 24 h for severe postpartum preeclampsia.Methods: We systematically searched the Cochrane, Embase, Web of science and Pubmed database from inception till May 15 2019. Studies included type is limited to randomized controlled (...) trial (RCT). Pooled risks difference (RDs), odds risks (ORs), mean difference (MD), standard mean difference (SMD) and 95% confifidence intervals (CIs) were used to summarize the effect sizes.Results: Totally studies included are 7 randomized controlled trials (RCTs). Shortened magnesium sulfate treatment has the same risk as eclampsia (RD 0.00, 95%CI-0.01-0.01) and total complications (OR 0.78, 95% CI 0.53-1.15), however, significant difference was observed in both groups pertaining to flushing
Correction: Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis. 32300004 2020 04 22 2044-6055 10 4 2020 Apr 16 BMJ open BMJ Open Correction: Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis. e032240corr1 10.1136/bmjopen-2019-032240corr1 eng Journal Article Published Erratum 2020 04 16 England BMJ Open 101552874 2044-6055 IM BMJ Open. 2020 Mar 19;10(3):e032240
Comparative evaluation of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia: a meta-analysis of randomized controlled trials. The comparative efficacy of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia remains controversial.We searched Mediline (OvidSP), EMBASE (OvidSP) and Cochrane Central Register of Controlled Trials (CENTRAL) to identify trials that compared epidural (...) bupivacaine and magnesium sulfate combination (intervention) with bupivacaine alone (control). Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework was used to assess the quality of evidence.Eleven studies fulfilled our inclusion criteria after screening. We found that epidural bupivacaine combined with magnesium sulfate could prolong the time for first rescue analgesics (SMD 4.96; 95% CI [2.75, 7.17], P < 0.00001, I2 = 98%), reduce the number of patients who need rescue
Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis. Prevention of type 2 diabetes (T2D) with diet or diet supplementation is challenging. This article aims to draw conclusive associations between magnesium intake and T2D incidence and evaluate the effect of magnesium supplementation on glucose metabolism. Databases were searched for related articles from inception to May 15, 2019. Prospective (...) cohort studies investigating the relevant relationship as well as randomized controlled trials (RCTs) assessing the effect of magnesium supplementation were eligible. We conducted trial sequential analysis (TSA) to prove the sufficiency of the current evidence. Twenty-six publications involving 35 cohorts were included in the analysis. Compared to the lowest magnesium intake, the highest level was associated with a 22% lower risk for T2D; the risk was reduced by 6% for each 100 mg increment in daily
Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials. Effectiveness of controlled hypotension has been proven in alleviating intraoperative bleeding. Many recent studies emphasized the efficacy of dexmedetomidine and magnesium in providing controlled hypotension during various surgeries. The present meta-analysis of randomized controlled trials (RCTs) was performed (...) to evaluate comprehensively the effects and safety of these two medications.Literature search was performed in four databases from inception to April 2019. All RCTs that used dexmedetomidine and magnesium as hypotensive agents were enrolled. The outcomes contained bleeding condition of surgical site, hemodynamic parameters, duration of surgeries, number of patients requiring opioid/analgesia administration, recovery period, and adverse events emerged during surgeries.Ten studies with 663 patients met
The Association Between Serum Magnesium and Premenstrual Syndrome: a Systematic Review and Meta-Analysis of Observational Studies. A number of studies have assessed the association between serum magnesium (Mg) and premenstrual syndrome (PMS) in different population, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between Mg and PMS. PubMed, Cochrane's library, ScienceDirect, Scopus, Google Scholar (...) , and ISI web of science databases were searched for all available literature until January 2019 for studies evaluating the association between Mg and PMS. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of observational studies. A total of 13 studies out of 196 met our inclusion criteria and were included in our systematic review and meta-analysis. There were no associations between serum magnesium and PMS (WMD - 0.04; 95% CI, - 0.14 to 0.06; P = 0.46) during follicular
Magnesium sulphate for foetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis. Ordinary meta-analyses indicate that magnesium sulphate (MgSO4 ) treatment to women at imminent risk for preterm delivery decreases the offspring's risk of cerebral palsy (CP). However, repetitive testing of cumulative data calls for statistical caution, e.g., by trial sequential analysis (TSA), for which there were previously insufficient
