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Latest & greatest articles for nifedipine
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Randomized Controlled Trials of Tianma Gouteng Decoction Combined with Nifedipine in the Treatment of Primary Hypertension: A Systematic Review and Meta-Analysis. Hypertension is a primary risk factor for cardiovascular disease (CVD). Tianma Gouteng decoction (TGD), originating from Zabingzhengzhixinyi, has been used for thousands of years in China to treat hypertension, giddiness, and migraine. This updated meta-analysis aimed at assessing the efficacy and safety of TGD combined (...) with nifedipine in the treatment of primary hypertension.Related research published prior to September 1, 2019, was found in electronic databases without language limitations. Fourteen studies were selected and analyzed for specified criteria, including the quality of the studies. All outcomes were recorded exhaustive. Data management and analysis were performed using RevMan 5.3 software.A total of 1,537 (769 cases in the experimental group and 768 cases in the control group) patients were enrolled. The total
Hypertension in pregnancy: NifedipineNifedipine | Prescribing information | Hypertension in pregnancy | CKS | NICE Search CKS… Menu Nifedipine Hypertension in pregnancy: Nifedipine Last revised in October 2019 Nifedipine Contraindications and cautions Nifedipine is not specifically licensed for the treatment of hypertension in pregnancy. Nifedipine should not be prescribed to people with: Cardiogenic shock. Clinically significant aortic stenosis. Unstable or acute angina. Recent history (...) (within 4 weeks) of myocardial infarction. Nifedipine should be used with caution in people with: Severe hypotension (systolic blood pressure less than 90 mm Hg). Hepatic impairment. Poor cardiac reserve. Diabetes mellitus — may require adjustment of diabetes treatment as nifedipine can affect blood sugar. [ ; ] Adverse effects Adverse effects of nifedipine include: Neurological — headache, migraine, paraesthesia, tremor, asthenia, vertigo, visual disturbance. Cardiac — vasodilation, hypotension
Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. Hypertension is the most common medical disorder in pregnancy, complicating one in ten pregnancies. Treatment of severely increased blood pressure is widely recommended to reduce the risk for maternal complications. Regimens for the acute treatment of severe hypertension typically include intravenous medications. Although (...) effective, these drugs require venous access and careful fetal monitoring and might not be feasible in busy or low-resource environments. We therefore aimed to compare the efficacy and safety of three oral drugs, labetalol, nifedipine retard, and methyldopa for the management of severe hypertension in pregnancy.In this multicentre, parallel-group, open-label, randomised controlled trial, we compared these oral antihypertensives in two public hospitals in Nagpur, India. Pregnant women were eligible
Systematic review and meta-analysis of randomized controlled trials of atosiban versus nifedipine for inhibition of preterm labor. Two tocolytic drugs-atosiban and nifedipine-are currently used for first-line treatment of preterm labor (PTL).To compare the efficacy and safety of atosiban with nifedipine for PTL treatment.In May 2017, we searched PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Clinical Trials with search terms including "nifedipine", "atosiban (...) ", and "preterm labor".Randomized controlled trials of women with PTL.Data were extracted for study design, patient characteristics, risk of bias domains, and study outcomes. A random-effects model was used to generate pooled risk ratios (RRs) and 95% confidence intervals (CIs).We included seven studies that enrolled 992 patients. There was no significant difference between atosiban and nifedipine for pregnancy prolongation of 48 hours or more regarding efficacy (RR 1.06, 95% CI 0.92-1.22; P=0.440
Nifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial To study the tocolytic action of nifedipine combined with sildenafil citrate (SC) and if the combination is superior to nifedipine alone in inhibiting threatened preterm labour (PTL).Prospective randomised study.An Egyptian university hospital.Women with threatened PTL who received either nifedipine with SC or nifedipine alone.Patients were randomly allocated to receive either (1 (...) ) nifedipine 20 mg orally (stat dose), followed by 10 mg orally every 6-8 hours at the same time as vaginal administration of SC (25 mg at 8-hourly intervals) or (2) nifedipine alone. Medications were continued for 48-72 hours.The percentage of women who remained undelivered during hospitalisation.From January 2015 to November 2016, 239 women were randomised. The baseline characteristics of participants were similar. Nifedipine combined with SC was associated with more women remaining undelivered (81.8
Cardiogenic Shock after Nifedipine Administration in a Pregnant Patient: A Case Report and Review of the Literature We present a case of a 21-year-old Caucasian woman at 27 weeks of pregnancy who was admitted to the obstetric department for pre-term labor. She received 10 mg of nifedipine 4 times in 1 h, according to the internal protocol. Shortly after, she brutally deteriorated with pulmonary edema and hypoxemia requiring transfer to the intensive care unit (ICU) for mechanical ventilation (...) . She finally improved and was successfully extubated after undergoing a percutaneous valvuloplasty of the mitral valve. This case illustrates a severe cardiogenic shock after administration of nifedipine for premature labor in a context of unknown rheumatic mitral stenosis. Nifedipine induces a reflex tachycardia that reduces the diastolic period and thereby precipitates pulmonary edema in case of mitral stenosis. This case emphasizes the fact that this drug may be severely harmful and should never
Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis Chagas disease is a neglected tropical disease. About 6 to 8 million people are chronically infected and 10% to 15% develop irreversible gastrointestinal disorders, including megaesophagus. Treatment focuses on improving symptoms, and isosorbide and nifedipine may be used for this purpose.We conducted a systematic review to evaluate the effectiveness of pharmacological treatment for Chagas' megaesophagus (...) . We searched MEDLINE, Embase and LILACS databases up to January 2018. We included both observational studies and RCTs evaluating the effects of isosorbide or nifedipine in adult patients with Chagas' megaesophagus. Two reviewers screened titles and abstracts, selected eligible studies and extracted data. We assessed the risk of bias using NIH 'Quality Assessment Tool for Before-After (Pre-Post) Studies with No Control Group' and RoB 2.0 tool. Overall quality of evidence was assessed using GRADE.We
Nifedipine Top results for nifedipine - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4 (...) ) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for nifedipine The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you
Hydralazine vs nifedipine for acute hypertensive emergency in pregnancy: a randomized controlled trial There is a paucity of good quality evidence regarding the best therapeutic option for acute control of blood pressure during acute hypertensive emergency of pregnancy.We sought to compare the efficacy of intravenously administered hydralazine and oral nifedipine for acute blood pressure control in acute hypertensive emergency of pregnancy.In this double-blind, randomized, controlled trial (...) , pregnant women (≥24 weeks period of gestation) with sustained increase in systolic blood pressure of ≥160 mm Hg or diastolic blood pressure of ≥110 mm Hg were randomized to receive intravenous hydralazine injection in doses of 5, 10, 10, and 10 mg and a placebo tablet or oral nifedipine (10 mg tablet up to 4 doses) and intravenous saline injection every 20 minutes until the target blood pressure of 150 mm Hg systolic and ≤100 mm Hg diastolic was achieved. Crossover treatment was administered
Raynaud's phenomenon: NifedipineNifedipine | Prescribing information | Raynaud's phenomenon | CKS | NICE Search CKS… Menu Nifedipine Raynaud's phenomenon: Nifedipine Last revised in February 2020 Nifedipine Contraindications and cautions Do not prescribe nifedipine for: People with known hypersensitivity to nifedipine or other dihydropyridines (theoretical risk of cross reactivity). People with cardiogenic shock, significant aortic stenosis, or unstable angina, or within 1 month of myocardial (...) infarction. Women who are pregnant or breastfeeding — seek specialist advice. Children below 18 years of age— seek specialist advice. People taking rifampicin — effective plasma levels of nifedipine may not be achieved owing to enzyme induction. People with gastrointestinal conditions such as inflammatory bowel disease or previous obstruction. Prescribe nifedipine with caution in: Hypotension — this will be aggravated, as nifedipine is an antihypertensive drug. Poor cardiac reserve — exacerbation
Chilblains: NifedipineNifedipine | Prescribing information | Chilblains | CKS | NICE Search CKS… Menu Nifedipine Chilblains: Nifedipine Last revised in June 2018 Nifedipine The use of nifedipine in the treatment and prophylaxis of chilblains is off-label and the evidence to support its use is based on limited small studies — for more information see the section. Contraindications and cautions [ ; ] Do not prescribe nifedipine: To people with known hypersensitivity to nifedipine, other (...) dihydropyridines (theoretical risk of cross-reactivity) or any of the excipients. To people with unstable angina, cardiogenic shock, significant aortic stenosis, unstable angina, or within 1 month of myocardial infarction. To women who are pregnant or breastfeeding — seek specialist advice if these women require treatment. To children under the age of 18 years — safety in children has not been established. To people taking rifampicin. Rifampicin induces the cytochrome P450 system —bioavailability of nifedipine
Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial. We aimed to confirm the proposed superiority of oral nifedipine 60 mg per day over placebo for treatment of chronic chilblains in primary care.We performed a randomized, placebo-controlled, double-blind, crossover trial, closely following (...) the design of the older trial. A total of 32 patients with chronic chilblains were randomly assigned to nifedipine (30 mg controlled release twice a day) or placebo. The primary outcome was patient-reported complaints; the secondary outcome was patient-reported disability. Both were assessed from daily ratings on 100-mm visual analogue scales recorded in a diary. We took ambient temperatures into account and checked for a carry-over effect, and monitored for adverse effects.After 6 weeks of treatment
Nifedipine maintenance tocolysis and perinatal outcome: an individual participant data meta-analysis. Preterm birth is the leading cause of neonatal mortality and morbidity in developed countries. Whether continued tocolysis after 48 hours of rescue tocolysis improves neonatal outcome is unproven.To evaluate the effectiveness of maintenance tocolytic therapy with oral nifedipine on the reduction of adverse neonatal outcomes and the prolongation of pregnancy by performing an individual patient (...) data meta-analysis (IPDMA).We searched PubMed, Embase, and Cochrane databases for randomised controlled trials of maintenance tocolysis therapy with nifedipine in preterm labour.We selected trials including pregnant women between 24 and 36(6/7) weeks of gestation (gestational age, GA) with imminent preterm labour who had not delivered after 48 hours of initial tocolysis, and compared maintenance nifedipine tocolysis with placebo/no treatment.The primary outcome was perinatal mortality. Secondary
