Latest & greatest articles for osteoarthritis

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Top results for osteoarthritis

1. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Full Text available with Trip Pro

Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library (...) displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Ann Fam Med Actions . 2020 May;18(3):235-242. doi: 10.1370/afm.2520. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial , , , , , , , Affiliations Expand Affiliations 1 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong reginasit@cuhk.edu.hk. 2 Jockey Club School of Public Health and Primary Care

2020 EvidenceUpdates

2. Exercise-induced osteoarthritis: Running into problems?

Exercise-induced osteoarthritis: Running into problems? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca June 15, 2020 (...) Exercise-induced osteoarthritis: Running into problems? Clinical Question: Does running increase the risk of developing osteoarthritis? Bottom Line: Based on low-quality observational data, running likely does not increase the risk of developing osteoarthritis, except possibly in elite athletes. Additionally, recreational running may be associated with lowering the risk of knee osteoarthritis. Exercise is one of the most effective treatments for reducing osteoarthritic pain. Evidence: • Systematic

2020 Tools for Practice

3. The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial

The effectiveness of Kinesio Taping((R)) for mobility and functioning improvement in knee osteoarthritis: a randomized, double-blind, controlled trial The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 May 6;269215520916859. doi: 10.1177/0269215520916859. Online ahead of print. The Effectiveness of Kinesio Taping ® for Mobility and Functioning Improvement in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial , Affiliations Expand Affiliation 1 Department of Rehabilitation, Medical Academy

2020 EvidenceUpdates

4. Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. (Abstract)

Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial. Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N (...)  = 220) with symptomatic, radiologically confirmed knee osteoarthritis were recruited between April 20, 2015, and January 10, 2017. The last participant visit occurred on August 15, 2017.Participants were randomized to biomechanical footwear involving shoes with individually adjustable external convex pods attached to the outsole (n = 111) or to control footwear (n = 109) that had visible outsole pods that were not adjustable and did not create a convex walking surface.The primary outcome was knee

2020 JAMA

5. Inferior stabilization of cementless compared with cemented dual-mobility cups in elderly osteoarthrosis patients: a randomized controlled radiostereometry study on 60 patients with 2 years` follow-up Full Text available with Trip Pro

Inferior stabilization of cementless compared with cemented dual-mobility cups in elderly osteoarthrosis patients: a randomized controlled radiostereometry study on 60 patients with 2 years` follow-up Inferior Stabilization of Cementless Compared With Cemented Dual-Mobility Cups in Elderly Osteoarthrosis Patients: A Randomized Controlled Radiostereometry Study on 60 Patients With 2 Years' Follow-Up - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Actions Cite Share Permalink Copy Page navigation Acta Orthop Actions . 2020 Feb 6;1-8. doi: 10.1080/17453674.2020.1720978. Online ahead of print. Inferior Stabilization of Cementless Compared With Cemented Dual-Mobility Cups in Elderly Osteoarthrosis Patients: A Randomized Controlled Radiostereometry Study on 60 Patients With 2 Years' Follow-Up , , , Affiliations Expand

2020 EvidenceUpdates

6. Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

weeks (three doses). Co-primary end points were change from baseline to week 24 in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Physical Function, and Patient's Global Assessment of OA (PGA-OA). Joint safety and neurological assessments continued throughout the 48-week study. Results: From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically (...) Full-text links Cite Abstract Objective: Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods: This double-blind, randomised, phase III study enrolled adults in Europe and Japan with moderate-to-severe OA who had not responded to or could not tolerate standard-of-care analgesics. Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8

2020 EvidenceUpdates

7. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis Full Text available with Trip Pro

of knee osteoarthritis: results from the Framingham Osteoarthritis Study. Paper presented at: Seminars in arthritis and rheumatism; 1990. doi:10.1099/00221287-136-2-327 - - Kon E, Filardo G, Drobnic M, et al. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthroscopy. 2012;20(3):436–449. doi:10.1007/s00167-011-1713-8 - - Raeissadat SA, Tabibian E, Rayegani SM, Rahimi-Dehgolan S, Babaei-Ghazani A. An inestigation into the efficacy of intra-articular ozone (O2-O3 (...) MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial) - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show

2020 EvidenceUpdates

8. Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. (Abstract)

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial. A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.To determine the effects of intravenous zoledronic acid on knee cartilage volume loss in patients with symptomatic knee (...) osteoarthritis and bone marrow lesions.A 24-month multicenter, double-blind placebo-controlled randomized clinical trial conducted at 4 sites in Australia (1 research center and 3 hospitals). Adults aged 50 years or older with symptomatic knee osteoarthritis and subchondral bone marrow lesions detected by magnetic resonance imaging (MRI) were enrolled from November 2013 through September 2015. The final date of follow-up was October 9, 2017.Intravenous infusion with either 5 mg of zoledronic acid in a 100-mL