Association of magnesium intake with type 2 diabetes and total stroke: an updated systematic review and meta-analysis. The detailed associations between type 2 diabetes (T2D) and total stroke and magnesium intake as well as the dose-response trend should be updated in a timely manner.Systematic review and meta-analyses.PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov were rigorously searched from inception to 15 March 2019.Prospective cohort studies investigating (...) %) and 12% for ischaemic stroke (RR 0.88 (95% CI 0.81 to 0.95); p=0.001; AR reduction 0.246%) when comparing the highest magnesium intake to the lowest. The inverse association still existed when studies on T2D were adjusted for cereal fibre (RR 0.79; p<0.001) and those on total stroke were adjusted for calcium (RR 0.89; p=0.040). Subgroup analyses suggested that the risk for total and ischaemic stroke was significantly decreased in females, participants with ≥25 mg/m2 body mass index and those with ≥12
Association between reduced serum levels of magnesium and the presence of poor glycemic control and complications in type 1 diabetes mellitus: A systematic review and meta-analysis. To evaluate the association between reduced serum magnesium levels and poor glycemic control and/or complications in patients with type 1 diabetes mellitus through a systematic review and meta-analysis.The articles were selected using the Medline/PubMed, Web of Science, Scopus and Scielo databases. Eligibility (...) criteria were cross-sectional, cohort or case-control observational studies that assessed the association between reduced magnesium levels and poor glycemic control and/or complications in patients with type 1 diabetes mellitus.Nine articles were included in the systematic review and two in the meta-analysis, all articles being cross-sectional. Among the seven studies that were designed to evaluate glycemic control, five showed an association between reduced levels of magnesium and poor glycemic
Effects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials. The effects of magnesium (Mg) supplementation on vascular function have been evaluated in some randomized controlled trials (RCT) but their results are conflicting.A systematic review and meta-analysis were conducted to summarize the effects of oral Mg supplementation on vascular function in RCT.The databases MEDLINE (PubMed), Embase, Web of Science and Cochrane
Magnesium and health outcomes: an umbrella review of systematic reviews and meta-analyses of observational and intervention studies. To map and grade all health outcomes associated with magnesium (Mg) intake and supplementation using an umbrella review.Umbrella review of systematic reviews with meta-analyses of observational studies and randomized controlled trials (RCTs) using placebo/no intervention as control group. We assessed meta-analyses of observational studies based on random-effect
The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis. Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. In addition (...) to searching through Clinicaltrials.gov/ and references for oral magnesium supplement studies, we performed a database search in Medline, CINAHL, CENTRAL, and Embase. We contacted the authors of the included trials to ask for additional information. We included randomized controlled trials that compared oral magnesium supplements versus placebo, in addition to standard asthma treatment in mild-moderate asthmatic adults and children (older than 6 years). Two reviewers independently performed the study
Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis. Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered (...) and inconclusive.Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL). We included studies that investigated the association between serum magnesium with mortality risk in CKD and ESRD patients. Unadjusted and adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) were pooled.Twenty studies involving 200,934 participants were included, and the results showed that there was a strong association between hypomagnesemia
Intravenous Magnesium Sulfate to Treat Acute Headaches in the Emergency Department: A Systematic Review - A Comment. 32108943 2020 03 02 1526-4610 60 3 2020 Mar Headache Headache Intravenous Magnesium Sulfate to Treat Acute Headaches in the Emergency Department: A Systematic Review - A Comment. 624 10.1111/head.13746 Mauskop Alexander A Department of Neurology, SUNY Downstate Medical Center, New York Headache Center, New York, NY, USA. eng Journal Article United States Headache 2985091R 0017 (...) -8748 IM 2019 11 27 2020 2 29 6 0 2020 2 29 6 0 2020 2 29 6 0 ppublish 32108943 10.1111/head.13746 References Miller AC, Pfeffer KB, Lawson MR, Sewell KA, King AR, Zehtabchi S. Intravenous magnesium sulfate to treat acute headaches in the emergency department: A systematic review. Headache. 2019;59:1674-1686. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulfate relieves migraine attacks in patients with low serum ionized magnesium levels: A pilot study. Clin Sci. 1995;89:633-636