Latest & greatest articles for type 1 diabetes

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Top results for type 1 diabetes

1. Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes. Full Text available with Trip Pro

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes. The cardiovascular effects of ertugliflozin, an inhibitor of sodium-glucose cotransporter 2, have not been established.In a multicenter, double-blind trial, we randomly assigned patients with type 2 diabetes and atherosclerotic cardiovascular disease to receive 5 mg or 15 mg of ertugliflozin or placebo once daily. With the data from the two ertugliflozin dose groups pooled for analysis, the primary objective was to show (...) -mg dose of ertugliflozin and in 57 patients (2.1%) who received the 15-mg dose, as compared with 45 patients (1.6%) who received placebo.Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, ertugliflozin was noninferior to placebo with respect to major adverse cardiovascular events. (Funded by Merck Sharp & Dohme and Pfizer; VERTIS CV ClinicalTrials.gov number, NCT01986881.).Copyright © 2020 Massachusetts Medical Society.

2020 NEJM

2. t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes

t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes t:slim X2 insulin pump for managing blood glucose levels in type 1 diabetes Medtech innovation briefing Published: 22 September 2020 www.nice.org.uk/guidance/mib227 pathways Summary Summary • The technology technology described in this briefing is the t:slim X2 insulin pump. It is used for managing blood glucose levels in type 1 diabetes. • The innovative aspects innovative aspects are using advanced algorithms (...) with a continuous glucose monitor to predict low glucose and suspend insulin delivery. The technology software, Control-IQ, can also adjust basal insulin and give correction doses. • The intended place in therapy place in therapy would be as an alternative to other sensor-augmented insulin pumps for people with type 1 diabetes. • The main points from the evidence main points from the evidence summarised in this briefing are from 6 studies (including 4 randomised controlled trials, 1 randomised crossover study

2020 National Institute for Health and Clinical Excellence - Advice

3. Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials

Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search (...) Lancet Diabetes Endocrinol Actions . 2020 Sep 21;S2213-8587(20)30313-2. doi: 10.1016/S2213-8587(20)30313-2. Online ahead of print. Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials , , , , , , , , Affiliations Expand Affiliations 1 KfH Kidney Center, Munich, Germany; Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany. Electronic address: johannes.mann

2020 EvidenceUpdates

4. Effect of 6 Months of Flash Glucose Monitoring in Youth With Type 1 Diabetes and High-Risk Control: A Randomized Controlled Trial

Effect of 6 Months of Flash Glucose Monitoring in Youth With Type 1 Diabetes and High-Risk Control: A Randomized Controlled Trial Effect of 6 Months of Flash Glucose Monitoring in Youth With Type 1 Diabetes and High-Risk Glycemic Control: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 (...) . Effect of 6 Months of Flash Glucose Monitoring in Youth With Type 1 Diabetes and High-Risk Glycemic Control: A Randomized Controlled Trial , , , , , , , , , , Affiliations Expand Affiliations 1 Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. 2 Centre for Biostatistics, Division of Health Sciences, University of Otago, Dunedin, New Zealand. 3 Department of Paediatrics and Child Health, University of Otago, Wellington, Wellington, New

2020 EvidenceUpdates

5. Benefit/risk profile of dapagliflozin 5 mg in the DEPICT-1 and -2 trials in individuals with type 1 diabetes and body mass index >/=27 kg/m(2) Full Text available with Trip Pro

Benefit/risk profile of dapagliflozin 5 mg in the DEPICT-1 and -2 trials in individuals with type 1 diabetes and body mass index >/=27 kg/m(2) Benefit/risk profile of dapagliflozin 5 mg in the DEPICT-1 and -2 trials in individuals with type 1 diabetes and body mass index ≥27 kg/m 2 - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable (...) ahead of print. Benefit/risk profile of dapagliflozin 5 mg in the DEPICT-1 and -2 trials in individuals with type 1 diabetes and body mass index ≥27 kg/m 2 , , , , , , , , , Affiliations Expand Affiliations 1 Clinical and Experimental Endocrinology, UZ Gasthuisberg, University of Leuven, Leuven, Belgium. 2 State University of New York at Buffalo, Williamsville, New York, USA. 3 Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich, University of Tübingen, Tübingen