2020 JAMA

9. Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. (Abstract)

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving pain and improving physical function differ between these two therapies is uncertain.We conducted a randomized trial to compare physical therapy with glucocorticoid injection in the primary care (...) setting in the U.S. Military Health System. Patients with osteoarthritis in one or both knees were randomly assigned in a 1:1 ratio to receive a glucocorticoid injection or to undergo physical therapy. The primary outcome was the total score on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 1 year (scores range from 0 to 240, with higher scores indicating worse pain, function, and stiffness). The secondary outcomes were the time needed to complete the Alternate Step Test

2020 NEJM

10. Exercise for osteoarthritis pain: how strong is the evidence?

J, et al. Sports Med. 2019 May; 49(5):743-61. 6. Kolasinski SL, Neogi T, Hochberg MC, et al. Arthritis Rheumatol. 2020 Feb; 72(2):220-33. 7. McAlindon TE, Bannuru RR, Sullivan MC, et al. Osteoarthritis Cartilage. 2014 Mar; 22(3):363-88. 8. Juhl C, Christensen R, Roos EM, et al. Arthritis Rheumatol. 2014; 66(3):626-36. Tools for Practice is a biweekly article summarizing medical evidence with a focus on topical issues and practice modifying information. It is coordinated by G. Michael Allan, MD (...) Exercise for osteoarthritis pain: how strong is the evidence? Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research. www.acfp.ca March

2020 Tools for Practice

11. American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

an evidence- based guideline for the comprehensive management of osteoarthritis (OA) as a collabora- tion between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommenda- tions for the management of hand, hip, and knee OA. Methods. We identified clinically relevant population, intervention, comparator, outcomes questions and critical outcomes in OA. A Literature Review T eam performed a systematic literature review to summarize evidence supporting (...) , technology, and practice. ACR recommendations are not intended to dictate payment or insurance decisions. These recommendations cannot adequately convey all uncertainties and nuances of patient care. The American College of Rheumatology is an independent, professional, medical and scientific society that does not guarantee, warrant, or endorse any commercial product or service.KOLASINSKI ET AL 2 ???| INTRODUCTION Osteoarthritis (OA) is the most common form of arthritis, affecting an estimated 302 million

2020 American College of Rheumatology

12. Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial. (Abstract)

Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial. MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone and cartilage in preclinical osteoarthritis models.To evaluate the efficacy, safety, and tolerability of MIV-711 in participants with symptomatic, radiographic knee osteoarthritis.26-week randomized, double-blind, placebo-controlled phase 2a study with a 26-week open-label safety extension substudy (...) . This treatment may merit further evaluation as a disease-modifying osteoarthritis drug.Medivir.

2020 Annals of Internal Medicine

13. Technology-assisted rehabilitation following total knee or hip replacement for people with osteoarthritis: a systematic review and meta-analysis Full Text available with Trip Pro

PMCID: DOI: Item in Clipboard Technology-assisted Rehabilitation Following Total Knee or Hip Replacement for People With Osteoarthritis: A Systematic Review and Meta-Analysis Xia Wang et al. BMC Musculoskelet Disord . 2019 Show details BMC Musculoskelet Disord Actions , 20 (1), 506 Authors , , , , Affiliations 1 Level 10 Kolling Institute, Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. xia.wang (...) … Show more similar articles References Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1545–1602. doi: 10.1016/S0140-6736(16)31678-6. - - - Australian Orthopaedic Association National Joint Replacement Registry . Analysis of state and territory health data all arthroplasty, annual report

2020 EvidenceUpdates

14. Partial knee replacement could be first choice for some patients with osteoarthritis. (Abstract)

Partial knee replacement could be first choice for some patients with osteoarthritis. The studyBeard D, Davies L, Cook J, et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet 2019;394:746-56.The study was funded by the NIHR Health Technology Assessment Programme (project number 08/14/08).To read the full NIHR Signal, go to https

2019 BMJ

15. Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. (Abstract)

Intraarticular injection of platelet-rich plasma in knee osteoarthritis: single versus triple application approach. Pilot study. To compare the clinical effectiveness of the triple intra-articular injection of platelet-rich plasma (PRP) with respect to the single injection in patients with mild osteoarthritis of the knee.A total of 35 patients with a clinical and radiographic diagnosis of osteoarthritis grade I and II were analyzed. They were randomized into two groups: single application (18 (...) ±7.3; p lt 0.05) at the end of the study. The triple application showed better improvement in the VAS (p= 0.0007) and the total WOMAC (p= 0.0209) scores when comparing the final results between groups.The triple infiltration of PRP in patients with mild knee osteoarthritis is clinically more effective than the single application at 48 weeks of follow-up.

