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Latest & greatest articles for urinary tract infection
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use, patients should be thoroughly evaluated for the source of signs and symptoms before attributing them to the urinarytract. The presence of bacteria in the urine of catheterised patients is common and inevitable but ASB does not necessarily indicate presence of infection. 6 | Catheter-associated lower urinarytractinfection in women35 Management of suspected bacterial lower urinarytractinfection in adult women The following statements are reproduced, with permission, from The Infectious (...) Management of suspected bacterial lower urinarytractinfection in adult women Management of suspected bacterial lower urinarytractinfection in adult women A national clinical guideline September 2020 SIGN160Key to evidence statements and recommendations Levels of evidence 1 ++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 – Meta-analyses, systematic reviews
Urinarytractinfections in children. Urinarytractinfections (UTIs) in children are among the most common bacterial infections in childhood. They are equally common in boys and girls during the first year of life and become more common in girls after the first year of life. Dividing UTIs into three categories; febrile upper UTI (acute pyelonephritis), lower UTI (cystitis), and asymptomatic bacteriuria, is useful for numerous reasons, mainly because it helps to understand the pathophysiology (...) of the infection. A single episode of febrile UTI is often caused by a virulent Escherichia coli strain, whereas recurrent infections and asymptomatic bacteriuria commonly result from urinarytract malformations or bladder disturbances. Treatment of an upper UTI needs to be broad and last for 10 days, a lower UTI only needs to be treated for 3 days, often with a narrow-spectrum antibiotic, and asymptomatic bacteriuria is best left untreated. Investigations of atypical and recurrent episodes of febrile UTI
Recurrent Lower UrinaryTractInfections in Females Date of origin: 1995 Last review date: 2014 ACR Appropriateness Criteria ® 1 Recurrent Lower UTIs in Women American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Recurrent Lower UrinaryTractInfections in Women Variant 1: “Uncomplicated” with no underlying risk factors. Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without and with IV contrast 2 ???? X-ray abdomen 2 ?? CT abdomen and pelvis without (...) ; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Recurrent Lower UTIs in Women Clinical Condition: Recurrent Lower UrinaryTractInfections in Women Variant 2: “Complicated,” or patients who are nonresponders to conventional therapy, get frequent reinfections or relapses, and have known underlying risk factors. (See Appendix 1.) Radiologic Procedure Rating Comments RRL* CT abdomen and pelvis without and with IV contrast 7 CT urography protocol is preferred
Role of Vaccines for Recurrent UrinaryTractInfections: A Systematic Review. Recurrent urinarytractinfections (rUTIs) can be a difficult condition to treat, and the role of vaccines is unclear.To systematically review the role of vaccines in the treatment of rUTIs, looking at efficacy, adverse events, and discontinuation from treatment.We systematically reviewed the role of vaccines for rUTIs using the Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA (...) % to 13% across studies, and treatment withdrawal or exclusion due to adverse events was reported in 11 patients.Vaccines seem to have a short-term role in the prevention of recurrent urinarytractinfections with tolerable side effects. However, due to lack of uniformity of definitions and long-term follow-up, more work needs to be done with inclusion of other high-risk patient groups.In this study, we look at the role of vaccines for recurrent urinarytractinfections. We found that they seem
A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinarytractinfections. Urinarytractinfection (UTI) is caused by the invasion of the pathogen in the urinary system that can manifest as symptomatic or asymptomatic bacteriuria. This study was conducted to investigate antibiotic resistance patterns, and the correlation between biofilm formations with virulence (...) factors in uropathogenic E. coli isolates retrieved from UTI. We searched Scopus and Google Scholar, PubMed, Web of sciences for studies published in the English language between 1st 2005 to 31st December 2019. The Mesh terms and text words included "biofilms", OR "biofilm formation", AND "antibiotic resistance", OR "drug-resistance", OR "antimicrobial drug resistance", AND "urinarytractinfections", OR "UTI", AND "biofilm related-genes", AND "virulence factors" AND "correlation", AND "Uropathogenic
Prevalence of Bladder and Bowel Dysfunction in Toilet-Trained Children With UrinaryTractInfection and/or Primary Vesicoureteral Reflux: A Systematic Review and Meta-Analysis. Introduction: Urinarytractinfection (UTI) in children leads to renal scarring in 10-15% of patients. Urinarytract anomalies and bladder and bowel dysfunction (BBD) are documented risk factors for recurrent UTIs. Estimates of baseline prevalence of BBD in children with UTI will help the clinician in the management