Progesterone and nifedipine for maintenance tocolysis after arrested preterm labor: A systematic review and meta-analysis of randomized controlled trial. No treatment is recommended for routine maintenance tocolysis after an arrested preterm birth. Our present study aimed to evaluate the effect of progesterone and nifedipine as maintenance tocolysis therapy after an arrested preterm birth.For relevant studies, we systematically searched the literature in databases of PubMed, Embase (...) , and the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library. Only randomized controlled trials were included.Nine trials were included in our review. Nifedipine and progesterone were used for maintenance tocolysis. Compared to placebo treatment or no treatment, maintenance tocolysis with progesterone could significantly prolong the delivery gestational weeks [standard mean difference (SMD) 1.64; 95% confidence interval (CI), 1.21, 2.07; p < 0.00001], reduce the proportion
Comparative efficacy of tamsulosin versus nifedipine for distal ureteral calculi: a meta-analysis. The aim of this study was to systematically compare the therapeutic effect and safety of tamsulosin with nifedipine in medical expulsive therapy for distal ureteral calculi.Databases, including PubMed, EMBASE, the Cochrane Library, and Clinical Trial Register Centers, were comprehensively searched. Relevant randomized controlled trials (RCTs) were selected, and quality assessment was performed (...) according to the Cochrane Handbook. RevMan software was used to analyze the outcome measures, which consisted of expulsion rate, expulsion time, and complications.Twelve RCTs consisting of 4,961 patients were included (tamsulosin group, 2,489 cases; nifedipine group, 2,472 cases). Compared with nifedipine, tamsulosin significantly increased the expulsion rate (risk ratio =1.29, 95% CI [1.25, 1.33], P<0.0001) and reduced the expulsion time (standard mean difference =-0.39, 95% CI [-0.72, -0.05], P=0.02
Comparison of Tamsulosin, Nifedipine, and Placebo for Ureteric Colic. Clinical question Do calcium channel blockers or alpha blockers improve renal stone passage when compared with placebo? Article chosen Pickard R, Starr K, MacLennan G, et al. Medical expulsive therapy in adults with ureteric colic: a multicentre, randomised, placebo-controlled trial. Lancet 2015;386(9991):25-31, doi: 10.1016/S0140-6736(15)60933-3.
Oral nifedipine versus intravenous labetalol for severe hypertension during pregnancy: a systematic review and meta-analysis. Oral nifedipine is recommended along with labetalol and hydralazine for treatment of severe hypertension during pregnancy by most authorities. Although nifedipine is cheap and easily administered, the usage pattern among health care providers suggests a strong preference for labetalol despite lack of evidence for the same.To determine the efficacy and safety of oral (...) nifedipine for treatment of severe hypertension of pregnancy compared with intravenous labetalol.We systematically searched for articles comparing oral nifedipine with intravenous labetalol for the treatment of severe hypertension during pregnancy in any language, over Medline, Cochrane Central Register of Clinical Trials and Google Scholar from inception till February 2014.We included all RCTs that compared intravenous labetalol with oral nifedipine for treatment of severe hypertension during pregnancy
Oral nifedipine versus intravenous labetalol for the treatment of severe hypertension in pregnancy. 25464243 2015 08 28 2015 02 02 1874-1754 178 2015 Jan 15 International journal of cardiology Int. J. Cardiol. Oral nifedipine versus intravenous labetalol for the treatment of severe hypertension in pregnancy. 162-4 10.1016/j.ijcard.2014.10.111 S0167-5273(14)02048-8 Shi Qingquan Q (a)Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu (...) China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address: email@example.com. eng Letter Meta-Analysis 2014 10 22 Netherlands Int J Cardiol 8200291 0167-5273 0 Antihypertensive Agents I9ZF7L6G2L Nifedipine R5H8897N95 Labetalol IM Administration, Oral Antihypertensive Agents administration & dosage Female Humans Hypertension diagnosis drug therapy epidemiology Infusions, Intravenous Labetalol administration & dosage Nifedipine administration
A comparison of nifedipine and tamsulosin as medical expulsive therapy for the management of lower ureteral stones without ESWL. Administration of nifedipine or tamsulosin has been suggested to augment stone expulsion rates. We aimed to compare the stone expulsion rates and adverse effects associated with the use of nifedipine or tamsulosin as medical expulsive therapy (MET) for the management of lower ureteral stones (LUS) without extracorporeal shock wave lithotripsy (ESWL) via a literature (...) review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from the Medline, EMBASE, Cochrane CENTRAL, and Google Scholar databases. Finally, a total of 7 RCTs with 3897 patients were included. Our meta-analysis showed that tamsulosin could significantly increase the stone expulsion rate relative to nifedipine in patients with LUS (random-effects model; risk ratio [RR] = 0.81; 95% confidence interval [CI] = 0.75-0.88; P < 0.00001). The subgroup analysis indicated