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Latest & greatest articles for multiple sclerosis
The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on multiple sclerosis or other clinical topics then use Trip today.
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Siponimod (Mayzent) - secondary progressive multiplesclerosis (SPMS) 1 Published 12 October 2020 1 SMC2265 siponimod 250 microgram and 2mg film-coated tablets (Mayzent®) Novartis Pharmaceuticals UK Ltd 04 September 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following a full submission siponimod (...) (Mayzent®) is accepted for use within NHSScotland. Indication under review: treatment of adult patients with secondary progressive multiplesclerosis (SPMS) with active disease evidenced by relapses or imaging features of inflammatory activity. In a randomised, double-blind, placebo-controlled phase III study, siponimod was associated with a reduction in disability progression confirmed after 3 months in patients with SPMS. This advice applies only in the context of an approved NHSScotland Patient
Ofatumumab versus Teriflunomide in MultipleSclerosis. Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiplesclerosis are not known.In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiplesclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks (...) neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups.Among patients with multiplesclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II
EAN guideline on palliative care of people with severe, progressive multiplesclerosis EAN guideline on palliative care of people with severe, progressive multiplesclerosis A. Solari a , A. Giordano a,b , J. Sastre-Garriga c ,S.K€ opke d,e , A. C. Rahn e , I. Kleiter f , K. Aleksovska g , M. A. Battaglia h , J. Bay i , M. Copetti j , J. Drulovic k , L. Kooij l , J. Mens l , E. R. Meza Murillo c , I. Milanov m , R. Milo n,o , T. Pekmezovic p , J. Vosburgh q , E. Silber r , S. Veronese s , F (...) . Patti t , R. Voltz u,v , D. Oliver w and on behalf of the guideline task force , * a Unit of Neuroepidemiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; b Department of Psychology, University of Turin, Turin, Italy; c Department of Neurology/Neuroimmunology, MultipleSclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d’Hebron, Universitat Aut onoma de Barcelona, Barcelona, Spain; d Institute of Clinical Nursing Science, University of Cologne, Cologne; e Institute
Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiplesclerosis: the MS-SMART four-arm RCT Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiplesclerosis: the MS-SMART four-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try (...) Stutters 1 , David MacManus 1 , Ferran Prados 1, 4, 5 , Ian Marshall 2 , Bhavana Solanky 1 , Rebecca S Samson 1 , Frederik Barkhof 1, 4, 6 , Sebastien Ourselin 7 , Marie Braisher 1 , Moira Ross 3 , Gina Cranswick 3 , Sue H Pavitt 8 , Sharmilee Gnanapavan 9 , Gavin Giovannoni 9 , Claudia AM Gandini Wheeler-Kingshott 1, 10 , Clive Hawkins 11 , Basil Sharrack 12 , Roger Bastow 13 , Christopher J Weir 3 , Nigel Stallard 14 , Siddharthan Chandran 2 , Jeremy Chataway 1, 15, * 1 Queen Square Multiple
Dietary interventions for multiplesclerosis-related outcomes. Multiplesclerosis (MS) is a common demyelinating disease of the central nervous system. Although the exact pathogenesis remains unknown, the leading theory is that it results from immune system dysregulation. Approved disease-modifying therapy appears to modulate the immune system to improve MS-related outcomes. There is substantial interest in the ability of dietary interventions to influence MS-related outcomes. This is an update (...) of the Cochrane Review 'Dietary interventions for multiplesclerosis' (Farinotti 2003; Farinotti 2007; Farinotti 2012).To assess the effects of dietary interventions (including dietary plans with recommendations for specific whole foods, macronutrients, and natural health products) compared to placebo or another intervention on health outcomes (including MS-related outcomes and serious adverse events) in people with MS.On 30 May 2019, we searched CENTRAL, MEDLINE, Embase, and Web of Science. We also searched
Siponimod (Mayzent) - multiplesclerosis Search Page - Drug and Health Product Register Language selection Search and menus Search Search website Search Topics menu You are here: Summary Basis of Decision - - Health Canada Expand all Summary Basis of Decision (SBD) for Contact: Summary Basis of Decision (SBD) documents provide information related to the original authorization of a product. The for is located below. Recent Activity for SBDs written for approved after September 1, 2012
