Latest & greatest articles for prostate cancer

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Top results for prostate cancer

1. Darolutamide (Nubeqa) - non-metastatic castration resistant prostate cancer (nmCRPC)

submission darolutamide (Nubeqa®) is accepted for use within NHSScotland. Indication under review: Darolutamide is indicated for the treatment of adult men with non-metastatic castration resistant prostate cancer (nmCRPC) who are at high risk of developing metastatic disease. In a phase III study in men with high risk nmCRPC, treatment with darolutamide was superior to placebo for metastasis-free survival. High risk was defined as prostate specific antigen (PSA) doubling time =10 months and PSA =2 (...) castration resistant prostate cancer (nmCRPC) who are at high risk of developing metastatic disease. 1 Dosing Information The recommended dose of darolutamide is 600mg (two whole tablets of 300mg) taken orally, with food, twice daily, equivalent to a total daily dose of 1200mg. Medical castration with a luteinising hormone-releasing hormone (LHRH) analogue should be continued during treatment of patients not surgically castrated. If a dose is missed, the dose should be taken as soon as the patient

2020 Scottish Medicines Consortium

2. Olaparib (Lynparza) for metastatic castration-resistant prostate cancer (mCRPC)

Olaparib (Lynparza) for metastatic castration-resistant prostate cancer (mCRPC) Olaparib (Lynparza®) for metastatic castration-resistant prostate cancer (mCRPC) - Repository of AIHTA GmbH English | Browse - - - Olaparib (Lynparza®) for metastatic castration-resistant prostate cancer (mCRPC) Grössmann, N. (2020): Olaparib (Lynparza®) for metastatic castration-resistant prostate cancer (mCRPC). Oncology Fact Sheet Nr. 23. Preview - Sie müssen einen PDF-Viewer auf Ihrem PC installiert haben wie z

2020 Austrian Institute of Health Technology Assessment

3. Apalutamide (prostate cancer) - Addendum to Commission A20-20

a CHAARTED RCT, open- label, parallel- group Adult patients with pathologically or clinically confirmed metastatic prostate cancer and ECOG-PS = 2 b Docetaxel + ADT (N = 397) ADT (N = 393) Screening: ND Treatment: until disease progression, withdrawal of informed consent, unacceptable toxicity, or ? For docetaxel: maximum of six 21-day cycles or ? For ADT: until the development of resistance c Follow-up observation: maximum of 10 days after randomization 343 centres in the USA 07/2006–ND Data cut-off (...) Apalutamide (prostate cancer) - Addendum to Commission A20-20 1 Translation of addendum A20-62 Apalutamid (Prostatakarzinom) – Addendum zum Auftrag A20-20 (Version 1.0; Status: 6 August 2020). Please note: Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 6 August 2020 1.0 Commission: A20-62 Version: Status: IQWiG

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

4. Apalutamide (prostate cancer) - Benefit assessment according to §35a Social Code Book V

advice Due to the corona pandemic, no external experts were involved. IQWiG employees involved in the dossier assessment ? Annette Christoph ? Christiane Balg ? Sabine Ostlender ? Min Ripoll ? Ulrike Seay ? Dorothea Sow ? Sibylle Sturtz ? Volker Vervölgyi Keywords: Apalutamide, Prostatic Neoplasms – Castration-Resistant, Benefit Assessment, NCT01946204 Extract of dossier assessment A20-36 Version 1.0 Apalutamide (prostate cancer) 29 June 2020 Institute for Quality and Efficiency in Health Care (IQWiG (...) in favour of apalutamide + ADT in comparison with placebo + ADT. This results in a hint of lesser harm of apalutamide + ADT in comparison with watchful waiting + ADT. Overall, however, it is questionable whether the effect is actually to be attributed to the outcome category of AEs or whether it rather reflects the disease symptoms. The events occurring under the SOC comprised typical locoregional symptoms of prostate cancer, e.g. urinary retention and hydronephrosis. Probability and extent of added