The effectiveness of nurse-led interventions for preventing urinarytractinfections in older adults in residential aged care facilities: A systematic review. To explore the effectiveness of nurse-led interventions to prevent urinarytractinfections in older adults living in residential aged care facilities.While most empirical studies focus on the treatment of urinarytractinfections, few studies have examined the effectiveness of nurse-led interventions in preventing urinarytract (...) infections.Systematic review.Eight electronic databases were searched for relevant studies published between 2008-2018. The inclusion criteria were as follows: (a) a focus on older adults, (b) evaluation of nurse-led interventions, focusing on prevention of urinarytractinfection, (c) implemented in residential aged care facilities, and (d) outcomes reported as incidence or prevalence of urinarytractinfection. The selected papers were critically appraised using the Mixed Methods Appraisal Tool. The data were
Bacterial meningitis in febrile young infants acutely assessed for presumed urinarytractinfection: a systematic review. Urinarytractinfections, the most common severe bacterial infections in young infants, may be associated with co-existing meningitis. There is no consensus on when to perform a lumbar puncture in these infants. Our aim was to quantify the frequency of co-existing bacterial meningitis in febrile young infants acutely assessed for presumed urinarytractinfections. We (...) systematically reviewed PubMed, EMBASE, and the Cochrane Library for studies including infants ≤ 3 months with suspected/confirmed urinarytractinfections, who underwent a lumbar puncture. Two investigators independently reviewed articles for inclusion and extracted relevant data. Our outcomes were culture-confirmed meningitis and identification of low-/high-risk criteria of meningitis. Overall 20/2079 studies, including 4191 infants, met inclusion criteria. A total of 11 infants had bacterial meningitis
Is Non-Steroidal Anti-Inflammatory Therapy Non-Inferior to Antibiotic Therapy in Uncomplicated UrinaryTractInfections: a Systematic Review. Amid growing antimicrobial resistance, there is an increasing focus on antibiotic stewardship efforts to reduce inappropriate antibiotic prescribing. In this context, novel approaches for treating infections without antibiotics are being explored. One such strategy is the use of non-steroidal anti-inflammatory drugs (NSAIDs) for uncomplicated urinary (...) tractinfections (UTIs). Therefore, we conducted a systematic review of randomized controlled trials to evaluate the rates of symptom resolution and infectious complications in adult women with uncomplicated UTIs treated with antibiotics versus NSAIDs.We systematically searched PubMed, CINHAL, Scopus, Web of Science Core Collection, EMBASE, and ClinicalTrials.gov from inception until January 13, 2020, for randomized controlled trials comparing NSAIDs with antibiotics for treatment of uncomplicated
The effect of bladder catheterization on the incidence of urinarytractinfection in laboring women with epidural analgesia: a meta-analysis of randomized controlled trials. There is conflicting evidence on whether intermittent catheterization (IC) is less associated with urinarytractinfection (UTI) and more likely to prevent urinary retention than continuous catheterization (CC). We aimed to compare the effect of IC with that of CC on the incidence of postpartum UTI, urinary retention (...) ) were included in this review. The meta-analyses indicated that there was no significant difference between the IC and CC group in the incidence of postpartum UTI (RR = 1.25, 95% CI: 0.91 to 1.71, P = 0.16), postpartum urinary retention (RR = 0.76, 95% CI: 0.21 to 2.77, P = 0.68) and postpartum hemorrhage (RR = 1.72, 95% CI: 0.60 to 4.95, P = 0.31). GRADE assessment results showed that the quality of evidence was low.Based on the available evidence, there is no measurable difference in rates of UTI
The impact of catheter-based bladder drainage method on urinarytractinfection risk in spinal cord injury and neurogenic bladder: A systematic review. To systematically compare the impact of catheter-based bladder drainage methods on the rate of urinarytractinfections (UTIs) amongst patients with neurogenic bladder.A search of Cochrane Library, Embase, Medline, and Grey literature to February 2019 was performed using methods prepublished on PROSPERO. Reporting followed the Preferred
[Relative frequency of urinarytractinfections in patients affected by diabetes mellitus type 2 treated with metformin and SGLT2 inhibitor. Introduction and aim: The of this research was to conduct a network meta-analysis based on a systematic literature search to compare the relative frequency of urinarytractinfections using sodium-glucose cotransporter-2 (SGLT2) inhibitors combined with metformin in the therapy of type 2 diabetes. Method: MEDLINE and EMBASE databases were searched (...) to identify publications of randomized, controlled trials investigating SGLT2 inhibitors combined with metformin in the therapy of type 2 diabetes and providing information on the frequency of urinarytractinfections. Results: 10 165 unique citations were screened to identify 10 publications to be included in the network meta-analysis. The network meta-analysis showed reduced risk of urinarytractinfections for low-dose ertugliflozin compared to other SGLT2 inhibitors (ertugliflozin 5 mg vs