2020 EvidenceUpdates

6. Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment. (Abstract)

Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment. It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes.We conducted a 26-week, randomized, double-blind, double-dummy, phase 2 trial to investigate the efficacy and safety (...) of once-weekly insulin icodec as compared with once-daily insulin glargine U100 in patients who had not previously received long-term insulin treatment and whose type 2 diabetes was inadequately controlled (glycated hemoglobin level, 7.0 to 9.5%) while taking metformin with or without a dipeptidyl peptidase 4 inhibitor. The primary end point was the change in glycated hemoglobin level from baseline to week 26. Safety end points, including episodes of hypoglycemia and insulin-related adverse events

2020 NEJM

7. Semaglutide (Rybelsus) - For the treatment of adults with insufficiently controlled type 2 diabetes (T2D) to improve glycaemic control as an adjunct to diet and exercise

Semaglutide (Rybelsus) - For the treatment of adults with insufficiently controlled type 2 diabetes (T2D) to improve glycaemic control as an adjunct to diet and exercise 1 Published 7 September 2020 Product update SMC2287 semaglutide 3mg, 7mg and 14mg tablets (Rybelsus®) Novo Nordisk 7 August 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and, following review by the SMC executive, advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs (...) ) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following assessment under the abbreviated process semaglutide (Rybelsus®) is accepted for restricted use within NHSScotland. Indication under review: for the treatment of adults with insufficiently controlled type 2 diabetes mellitus to improve glycaemic control as an adjunct to diet and exercise ? As monotherapy when metformin is considered inappropriate due to intolerance or contraindications ? In combination with other

2020 Scottish Medicines Consortium

8. Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists: a systematic literature review and indirect treatment comparison Full Text available with Trip Pro

Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists: a systematic literature review and indirect treatment comparison Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists: a systematic literature review and indirect treatment comparison - PubMed This site needs JavaScript to work properly. Please enable (...) options Display options Format Share Permalink Copy Page navigation Diabetes Obes Metab Actions . 2020 Jul 6. doi: 10.1111/dom.14136. Online ahead of print. Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists: a systematic literature review and indirect treatment comparison , , , , , , , , Affiliations Expand Affiliations 1 Translational and Clinical Research Institute, Newcastle University, Newcastle upon

2020 EvidenceUpdates

9. Use of Factory-Calibrated Real-time Continuous Glucose Monitoring Improves Time in Target and HbA1c in a Multiethnic Cohort of Adolescents and Young Adults With Type 1 Diabetes: The MILLENNIAL Study

Use of Factory-Calibrated Real-time Continuous Glucose Monitoring Improves Time in Target and HbA1c in a Multiethnic Cohort of Adolescents and Young Adults With Type 1 Diabetes: The MILLENNIAL Study Use of Factory-Calibrated Real-time Continuous Glucose Monitoring Improves Time in Target and HbA 1c in a Multiethnic Cohort of Adolescents and Young Adults With Type 1 Diabetes: The MILLENNIAL Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Jul 28;dc200736. doi: 10.2337/dc20-0736. Online ahead of print. Use of Factory-Calibrated Real-time Continuous Glucose Monitoring Improves Time in Target and HbA 1c in a Multiethnic Cohort of Adolescents and Young Adults With Type 1 Diabetes: The MILLENNIAL Study , , , , , , , Affiliations Expand Affiliations 1 Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester, U.K. hood.thabit@mft.nhs.uk. 2 Division of Diabetes

2020 EvidenceUpdates

10. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial

Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial - PubMed This site needs JavaScript to work properly (...) Actions Cite Display options Display options Format Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Jul 21;dc192316. doi: 10.2337/dc19-2316. Online ahead of print. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial , , , , , , , , Affiliations Expand Affiliations 1 Dallas Diabetes Research Center at Medical City