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

5. Enzalutamide (prostate cancer) - Benefit assessment according to §35a Social Code Book V (expiry of the decision)

and scientific advice No advisor on medical and scientific questions was available for the present dossier assessment. IQWiG employees involved in the dossier assessment ? Selver Altin ? Christiane Balg ? Klaus Gossens ? Tatjana Hermanns ? Katharina Hirsch ? Florina Kerekes ? Min Ripoll ? Volker Vervölgyi Keywords: Enzalutamide, Prostatic Neoplasms – Castration-Resistant, Benefit Assessment, NCT02003924 Extract of dossier assessment A20-46 Version 1.0 Enzalutamide (prostate cancer) 12 August 2020 Institute (...) enzalutamide treatment. Treatment with enzalutamide + ADT was continued until radiographic disease progression or, if the investigator deemed it to be of clinical benefit, beyond said progression. Patients of either study arm who had failed to qualify or elected not to participate in the open- label enzalutamide extension phase discontinued treatment with the study drug and proceeded to follow-up observation. Extract of dossier assessment A20-46 Version 1.0 Enzalutamide (prostate cancer) 12 August 2020

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

6. Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study. Full Text available with Trip Pro

Prostate Cancer Care and Outcomes Study (PCOS).General health and disease specific quality of life were self-reported at seven time points over a 15 year period, using the 12-item Short Form Health Survey scale, University of California, Los Angeles prostate cancer index, and expanded prostate cancer index composite short form (EPIC-26). Adjusted mean differences were calculated with controls as the comparison group. Clinical significance of adjusted mean differences was assessed by the minimally (...) Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study. To assess treatment related changes in quality of life up to 15 years after diagnosis of localised prostate cancer.Population based, prospective cohort study with follow-up over 15 years.New South Wales, Australia.1642 men with localised prostate cancer, aged less than 70, and 786 controls randomly recruited from the New South Wales electoral roll into the New South Wales

2020 BMJ

7. Therapies for Clinically Localized Prostate Cancer

differences may be limited to men age 65 and older or those with intermediate-risk disease. Active monitoring using PSA-based monitoring probably results in little to no difference in all-cause or prostate cancer mortality compared with RP or EBR plus AD over 10 years. Metastases were infrequent, but AM probably results in a small increase compared with RP and EBR+AD. Effects may not vary by patient or tumor risk factors. Harms were lowest with AM compared with RP or EBR plus AD or AS versus photodynamic (...) cancer (CLPC) detected clinically rather than by prostate-specific antigen (PSA) screening, radical prostatectomy (RP) may reduce mortality and metastases more than watchful waiting (WW) but causes more harms. Mortality reductions may be limited to men age 65 and older and those with intermediate-risk disease. • Active monitoring (AM) probably results in little to no mortality difference versus RP or external beam radiation (EBR)+androgen deprivation (AD) in PSA-detected CLPC and may result in fewer

2020 Effective Health Care Program (AHRQ)

8. Abiraterone for treating metastatic prostate cancer

diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC) in adult men in combination with androgen deprivation therapy (ADT); metastatic castration-resistant prostate cancer (mCRPC) in adult men who are asymptomatic or mildly symptomatic after failure of ADT in whom chemotherapy is not yet clinically indicated; and metastatic castration-resistant prostate cancer (mCRPC) in adult men whose disease has progressed on or after a docetaxel-based chemotherapy regimen. Subsidy status Generic (...) Abiraterone for treating metastatic prostate cancer '); } else { document.write(' '); } ACE | Abiraterone for treating metastatic prostate cancer Search > > Abiraterone for treating metastatic prostate cancer - Abiraterone for treating metastatic prostate cancer Published on 1 October 2020 Guidance Recommendations The Ministry of Health’s Drug Advisory Committee has recommended: Generic abiraterone acetate 250 mg tablet (Abiranat) in line with its registered indications for treating: newly

2020 Appropriate Care Guides, Agency for Care Effectiveness (Singapore)

9. Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data. (Abstract)

Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data. It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a systematic review of randomised controlled trials (RCTs) comparing these radiotherapy (...) approaches.We used a prospective framework for adaptive meta-analysis (FAME), starting the review process while eligible trials were ongoing. RCTs were eligible if they aimed to compare immediate adjuvant radiotherapy versus early salvage radiotherapy, following radical prostatectomy in men (age ≥18 years) with intermediate-risk or high-risk, localised or locally advanced prostate cancer. We searched trial registers and conference proceedings until July 8, 2020, to identify eligible RCTs. By establishing

2020 Lancet

10. Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer. (Abstract)

) in cohort A, 0.83 (95% CI, 0.11 to 5.98) in cohort B, and 0.55 (95% CI, 0.29 to 1.06) in the overall population.Among men with metastatic castration-resistant prostate cancer who had tumors with at least one alteration in BRCA1, BRCA2, or ATM and whose disease had progressed during previous treatment with a next-generation hormonal agent, those who were initially assigned to receive olaparib had a significantly longer duration of overall survival than those who were assigned to receive enzalutamide (...) Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer. We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician's choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying alterations in homologous recombination repair genes and whose disease had progressed during previous treatment with a next-generation hormonal agent. The results of the final