Urinarytractinfection in children with nephrotic syndrome: A systematic review and meta-analysis. Urinarytractinfection (UTI) is among the most common infection diseases in children with nephrotic syndrome (NS), resulting in treatment failure and relapse. No systematic reviews have estimated the prevalence of UTI in children with NS on a global scale, therefore, did the first systematic review and meta-analysis study to estimate the prevalence of UTI in children with NS in different
Antibiotics and Cure Rates in Childhood Febrile UrinaryTractInfections in Clinical Trials: A Systematic Review and Meta-analysis. Urinarytractinfections (UTIs) are common bacterial infections among children.To systematically review the antimicrobials used for febrile UTIs in paediatric clinical trials and meta-analyse the observed cure rates and reasons for treatment failure.We searched Medline, Embase and Cochrane central databases between January 1, 1990, and November 24, 2016, combining (...) MeSH and free-text terms for: "urinarytractinfections", AND "therapeutics", AND "clinical trials" in children (age range 0-18 years). Two independent reviewers assessed study quality and performed data extraction. The major outcome measures were clinical and microbiological cure rates according to different antibiotics.We identified 2762 published studies and included 30 clinical trials investigating 3913 cases of paediatric febrile urinarytractinfections. Children with no underlying condition
Fosfomycin Trometamol versus Comparator Antibiotics for the Treatment of Acute Uncomplicated UrinaryTractInfections in Women: A Systematic Review and Meta-Analysis. We performed a systematic review and meta-analysis to compare the effectiveness and safety profile of fosfomycin vs comparator antibiotics in women with acute uncomplicated cystitis.Relevant databases were searched using methods recommended by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis
Increased fluid intake to prevent urinarytractinfections: systematic review and meta-analysis. Approximately 15% of community-prescribed antibiotics are used in treating urinarytractinfections (UTIs). Increase in antibiotic resistance necessitates considering alternatives.To assess the impact of increased fluid intake in individuals at risk for UTIs, for impact on UTI recurrence (primary outcome), antimicrobial use, and UTI symptoms (secondary outcomes).A systematic review.The authors
The incidence of urinarytractinfection of different routes of catheterization following gynecologic surgery: a systematic review and meta-analysis of randomized controlled trials. We performed a systematic review of randomized controlled trials to assess the incidence of urinarytractinfection (UTI) and complications of different urinary drainage methods (indwelling urinary catheterization, suprapubic catheterization, and intermittent catheterization.).PubMed, EMBASE, and Cochrane Library (...) were systematically searched from their inception to March 2018. We selected randomized controlled trials (RCTs) comparing at least two of the three possible urinary drainage routes after gynecologic surgery. A meta-analysis was performed using the RevMan software, and a random-effects model was used to pool the effect size. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to rate the quality of evidence.Fifteen RCTs met eligibility criteria (N = 1607
Outcome of Different Approaches to Reduce UrinaryTractInfection in Patients with Spinal Cord Lesions: A Systematic Review. Neurogenic bladder disorders are common among patients with spinal cord lesions, which often result in upper and lower urinarytract complications. Urinarytractinfection (UTI) has remained the most frequent type of infection in this population. Our aim is to review systematically the literature on the outcome of different intervention methods to reduce UTI incidence
Association of Toll-like 4 receptor gene polymorphism (rs4986790, rs4986791) with the risk of urinarytractinfection: A systematic review and meta-analysis. Recently published studies had shown that there may be a potential link between the Single nucleotide polymorphism (SNP) of Toll-like receptor-4 (TLR4), and the risk of urinarytractinfection (UTI); however, no consensus was reached. To further understand the relationship between TLR SNPs and urinarytractinfections, we searched (...) for related studies published in PubMed, EMBASE, and Web of Science before October 30, 2018, for further systematic review and meta-analysis. Our study accrued 10 case-control studies, which included 1476 urinarytractinfection patients and 1449 healthy controls in TLR4(rs4986790, rs4986791). R3.4.2 and Stata 15.0 software were used for the analysis. In general, there was no statistically significant association between rs4986790 and urinarytractinfection in the four genetic models. However