2020 EvidenceUpdates

11. Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA) Full Text available with Trip Pro

Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Sep;43(9):2025-2033. doi: 10.2337/dc20-0408. Epub 2020 Jul 13. Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA) , , , , , , , , , , Affiliations Expand Affiliations 1 Steno Diabetes Center (...) of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA) Alexander S Christensen et al. Diabetes Care . 2020 Sep . Free PMC article Show details Display options Display options Format Diabetes Care Actions . 2020 Sep;43(9):2025-2033. doi: 10.2337/dc20-0408. Epub 2020 Jul 13. Authors , , , , , , , , , , Affiliations 1 Steno Diabetes Center Copenhagen, Gentofte

2020 EvidenceUpdates

12. Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study

Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Diabetes Care Actions . 2020 Aug 14;dc201104. doi: 10.2337/dc20-1104. Online ahead of print. Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study , , , , , , Affiliations Expand Affiliations 1 (...) . PMID: 32801130 DOI: Item in Clipboard Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study Louise A Donnelly et al. Diabetes Care . 2020 . Show details Display options Display options Format Diabetes Care Actions . 2020 Aug 14;dc201104. doi: 10.2337/dc20-1104. Online ahead of print. Authors , , , , , , Affiliations 1 Population Health & Genomics, School of Medicine, University of Dundee, Dundee, U.K. 2 Institute of Biomedical & Clinical Science, University of Exeter Medical

2020 EvidenceUpdates

13. Sotagliflozin added to optimised insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes: a pooled analysis of inTandem1 and inTandem2

Sotagliflozin added to optimised insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes: a pooled analysis of inTandem1 and inTandem2 Sotagliflozin added to optimised insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes: a pooled analysis of inTandem1 and inTandem2 - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History (...) Metab Actions . 2020 Jul 3. doi: 10.1111/dom.14127. Online ahead of print. Sotagliflozin added to optimised insulin therapy leads to HbA1c reduction without weight gain in adults with type 1 diabetes: a pooled analysis of inTandem1 and inTandem2 , , , , , , , Affiliations Expand Affiliations 1 Endocrine and Metabolic Consultants, Rockville, Maryland, USA. 2 Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. 3 Diabetes Centers of America-Dallas

2020 EvidenceUpdates

14. Time in Range for Multiple Technologies in Type 1 Diabetes: A Systematic Review and Network Meta-analysis

Time in Range for Multiple Technologies in Type 1 Diabetes: A Systematic Review and Network Meta-analysis Time in Range for Multiple Technologies in Type 1 Diabetes: A Systematic Review and Network Meta-analysis - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get the latest (...) ? Report format: Send at most: Send even when there aren't any new results Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Display options Display options Format Share Permalink Copy Page navigation Review Diabetes Care Actions . 2020 Aug;43(8):1967-1975. doi: 10.2337/dc19-1785. Time in Range for Multiple Technologies in Type 1 Diabetes

2020 EvidenceUpdates

15. Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020 American Diabetes Association's Standards of Medical Care in Diabetes Clinical Guideline. (Abstract)

Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020 American Diabetes Association's Standards of Medical Care in Diabetes Clinical Guideline. The American Diabetes Association (ADA) updates the Standards of Medical Care in Diabetes annually to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of diabetes.To develop the 2020 Standards, the ADA Professional (...) Practice Committee, comprising physicians, adult and pediatric endocrinologists, diabetes educators, registered dietitians, epidemiologists, pharmacists, and public health experts, continuously searched MEDLINE (English language only) from 15 October 2018 through August-September 2019 for pertinent studies, including high-quality trials that addressed pharmacologic management of type 2 diabetes. The committee selected and reviewed the studies, developed the recommendations, and solicited feedback from