2019 Acta reumatologica portuguesa Controlled trial quality: uncertain

16. Temporomandibular Joints with Larger-Than-Average Horizontal Condylar Angles May Be Indicative of Internal Derangement and Degenerative Joint Disease

Temporomandibular Joints with Larger-Than-Average Horizontal Condylar Angles May Be Indicative of Internal Derangement and Degenerative Joint Disease UTCAT3418, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Temporomandibular Joints with Larger-Than-Average Horizontal Condylar Angles May Be Indicative of Internal Derangement and Degenerative Joint Disease Clinical Question Are temporomandibular joints with a greater (...) -than-average horizontal condylar angle, as measured by cone-beam computed tomography, at greater risk for joint disease in the long term? Clinical Bottom Line A greater-than-average horizontal condylar angle (HCA) is associated with degenerative joint changes. This is supported by a retrospective study of patients with unilateral osteoarthritic joint changes. Two small studies show that a 3D reconstructed model based on CBCT is a more accurate method of measuring the HCA than 2D CBCT images. Best

2019 UTHSCSA Dental School CAT Library

17. Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial. (Abstract)

Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial. Hand osteoarthritis is a prevalent joint condition that has a high burden of disease and an unmet medical need for effective therapeutic options. Since local inflammation is recognised as contributing to osteoarthritic complaints, the Hand Osteoarthritis Prednisolone Efficacy (HOPE) study aimed to investigate the efficacy and safety of short (...) discontinued the study because of an adverse event: one (2%) patient receiving prednisolone (for a myocardial infarction) and three (7%) patients receiving placebo (for surgery of the bowel and for an infected leg haematoma and for Lyme disease arthritis of the knee).Treatment with 10 mg prednisolone for 6 weeks is efficacious and safe for the treatment of patients with painful hand osteoarthritis and signs of inflammation. The results of our study provide clinicians with a new short-term treatment option

2019 Lancet

18. Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial. (Abstract)

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial. Sprifermin is under investigation as a disease-modifying osteoarthritis drug.To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients with osteoarthritis.FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) was a 5-year (...) Osteoarthritis Index (WOMAC) scores. The minimal clinically important difference (MCID) is unknown for the primary outcome; for total WOMAC score in patients with hip and knee osteoarthritis, the absolute MCID is 7 U (95% CI, 4 to 10 U) and the percentage MCID is 14% (95% CI, 9% to 18%).Among 549 participants (median age, 65.0 years; 379 female [69.0%]), 474 (86.3%) completed 2-year follow-up. Compared with placebo, the changes from baseline to 2 years in total femorotibial joint cartilage thickness were

2019 JAMA

19. Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip or Ankle: A Review of Clinical Effectiveness

Project Number: RC1154-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of intra-articular hyaluronic acid for patients with osteoarthritis of the hip or ankle joint? Key Message One systematic review (SR) on the effectiveness of hyaluronic acid for pain and discomfort associated with hip osteoarthritis and one SR for pain associated with ankle osteoarthritis were included. With respect (...) Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip or Ankle: A Review of Clinical Effectiveness Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip or Ankle: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip or Ankle: A Review of Clinical Effectiveness Intra-Articular Hyaluronic Acid for Osteoarthritis of the Hip or Ankle: A Review of Clinical Effectiveness Last updated: July 11, 2019

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

20. Intra-Articular Hyaluronic Acid for Viscosupplementation in Osteoarthritis of the Hand, Shoulder, and Temporomandibular Joint: A Review of Clinical Effectiveness and Safety

Intra-Articular Hyaluronic Acid for Viscosupplementation in Osteoarthritis of the Hand, Shoulder, and Temporomandibular Joint: A Review of Clinical Effectiveness and Safety Intra-Articular Hyaluronic Acid for Viscosupplementation in Osteoarthritis of the Hand, Shoulder, and Temporomandibular Joint: A Review of Clinical Effectiveness and Safety | CADTH.ca Find the information you need Intra-Articular Hyaluronic Acid for Viscosupplementation in Osteoarthritis of the Hand, Shoulder (...) , and Temporomandibular Joint: A Review of Clinical Effectiveness and Safety Intra-Articular Hyaluronic Acid for Viscosupplementation in Osteoarthritis of the Hand, Shoulder, and Temporomandibular Joint: A Review of Clinical Effectiveness and Safety Last updated: July 25, 2019 Project Number: RC1155-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness and safety of intra-articular hyaluronic acid for patients

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review