2020 NEJM

11. Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide. (Abstract)

Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide. Darolutamide is a structurally distinct androgen-receptor inhibitor that is approved for the treatment of nonmetastatic, castration-resistant prostate cancer. In the planned primary analysis of a phase 3 trial, the median metastasis-free survival was significantly longer with darolutamide (40.4 months) than with placebo (18.4 months). The data for the analysis of overall survival were immature at the time (...) . The incidence of adverse events after the start of treatment was similar in the two groups; no new safety signals were observed.Among men with nonmetastatic, castration-resistant prostate cancer, the percentage of patients who were alive at 3 years was significantly higher among those who received darolutamide than among those who received placebo. The incidence of adverse events was similar in the two groups. (Funded by Bayer HealthCare and Orion Pharma; ARAMIS ClinicalTrials.gov number, NCT02200614

2020 NEJM

12. Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer

Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced (...) ):3042-3050. doi: 10.1200/JCO.20.00315. Epub 2020 Jul 24. Cancer and Leukemia Group B 90203 (Alliance): Radical Prostatectomy With or Without Neoadjuvant Chemohormonal Therapy in Localized, High-Risk Prostate Cancer , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 Memorial Sloan Kettering Cancer Center, New York, NY. 2 Department of Biostatistics and Bioinformatics, Duke University, Durham, NC. 3 The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital

2020 EvidenceUpdates

13. Prostate Cancer Part 1: Diagnosis and Referral in Primary Care

Cancer Tips, Advice, and Support – Prostate Centre Canada – Canadian Cancer Society – Diagnostic Code: 185 (malignant neoplasm of prostate) Abbreviations CCO - Cancer Care Ontario DRE - digital rectal exam ERSPC - European Randomized Study of Screening for Prostate Cancer LUTS - lower urinary tract symptoms PSA - prostate specific antigen This guideline is based on scientific evidence current as of November 2017 (refer to Methodology ). The guideline was developed by the BC Cancer Primary Care (...) the age of 60 when they are diagnosed and most men will survive their prostate cancer. It is estimated that 1 in 29 men who are diagnosed with prostate cancer would be expected to die of the disease. The following risk factors are associated with an increased risk of prostate cancer and should be considered when assessing men who present with symptoms or with questions about testing: Men of African descent. Family history of prostate cancer (paternal side; first-degree relatives (i.e., father

2020 Clinical Practice Guidelines and Protocols in British Columbia

14. Prostate Cancer Part 2: Follow-up in Primary Care

Treatment, Cancer Care Ontario, A Palliative Care Approach for Primary Care, HealthLinkBC – Advance Care Planning, Provincial Health Services Authority Trans Care BC – A Primary Care Toolkit – Gender-affirming Care for Trans, Two-spirit, and Gender Diverse Patients in BC, ​ ​ Diagnostic Code: 185 (malignant neoplasm of prostate) Abbreviations ACP - advance care plan ADT - androgen deprivation therapy AGREE - appraisal of guidelines for research and evaluation CBC - complete blood count CCO - Cancer Care (...) diagnosis onwards (see ). Follow-up Prostate Cancer Care Primary care practitioners provide an essential role for the continuity of patient care in all settings, both directly and through the coordination of care with other health care professionals. This reduces the fragmentation of care, improves patient safety, and enhances the overall quality of patient care. PSA Testing for Surveillance of Recurrent Disease In the absence of specific evidence to guide prostate-specific antigen (PSA) testing

2020 Clinical Practice Guidelines and Protocols in British Columbia

15. Retzius-sparing versus standard robotic-assisted laparoscopic prostatectomy for the treatment of clinically localized prostate cancer. (Abstract)