2020 Annals of Internal Medicine

16. A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes. (Abstract)

A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes. A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes.In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, in a 3:1 ratio, children 6 to 13 years of age who had type 1 diabetes to receive treatment with the use of either a closed-loop system of insulin delivery (closed-loop group) or a sensor-augmented (...) that the system was in the closed-loop mode was 93% (interquartile range, 91 to 95). No episodes of diabetic ketoacidosis or severe hypoglycemia occurred in either group.In this 16-week trial involving children with type 1 diabetes, the glucose level was in the target range for a greater percentage of time with the use of a closed-loop system than with the use of a sensor-augmented insulin pump. (Funded by Tandem Diabetes Care and the National Institute of Diabetes and Digestive and Kidney Diseases

2020 NEJM

17. Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis. (Abstract)

Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis. Several pharmacologic options for type 2 diabetes are available.To compare benefits and harms of glucose-lowering drugs in adults with type 2 diabetes.Several databases from inception through 18 December 2019 and ClinicalTrials.gov on 10 April 2020.English-language randomized trials that had at least 24 weeks of intervention and assessed the effects of glucose-lowering drugs (...) in some estimates for patients at low cardiovascular risk.In diabetic patients at low cardiovascular risk, no treatment differs from placebo for vascular outcomes. In patients at increased cardiovascular risk receiving metformin-based background therapy, specific GLP-1 RAs and SGLT-2 inhibitors have a favorable effect on certain cardiovascular outcomes.European Foundation for the Study of Diabetes, supported by an unrestricted educational grant from AstraZeneca. (PROSPERO: CRD42019122043).

2020 Annals of Internal Medicine

18. Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

% of adult-onset diabetes is late-onset type 1 (101). These patients have an increased risk of diabetic ketoacidosis, and there are no CV outcomes trial data for patients with type 1 diabetes. Patients taking insulin or an insulin secretagogue (i.e., a sulfonylurea or glinide) should be advised of the risk of hypoglycemic events when adding an SGLT2 inhibitor for CV bene?t, especially if HbA1c is already well-controlled at baseline. In these patients, discontinuing or weaning the sulfonylurea or glinide (...) Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes EXPERT CONSENSUS DECISION PATHWAY 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes A Report of the American College of Cardiology Solution Set Oversight Committee Endorsed by the American Diabetes Association Writing Committee Sandeep R. Das, MD, MPH, FACC, Co-Chair Brendan M. Everett, MD, MPH, FACC, Co-Chair Kim K. Birtcher, PHARMD, MS

2020 American College of Cardiology

19. Mobile-Enhanced Peer Support for African Americans with Type 2 Diabetes: a Randomized Controlled Trial

Affiliations 1 Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. capresley@uabmc.edu. 2 Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 3 Cooper Green Mercy Health Services, Birmingham, AL, USA. PMID: 32700215 DOI: Item in Clipboard Mobile-Enhanced Peer Support for African Americans with Type 2 Diabetes: a Randomized Controlled Trial (...) -based DSME with and without peer support led to improved glycemic control. Peer support linked to clinical care led to a larger reduction in diabetes distress, which has important implications for the overall wellbeing of adults with type 2 diabetes. Keywords: diabetes self-management education; mobile health; peer support. Similar articles Tang TS, Funnell MM, Sinco B, Spencer MS, Heisler M. Tang TS, et al. Ann Fam Med. 2015 Aug;13 Suppl 1(Suppl 1):S27-35. doi: 10.1370/afm.1819. Ann Fam Med. 2015

2020 EvidenceUpdates

20. Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

Incretin in Diabetes (REWIND) trial. Methods: REWIND is a randomised, double-blind placebo-controlled trial at 371 sites in 24 countries. We included men and women (aged ≥50 years) with either established or newly diagnosed type 2 diabetes and additional cardiovascular risk factors, glycated haemoglobin of up to 9·5% (80 mmol/mol) on a maximum of two oral glucose-lowering drugs with or without basal insulin, and a body-mass index of at least 23 kg/m 2 . Participants were randomly assigned (1:1 (...) Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. Get

2020 EvidenceUpdates