Ozanimod (Zeposia) - To treat relapsing forms of multiplesclerosis Drug Approval Package: ZEPOSIA U.S. Department of Health and Human Services Search FDA Submit search Drug Approval Package: ZEPOSIA Company: Celgene Corporation Application Number: 209899 Approval Date: 03/20/2020 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA Approval Letter and Labeling (PDF) (PDF) FDA Application Review Files (PDF) (PDF) (PDF) (PDF) (PDF
Immediate and Sustained Effects of Interventions for Changing Physical Activity in People with MultipleSclerosis: Meta-Analysis of Randomized Controlled Trials. To examine the immediate and sustained effects of interventions for changing physical activity behavior in people with multiplesclerosis (MS), and explore factors that might moderate intervention effects on physical activity behavior (e.g., intervention type and duration, type of physical activity measurement, intensity of theory
A Systematic Review of the Incidence, Prevalence, Costs, and Activity/Work Limitations of Amputation, Osteoarthritis, Rheumatoid Arthritis, Back Pain, MultipleSclerosis, Spinal Cord Injury, Stroke, and Traumatic Brain Injury in the United States: A 2019 To present recent evidence on the prevalence, incidence, costs, activity limitations, and work limitations of common conditions requiring rehabilitation.This was a systematic review. Medline (PubMed), SCOPUS, Web of Science, and the grey (...) literature were searched for relevant articles about amputation, osteoarthritis, rheumatoid arthritis, back pain, multiplesclerosis, spinal cord injury, stroke, and traumatic brain injury. Two investigators independently reviewed articles and selected those for inclusion. Quality grading was performed using the Methodological Evaluation of Observational Research Checklist and Newcastle-Ottawa Quality Assessment Form.110 articles were included. The prevalence of back pain in the past 3 months is 33.9
The Involvement of HLA Class II Alleles in MultipleSclerosis: A Systematic Review with Meta-analysis. MultipleSclerosis (MS) displays a heterogeneous clinical onset and progression, which are mostly unpredictable, but demyelination of the central nervous system (CNS) leads to substantial deficits of sensory, motor, autonomic, and neurocognitive functions. Considering all genetic studies on MS, including the advanced genome-wide association studies, the risk linked to HLA alleles remains
Patient needs and preferences in relapsing-remitting multiplesclerosis: A systematic review. Considering the multiple treatments approved for multiplesclerosis (MS) by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), determining a treatment strategy for patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) can be challenging. To date, an overview of the needs and preferences of patients at each treatment decision-making moment is lacking
Cerebrospinal fluid neurofilament light chain in multiplesclerosis and its subtypes: a meta-analysis of case-control studies. Neurofilament is a biomarker of axonal injury proposed as a useful adjunct in the monitoring of patients with multiplesclerosis (MS). We conducted a systematic review and meta-analysis of case-control studies that have measured neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of people with MS (pwMS), in order to determine whether, and to what degree
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide
The roles played by TLR4 in the pathogenesis of multiplesclerosis; A systematic review article. Multiplesclerosis (MS) is a world-wide pro-inflammatory based disease, which is prevalent among young individuals. The etiology of the disease and its related complications are yet to be clarified. It has been hypothesized that environmental factors, including pathogen-associated molecular patterns (PAMPs) and the internal factors such as damage-associated molecular patterns (DAMPs), may
Predictive medicine in multiplesclerosis: A systematic review. One of the main challenges in multiplesclerosis (MS) is to predict disease progression based on patient characteristics and therapeutic strategies. We therefore performed a systematic review to critically appraise the composite tools available for this purpose.We performed electronic database searches in MEDLINE, EMBASE, Web of Science and the Cochrane Library. We included studies in English or French that developed
Central vein sign for multiplesclerosis: A systematic review and meta-analysis. To systematically review the diagnostic value of the central vein sign (CVS) in multiplesclerosis (MS) and to meta-analyse the proportion of positive lesions for CVS needed to distinguish MS from non-MS mimics.A literature review was performed and a proportion meta-analysis was performed to examine the proportion of the CVS in MS lesions. Studies reporting a threshold of the CVS containing lesions with 100