Retzius-sparing versus standard robotic-assisted laparoscopic prostatectomy for the treatment of clinically localized prostate cancer. Robotic-assisted laparoscopic prostatectomy (RALP) is widely used to surgically treat clinically localized prostate cancer. It is typically performed using an approach (standard RALP) that mimics open retropubic prostatectomy by dissecting the so-called space of Retzius anterior to the bladder. An alternative, Retzius-sparing (or posterior approach) RALP (RS (...) , of whom 502 completed the trials. Mean age of participants was 64.6 years and mean prostate-specific antigen was 6.9 ng/mL. About 54.2% of participants had cT1c disease, 38.6% had cT2a-b disease, and 7.1 % had cT2c disease. Primary outcomes RS-RALP probably improves continence within one week after catheter removal (risk ratio (RR) 1.74, 95% confidence interval (CI) 1.41 to 2.14; I2 = 0%; studies = 4; participants = 410; moderate-certainty evidence). Assuming 335 per 1000 men undergoing standard RALP

2020 Cochrane

16. Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT Full Text available with Trip Pro

Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from (...) the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} At 10-year median follow-up, there was no difference in disease-specific mortality between active monitoring, radical prostatectomy and radical radiotherapy treatments, which caused different side-effect profiles. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , & . Freddie C Hamdy 1

2020 NIHR HTA programme

17. Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline

Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline - American Urological Association advertisement Toggle navigation About Us AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular Tumors Penis Retroperitoneum Cytology Online Learning For Medical Students Exams/LLL (...) independently of androgen signaling resulting in CRPC. With a greater understanding of tumor biology, there is hope for continued development of innovative treatment options that further improve survival for men with CRPC. Non-metastatic castration-resistant prostate cancer Men with a rising PSA but no visible metastatic disease on conventional imaging despite medical or surgical castration represent a uniquely distinct disease state. The advent of improved imaging including next generation positron

2020 American Urological Association

18. Prostate cancer: NCCP advice for Medical Professionals on the management of patients undergoing Prostate Cancer Radiotherapy in response to the current novel coronavirus (COVID-19) outbreak

Prostate cancer: NCCP advice for Medical Professionals on the management of patients undergoing Prostate Cancer Radiotherapy in response to the current novel coronavirus (COVID-19) outbreak Version: 2 Department: NCCP Radiation Oncology Working Group Update date: 30/06/2020 Code: RO_COVID19_7 Page 1 of 3 NCCP advice for medical professionals on the management of patients undergoing Prostate Cancer Radiotherapy in response to the current novel coronavirus (COVID-19) pandemic This document (...) ) - https://www.gov.ie/en/campaigns/c36c85-covid-19- coronavirus/ ? Ireland’s National Action Plan in response to COVID-19 (Coronavirus) - https://www.gov.ie/en/campaigns/c36c85-covid-19-coronavirus/ 2 Purpose The purpose of this guidance document is to provide guidance to medical professionals on the management of patients undergoing Prostate Cancer Radiotherapy during the COVID-19 pandemic. In general prostate cancers are either low risk and delaying treatment does not impact outcomes or patients

2020 Health Service Executive (Ireland) - Clinical Guidelines

19. NCCP guidance for Medical Professionals on the management of patients with Prostate Cancer in response to the current novel coronavirus (COVID-19) outbreak

NCCP guidance for Medical Professionals on the management of patients with Prostate Cancer in response to the current novel coronavirus (COVID-19) outbreak Version: 4 Department: Prostate Guideline Development Group/Leads Group Update date: 11/06/2020 Revision date: Page 1 of 4 NCCP guidance for Medical Professionals on the management of patients with Prostate Cancer in response to the current novel coronavirus (COVID-19) pandemic This document relates to patients who do not have COVID-19 (...) - coronavirus/ ? Ireland’s National Action Plan in response to COVID-19 (Coronavirus) - https://www.gov.ie/en/campaigns/c36c85-covid-19-coronavirus/ Version: 4 Department: Prostate Guideline Development Group/Leads Group Update date: 11/06/2020 Revision date: Page 2 of 4 2 Purpose The purpose of this guidance document is to provide guidance to medical professionals on the management of patients referred to urology clinics, patients awaiting biopsy tests and patients diagnosed with prostate cancer during

2020 Health Service Executive (Ireland) - Clinical Guidelines

20. Metastatic castration-naive and castration-sensitive prostate cancer: CUA/CUOG

Metastatic castration-naive and castration-sensitive prostate cancer: CUA/CUOG Metastatic castration-naive and castration-sensitive prostate cancer: CUA/CUOG To view this page ensure that Adobe Flash Player version 10.0.0 or greater is installed. Besides, it's possible to , or you can view flippdf Either scripts and active content are not permitted to run or Adobe Flash Player version 10.0.0 or greater is not installed. Besides, it's possible to , or you can view flippdf

2020 Canadian Urological Association